ライフサイエンスコーパス: simple

1 erapy (ART), now highly effective, safe, and simple.

2 entry 22.6 years, 50.6% males) with CHD (49% simple, 39% moderate, and 12% complex) prospectively fol

3 METHODS AND We measured the Life's Simple 7 ideal cardiovascular health metrics in 4195 bla

4 usted population attributable risk for these Simple 7 metrics combined was 37.1%.

5 3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moi

6 These observations rule out simple acoustical cues as a basis for voice selectivity

7 To facilitate our search, we used a simple adamantyl ligand core that by avoiding stereochem

8 ve goal in this area, the dehydrogenation of simple alkanes to yield alkenes (specifically monoenes)

9 entire range of pi systems studied, with the simple alkene emerging as the most powerful partner.

10 de water, thus representing an operationally simple alternative to traditional cross-coupling macrocy

11 This finding provides a simple analogy for various periodic crack systems that e

12 tide separation process in CZE is relatively simple and can be predicted to a much higher precision t

13 which is aimed at 'detecting and genotyping simple and complex genetic variants in an individual or

14 myeloid C-type lectin receptor langerin for simple and complex ligands augmented by structural insig

15 tures have implications for the formation of simple and complex rearrangements underlying human patho

16 The methodology is conceptually simple and computationally practical, and provides a bro

17 nalyzing biomedical data, but the absence of simple and consistent tools has made exploratory and sys

18 Herein, a novel approach for rapid, simple and cost-effective discrimination/clustering, as

19 hemes, we herein report the development of a simple and cost-effective optofluidic platform, integrat

20 sized on a large scale via two operationally simple and discrete solid-state processes.

21 genious sensing approaches with interest for simple and disposable paper-based (bio)sensing applicati

22 In this paper, a simple and effective analytical procedure based on dispe

23 The device presented in this work is simple and effective for point-of-use multiplexing of im

24 Here we develop a simple and efficient crosstalk reduction approach for si

25 A simple and efficient hydrodeoxygenation strategy is desc

26 A simple and efficient one-pot annulation of arylidenones,

27 A simple and efficient two-dimensional multifocus confocal

28 This work presents an inexpensive, simple and fast procedure to purify trypsin based on aff

29 ata acquisition with confocal microscopy are simple and fast, the method can serve as a primary scree

30 ng methods are avoided to keep the algorithm simple and fast.

31 These findings demonstrate a simple and general mechanism for conferring temporal fle

32 The method suggests a simple and general way to flexibly use broadband current

33 ce as infants, even though target words were simple and highly familiar.

34 pseudobenzylic position in an operationally simple and inexpensive procedure.

35 The model is simple and intuitive and is the basis for many motif dis

36 specific peptide aptamer to create a novel, simple and label-free tool to detect abnormalities at an

37 clinical hand prostheses are controlled in a simple and limited way that allows the activation of one

38 of microfluidic devices or microchambers as simple and low-cost means of maintaining bladder cancer

39 An operationally simple and metal-free cross-coupling of quinone monoacet

40 Here we describe a simple and powerful method involving elution of histones

41 We describe a simple and powerful methodology to characterize residual

42 CART analysis generated a simple and practical algorithm based on the combination

43 investigated to estimate the viability as a simple and rapid method for analysis of nutrient element

44 Here we describe a simple and reproducible method to generate mMSCs by util

45 o the organic semiconductor thin films via a simple and robust templated meniscus-guided coating meth

46 The RF technique is simple and safe, with results equivalent to the PF techn

47 We have employed relatively simple and sensitive assays to determine the function of

48 ss of such projects is dependent on applying simple and standardized methods.

49 Random survival forests are a simple and straightforward machine-learning approach for

50 There is a lack of simple and validated severity assessments that are feasi

51 ical saline, we demonstrate realization of a simple and versatile biosensor platform capable of high

52 In this work, a sensitive, simple and viable spectrophotometry method to determine

53 ughputs by orders of magnitude in a compact, simple, and cost-effective platform.

54 ed none (95% CI: 0%, 0.4%) of 904 women with simple-appearing cysts with an adequate reference standa

55 Here, we introduce a simple approach to orient the insertion of the light-dri

56 Proteins synthetically modified with a simple aromatic boronate motif are actively trafficked t

57 Here, we describe Leapfrog, a simple automated BLAST pipeline that leverages increased

58 encoding, but this has mostly been tested in simple behavioral tasks.

