ライフサイエンスコーパス: silencing

1 ible for histone H2A ubiquitination and gene silencing.

2 n the Drosophila heart using RNAi-based gene silencing.

3 ls of the E2(WT) protein occurred upon ChlR1 silencing.

4 but not HRDE-1, for small RNA-dependent gene silencing.

5 to initiate small-RNA-induced heritable gene silencing.

6 with function of the PRC1 in epigenetic gene silencing.

7 ase ROS1 is also required for d35S::LUC anti-silencing.

8 (H3K27me3) is implicated in epigenetic gene silencing.

9 essential to ensure prompt and efficient SAC silencing.

10 ate-limiting factors for miRNA-mediated gene silencing.

11 yte contractility, which was rescued by CD36 silencing.

12 ation are not sufficient to cause release of silencing.

13 3 currents were observed upon STIM1 or TRPC1 silencing.

14 dissection of MCC generation and checkpoint silencing.

15 n specific transcriptional cascades and gene silencing.

16 with or without SIRT3 enforced expression or silencing.

17 es, features characteristic of mitochondrial silencing.

18 c activation of MAPK signaling by epigenetic silencing.

19 oteins whose mutations also caused d35S::LUC silencing.

20 omic CRISPR arrays for use in future invader silencing.

21 liferation could be partially rescued by p21 silencing.

22 microRNA-guided Argonaute 1 complex and gene silencing.

23 uction, DNA methylation, and transcriptional silencing.

24 RIP13 promote MCC disassembly and checkpoint silencing.

25 ss, HDAC activity contributed to stable gene silencing.

26 lly inherited in cis, leading to stable gene silencing.

27 higher affinity continually led to stronger silencing.

28 he sequence, restored strong miR159-mediated silencing.

29 trimethylation (H3K9me3) for transcriptional silencing.

30 tain acetylated H3K14ac and H3K27ac for ASS1 silencing.

31 eters as means to reduce heritable transgene silencing.

32 triggers, which together result in HBV gene silencing.

33 We demonstrated marked though distinct anti-silencing activity in the pluripotent state and during P

34 K27me3 predominantly at promoters, where its silencing activity is well documented.

35 oy activity and seed sequence-dependent gene silencing activity.

36 Importantly, silencing AL L5 feedback reduced visual responses of V1

37 Gene silencing also revealed that Snail enhanced the permeabi

38 nsporter gene revealed that in vitro SLC16A5-silencing altered cellular responses to cisplatin treatm

39 nhibition of pluripotency factors since LKB1-silencing and AMPK-inhibition abrogated, while LKB1-over

40 contains a functional RNA duplex with paired silencing and carrier sequences stabilized by a miR-30 s

41 ese regulatory elements, resulting in AMIGO2 silencing and changes in PTK7 proteolytic processing.

42 uctures that accommodate transcription, gene silencing and DNA replication.

43 Rapid optogenetic silencing and electrical stimulation indicated that shor

44 This was confirmed by specific LCK gene silencing and ex vivo combined treatment of cells from P

45 Using a combination of protein silencing and forced expression of wild-type/constitutiv

46 s, where DNA methylation associates with the silencing and inaccessibility at promoters.

47 ract antiviral responses, including the gene-silencing and innate immunity machineries.

48 on involve the use of viral vectors prone to silencing and insertional mutagenesis or the use of nonh

49 tion in mobile genetic element (transposons) silencing and maintenance of genome integrity.

50 siRNA inheritance but is required for target silencing and maintenance of siRNA-dependent chromatin o

51 A biogenesis but is essential for transposon silencing and male fertility.

52 mice and short hairpin RNA (shRNA)-mediated silencing and miR-155 transfection approaches, we found

53 Small interfering RNA-mediated PPARalpha silencing and PPARalpha blockade by the antagonist GW647

54 e Mason-Pfizer monkey virus can override the silencing and promote transcription of chimeric proviral

55 ficiency results in impaired transcriptional silencing and repair of DSBs by homologous recombination

