ライフサイエンスコーパス: simplification

1 NNRTI-containing regimen and want a regimen simplification.

2 y means other than reformulation and regimen simplification.

3 that important information is lost in their simplification.

4 t the KPR model for non-equilibrium topology simplification.

5 tion an important tool especially for sample simplification.

6 ied strategies and outcomes of kinetic model simplification.

7 ow equilibrium, resulting in global topology simplification.

8 sole determinant of non-equilibrium topology simplification.

9 perience virologic failure by 48 weeks after simplification.

10 resent a model of adolescent-onset dendritic simplification.

11 type IIA enzymes), does not exhibit topology simplification.

12 ment in fast processing, this is a dangerous simplification.

13 nsitivity analysis allows model reduction or simplification.

14 TGF-beta signaling coincident with alveolar simplification.

15 than the existing approach based on food web simplification.

16 structural features through two-dimensional simplification.

17 ont lineages secondarily underwent flagellar simplification.

18 es, but also extreme physiologic and genomic simplification.

19 egimen considering a regimen modification or simplification.

20 anoparticle sizing techniques through design simplifications.

21 have been eliminated through the use of two simplifications.

22 e speakers lose features due to a process of simplification?

23 As the principal simplification, a generic spectrum of the constituent pa

24 displays efficient non-equilibrium topology simplification activity, and for E. coli topoisomerase I

25 poisomerases that span the range of topology simplification activity.

26 This simplification allows enzymatic analysis of the isolated

27 ype one, and often the nature of the pattern simplification allows one to deduce how the wild-type ge

28 This simplification allows the emergence of a realistic troph

29 Simplification, altered connectivity, and mimicking of t

30 e tree, showing a tendency towards molecular simplification and a homogeneous reduction of ribosomal

31 manipulation have become a valuable tool for simplification and automation of molecular biology proto

32 e with high fidelity and promise substantial simplification and concatenation of photonic quantum cir

33 Extensive parallel gene divergence during simplification and constraint leading to CM suggest a de

34 nalysis of this connection between landscape simplification and insecticide use by examining cross-se

35 nsitivity, quantification readout, procedure simplification and multi-functionalization of paper-base

36 The molecular mechanisms leading to synaptic simplification and neuronal apoptosis in human immunodef

37 and provides a rational basis for treatment simplification and optimization.

38 dominant-negative form of MBP20 led to leaf simplification and partly suppressed the increased leaf

39 erized by lung injury, resulting in alveolar simplification and reduced pulmonary function.

40 t without increasing the number of patterns, simplification and referential relation linking play a k

41 hippocampal and cortical neurons resulted in simplification and retraction of dendritic arbors, witho

42 Simplification and rigidization led to fragments with hi

43 nowledging that the proposed view is still a simplification and should not be taken as a rigorous mod

44 Key components included the simplification and standardization of pressure ulcer-spe

45 Further simplification and standardization of these technologies

46 ng alone is insufficient to explain topology simplification and that the 'exit gate' may be an import

47 The results provide a considerable simplification and unification of a previously disparate

48 e comparability and effectiveness of various simplifications and approximations of existing frailty p

49 brane capacitance that disposes of the usual simplifications and assumptions, yet is immune to such i

50 A number of existing models rely on simplifications and do not take into account F-actin fra

51 trans-4, 5-dehydrolysine led to significant simplifications and narrowing of the EPR signal, showing

52 o II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Su

53 Abeta-induced dystrophic neurites, dendritic simplification, and dendritic spine loss in both neurons

54 y, reproducibility, usability, assay process simplification, and incorporation of portable time-resol

55 The weekend effect is a simplification, and just one of several patterns of week

56 In some contexts, default rules, simplification, and social norms have had even larger ef

57 magnetization transfers results in spectral simplification, and therefore larger protein assemblies

58 g therapy include convenience, tolerability, simplification, anticipation of potential new drug inter

59 The new chemotype ensued from a molecular simplification approach applied to our previously report

60 y activity and selectivity was proven by the simplification approach by removing a methyl group at th

61 he validity of the tQSSA and for its various simplifications are also of relevance at low molecule nu

62 Three simplifications are made.

63 n the 3D reality of the jellyfish and the 2D simplification, as well as the rigidity of the time vary

64 ed to hyperoxia as neonates display alveolar simplification associated with a reduced number of alveo

65 The simplification associated with transcriptomic profiling

66 analytical and general model resulting from simplifications assuming small phenotypic variance.

