ライフサイエンスコーパス: simian virus 40

1 ing T antigen (T-ag) the helicase encoded by simian virus 40.

2 rus-1, Helicobacter pylori, hepatitis C, and simian virus 40.

3 RI site (1.0 map unit) in the late region of simian virus 40.

4 en (LTag) is encoded by the DNA tumour virus simian virus 40.

5 mphoid vein endothelial cells transformed by simian virus 40.

6 The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helic

7 ein that is also found in the polyomaviruses simian virus 40 and BK virus.

8 Simian virus 40 and JC virus, two closely related member

9 d to explain the structure of polyoma virus, Simian Virus 40 and L-A virus capsids, which are conside

10 small DNA tumor viruses, such as adenovirus, simian virus 40 and papillomavirus, push infected cells

11 ns from two unrelated, nonenveloped viruses: simian virus 40 and satellite tobacco mosaic virus.

12 alized by combination of the early region of simian virus 40 and telomerase and then were transformed

13 including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simple

14 k human papillomaviruses, hepatitis B virus, simian virus 40, and human T-cell leukemia virus type 1.

15 Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human dise

16 interactions of a whole nonenveloped virus (simian virus 40), as well as those of the hepatitis delt

17 lorotic mottle virus, hepatitis B virus, and simian virus 40 assembling on ssRNA and dsDNA substrates

18 a collection of novel T antigens that, like simian virus 40, can be used to discover and study key c

19 We investigated the roles of simian virus 40 capsid proteins in the viral life cycle

20 ically to site II, the central region of the simian virus 40 core origin.

21 The transformation potential of Simian Virus 40 depends on the activities of large T-ant

22 meric human pol-prim lacking p68 to initiate simian virus 40 DNA replication in vitro and to synthesi

23 porated into RPA heterotrimers and supported simian virus 40 DNA replication in vitro, the RPA2(D) mu

24 tigen residue Thr124 regulates initiation of simian virus 40 DNA replication.

25 equired for the initiation and elongation of simian virus 40 DNA replication.

26 When placed downstream of a simian virus 40-driven promoter-luciferase construct, th

27 ron in HPV31 with a heterologous intron from simian virus 40 (E6SR2) resulted in replication levels s

28 ion assays, the mutant protein activated the simian virus 40 early and human cytomegalovirus UL112 pr

29 2P mutant virus transactivated an endogenous simian virus 40 early promoter 4 h earlier and to higher

30 imian cytomegalovirus immediate-early or the simian virus 40 early promoter, and provide an alternati

31 bserved by replacing the oriLyt(PM) with the simian virus 40 early promoter.

32 ransgenic (Tg) mice with ORF74 driven by the simian virus 40 early promoter.

33 disrupted by an intron under control of the simian virus 40 early promoter.

34 s through the successive introduction of the Simian Virus 40 Early Region and the telomerase catalyti

35 e nearly opposite mechanisms utilized by the simian virus 40 enhancer and p53.

36 Although the small DNA tumor virus SV40 (simian virus 40) fails to replicate in human cells, unde

37 The major capsid protein Vp1 of simian virus 40 forms a series of disulfide-linked inter

38 y transfection with a plasmid containing the simian virus 40 genome.

39 , we investigate the dynamic behavior of the Simian Virus 40 hexameric helicase bound to DNA by perfo

40 -linked Vp1 homooligomers are present in the simian virus 40-infected cytoplasm and that they are der

41 Simian virus 40 infection was not inhibited in PDI-downr

42 In contrast, uptake of simian virus 40 into the same cells is dependent on cave

43 The site I regulatory region of simian virus 40, involved in the repression of transcrip

44 We show that the nuclear entry of simian virus 40 involves a dynamic interplay between two

45 e large tumor antigen (T antigen) encoded by simian virus 40 is an amazing molecular machine because

46 of a recombinant virus in the late region of simian virus 40 is presented.

47 on prostate tumorigenesis in mice expressing simian virus 40 large T antigen (LT).

48 sing these genes or the known viral oncogene simian virus 40 large T antigen (LTAg).