56 a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline g

57 on, this change was not associated with gene silencing and was essentially absent in AMLs with DNMT3A

58 sum of Ca(2+) stabilizing (Ca(2+) signalling silencing) and Ca(2+) destabilizing (arrhythmogenic unst

59 A combination of phylogenetic analyses, gene silencing, and biochemical analyses coupled with structu

60 ivity of MORC2 is critical for HUSH-mediated silencing, and the most common alteration affecting the

61 e accession, Pla-1, lacked both symptoms and silencing, and was immune to wild-type infectious clones

62 YDROGENASE1 (CAD1) by a hairpin-RNA-mediated silencing approach, which resulted in only 5% residual C

63 These features of Ca(2+) signalling silencing are distinct and in contrast to the changes at

64 lysis showed that genes affected by TRAF3IP2 silencing are involved in epidermal differentiation, wit

65 mechanisms underlying opposition to Polycomb silencing are poorly understood.

66 and the potential for targeted chemogenetic silencing as a new treatment modality in neuropathic pai

67 ld type does not result in the same level of silencing as direct transformation into the wild type.

68 While ECs can take up asparagine, silencing asparagine synthetase (ASNS, which converts gl

69 red histone modifications implicated in gene silencing associate with aberrant autoantigen expression

70 lants, as a factor promoting transcriptional silencing at the transgenic RD29A promoter.

71 Arabidopsis SAC3B dysfunction causes gene silencing at transgenic and endogenous loci, accompanied

72 HIV MDSC overexpressed B7-H4 and silencing B7-H4 increased the production of IL-2 and IFN

73 Silencing beta1 integrin efficiently inhibited RCP-induc

74 Silencing BmAce1 impacted motor control and development

75 Silencing BmAce2 resulted in about 26% mortality, faster

76 rol and development to a greater extent than silencing BmAce2, although both treatment groups suffere

77 Gene silencing by Polycomb complexes is central to eukaryotic

78 Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpr

79 Thus, silencing calcium waves in the auditory thalamus induces

80 Silencing CeAL CRF projections in the BNSTDL during cont

81 chromatin binding proteins involved in gene silencing, chromosome packaging, and chromosome segregat

82 coded by let-7 target mRNAs, were reduced by silencing CircPVT1.

83 Silencing CNOT3 in colorectal cancer cells resulted in r

84 hase revealed that small RNA (sRNA)-mediated silencing, combined with the use of repetitive regulator

85 chanisms also collaborate with miRNA-induced silencing complex (miRISC) to support robust gene expres

86 RNA-induced silencing complex (RISC) is composed of miRNAs and AGO p

87 ranscripts to be degraded by the RNA-induced silencing complex (RISC).

88 el interaction between the major RNA-induced silencing complex component Argounaute-2 (Ago2) and the

89 lex genes (an ovarian steroid-regulated gene silencing complex) in untreated LCLs from women with PMD

90 ed forms that may associate with RNA-induced silencing complexes (RISC).

91 nterneurons, suggesting that their sustained silencing could be causally involved in the development

92 Silencing CSN or desmosome components shifts the balance

93 Silencing CYLD in hippocampal neurons abolishes NMDA-ind

94 PHD3 silencing decreased hypoxic activation of HIF-1alpha C-t

95 Silencing did not require H3K9me3 or DNA methylation.

96 egulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiqu

97 Egr-1 silencing does not affect levels of cyclin-dependent pro

98 Somatic silencing does not require somatic nuclear RNAi but inst

99 SIR complex-mediated de novo heterochromatic silencing due to the presence of antagonistic histone po

100 nherent danger in cells that lose epigenetic silencing during developmental reprogramming.

101 he A2UCOE is conferred, and whether the anti-silencing effect from the A2UCOE is confined within a co

102 within a core region, we evaluated the anti-silencing effect of different sub-domains.

103 These results demonstrate that Twist1's silencing effect on Foxa1 expression is largely responsi

104 miRNA provides the specificity to guide the silencing effector Argonaute (AGO) protein to target mRN

105 ould fully explain the discrepancy of miR159 silencing efficacy.

