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1 with an increase in hepatic Factor VII gene silencing of 28% (rHSA/siRNA) compared to 4% (naked siRN
6 attention, yet the initiation of epigenetic silencing of a new transgene, virus, or transposable ele
7 hypermethylation was further correlated with silencing of a serial of testis determining genes, inclu
8 hat directly links junction integrity to the silencing of a set of mRNAs that critically affect epith
10 we hypothesize that the palindromes aid the silencing of active elements and influence transposition
13 Consistent with data in the murine context, silencing of AID in human bone marrow cells skews differ
14 teinase proteolysis in the NOTCH pathway, or silencing of alpha2beta1 integrin or JAG1, reduced the p
18 this key issue is addressed by RNAi-mediated silencing of an immune gene in a lepidopteran host Spodo
21 literature suggested that pretranscriptional silencing of AQP1 in salivary glands is mediated by meth
23 ts (COOLAIR) in the cold-induced, epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC), a regu
25 in profile of the transgenic plants, whereas silencing of AtPyrP2 decreased accumulation of riboflavi
28 microRNAs in TEMC biology and indicates that silencing of both genes is necessary to increase the eff
29 silencing of DUSP1, silencing of ZFP36, nor silencing of both together prevented the repression of I
36 nal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoint
37 sions precedes mesothelioma; this results in silencing of Cdkn2a (Ink4a/Arf) and loss of p16 and p19
43 cancer cells formed larger mammospheres and silencing of CK5 using small hairpin RNA abolished this
44 This effect is recapitulated in vivo, where silencing of Cks1 and Cks2 decreases treslin phosphoryla
48 ample of EGFR deregulation in cancer through silencing of components of the nuclear import pathway.
51 aintenance of heterochromatin needed for the silencing of developmental genes in the adult heart.
52 ell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bo
53 ion of proximal homeobox gene expression and silencing of distal-associated genes, whereas limb trunc
55 induced increased expression of Duox-1, and silencing of Doux-1 improved the rate of cell wound repa
58 erms of repression by dexamethasone, neither silencing of DUSP1, silencing of ZFP36, nor silencing of
64 was suppressed most frequently by epigenetic silencing of either STING or the cyclic GMP-AMP synthase
66 ced expression of IL-6 and TNF-alpha whereas silencing of endogenous CLIP170 potentiated the levels o
68 rotein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repre
70 effects of miR-519d overexpression, whereas silencing of EphA4 phenocopied the effect of miR-519d.
75 Crucially, resembling paclitaxel treatment, silencing of FOXM1 and KIF20A similarly promotes abnorma
76 dhesion, axon guidance, and gliogenesis upon silencing of FoxO6 We then show that FoxO6 binds to DAF-
83 lence of Xcm avrb6 deletion strains, whereas silencing of GhSWEET10 compromises cotton susceptibility
88 monstrate that the acute, cell type-specific silencing of HA neurons during wakefulness is sufficient
89 TMNv HA neurons in vivo We found that acute silencing of HA neurons during wakefulness promotes slow
90 fficient to relieve the post-transcriptional silencing of HAC1 mRNA, yet the precise mechanism by whi
93 ells with the HIF-1alpha inhibitor PX-478 or silencing of HIF-1alpha (small interfering HIF-1alpha) a
95 harmacological inhibition as well as genetic silencing of histone deacetylase 6 (HDAC6) increase alph
98 AC, PARPi monotherapy combined with targeted silencing of HuR significantly reduced tumor growth comp
99 wth, and upregulated RAS/MAPK signaling with silencing of hypermethylated genes, which normally inhib
102 1B-induced IRF1 protein expression at 4-6 h, silencing of IL1B plus dexamethasone-induced DUSP1 signi
104 recordings in vivo combined with optogenetic silencing of interneurons to investigate how dendritic e
109 d the highest efficiency in siRNA uptake and silencing of kinesin spindle protein at peptide:siRNA w/
113 ency is characterized mainly by a reversible silencing of LTR promoter-driven transcription of an int
114 increased tumor biodistribution, and greater silencing of luciferase compared to our previously-optim
117 s (CXCL1, CXCL2, CCL3, CCL4, IL6, and CSF3), silencing of major inflammatory intracellular signaling
122 ally significant is the stable and heritable silencing of master regulators that would specify altern
136 thermore, we discovered that miR858-mediated silencing of MYB83 is tightly regulated through a feedba
137 We specifically demonstrate the presence and silencing of MYC, JUN, and SOX2 mRNAs by miR-24 and miR-
138 s running bouts, that selective chemogenetic silencing of natural GAD65LH cell activity depresses vol
139 bBSK1 blocked BR-induced TMV resistance, and silencing of NbBES1/BZR1 blocked Bikinin-reduced TMV res
142 models of DCIS, we found that RNAi-mediated silencing of NEMO increased tumor invasion and progressi
143 e results suggest that selective optogenetic silencing of nociceptive bladder afferents may represent
150 4-deficient lung fibroblasts is inhibited by silencing of nuclear factor erythroid-derived 2-like 2 (