49 The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred

50 Simian virus 40 large T antigen (T Ag) is capable of imm

51 The simian virus 40 large T antigen (T antigen) inactivates

52 Simian virus 40 large T antigen (TAg) contributes to cel

53 Transgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes dev

54 from the cryptdin-2 gene (Defcr2) to express simian virus 40 large T antigen (TAg) in prostatic NE ce

55 genic mice were developed that expressed the simian virus 40 large T antigen (TAg) in urothelial cell

56 Simian virus 40 large T antigen (TAg) is a viral oncopro

57 At least three domains of simian virus 40 large T antigen (TAg) participate in cel

58 Simian virus 40 large T antigen (TAg) transforms cells i

59 Other viral SF3 helicases, such as the simian virus 40 large T antigen and the papillomavirus E

60 nes had been immortalized by the addition of simian virus 40 large T antigen and the telomerase subun

61 Simian virus 40 large T antigen contains an amino termin

62 The simian virus 40 large T antigen contributes to neoplasti

63 Transgenic mice expressing simian virus 40 large T antigen in enterocytes develop i

64 capable of collaborating with hTERT and the simian virus 40 large T antigen in the transformation of

65 In contrast, expression of simian virus 40 large T antigen induces sustained cardio

66 Simian virus 40 large T antigen is a multifunctional onc

67 Alignment of NLS2(APC) with the simian virus 40 large T antigen NLS (NLS(SV40 T-ag)) rev

68 The simian virus 40 large T antigen nuclear localization sig

69 the matched WI-38 (parental) and WI-38-VA13 (simian virus 40 large T antigen transformed) cell pair,

70 We show that the oncogenes simian virus 40 large T antigen, c-Myc, and cyclin E ind

71 function failed to mimic the introduction of simian virus 40 large T antigen, indicating that large T

72 mice expressing the first 127 amino acids of simian virus 40 large T antigen, under the control of th

73 ologue, p185 (Cul7), has been isolated as an simian virus 40 large T antigen-binding protein.

74 h arrest is bypassed in cells expressing the simian virus 40 large T antigen.

75 Wild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle an

76 the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding do

77 use Nkx2.5 gene to drive the expression of a simian virus 40 large T-antigen (TAg) gene flanked by si

78 portin-alpha binds the prototypical NLS from simian virus 40 large T-antigen preferentially at the ma

79 ombination with the J-domain function of the simian virus 40 large T-antigen protein.

80 oviral transduction of temperature-sensitive simian virus 40 large tumor (T) antigen.

81 tatic gastric cancer initiated by expressing simian virus 40 large tumor antigen (SV40 TAg), under co

82 Simian virus 40 large tumor antigen is required for DNA

83 ice harboring a mutant temperature-sensitive simian virus 40 large tumor antigen under the control of

84 MECs that were immortalized with simian virus 40 large-T antigen differed from nonimmorta

85 The high-resolution structural data for simian virus 40 large-T-antigen helicase revealed a set

86 We show that the addition of the simian virus 40 large-T-antigen nuclear localization sig

87 The structure of the highly efficient simian virus 40 late polyadenylation signal (LPA signal)

88 The simian virus 40 late polyadenylation signal (SVLPA) form

89 ther one or both plasmids were replicated by simian virus 40-mediated DNA replication, even with the

90 The transcriptional regulatory region of the simian virus 40 minichromosome that is being transcribed

91 ther deleted (P13(-/-)) or replaced with the simian virus 40 minimal promoter plus five copies of Gal

92 function as that of the monkey polyomavirus simian virus 40 miRNAs.

93 , even when this segment was replaced with a simian virus 40 NLS that ensured nuclear localization.

94 iven either by a broadly expressed promoter, simian virus 40, or by a brain-specific promoter taken f

95 ur results indicate that the addition of the simian virus 40 origin of replication to the papillomavi

96 assembly of the complex that forms over the simian virus 40 origin to initiate DNA replication is no

97 vity is required for T antigen to unwind the simian virus 40 origin.

98 Here, we demonstrated that the simian virus 40 progeny accumulated at the nuclear envel

99 suppressed expression of luciferase from the simian virus 40 promoter and from the beta interferon (I

100 th glucocorticoid response element (GRE) and simian virus 40 promoter factor 1 (Sp1) binding sites in

101 n both brain and peripheral tissues when the simian virus 40 promoter is used, but the expression of

102 XRE conferred oltipraz responsiveness on the simian virus 40 promoter of pGL3-Promoter.

103 MLV long terminal repeat (MNDU3) promoter, a simian virus 40 promoter, and three cellular promoters:

104 n be replaced with the constitutively active simian virus 40 promoter, which in turn eliminates the r

105 trolled by this HRE concatemer and a minimal simian virus 40 promoter.