106 NA structure in MYB33 correlated with strong silencing efficacy; introducing mutations to disrupt eit

107 A-complexed NPs exhibited excellent GFP gene silencing efficiency in GFP-MDA-MB-468 TNBC cells withou

108 opose an alternative therapeutic strategy of silencing either of the PKM isoforms along with AMPK in

109 Notably, these silencing events often occur within introns of transcrip

110 Gene silencing experiments targeting alpha1D reduced the migr

111 (MAPK)-dependent phosphorylation of the RNA-silencing factor HIV TAR-RNA-binding protein (TRBP) prom

112 m of translation suppression by the ribosome-silencing factors.

113 siRNA-L2 facilitated significant tumor gene silencing for 7 d after two i.v. doses.

114 ve highlighted great challenges of transgene silencing for transgenic plants facing climate change.

115 rom different mechanisms to the overall anti-silencing function of the CBX3 element.

116 ncies, explaining their different downstream silencing functions.

117 tumors overexpressing GCS, but reduced after silencing GCS expression or inhibiting this enzyme.

118 We use gene silencing, gene expression analysis, genetic mapping and

119 Conversely, EVI1 silencing had no effect on constitutive ERK activity in

120 While Hey2 silencing has no effect on radiation-induced EndoMT in v

121 litates SREBP-1 processing in WT mice, while silencing hepatic Osbpl3 reverses the lipogenic phenotyp

122 Silencing Hs-Tyr by RNA interference made the treated ne

123 Ezh2 activates Id3 while silencing Id2, Prdm1 and Eomes, promoting the expansion

124 fers anti-apoptotic attributes.NF-kappaB p65 silencing identified that these proteins induce TREM-1 i

125 escent protein (GFP)-reported, RNAi-mediated silencing in a HepG2/GFP-shRNA RNAi sensor line.

126 Fetuin-A (FetA) were conducted by using gene silencing in a mouse asthma model, human dendritic cell

127 Accordingly, tensin silencing in AMPK-depleted fibroblasts impedes enhanced

128 HMGB1 silencing in cord blood ECFC-derived cells confirmed its

129 tal liver lysates demonstrated developmental silencing in IGF2BP1.

130 TREM-1 silencing in macrophages exposed to HIV-related proteins

131 ed to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed

132 e with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia

133 siRNA-mediated LPP silencing in ovarian tumor-bearing mice improved paclita

134 ltration and oxidative stress, whereas TRPA1 silencing in Schwann cells reduced both allodynia and ne

135 rgonaute-2 in-vitro, as well as the enhanced silencing in the context of the trivalent N-acetylgalact

136 nd invasion of ovarian cancer cells, whereas silencing in vivo inhibits tumour growth, increases cisp

137 quirements that mirror yeast epigenetic gene silencing in vivo.

138 mouse brains, we demonstrated that LRP1 gene silencing increases expression of proinflammatory mediat

139 SOCS1 silencing inhibited cell migration and invasion as well

140 ASXL3 silencing inhibited proliferation, clonogenicity, and te

141 Despite this evidence of "silencing", intracellular free calcium imaging showed th

142 Calcium signalling silencing is a part of the mechanisms that contribute to

143 of different tissues and virus-induced gene silencing is an efficient way to identify host proteins

144 We previously demonstrated that ASS1 silencing is controlled by HIF-1alpha and Arg starvation

145 We find that silencing is dependent on germline nuclear RNAi factors

146 How target silencing is maintained in subsequent generations is poo

147 lecular basis of transgene susceptibility to silencing is poorly characterized in plants; thus, we ev

148 We found that identity-based silencing is targeted by 21- to 22-nucleotide or 24-nucl

149 Using gene silencing it was demonstrated that Snail positively regu

150 Moreover, silencing Kenyon cells decreases the normal chronic acti

151 bute to the pathogenesis of cancer either by silencing key tumor suppressor genes or by activating on

152 Conversely, JMJD2B silencing led to an enhancement of the DNA-damage driven

153 The higher levels of 18:3n-3 in DGAT1-silencing lines are likely due to the compensatory activ

154 Silencing LZK reduced cell viability and proliferation o

155 s an evolutionarily widespread and versatile silencing mechanism that plays an important role in vari

156 apping and simultaneous function of multiple silencing mechanisms has obscured this area of investiga

157 ts of eukaryotic life, primarily through RNA silencing mechanisms.