59 s reaction was initiated by the screening of simple binary and ternary admixtures of Pd/charcoal in c

60 Simple BLAST searches may reveal homology to a known tox

61 The nematode Caenorhabditis elegans uses simple building blocks from primary metabolism and a str

62 truction of highly intricate structures from simple building blocks remains one of the most difficult

63 dium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chem

64 increasingly complex reaction networks from simple building blocks.

65 can be used over time and space to produce a simple but general quantitative assessment of progress t

66 This simple but powerful approach, employing chimeric protein

67 f adaptation can be investigated through the simple but powerful technique of laboratory evolution.

68 ollen tube guide and wall plasticizer into a simple but widely applicable model of tip growth.

69 A simple cascade for tuberculosis transmission has been pr

70 Nonetheless, simple catalytic routes to new heterocyclic cores are in

71 s buffer (50mmolL(-1), pH 9), representing a simple, cheap and chemically friendly sample preparation

72 ndividuals of Y. luopingensis indicates that simple chelate claspers in males are plesiomorphic for h

73 This simple chemical approach addresses several key challenge

74 otics that proceeds in 6-8 linear steps from simple chemical building blocks.

75 Conclusion An mPICH score was developed as a simple clinical and imaging grading scale for acute prog

76 VD may be estimated in patients with FH with simple clinical predictors.

77 rrent Neural Network, and Random Forest, the simple CNN architecture with only one convolutional laye

78 In the present study a simple colorimetric sensor should be developed and teste

79 ing targeted MS to validate and evaluate the simple combination of metabolites that effectively predi

80 re we demonstrate the feasibility of using a simple commercial inkjet printer to fabricate a thin-fil

81 gabar pressure stabilizes very hydrogen-rich simple compounds having new clathrate-like structures an

82 this end, using an empirical approach and a simple conceptual model, we propose a framework of how e

83 The process can be performed using a simple confined impingement jets mixer and provides an e

84 duces behavioural results, by implementing a simple constraint of continuity for binding successive s

85 induction in the zebrafish tailbud is not a simple continuation of gastrulation events.

86 nflammatory bowel diseases are shifting from simple control of symptoms toward full control of these

87 8%) from alpha-diazoesters using 5 mol% of a simple copper(I) salt as catalyst.

88 We have developed a simple, cost-effective, portable surface enhanced Raman

89 the within-subject correlation (ignored in a simple Cox model, robust standard errors in a variance-c

90 structure that is captured in situ through a simple crosslinking reaction.

91 bird movement within this landscape based on simple decision rules drawn from statistical mechanics.

92 t-finned pilot whales is more complex than a simple dichotomy of deep and shallow diving states, and

93 uted for a high-carbohydrate snack, may be a simple dietary strategy to help manage total cholesterol

94 n of extra-virgin olive oil (EVOO) - after a simple dilution - for determining its phenolic compounds

95 The intervention is simple, does not require surgery, provides pain relief,

96 Instead simple dose-response models are still often used althoug

97 ng phage system, we may provide a relatively simple, economical, and environmentally friendly process

98 Simple effective tools to monitor the long treatment of

99 in a relevant microenvironment thanks to its simple, effective and user-friendly operation.

100 rate, amplify, mix and modulate sound in one simple electronic device would open up a new world in ac

101 for organelles that were once thought to be simple energy converters.

102 A comprehensive study of this simple enzyme mimic provides insight into analogous beha

103 as ageing and rejuvenation, through a set of simple equations describing excitations in the PEL.

104 h the Drosophila giant fiber system (GFS), a simple escape response neuronal circuit, by increasing t

105 II)-catalyzed diamination of the alkene with simple exogenous secondary amines under extraordinarily

106 This simple experiment reveals a surprisingly complex pathway

107 urrounding tissue excitability also offers a simple explanation of the clinically reported difference

108 The proposed method enables simple fabrication of objects with complex geometries an

109 ivatives can be accessed in an operationally simple fashion without purification of intermediates.

110 The proposed method is simple, fast (<12.0min), present linear calibration curv

111 A simple, fast, sensitive, and robust gas chromatography-m

112 Despite its generality, simple features (such as drift), common to single molecu

113 limitations due to its low-cost, rapid, and simple features, but the poor analytical sensitivity of

114 Sample preparation can be carried out by simple fine filtering of cell-conditioned medium prior t

115 fate can be simultaneously assessed through simple fluorescent imaging for each lineage reporter.

116 A simple formylation reaction of aryl halides, aryl trifla

117 naphthalene series has been synthesized in a simple four-step sequence.