106 a luciferase reporter vector containing the simian virus 40 promoter.

107 Simian Virus 40 replication requires only one viral prot

108 ormation by Vp1, the major capsid protein of simian virus 40, requires an interdigitation of structur

109 ntified mutations that, when engineered into simian virus 40, resulted in T antigen mutants that were

110 Because of the promise of recombinant simian virus 40 (rSV40) vectors, we tested their ability

111 Mouse and human cytomegalovirus, and simian virus 40 showed only low levels of infection or G

112 Simian (simian virus 40, simian agent 12 [Sa12], and lymphotropi

113 The simian virus 40 small t (SV40ST) oncoprotein interacts w

114 The tumor antigens simian virus 40 small t antigen (ST) and polyomavirus sm

115 Simian virus 40 small t antigen (st) is required for opt

116 nce of Ras, Myc cooperated strongly with the simian virus 40 small t antigen to elicit aggressive anc

117 ) stimulation of the Ras/MAP kinase pathway, simian virus 40 small t antigen was expressed in Rat-1 f

118 Paradoxically, expression of tumor-promoting simian virus 40 small tumor antigen (ST), a reported PP2

119 Murine follicle cells, transformed with simian virus 40 (SV 40) T antigen-containing virus (SVF

120 Nucleolin significantly inhibited both simian virus 40 (SV-40) origin unwinding and SV-40 DNA r

121 previously seen to efficiently bind a 48 bp simian virus 40 (SV40) "pseudo-origin" (PO) substrate th

122 Human FIX minigene constructs containing a simian virus 40 (SV40) 3'-untranslated region (UTR) take

123 port the identification of miRNAs encoded by simian virus 40 (SV40) and define their functional signi

124 MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT

125 ins for miRNA expression from rhesus macaque simian virus 40 (SV40) and human JC virus.

126 Small DNA tumor viruses such as simian virus 40 (SV40) and polyomavirus (Py) take advant

127 Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence o

128 triction fragment taken from the VP1 gene in Simian Virus 40 (SV40) and various sequence mutants and

129 Simian virus 40 (SV40) appears to initiate cell lysis by

130 To determine whether similar changes in simian virus 40 (SV40) are necessary for disease inducti

131 The late mRNAs of simian virus 40 (SV40) are polycistronic.

132 ur viruses bovine papillomavirus (BPV-1) and Simian virus 40 (SV40) are the initiator proteins that r

133 yzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) by conventional and quantitative

134 The question of whether Simian Virus 40 (SV40) can cause human tumors has been o

135 The exposure of molecular signals for simian virus 40 (SV40) cell entry and nuclear entry has

136 adiation, on the replication of cellular and simian virus 40 (SV40) chromosomes in intact cells.

137 immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumo

138 Purified simian virus 40 (SV40) DNA is reconstituted into chromat

139 opo I) is needed for efficient initiation of simian virus 40 (SV40) DNA replication and for the forma

140 Although the mechanism of simian virus 40 (SV40) DNA replication has been extensiv

141 In the model system for simian virus 40 (SV40) DNA replication in vitro, synthes

142 quired for releasing torsional stress during simian virus 40 (SV40) DNA replication.

143 I) is required for the proper initiation of simian virus 40 (SV40) DNA replication.

144 estos exposure and approximately 50% contain simian virus 40 (SV40) DNA sequences.

145 Replication of simian virus 40 (SV40) DNA, a model for eukaryotic chrom

146 cleosomes on circular and unit-length linear simian virus 40 (SV40) DNAs incubated in nuclei of Xenop

147 n cassette for EGFP under the control of the simian virus 40 (SV40) early promoter was inserted into

148 , since T antigen repressed the JC virus and simian virus 40 (SV40) early promoters in glioma cells b

149 e recently reported that coexpression of the simian virus 40 (SV40) early region (ER), the gene encod

150 Here, we report that the simian virus 40 (SV40) early region, in particular, larg

151 Simian virus 40 (SV40) encodes two oncoproteins, large t

152 Simian virus 40 (SV40) enters cells by atypical endocyto

153 Nonenveloped viruses such as Simian Virus 40 (SV40) exploit established cellular path

154 DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoprote

155 Most of the simian virus 40 (SV40) genome is conserved among isolate

156 ved by titration of these repressors through simian virus 40 (SV40) genome replication to high copy n