158 In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evo

159 Silencing MICU1 in vitro increases oxygen consumption, d

160 evels of MKP-1 and PARP-1 proteins, and that silencing MKP-1 or PARP-1 increased cisplatin sensitivit

161 Silencing MKP-1 promoted PARP-1 ubiquitination, which de

162 een DNA methylation, a model epigenetic gene silencing modification, and autoantigen gene expression

163 Interestingly, Rbfox1 silencing modulates the splicing of the actin-remodeling

164 Silencing MYC expression phenocopied the CSC depletion e

165 These elements drive the translational silencing of a group of chemokine (CC/CXC) and chemokine

166 This study demonstrates that RNAi silencing of a member of the Bone Morphogenetic Protein

167 ion at goal locations to trigger optogenetic silencing of a subset of CA1 pyramidal neurons.

168 Consistent with data in the murine context, silencing of AID in human bone marrow cells skews differ

169 Conversely, silencing of ARHGAP21 enhanced Cdc42 activation and resc

170 elements, led to aggressive transposon-like silencing of canola-biased PUFA synthase transgenes.

171 Acute silencing of caspase-2 in cultured human cells recapitul

172 Silencing of CH-42, encoding a protein needed to make ch

173 In vivo silencing of CLIP170 in C57BL/6 mice by CLIP170-specific

174 siRNA mediated silencing of Cofilin/ADF provokes striking nuclear defec

175 e the activation of target cell programs and silencing of donor cell programs.

176 d heat, and this modulation was abolished by silencing of dry-air receptors.

177 esiRNA silencing of each component suggest that Smad3 and EZH2

178 Under the silencing of either PAP1 or PAP2, the level of snoRNAs i

179 rotein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repre

180 Finally, optogenetic silencing of existing DGCs during novel environmental ex

181 Further, the silencing of functional HvCERK1 gene in the resistant ge

182 Expression of PsAvh23 or silencing of GmADA2/GmGCN5 resulted in misregulation of

183 monstrate that the acute, cell type-specific silencing of HA neurons during wakefulness is sufficient

184 ctivation was responsible for mediating gene silencing of IL-27p28 and EBV-induced gene 3.

185 RNAi-mediated gene silencing of il17a in fibrotic mice arrested the progres

186 lect role of BRD4S-BRG1 complexes in genomic silencing of invasive retroelements.

187 Here, we demonstrate that gene silencing of KIND1 decreased keratinocyte proliferation

188 We demonstrate that premature silencing of LINE-1 elements decreases chromatin accessi

189 s (CXCL1, CXCL2, CCL3, CCL4, IL6, and CSF3), silencing of major inflammatory intracellular signaling

190 Silencing of Malat1 by Malat1 GapmeR significantly incre

191 CRISPR/Cas9-mediated deletion or silencing of MANTIS with small interfering RNAs or Gapme

192 A knockout, an antagonist, or a local silencing of MKP-1 attenuates depressive-like behaviors,

193 We specifically demonstrate the presence and silencing of MYC, JUN, and SOX2 mRNAs by miR-24 and miR-

194 In vitro, silencing of Nox5 in human mesangial cells was associate

195 ccRCC harboring epigenetic silencing of NSD1 displayed a specific genome-wide methy

196 4-deficient lung fibroblasts is inhibited by silencing of nuclear factor erythroid-derived 2-like 2 (

197 I channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake.

198 In end-stage mesothelioma, silencing of p16/Ink4a is sustained and deletion of p19/

199 Small interfering RNA-mediated silencing of parathyroid hormone 2 receptor (PTH2R), the

200 o play a key role in transmitting epigenetic silencing of PcG targets by linking PRC1 to formation of