67 ferulate biosynthesis appears to be an over-simplification, at least in alfalfa, and additional enzy

68 tial community composition change and forest simplification beyond this century.

69 sults point to a general process of topology simplification by local reconnection, with applications

70 There are various approaches for large data simplification by scaling its dimensions down that play

71 experiment therefore depends on the level of simplification chosen, not the size of the number factor

72 prehensive lipidomics analysis by separation simplification" (CLASS), and the other in which all lipi

73 Our greatest simplification comes from defining linkage disequilibriu

74 ur model resolves the paradox of topological simplification concomitant with chromosome 'condensation

75 The simplifications considered offer a more functional metho

76 marked airway hyperresponsiveness, alveolar simplification, decreased lung compliance, and decreased

77 Rho kinase reverses STI571-induced dendritic simplification, demonstrating that activity of the Rho p

78 vious experimental implementations have used simplifications dependent on knowing the factors in adva

79 astic condition of cnidarians is a secondary simplification, derived from an ancestral condition of t

80 We review two mathematical approaches to simplification, dimensionality reduction and the maximum

81 pping to fix problems, forcing functions and simplification, enhanced visual cues, and cautious use o

82 tissue culture methods need optimization and simplification for efficiency and minimization of time i

83 ysis (FBA) framework has provided conceptual simplifications for genome-scale dynamic analysis at ste

84 Against this background of overall simplification, genes conserved in multiple outcrossing

85 biological system and that the evidence for simplification gives us a language with which to phrase

86 Surprisingly, food web simplification had no effect on the growth of A. opacum

87 Traditionally, simplification has been imposed by training animals to e

88 Basal animals are surprisingly complex and simplification has been rampant in animal evolution.

89 Human-driven ecosystem simplification has highlighted questions about how the n

90 temporal perspective suggests that landscape simplification has inconsistent effects on insecticide u

91 ain or whether it is the result of secondary simplification has until now been hindered by lack of fo

92 We demonstrate that model simplifications (i.e. factorizations of the likelihood f

93 (119-113 Ma) and suggest that outflow tract simplification in actinopterygians is compatible with a

94 terized histologically by alveolar-capillary simplification in animal models, it is clinically define

95 lytical imperatives were sought: (1) overall simplification in data acquisition and analysis and (2)

96 morphological consequences of this adaptive simplification in the Pachydactylus radiation of geckos,

97 The methodological advance and thermodynamic simplification in the paper have implications in control

98 as lost in A. thaliana, contributing to leaf simplification in this species.

99 erpretation of the results is limited by the simplifications in country structure, vaccination policy

100 supports the validity of the assumptions and simplifications in our model.

101 nblastine, have not been easily subjected to simplifications in their structures by synthetic means o

102 Simplifications include the removal of the entire side-c

103 that both spine loss and dendritic branching simplification induced by Abeta exposure were mimicked b

104 ing of how different components of landscape simplification influence insecticide use over space and

105 One of the simplifications introduced in the control of such moveme

106 Implicit in this simplification is a crucial assumption that has never be

107 A significant conceptual simplification is achieved by applying inverse thinking,

108 This simplification is attainable without loss of the accurac

109 Fgfr4 (Fgfr3;4) global mutant mice, alveolar simplification is first observed at the onset of alveolo

110 Simplification is important for routine clinical practic

111 We find that topology simplification is not significantly dependent on circle

112 Simplification is obtained by mathematically breaking a

113 id, and phosphatidylserine, further spectrum simplification is obtained by the appearance of only the

114 Such simplification is often at odds with field observations

115 The key to this simplification is the realization that the step of activ

116 A typical simplification is to reduce the number of equations by m

117 any additional NMR experiments for spectral simplification, is easy to perform and has the potential

118 truction would cause unprecedented ecosystem simplification, loss of ecosystem services, and species

119 This simplification makes it possible to calculate the exact

120 s wholly random sampling unfeasible, two key simplifications may provide a solution.

