ライフサイエンスコーパス: silencing effect

1 nt upstream sequences revealed no detectable silencing effect.

2 sing cell line resulted in abrogation of the silencing effect.

3 entiation, partially alleviated the enhancer-silencing effect.

4 3' element completely abolished the enhancer-silencing effect.

5 tion observed in the parent ASO at a similar silencing effect.

6 duced REST nuclear accumulation and its gene-silencing effects.

7 ress on in vivo imaging of RNAi delivery and silencing effects.

8 pisomes, whereas the scs insulator displayed silencing effects.

9 erate in terms of miR loading and downstream silencing effects.

10 associated repressor complex, abolishing its silencing effect and resulting in the up-regulation of g

11 Furthermore, this eNOS silencing effect appeared to be reversible under the sti

12 Heritable silencing effects are gene suppression phenomena that ca

13 Gene-silencing effects are progressively enhanced with increa

14 ncing can result in significant 'off-target' silencing effects as demonstrated by the reduction of mu

15 Hek2p at a subtelomeric region and HMR, its silencing effects at these loci are likely direct.

16 displays comparable cellular uptake and gene silencing effect but less cytotoxicity compared with bra

17 GPNA confers its silencing effect by blocking protein translation.

18 We used Xenopus oocytes to compare silencing effected by the thyroid hormone receptor (TR)

19 from the Polycomb response elements, and the silencing effect can be blocked by the gypsy insulator.

20 Silencing effects can be triggered by nuclear transgenes

21 , and this promoter is susceptible to a gene silencing effect caused by the upstream segment (1-60) o

22 nsive analysis revealed that the GAA-induced silencing effect does not influence expression of neighb

23 omoter was unable to counter local chromatin silencing effects, each of the 6 highly conserved Ikzf1

24 he A2UCOE is conferred, and whether the anti-silencing effect from the A2UCOE is confined within a co

25 PPAA-g-PAO copolymers enhance antisense gene silencing effects in A2780 human ovarian cancer cells.

26 Lead material cKK-E12 showed potent silencing effects in mice (ED50 approximately 0.002 mg/k

27 We show that the silencing effect is mediated through the nascent mRNA, f

28 nd exogenous reporters demonstrates that the silencing effect is specific for the target gene contain

29 Gene expression analysis revealed the silencing effect is specific to the aflatoxin gene clust

30 We show here that the viRNA-mediated viral silencing effect is transmitted in a non-Mendelian manne

31 Here we report on off-target gene silencing effects observed in a large-scale knockdown ex

32 This silencing effect occurred as a result of APOB mRNA cleav

33 The anti-silencing effect of a targeted HAT is strengthened by in

34 er physiological conditions to reinforce the silencing effect of AtMYB4 at high activity.

35 Moreover, the anti-silencing effect of CBX3 was locally restricted and when

36 within a core region, we evaluated the anti-silencing effect of different sub-domains.

37 The anti-silencing effect of Gcn5p is abolished by a mutation tha

38 also indicated that Arn counteracts the gene-silencing effect of H-NS on a reporter gene.

39 The silencing effect of hsa-miR-877 was further demonstrated

40 To demonstrate the silencing effect of hypermethylation, we selected the EA

41 ue using mutated CXCR1 plasmids reversed the silencing effect of PLK2, thus demonstrating the specifi

42 We investigated the in vivo silencing effect of small interfering RNA (siRNA) duplex

43 This could be the result of a silencing effect of the methylated maternal ICR.

44 re, the epigenetic basis underlying the anti-silencing effect of the UCOE on juxtaposed promoters has

45 The silencing effect of this motif is also observed after bo

46 as a barrier, protecting transgenes against silencing effects of adjacent heterochromatin.

47 les is expected to interfere with the immune-silencing effects of apoptotic cells.

48 Finally, inhibition of SIRT1 strengthens the silencing effects of DNMT1 on the expression of tumor su

49 to reveal any X-linked gene that escapes the silencing effects of MSCI in primary spermatocytes.

50 c miniwhite reporter from both enhancing and silencing effects of surrounding genome, a phenomenon kn

51 n of Bob1 is also sufficient to override the silencing effects of the B29 silencer.

52 chromosome, in coordination with the direct silencing effects of the other MES proteins.

53 y due to the abrogation of the constitutive "silencing" effect of TRalpha2 in tissues expressing the

54 Conversely, p73beta elicited a silencing effect on a gain of function mutant, p53(281),

55 could generate effective RNAi-mediated gene silencing effect on experimental mice models.

56 These results demonstrate that Twist1's silencing effect on Foxa1 expression is largely responsi

57 king down both HMGA1 and MALT1 by RNAi had a silencing effect on NF-kappaB-responsive genes similar t

58 mposite cis-acting element that has a strong silencing effect on promoter activity.

59 ments upstream of bp -300 appeared to have a silencing effect on promoter activity.

60 ng leader of the setB gene provides a strong silencing effect on setB transcription.

61 tage, which likely contributes to its strong silencing effect on VSGs.

62 These data suggest that ethanol has acute silencing effects on adult neuronal activity, which supp

63 nces had a similar "homologous recombination silencing" effect on the nearby hot spots.

64 The Ag-specific silencing effects persisted beyond the duration of detec

65 dependent deacetylases, which through a gene silencing effect promoted longevity.

66 downstream of its binding site by causing a silencing effect similar to that of heterochromatin.

67 in human immune cells (BJAB), demonstrating silencing effects similar to those of a cationic, benchm

68 eed coats was associated with release of the silencing effect specifically on CHS7/CHS8, which occurr

69 These results show that the two miR-mediated silencing effects, viz.

70 The siRNA-NogoA silencing effect was evaluated in vitro and in vivo via

71 KRAS silencing effect was further assessed on the KRAS downst

72 Furthermore, an increased gene-silencing effect was observed with a tandemly repeated A

73 DNA, and in contrast to the PS-AS DNA, their silencing effect was still present after 4 days after a

74 Furthermore, no long-range silencing effects were detected across a large portion o

75 fferent cancer cells and trigger potent gene silencing effect, whereas peptides without cholesterol m

76 flanking sequences contributed to the strong silencing effect, which was greatly relieved by the simu