201 Silencing of PECAM-1 or key ER stress genes abrogated SS

202 Finally, silencing of PFKFB4-induced apoptosis in p53-deficient c

203 l activity of PKR appears to be complete, as silencing of PKR expression has no impact on viral propa

204 ssion of TRPM2 mutant channel (C1008-->A) or silencing of poly ADP-ribose polymerase in ECs of mice p

205 In RPE19 cells, silencing of PrP(C) decreases ferritin while over-expres

206 In contrast to permanent silencing of PV neurons, transient inhibition of GABA re

207 Silencing of Rab5 shifts receptor-triggered secretion fr

208 Finally, we show that epigenetic silencing of RAD51C and BRCA1 by promoter methylation is

209 found in a subset of glioblastoma (GBM) and silencing of RanBP6 promoted glioma growth in vivo.

210 rmine the mechanism for activation-dependent silencing of Rgs10 expression in microglia.

211 Inhibition or silencing of ROCK1 was sufficient to rescue keratinocyte

212 were observed after transient shRNA-mediated silencing of Rps19, but not several other tested ribosom

213 diated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arre

214 The silencing of SALL4 in cancer cells decreased the express

215 gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiesce

216 alling pathway is repressed by Myt1l through silencing of several members, including Hes1.

217 RNAi-mediated silencing of SLC13A5 expression in two human hepatoma ce

218 ase-2 (SHP-2), and SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells

219 ntified as a target gene of miR-199a-3p, and silencing of SOCS7 promoted STAT3 activation.

220 e used to treat disease caused by epigenetic silencing of specific loci.

221 Consistently, silencing of Stat3 in tumors reduced Jab1/Csn5 expressio

222 -early gene expression and produced a robust silencing of STN neurons as measured using whole-cell re

223 In vivo silencing of the FETUA gene in BALB/c mice results in a

224 Silencing of the HLA class-I APM is due to histone deace

225 rments proved to be decisive in vivo because silencing of the INSR attenuated clinical symptoms in an

226 Here we show that in rats, genetic silencing of the largest population of brainstem vagal p

227 Finally, the selective chemogenetic silencing of the LH-to-LHb pathway impairs aversion-driv

228 ulted in potent, dose-dependent, and durable silencing of the mRNA encoding glycolate oxidase and inc

229 In vitro silencing of the novel AKT3 variant resulted in signific

230 by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via tra

231 uired for improved load-bearing capacity and silencing of the spindle assembly checkpoint.

232 Here, we show that the optogenetic silencing of the VH prevented the recall of contextual f

233 Consistent with this model, silencing of TNFalpha and MEKK4 dramatically reduces cys

234 ivity and subsequently refined by epigenetic silencing of transcripts associated with memory lymphocy

235 ecture, DNA repair and genome stability, and silencing of transposon and gene expression.

236 We show that silencing of transposons in the pericentromeric heteroch

237 ciate with PiwiL2, a protein involved in the silencing of transposons.

238 Silencing of TTP in endometriotic and endometrial epithe

239 or of host defenses consisting of RNAi-based silencing of viral genes.

240 l changes observed following transcriptional silencing of wag31 in M. tuberculosis.

241 Silencing of XPO1 by either shRNA or selinexor significa

242 tion with HSA did not hinder the activity of silencing oligonucleotides inside cells, and the degrada

243 Silencing or acute inhibition of the formin mDia1 suppre

244 mMSCs was carried out in vitro through gene silencing or chemical inhibition of key components.

245 Interestingly, gene silencing or editing experiments revealed that SNAT7 is

246 dulate MCT1-dependent cancer cell migration, silencing or genetic deletion of MCT1 in vivo inhibited

247 We found that silencing or genetic knockout of INPP5E in human and mur

248 Here, we report that silencing or inhibition of endogenous TAK1 in hepatoma c

249 thine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses PDA.

250 formation, irrespective of HIF-1 Conversely, silencing or pharmacologic inhibition of LOX activity bl

251 he mechanisms that activate some genes while silencing others are critical to ensure precision in lin

252 50 nM or 100 nM siRNA, showed high levels of silencing, particularly in primary airway epithelial cel

253 -NS is a NAP that also plays a major role in silencing pathogen genes.