121 e ask whether, and to what extent, landscape simplification, measured as the percentage of arable lan

122 de that poses more challenges to traditional simplification methods based on collision activated diss

123 We also speculate whether topology simplification might simply be an evolutionary relic, wi

124 ht implementation of the graph traversal and simplification modules that achieves comparable assembly

125 Consequently, approximations and simplifications must often be used which increase the ri

126 the mounting interest in promoting ease and simplification ("navigability"); in increasing effective

127 resources, and psychological variables is a simplification neglecting various intervening variables.

128 nt discontinuations for adverse events after simplification; no significant changes in CD4 cell count

129 gene structures were very complex, and that simplification, not embellishment, has dominated subsequ

130 udies for the more general SLE outcome are a simplification of a complex multivariate genetic associa

131 Unfortunately, even with the simplification of a constant drug efficacy, we show that

132 restrained differentiation, resulting in the simplification of a pseudostratified epithelium into a c

133 ific overexpression of EMAPII in mice caused simplification of alveolar structures, apoptosis, and ma

134 Simplification of alveolar-capillary structure is highly

135 hronic stressor that produces retraction and simplification of apical dendrites of hippocampal CA3 py

136 -dependent diabetes undergoes retraction and simplification of apical dendrites of the CA3 pyramidal

137 this review, we call for standardization and simplification of assay methods and stress the importanc

138 cation of the apical dendritic tree preceded simplification of basal dendrites.

139 ecision-making, resulting in a possible over-simplification of behavioral types.

140 As part of a program aimed at structural simplification of bioactive natural products utilizing m

141 More significantly, simplification of catalytic mechanisms through the incor

142 iency virus (HIV) include once-daily dosing, simplification of co-treatment for tuberculosis, preserv

143 Significantly, IVA allows unprecedented simplification of complex cloning procedures: five simul

144 Simplification of complex fluorescent decays by phasor d

145 eas hyperactivation of RhoA causes a drastic simplification of dendritic branch patterns that is depe

146 Abl kinases by STI571 leads to a remarkable simplification of dendritic branching similar to the phe

147 The continuing simplification of design along with continued reduction

148 es, providing a new means for retrosynthetic simplification of differentiated diol and polyol targets

149 Consequently, simplification of diverse ecosystems will likely have gr

150 Aiming at a simplification of dosimetry, we analyzed the accuracy of

151 a profound loss of genera and families, and simplification of ecosystems, with the loss of small fis

152 Simplification of electrochemically mediated atom transf

153 phylogeny reconstruction are a considerable simplification of epidemic process, as they assume that

154 technique provides charge reduction for the simplification of ESI spectra, without need for any radi

155 The simplification of fabrication processes that can define

156 ted: suppression of background fluorescence, simplification of FCS reaction studies, and investigatio

157 treme low pH, suggesting that there may be a simplification of food webs with ocean acidification.

158 Reductions in bivalve size and simplification of gastropod trophic structure further im

159 orizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that p

160 New approaches for the simplification of glycoconjugate synthesis are overcomin

161 ative application of this principle leads to simplification of imine libraries containing up to 16 me

162 ion causes pleiotropic defects, most notably simplification of inflorescences into single flowers, re

163 ount of protein required and the substantial simplification of labeling strategies.

164 obligate endoparasitic lifestyle led to the simplification of many orthologous gene families involve

165 ristics for enhanced sensing performance and simplification of microsystems.

166 is moved to be controlled, allowing for the simplification of multicomponent mixtures within a mass

167 Thus, it is not surprising that secondary simplification of novel locomotory traits has occurred s

168 rivers due to low model resolutions and the simplification of NP chemistry and sediment transport.

169 By stepwise simplification of our models, we found that the gamma-me

170 imer set has been designed, allowing for the simplification of previously described assays.

171 st is driving a trend in miniaturization and simplification of procedures.

172 In addition, simplification of product ion spectra generated from dis

173 reproducibility, overlap between fractions, simplification of protein mixtures, and enrichment of lo

174 mass mapping approaches involves structural simplification of proteins with the use of a protease fo

175 A method for spectral simplification of proton NMR spectra of blood plasma is

176 lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations lead

177 rived to provide theoretical support for the simplification of reaction kinetics and the approximatio

178 easurements, (iii) short analysis time, (iv) simplification of sample preparation and (v) effective s

179 ential amplitudes, reduced endplate size and simplification of secondary synaptic folds, which were c

180 ftware for combined synthesis, inference and simplification of signal transduction networks.