151 I channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake.
153 e orthologous ZmSHR1 gene to avoid potential silencing of OsSHR2, stomatal cell files were observed b
155 ade of OXT receptors as well as chemogenetic silencing of OXT neurons within the PVN prevented the ef
159 o play a key role in transmitting epigenetic silencing of PcG targets by linking PRC1 to formation of
164 l activity of PKR appears to be complete, as silencing of PKR expression has no impact on viral propa
166 ssion of TRPM2 mutant channel (C1008-->A) or silencing of poly ADP-ribose polymerase in ECs of mice p
168 ference model within the Orf50 region, where silencing of previously expressed isoforms by transcript
174 ased overexpression and CRISPR/Cas9-mediated silencing of Qki5, we identified regulated expression of
178 induce marked dephosphorylation of MEK/ERK, silencing of RAF-MEK-ERK pathway transcriptional output,
182 Nova2 increased beta cell apoptosis, whereas silencing of Rbfox1 and Rbfox2 increased insulin content
183 essive heterochromatin structure and loss of silencing of reporter genes in constitutive heterochroma
187 ating that HDAC enzymes are required for LPS silencing of Rgs10 Furthermore, we used chromatin immuno
192 were observed after transient shRNA-mediated silencing of Rps19, but not several other tested ribosom
193 ed Arabidopsis more susceptible, whereas RNA silencing of RTP1 led to enhanced resistance to P. paras
194 diated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arre
196 ly mutated in GCB DLBCL; the transcriptional silencing of S1PR2 by FOXP1 represents an alternative me
199 gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiesce
202 er in tumor-induced MDSCs, and inhibition or silencing of SETD1B diminished iNOS expression in tumor-
204 ssential role in the meiotic progression and silencing of sex chromosomes in the male germline, which
208 ase-2 (SHP-2), and SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells
213 pment involves the successive activation and silencing of specific gene expression programs and is dr
215 IF1alpha and HIF2alpha protein levels due to silencing of Spry2 also up-regulated HIFalpha target gen
217 -early gene expression and produced a robust silencing of STN neurons as measured using whole-cell re
218 This frequency-dependent mobilization or silencing of sub-pools in the RRP in terminals of granul
220 (6)-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with thei
221 Our results show that both blocking and silencing of SVIP lead to significant reduction in VTV f
224 n of TNF by priming chromatin to prevent the silencing of target genes of the transcription factor NF
227 mice, the exposure to HFD induces epigenetic silencing of the Ankrd26 gene, which contributes to the
231 show that loss of JMJ24 results in increased silencing of the DNA transposon AtMu1c, while overexpres
234 COLDAIR, associates with Polycomb to mediate silencing of the floral repressor FLOWERING LOCUS C (FLC
235 FMR1 expression and significantly delayed re-silencing of the FMR1 gene in AZA-treated FXS cells.
237 integrative analysis, we discovered frequent silencing of the histone H3 K36 methyltransferase NSD1 a
239 Here, we show that CRISPR-Cas9-mediated silencing of the HuR locus increases the relative sensit
240 ed/inactivated with aging and identified the silencing of the IL7R gene and the IL-7 signaling pathwa
241 treatment or knockdown of hnRNP E1 relieves silencing of the inhibin betaA transcript, resulting in
242 rments proved to be decisive in vivo because silencing of the INSR attenuated clinical symptoms in an
247 xpression is correlated with transcriptional silencing of the MLV promoter through the deposition of
248 ulted in potent, dose-dependent, and durable silencing of the mRNA encoding glycolate oxidase and inc
249 g leads to heterochromatinization and stable silencing of the NCoR gene, suggesting that NCoR loss ca
252 by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via tra
253 ng this signal with morpholino technology or silencing of the polyadenylation factor CPSF1 caused a s
259 l phenotype observed following RNAi-mediated silencing of the Trypanosoma brucei SODA ortholog sugges
262 sability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-
263 trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated the metastatic pheno
265 Our results demonstrate that epigenetic silencing of these SiM-miRNAs can result in increased AR
267 argely by FGF5 activation of FGFR2, as siRNA silencing of this ligand or receptor, respectively, inhi
269 mice, we examined the effects of optogenetic silencing of TMNv HA neurons in vivo We found that acute
271 ivity and subsequently refined by epigenetic silencing of transcripts associated with memory lymphocy
272 role in the recognition and transcriptional silencing of transposable elements (TEs), consistent wit
273 iction pathway and illustrate how epigenetic silencing of transposable elements rewires host gene exp
277 ms in gene body DNA methylation, euchromatic silencing of transposons and repeats, as well as silenci
281 In primary haematopoietic cell cultures, silencing of TRIB3 facilitated megakaryocyte differentia
282 In the haematopoietic cell line UT7/mpl, silencing of TRIB3 increased basal and thrombopoietin-st
285 se with CXCR4 mutations show transcriptional silencing of tumor suppressors associated with acquisiti
290 HIV-1 latency is characterized by reversible silencing of viral transcription driven by the long term
294 zyme Q10 (CoQ10) biosynthesis gene Coq2, the silencing of which disrupted slit diaphragm morphology.
295 oncoding RNA (lncRNA) is thought to catalyze silencing of X-linked genes in cis during X-chromosome i
297 levels, after small interfering RNA-mediated silencing of YAP in Sk-Hep1, SNU182, HepG2, or pancreati
299 y dexamethasone, neither silencing of DUSP1, silencing of ZFP36, nor silencing of both together preve
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