118 tion under various conditions and provides a simple framework for identifying new conditions that tol

119 ecular-level nonequilibrium physics, yet the simple functional form leads to a continuum-level expres

120 ons used by chemists are often restricted to simple functional-group interconversions.

121 actical logic technology and have stalled at simple functionality demonstrations.

122 Elaboration of this simple functionalization allows preparation of conjugate

123 sed on these patterns we propose DEBlipid, a simple, general model of energy allocation that is close

124 The simple generalized equation can be expressed as Wh = p(l

125 or non-oscillatory in data simulated from a simple genetic oscillator model and in experimental data

126 To capture this, we develop a simple geometric measure, inness, that maps this force f

127 Previous research has looked for simple geometric rules describing the attack trajectorie

128 In our proposal, they are created by simple geometrical modifications of an existing and expe

129 lied onto a paper-based sensor surface via a simple "graft-to" immersion process to render the surfac

130 lly and numerically study this phenomenon in simple granular materials.

131 different guide RNA scoring functions in one simple graphical interface.

132 We use a simple habituation-dishabituation paradigm in which anim

133 Finally, simple HCA algorithms were performed on all of the data

134 A simple heat/cool cycle can be used to significantly affe

135 localization has been hindered by a lack of simple, high-throughput methods for mapping the transcri

136 The server provides a simple home page for basic use, requiring only two files

137 Thus we show a route by which simple hybrid inorganic-organic monomers, such as compou

138 hlia-like MoS2 nanosheets were prepared by a simple hydrothermal method and characterized using diffe

139 ree immunoassay, CuONRs, synthesized using a simple hydrothermal method, were deposited onto epoxy-ac

140 in situ and extremely rapidly, allowing for simple imaging of the same region of interest and excell

141 c acid (TA, the shell) was self-assembled by simple incubation in water.

142 t clustering can be induced several times by simple injection of new fuel.

143 on between the red and blue states through a simple kinetic model.

144 arting with clinical samples and following a simple laboratory workflow.

145 Simple lag hypotheses have become prominent in disequili

146 making systems thought to contribute even to simple learning.

147 s from anaesthetized mice we first show that simple light steps can excite a subset of VPM neurons.

148 and temporal decimation techniques based on simple local averaging provide order-of-magnitude speedu

149 This analysis demonstrates a simple logistic regression approach for testing a priori

150 A simple, low cost and user-friendly method for the fabric

151 e (CuPc) thin film transistors (TFTs) with a simple, low-cost UV-ozone (UVO)-treated polymeric gate d

152 Using a simple LRU cache model, we show that the Classical algor

153 lasmonic optical antenna (POA) array using a simple lumped coupled circuit (LCC) model.

154 ghted averaging of people's confidences, and simple majority voting can often approximate that limit.

155 microtubule filament density, and present a simple means to extract absolute values of the elastic m

156 This work provides a simple means to implement complex routing networks and s

157 The identified mechanism provides a simple means to spare specific substrates from an adapto

158 ric emptying scintigraphy (GES) allows for a simple measure of FA.

159 This protocol describes a simple, metal- and additive-free method of conversion of

160 ssing ortho-EMe (E=S, O) groups represents a simple, metal-free method for the formation of C3-boryla

161 A simple method for accessing perfluoroalkyl-substituted e

162 INTERPRETATION: We developed a simple method that can be easily integrated into contemp

163 2016, 144, 204105), we developed a simple method that resolves these issues.

164 There is thus a need for a simple method to characterize both fully and partially o

165 Here, the authors report a simple method to produce well-dispersed transition metal

166 In addition to developing a simple method, this study articulates unique physical pr

167 We created a robust but simple methodology to measure the prevalence of inaccura

168 Although relative simple methods based on the similarity between the word

169 We have developed new, simple methods to access these parameters, thus providin

170 The optimized method is simple, mild, and highly regioselective with a broad sub

171 An operationally simple, mild, redox-neutral method for the cross-couplin

172 The inks are synthesized via simple mixing of evaporant, surfactant, and plasticizer

173 This simple mode of pallium construction shares distinct trai

174 The insights disclosed by our simple model contribute a more intimate understanding of

175 intensity can be described via a relatively simple model derived essentially from first principles.