181 We show that soil biodiversity loss and simplification of soil community composition impair mult

182 protonated counterparts, allows significant simplification of spectra, and facilitates NOE assignmen

183 in grammatical and speech sound errors and a simplification of spoken syntax relative to age-matched

184 dely applicable and will lead to substantial simplification of strategies for synthesis of polyketide

185 cs and microwave concepts and allowing for a simplification of structure design and analysis; in prac

186 c allylic alkylation a powerful key step for simplification of synthetic strategy to complex molecula

187 bits multiple unambiguous losses or bouts of simplification of the adhesive system.

188 Simplification of the algorithm by removing age did not

189 as we show here, all composite numbers admit simplification of the algorithm to a circuit equivalent

190 Simplification of the apical dendritic tree preceded sim

191 This paper proposes a least-squares simplification of the binomial likelihood model motivate

192 ury is the loss of unique ultrastructure and simplification of the cell shape, called foot process ef

193 These results permit a simplification of the cellular model.

194 es based on their relaxation times and allow simplification of the complex spectra.

195 In considering simplification of the current resuscitation scheme, a lo

196 observations that it also leads to strategic simplification of the ecological food web, and generates

197 There is a need for standardization and simplification of the existing methods for molecular det

198 The possible simplification of the fabrication process of complementa

199 duction and diversity through 2 years caused simplification of the food web and deep reductions in co

200 , the latter description is widely used as a simplification of the former.

201 the case of very heterogeneous glycan pools, simplification of the glycosylation pattern was achieved

202 beling strategy achieves spectral editing by simplification of the HalphaCalpha and aliphatic side ch

203 ene structure and gene content that parallel simplification of the Hydra life cycle.

204 The attraction with DIY kits is the simplification of the intervening steps going from basic

205 This protocol represents a considerable simplification of the isolation procedure and is particu

206 sult in improvement of long-term outcome and simplification of the management of transplant recipient

207 In the second case, by a simplification of the mechanisms for inter and intra-spe

208 This idea is a conceptual simplification of the membrane protein folding problem a

209 The model is a simplification of the natural history of prostate cancer

210 Further simplification of the new ESPGHAN guidelines might be ma

211 The model presented in this paper is a simplification of the organized chaos that constitutes t

212 SF3B1 in splicing and also demonstrate that simplification of the PB scaffold is feasible.

213 The model represents a simplification of the previously described coalescent wi

214 However, simplification of the procedures for analyzing samples w

215 ractive metallurgy offers both a substantial simplification of the process and a significant reductio

216 The new approach brings significant simplification of the process of fabricating PMMA device

217 al for small size and greater reliability by simplification of the pumping mechanism.

218 Optimization of detergent/protein ratios and simplification of the purification procedure also contri

219 mization of the detergent/protein ratio, and simplification of the purification procedure were respon

220 In this case, simplification of the regimen might still allow adequate

221 d depth of information that can be gained by simplification of the sample prior to the MS analysis th

222 proposed microbiosensor as probe tip allows simplification of the set-up used for the evaluation of

223 together, these findings provide a powerful simplification of the social network, where cores repres

224 Moreover, we introduce a complimentary simplification of the tQSSA rate law that is valid in st

225 isting memory technology, size reduction and simplification of the used material systems are essentia

226 ression at E14.5, which is associated with a simplification of the vascular tree at E18.5.

227 and Naor, and our proof is an adaptation and simplification of their argument.

228 verely glaucomatous optic nerves also showed simplification of their processes.

229 Simplification of this latter result provides a momentum

230 involved C-H bonds allows for a significant simplification of this parametric scheme, requiring only

231 lopment of this immunization scheme requires simplification of vaccine manufacture.

232 eal-world contexts often relies on strategic simplifications of decision problems.

233 great enough, non-local models are adequate simplifications of local models.

234 lectron microscopy, TEM) can only provide 2D simplifications of size and shape with a spatial resolut

235 This observation allowed further simplifications of the scaffold to generate new lead com

236 Previous simplifications of the tQSSA rate law are valid in a par

237 study indicates that the effects of food web simplification on the performance of A. opacum are compl

238 the Becke3LYP/6-31G level of theory without simplifications on the beta-diketiminate ancillary ligan

239 Signal decreases, presumably alveolar simplification, only appeared in the most severe BPD cas

240 ine, and tenofovir might be a useful regimen simplification option for virologically supressed adults

241 Our previous study showed that, despite simplifications, our discrete molecular dynamics approac

242 Rational design and substantial structural simplification permitted the expedient chemical synthesi

243 for the hypothesized link between landscape simplification, pest pressure, and insecticide use.