157 A phylogenetic analysis of 14 complete simian virus 40 (SV40) genomes was conducted in order to

158 Simian virus 40 (SV40) has been detected in human tumors

159 PCR-based evidence of infection by simian virus 40 (SV40) has been reported in varying prop

160 thway of cell entry by polyomavirus (Py) and simian virus 40 (SV40) have defined specific ganglioside

161 The simian virus 40 (SV40) hexameric helicase consists of a

162 The nonenveloped simian polyomavirus (PyV) simian virus 40 (SV40) hijacks the endoplasmic reticulum

163 The nonenveloped simian virus 40 (SV40) hijacks the three endoplasmic ret

164 e detected DNA from the macaque polyomavirus simian virus 40 (SV40) in human tumors, but possible rou

165 ith 1-Chl decreased DNA template activity in simian virus 40 (SV40) in vitro replication assays.

166 The simian virus 40 (SV40) in vitro replication system was p

167 We report that late in a simian virus 40 (SV40) infection in CV-1 cells, there ar

168 n associated with asbestos exposure and with Simian virus 40 (SV40) infection.

169 eplication caused by BLM in the well-defined simian virus 40 (SV40) intracellular and cell-free in vi

170 Simian virus 40 (SV40) is a DNA tumor virus known to ind

171 Simian virus 40 (SV40) is a potent DNA tumor virus that

172 idence that the transforming DNA tumor virus simian virus 40 (SV40) is associated with human malignan

173 African green monkey kidney (CV-1) cells by simian virus 40 (SV40) is characterized by stimulation o

174 Simian virus 40 (SV40) is known to cause tumourigenesis.

175 The nonenveloped polyomavirus simian virus 40 (SV40) is taken up into cells by a caveo

176 substantially reversed by expression of the simian virus 40 (SV40) large (T) and small (t) T antigen

177 We previously demonstrated that simian virus 40 (SV40) large T antigen (LT) binds to the

178 Simian virus 40 (SV40) large T antigen (LT) can immortal

179 Simian virus 40 (SV40) large T antigen (LT) is a multifu

180 Simian virus 40 (SV40) large T antigen (LT), for example

181 e demonstrated previously that expression of simian virus 40 (SV40) large T antigen (LT), without a v

182 Simian virus 40 (SV40) large T antigen (SVT) interferes

183 Simian virus 40 (SV40) large T antigen (T Ag) interacts

184 Mice that express the viral oncoprotein simian virus 40 (SV40) large T antigen (T-Ag) as a trans

185 We previously showed that wild-type (WT) simian virus 40 (SV40) large T antigen (TAg) inhibits ap

186 In parallel experiments, we found that simian virus 40 (SV40) large T antigen can mediate the s

187 We now find that targeting Bub1 by RNAi or simian virus 40 (SV40) large T antigen in normal human d

188 The J domain of simian virus 40 (SV40) large T antigen is required for e

189 trast to the virus harboring IN fused to the simian virus 40 (SV40) large T antigen NLS (SV40 NLS), a

190 ophilic channels between helicase domains of simian virus 40 (SV40) large T antigen play a critical r

191 The origin-binding domain (OBD) of simian virus 40 (SV40) large T-antigen (T-Ag) is essenti

192 Introduction of the viral oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequen

193 The simian virus 40 (SV40) large tumor (T) antigen is suffic

194 Simian virus 40 (SV40) large tumor antigen (LT) triggers

195 Cell cycle-dependent phosphorylation of simian virus 40 (SV40) large tumor antigen (T-ag) on thr

196 response against the tumor-specific antigen simian virus 40 (SV40) large tumor antigen (Tag) followi

197 munity directed toward the viral oncoprotein simian virus 40 (SV40) large tumor antigen (Tag) has pre

198 Simian virus 40 (SV40) large tumor antigen (Tag) represe

199 serted strong CstF binding site, an inserted simian virus 40 (SV40) late poly(A) signal, or a substit

200 o facilitate structure-based analysis of the simian virus 40 (SV40) life cycle.

201 wever, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the

202 Interaction of simian virus 40 (SV40) major capsid protein Vp1 with the

203 A DNA-binding domain (DBD) was identified on simian virus 40 (SV40) major capsid protein Vp1, and the

204 The folding and pentamer assembly of the simian virus 40 (SV40) major capsid protein Vp1, which t

205 intracellular folding and pentamerization of simian virus 40 (SV40) major capsid protein Vp1.