254 ences suggest that various components of RNA silencing pathway are involved in plant defense machiner

255 ng how interdependent targeting of different silencing pathways can potentiate the establishment of o

256 different lengths of the early intermittent silencing phase that largely determine their final life

257 In summary, we demonstrated that silencing PLK2 attenuates HDG-induced podocyte apoptosis

258 (mean change in firing rate: -8.0%), whereas silencing PM L5 feedback suppressed responses of high-SF

259 Silencing PnMYB134, on the other hand, decreased flavan-

260 Some features of Ca(2+) signalling silencing prevail in human AF suggesting that the Ca(2+)

261 Furthermore, Cdc42 silencing prevented HuR-mediated stimulation of cell mig

262 omatic and heterochromatic lncRNA-based gene silencing processes.

263 Upon PARP inhibition, ACLY silencing promotes genomic instability and cell death.

264 ith Ulp2 and one of its substrates, the rDNA silencing protein Tof2, through adjacent conserved inter

265 man body contains a set of programmable gene-silencing proteins named Argonaute.

266 Silencing PV+ interneurons of the NAc selectively inhibi

267 E-cadherin silencing relies on the formation of a complex between t

268 Gene silencing revealed that NaJAZi functions as a flower-spe

269 Gene silencing revealed that STAT4 was required for IL-6 tran

270 -wall muscles or hypodermis, however, enable silencing selectively in the rescued tissue but not in o

271 vidence that small RNAs embody the inherited silencing signal.

272 kinase genes assayed, we discovered 79 whose silencing significantly affected cryptococcal engulfment

273 aviors and stress calls, whereas optogenetic silencing specifically reduced facial nociception.

274 This was confirmed by silencing STAT3 in macrophages.

275 Silencing studies show that the RhoGEF Trio is crucial f

276 dy characterizing the affinity dependence of silencing suggests that siRNA-carrier affinity can signi

277 Nox4 silencing suppressed LPS-induced TNF-alpha and PCNA incr

278 vo Since the TCV CP also serves as the viral silencing suppressor, early translation of the CP from t

279 In this article, we report that silencing the INSR in inducible knockdown rats impairs s

280 These defects can be corrected by silencing the mitochondrial calcium uniporter (MCU).

281 tects neurons from excitotoxic cell death by silencing them.

282 Silencing thioredoxin-interacting protein abrogated reac

283 e we demonstrate that ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved

284 emory is then converted to stable epigenetic silencing through separate Polycomb factors, which sprea

285 MO-dependent control of ribosomal DNA (rDNA) silencing through the opposing actions of a STUbL (Slx5:

286 ethylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DN

287 Finally, we show that NOX4 silencing, through PKM2, sensitizes cultured and ex vivo

288 ncreased binding of the repressor factor RE1-silencing transcription (also known as neuron-restrictiv

289 RE1 silencing transcription factor (REST) is a transcription

290 ay and that it maintains genome integrity by silencing transposons.

291 This is surprising, as defective gene silencing underlies developmental abnormalities and dise

292 Virus-induced gene silencing (VIGS) and transient expression of Phytophthor

293 Through virus-induced gene silencing (VIGS) in a related crop species, maize (Zea m

294 Virus-induced gene silencing (VIGS) is used extensively for gene function s

295 rming protein Perfringolysin O (PFO), potent silencing was achieved in vitro with no detectable cytot

296 were validated in vivo by evidence that LZK silencing was sufficient to reduce tumor growth in a xen

297 of factors in initiating PIWI-directed gene silencing, we employed a Piwi-interacting RNA (piRNA)-ta

298 To identify genes involved in MeCP2 silencing, we screened a library of 60,000 shRNAs using

299 akes DNA contacts that are required for gene silencing, while chromosome compaction does not appear t

300 ctivation as well as the maintenance of gene silencing, while H2AX is important in DNA damage repair.