244 eral models of this non-equilibrium topology simplification phenomenon have been proposed.

245 at the United Nations Office in Geneva and a simplification process of the hypersensitivity/allergic

246 The success of this MS/MS simplification process stems from extensive secondary fr

247 es show distinct advantages based on process simplification, product quality and environmental footpr

248 This spectral simplification provides direct evidence that, for the ma

249 Similarly, landscape simplification reduced the phylogenetic congruence among

250 This simplification, relative to other vertebrates, allows us

251 The physiological basis of this perceptual simplification remains poorly understood.

252 ism underlying this non-equilibrium topology simplification remains speculative.

253 These simplifications remarkably save computation time compare

254 Common policy simplifications result in a 49-100% loss in biodiversity

255 A pervasive concern is that such landscape simplification results in an increase in insect pest pre

256 del postulates that non-equilibrium topology simplification scales with the bend angle imposed on the

257 nd indirect environmental costs of landscape simplification should be considered in design of land us

258 iew concludes by showing how seemingly small simplifications, such as assuming thermal equilibrium ac

259 Using an innovative graph simplification technique, which is ideally suited to bio

260 track of all parts of a perfect repeat and a simplification that ignores point mutations.

261 Applying the simplification that synapses between different cell type

262 n of 3D atomic similarities introducing some simplifications that allow us to extend its applicabilit

263 protein structure prediction make necessary simplifications that also prevent them from being as acc

264 were calculated while avoiding commonly made simplifications that do not apply to large pathogen popu

265 dary structure prediction admits a number of simplifications that make it computationally tractable f

266 unately, popular methodologies rely on model simplifications that sensitize them to interference from

267 investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of d

268 A new parameter more appropriate for the simplification, the EC20, has been proposed to express t

269 Despite this simplification, the product multiplicity and novelty ove

270 Using these simplifications, the difficulty of specifying a working

271 However, for reasons of simplification, this CO2-SLCF linkage was often disregar

272 ticipants enrolled and 2 discontinued before simplification to atazanavir-ritonavir alone.

273 n a systematic manner, (2) applying sentence simplification to improve the coverage of extraction pat

274 Here we use a key simplification to investigate the theoretical limits to

275 etroviral therapy might benefit from regimen simplification to reduce pill burden and dosing frequenc

276 To accomplish this, several simplifications to a log-normal Langmuir (LNL) isotherm

277 andwidth-efficiency, but require fundamental simplifications to become economically viable for access

278 e data on key model parameters and necessary simplifications to model structure and outcomes.

279 We prospectively tested two simplifications to the French mifepristone-misoprostol r

280 Political simplification undermines traditional structures of auth

281 rade forests in the future (phase IV, global simplification) unless new "development without destruct

282 Thus, a simplification usually made in the application of inform

283 how environmental change can cause ecosystem simplification via environmentally mediated changes in c

284 ss the seven-state region in 2007, landscape simplification was associated with insecticide applicati

285 county in cropland--my metric for landscape simplification--was positively correlated with insectici

286 A discussion of the simplifications we used in the context of the results in

287 To determine the robustness of this simplification, we compared two small helix-turn-helix t

288 With this simplification, we found that elimination of the lysine

289 However, several simplifications were followed by proof-of-principle demo

290 inetic parameters, a series of kinetic model simplifications were made, resulting in fewer kinetic pa

291 Nevertheless, a number of simplifications were still made and future work should e

292 Type II topoisomerases exhibit topology simplification, whereby products of their reactions are

293 These simplifications will allow for broader application of th

294 Therefore, simplification with better predictability of overall sur

295 we correlated alveolar-capillary structural simplification with reduced functional gas exchange as m

296 velopment has benefited from patient-centred simplification with several effective regimens now avail

297 virologic failure 12, 14, and 20 weeks after simplification, with plasma HIV-1 RNA levels of 4730, 12

298 alike, nonfasting lipid profiles represent a simplification without negative implications for prognos

299 Such simplification would greatly decrease the computational

300 This remarkable simplification yields the single sorbate-specific parame