206 H3 and unmodified H4 and H3 in transcribing simian virus 40 (SV40) minichromosomes were determined.

207 in the life cycle of the virus, we analyzed simian virus 40 (SV40) mutants in which structurally ded

208 The simian virus 40 (SV40) oncoprotein, large T antigen (T),

209 says, we have found that E7 can provide some simian virus 40 (SV40) or murine polyomavirus (PyV) ST f

210 tion of an HPV-16 plasmid and a heterologous simian virus 40 (SV40) ori plasmid that contains E2 bind

211 s in EBV nuclear antigen 1-expressing cells, simian virus 40 (SV40) oriT dramatically enhanced integr

212 ed DNA distortion was studied in a series of simian virus 40 (SV40) plasmid constructs whose relative

213 DTKSSTR, we found that the CMV promoters and simian virus 40 (SV40) poly(A) regions located in both e

214 We report that during activation of the simian virus 40 (SV40) pre-replication complex, SV40 T a

215 M also suppressed the constitutively active simian virus 40 (SV40) promoter and globally decreased c

216 the constitutive activity obtained with the Simian Virus 40 (SV40) promoter.

217 nt, being similar in strength to that of the simian virus 40 (SV40) promoter/enhancer.

218 nts were tested for their ability to support simian virus 40 (SV40) replication and to bind to single

219 Cell transformation by simian virus 40 (SV40) results mostly from the highly on

220 e kinetics of accumulation and processing of simian virus 40 (SV40) RNA in stage 6 oocytes of Xenopus

221 Simian virus 40 (SV40) small t antigen (ST) binding to N

222 This is reminiscent of the role of simian virus 40 (SV40) small t antigen.

223 adenoviruses that express high levels of the simian virus 40 (SV40) small-t (ST) antigen have been us

224 of 859 patients with transplant biopsies by simian virus 40 (SV40) staining and routine serum polyme

225 The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral o

226 her defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R

227 Two independent binding sites on simian virus 40 (SV40) T antigen for topoisomerase I (to

228 re cultured in cell lines immortalized using simian virus 40 (SV40) T antigen, suggesting the possibi

229 defined oncogenic alleles, specifically the simian virus 40 (SV40) T antigens and oncogenic Ras(12V)

230 d in cells that are driven to proliferate by simian virus 40 (SV40) T-antigen.

231 body against the virally encoded oncoprotein simian virus 40 (SV40) Tag have previously been demonstr

232 igenesis induced by transgenic expression of simian virus 40 (SV40) TAg in choroid plexus or intestin

233 The nonenveloped polyomavirus (PyV) simian virus 40 (SV40) traffics from the cell surface to

234 Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane t

235 yzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) using conventional polymerase cha

236 Simian virus 40 (SV40) was an accidental contaminant of

237 Simian virus 40 (SV40), a monkey polyomavirus that is be

238 operties of nonhuman polyomaviruses, such as simian virus 40 (SV40), but is not required for MCV sT-i

239 Simian virus 40 (SV40), family Polyomaviridae, in immuno

240 Naturally arising variants of simian virus 40 (SV40), generated by serial passage of t

241 antigen, the replicative DNA helicase of the simian virus 40 (SV40), is reported to function as a pai

242 -associated polyomaviruses (PyVs), including simian virus 40 (SV40), murine PyV, and Merkel cell PyV,

243 We show that, like its close relative simian virus 40 (SV40), SA12 expresses microRNAs that ar

244 simplex virus type 1, adenovirus type 5, and simian virus 40 (SV40), start their transcription and re

245 In the case of the nonenveloped polyomavirus simian virus 40 (SV40), the virus penetrates the endopla

246 5 (AV5), herpes simplex virus type 1 (HSV1), simian virus 40 (SV40), vaccinia (MVA), and cowpea mosai

247 cytosolic entry of the related polyomavirus simian virus 40 (SV40), we found that dependence on the

248 In contrast to simian virus 40 (SV40), where the repeats are nonoverlap

249 d in the United States was contaminated with simian virus 40 (SV40), which causes cancer in animals.

250 tropism, we studied the primate polyomavirus simian virus 40 (SV40), which uses the ganglioside GM1 a

251 of this regulation in melanoma cells using a simian virus 40 (SV40)-based in vitro DNA replication as

252 hibit the ability of a replication-defective simian virus 40 (SV40)-based viral vector to cause growt

253 Simian virus 40 (SV40)-derived gene delivery vectors wer

254 gh an indwelling portal vein catheter with a simian virus 40 (SV40)-derived vector carrying a ribozym

255 riggers ubiquitous regression of tumors in a simian virus 40 (SV40)-driven pancreatic islet tumor mod

256 btained by alignment with the VP1 protein of simian virus 40 (SV40).