176 This provides a simple model for tissue regeneration, implicating cellul

177 In addition, a simple model is derived to describe the energy density a

178 nteractions with associated benzene rings (a simple model of aromatic amino acid side chains) can swi

179 As simple model reactions, cycloaddition of ethylene to for

180 Our simple model, when expanded to complex microecological a

181 We produced several simple models inspired by the known anatomical structure

182 e the use of genetic programming to generate simple models of dielectric breakdown based on 82 repres

183 This study provides a simple modification to improve microbial models for incl

184 The simple molecular building blocks derived from CO2 and H2

185 Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c

186 This article shows that a simple monetary incentive can dramatically reduce electr

187 The use of this simple motif to provide active intracellular targeting p

188 Here we present a simple, multi-trap device, consisting of a single PDMS (

189 stereocenter-containing cyclopentanoids from simple N-alkynyloxazolidinones (Ox-ynamides).

190 euronal circuit in a marine worm reveals how simple networks of neurons can control behavior.

191 ligence-like brain functions can emerge from simple neural circuits, in this case the honeybee mushro

192 The reactions utilize a simple Ni-catalyst and work with a broad range of alkene

193 We present a simple non-invasive computational technique that, when c

194 Second, a simple nonlinear zonal advection with no ad hoc paramete

195 th the axiom of choice (ZFC) that there is a simple nuclear nonseparable [Formula: see text]-algebra,

196 er installation of the nucleobases, and even simple nucleophiles, such as azido or cyano anions, reac

197 ted indenones was accomplished starting from simple o-iodoketones and aldehydes.

198 predicted PBDE partitioning compared to the simple OC isotherm.

199 roposes that the observed spectral tuning of simple ocellar photoreceptors in the honey bee allows fo

200 We modeled this process by a simple one-dimensional diffusion process and stochastic

201 An operationally simple one-pot procedure generates products via a proces

202 that the organization of the domains is not simple or obvious.

203 The Multiple Organ Dysfunction Score is a simple organ-based score, and this result supports the u

204 hese results suggest that using a novel, yet simple, paradigm can result in meaningful pupil metrics

205 y that the conformational space available to simple peptide-based catalysts is more diverse than prec

206 Here we construct simple peptides that assemble into well-defined amyloid

207 For simple perceptual laboratory tasks, classic signal detec

208 sed maximum diameter (OR = 1.29, P < .0001), simple periappendiceal fluid (OR = 2.08, P = .002), comp

209 domized, multicenter trial to test whether a simple, personalized walking exercise program at home, m

210 ormancy can be imposed by the formation of a simple physical barrier around the seed through which ga

211 ion and act as potent inhibitors in trans of simple polyQ peptide aggregation.

212 We discount a simple possible mechanism by showing that the 3'-exonucl

213 s a step forward in the search of chemically simple, potent, and selective antagonists for the hA3AR,

214 one can design fast ion conductors following simple principles.

215 istry establishes the basis for a remarkably simple procedure for printing highly conductive (3 x 10(

216 in daily practice, although it is a safe and simple procedure which can provide valuable clinical inf

217 tetrazoles through a novel and operationally simple protocol effecting the direct conversion of arylb

218 Here we provide a simple protocol for building and applying ichips for env

219 This experimentally simple protocol provides structurally complex, biologica

220 ility of iron minerals it does not provide a simple proxy for long-term monitoring of biodegradation

221 Therefore, we developed a simple quantitative framework to select a low-fluorescen

222 The approach is simple, quick, and costs less than 10% of the price for

223 Conclusion A simple ranking system based on interinstitutional variat

224 These C-microPADs enable simple, rapid, and cost-effective bioassays and environm

225 Therefore a simple, rapid, label free, inexpensive, excellent, sensi

226 potential to be an alternative approach for simple, rapid, sensitive, and selective DNA detection.

227 Secondly, a simple ratio-based correction was applied to the rRNA-de

228 triplet pi,pi* ground states and provides a simple recipe for making ionic intermediates with distin

229 odulates the gain of the PLR, changing how a simple reflex circuit responds to physically identical s

230 idescence in some butterflies, demonstrating simple regulatory coordination of structural and pigment

231 epeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the al

232 Our results indicate that relatively simple resource footprints are highly representative of

233 prognostic information of CMR imaging into a simple risk score that showed incremental prognostic val

234 The purpose of this study was to describe a simple sarcopenia index using routinely available renal

235 esses, there is no guarantee that there is a simple scalar, such as fitness, that would describe long

236 We interpret these findings using simple scaling arguments and discuss their robustness to

237 trans-activation capacity and optimized for simple screening assays with luciferase or fluorescent r

238 Herein, we describe a simple, selective, and mild procedure for the constructi

239 A simple, sensitive and rapid method is proposed for simul

240 h as noradrenaline (NA) in living cells with simple, sensitive and selective assays are significantly

241 Accurate and efficient genotyping of simple sequence repeats (SSRs) constitutes the basis of

242 We show that a simple set of conditions implies roughly exponential inc

243 used for the supervised learning task and a simple setup is introduced to obtain the scattering patt

244 here is an increasing demand for realizing a simple Si based universal memory device working at ambie

245 tically command his paralysed arm to perform simple single-joint arm and hand movements and functiona

246 probability index provides an immediate and simple solution to an overt problem.