257 e T antigen gene of BKV, JC virus (JCV), and simian virus 40 (SV40).

258 man polyomavirus JC virus (JCV) with that of simian virus 40 (SV40).

259 T antigen, the DNA replication initiator of simian virus 40 (SV40).

260 cells with that of the related polyomavirus, simian virus 40 (SV40).

261 d with asbestos, has been recently linked to simian virus 40 (SV40).

262 a strong nuclear localization sequence (the simian virus 40 [SV40] NLS), suggesting an efficient mec

263 tection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40]) in 46% of stool samples from hos

264 polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was asso

265 The large tumor antigen of simian virus 40 (SVLT) is a potent oncogene.

266 d by transduction with the gene encoding the simian virus 40 T antigen (SV40Tag).

267 Previous work has shown that the Simian Virus 40 T antigen (T antigen) cannot transform m

268 inogenesis is initiated by expression of the Simian Virus 40 T antigen (TAg).

269 w- and high-risk HPV E7 proteins, as well as simian virus 40 T antigen and adenovirus E1A, can associ

270 Fusion of a simian virus 40 T antigen NLS to the cytoplasmic localiz

271 om DNA tumor viruses such as adenovirus E1a, simian virus 40 T antigen, and human papillomavirus E7 c

272 ns of the DNA tumor viruses, adenovirus E1A, simian virus 40 T antigen, and papillomavirus E7, each i

273 BPalpha in mouse cells cannot be reversed by simian virus 40 T antigen, by oncogenic ras, or by adeno

274 e interaction of RPA with papillomavirus E2, simian virus 40 T antigen, human polymerase alpha-primas

275 ed, which is in contrast to the half-life of simian virus 40 T antigen-transformed cells.

276 ouse embryo fibroblasts (MEF) expressing the simian virus 40 T antigen.

277 -mediated transformation, whereas fusing the simian virus 40 T-antigen nuclear localization signal to

278 ary tumor cells derived from C3(1)/Tag (Tag: simian virus 40 T-antigen) transgenic mice.

279 nd transforming growth factor alpha, but not simian virus 40 T-antigen, increase the rate of hepatocy

280 c-ha-ras, polyoma middle T antigen (PyMT) or simian virus 40 T/t antigen (T-ag) targeted to the mouse

281 al cancers intrinsic to the functions of the Simian virus 40 T/t-antigens that is associated with the

282 Twenty-four, 12-week-old simian virus-40 T-antigen-positive mice received six sub

283 that express rat insulin promoter regulated simian virus 40 Tag (RIP-Tag) develop large, local cance

284 g tendency by members of this family such as simian virus 40 TAg to oligomerize after binding ATP.

285 For nonenveloped viruses such as Simian Virus 40, the mechanism used to translocate viral

286 was sufficient to cause the classical NLS of simian virus 40 to require Nup124p for nuclear import.

287 an in vitro DNA replication system based on simian virus 40, to investigate MMR recruitment to repli

288 The simian virus 40 transcription elongation complex was pur

289 breast cancer MCF-7, normal fibroblast, and simian virus 40-transformed cells (by aphidicolin or ser

290 n initiating infection, particularly in 324K simian virus 40-transformed human fibroblasts.

291 eporter gene, cotransfected in human corneal simian virus 40-transformed keratinocytes (HCK), was tra

292 and cell proliferation after incubation with simian virus 40-transformed murine vascular endothelial

293 ls and with large telomeric clusters seen in simian virus 40-transformed normal fibroblasts.

294 eukemia virus LTRs in both LNCaP and WPMY-1 (simian virus 40-transformed prostate stromal cells).

295 cent and apoptotic responses in parental and Simian virus 40-transformed WI38 fibroblasts, respective

296 genes, a derivative of the tumor antigen of simian virus 40 tumor virus, to generate tumor cells, wh

297 tandem repeats of a supF reporter gene in a simian virus 40 vector in monkey COS cells.

298 A nonenveloped virus, simian virus 40, was not affected by methyl-beta-cyclode

299 tumor suppressor and the large T antigen of simian virus 40 were visualized in tumor xenografts of H

300 line transformed with the large T antigen of simian virus 40, were developed, and both were identifie