247 Herein, we report the simple solution-phase generation of highly reactive phos

248 academic, technological, or scientific - and simple solutions, here defined as solutions that are ine

249 SCN units modulate their firing according to simple spatial patterns (drifting or inverting gratings)

250 numbers of spikelets are preceded by higher simple spike firing rates but, following the complex spi

251 Thus, here we compared simple spike-complex spike interactions both within and

252 fire two distinct types of action potential: simple spikes and complex spikes.

253 ring rates but, following the complex spike, simple spikes are reduced in a manner that is graded wit

254 Because Purkinje cells can fire coincident simple spikes during cerebellar behaviours, we varied th

255 How an adult-born neuron with initially simple spindle-like morphology develops into a DGC, cons

256 This platform provides a simple stage for systematic derivation of the entire ran

257 There are currently no simple, standardized, objective assessments of itch for

258 apid generation of molecular complexity from simple starting materials is a key challenge in synthesi

259 patients with biopsy-proven NAFLD (353 with simple steatosis and 182 with NASH) and compared them wi

260 s able to successfully differentiate between simple steatosis and more severe NASH, based on a set of

261 in NAFLD and the inclusion of patients with simple steatosis and nonalcoholic steatohepatitis withou

262 d peroxidation in progression of NASH beyond simple steatosis.

263 e whose size and shape can be tunable in one simple step.

264 A simple stochastic model accounting for the essential ste

265 Here we demonstrate a simple strategy for the fabrication of an open porous 3D

266 Here, we developed a novel and simple strategy to greatly enhance the potency of the ex

267 Microbe showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that

268 of neural receptive fields going far beyond simple surround suppression.

269 This paper describes the development of simple, sustainable, and low-cost strategies for signal

270 rbohydrate-protein interactions on arrays of simple synthetic glycans, more complex natural glycosami

271 This work identifies simple synthetic parameters, such as stirring rate, that

272 A simple technique that employs an antibody coated polydim

273 However, simple techniques do not exist to quantify the contribut

274 ound to be convenient starting materials for simple, thermal, Ni-catalyzed radical formation and subs

275 icantly assist for the disabled, because the simple throat vibrations such as hum, cough and scream w

276 detection of CaLas from citrus tissues in a simple tissue printing format.

277 ces are air-stable, non-toxic, and extremely simple to fabricate.

278 reasing levels of accuracy, it is relatively simple to implement even for medium and large number of

279 tronics research is focused on the design of simple-to-use and cheaper biodevices, while improving th

280 al footprint, we saw the need for a fast and simple tool for data pre-processing that could run indep

281 CRISPR-generated models represent a new and simple tool to investigate the biology of HGSC, and the

282 or provide clinicians and researchers with a simple tool to screen for patients at high risk of devel

283 Subjects undertook simple-tracking, precision-hold, and maximum force-gener

284 in decoding stop codons has evolved beyond a simple tripeptide anticodon model.

285 a are consistent with TRAP SBPs undergoing a simple two-state transition from an open-unliganded to c

286 A simple ultrasound assisted-cloud point extraction (UA-CP

287 This vector approach enables simple uniform particles to form a vast collection of co

288 etwork, i.e. a collection of many relatively simple units coupled flexibly.

289 MeV combines cloud-based technologies with a simple user interface to allow users to access large pub

290 In this work, we develop a simple variational approach allowing one to find the bes

291 In purple photosynthetic bacteria a simple version of this photoenzyme catalyzes the reducti

292 ts had to memorize object arrays composed of simple visual features (color, orientation, and location

293 gesting this is a first step in developing a simple way of controlling plastic flow in non-metallic c

294 A simple way to express surface charge density of these pa

295 Here, we present a simple way to monitor disassembly of (19)F-labeled VLPs

296 available to assess both simultaneously in a simple way.

297 his collective decision-making by a group of simple yes/no units revealed in this study suggest that

298 Our findings lead to a simple yet comprehensive model for TRAPPIII function in

299 Overall, the cross point serves as a simple yet informative analytical parameter to analyze t

300 Herein, we demonstrate a simple yet novel luminescence assay for visual chiral di