ライフサイエンスコーパス: simultaneous

1 ic accuracy of the technique was assessed in simultaneous (18)F-FDG PET/MR scans of a canine model of

2 ceived kidney transplants (303 tx alone, 161 simultaneous, 27 pre).

3 Simultaneous ablation and labelling of cells using our s

4 We found that the simultaneous absence of Nod1 and Nod2 primed T cells for

5 e quantum yield determination that relies on simultaneous absorption and fluorescence emission (SAFE)

6 /sulfate heat stable salt, which enables the simultaneous absorption of CO2 and SO2/SO3 from the flue

7 (ELIT) has been configured to allow for the simultaneous acquisition of mass spectra via Fourier tra

8 g our method to single-view LSFM, permitting simultaneous acquisition of two high-resolution views ot

9 The findings reveal that simultaneous activation by a receptor activation loop (f

10 approaches yield structural snapshots of the simultaneous activation of both bonds of a beta-diketimi

11 Simultaneous activation of different sensory pathways el

12 sophila grooming sequence that is induced by simultaneous activation of different sensory pathways th

13 e effector activation (mTALE-Act) system for simultaneous activation of up to four genes in plants.

14 stage systems identification analyses of the simultaneous activity of MT and LIP during individual de

15 hat PET quantitation was not affected during simultaneous aggressive MRI.

16 Simultaneous allograft enterectomy and retransplantation

17 0 individual cells per assay, while offering simultaneous analysis of cellular communication effects

18 DBS sampling for the simultaneous analysis of immunosuppressants and creatini

19 eling and multispectral imaging have enabled simultaneous analysis of more than three markers within

20 calling algorithms are not optimised for the simultaneous analysis of multiple samples, or for non-hu

21 or barcoding and are in great demand for the simultaneous analysis of multiple targets.

22 A direct and simultaneous analysis of the age and isotopic compositio

23 We established our assay for the simultaneous analysis of three EMT-associated genes miR-

24 extraction (Pa-EME) was developed to enable simultaneous and high-throughput extraction of ionic and

25 pproach offers using just 1 muL of sample, a simultaneous and rapid "on-the-fly" detection (2 min) wi

26 1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one] using simultaneous and sequential dosing schedules.

27 generating photoacoustic (PA) signals using simultaneous and time-delayed pump and probe excitation

28 al was 68.5%, 63.6%, and 65.7% for tx alone, simultaneous, and precohorts (P = 0.86).

29 WGS analysis suggests nearly simultaneous, and recent, independent emergence of diffe

30 t long-term benzodiazepine use in those with simultaneous antidepressant and benzodiazepine new use,

31 The technique is based on the simultaneous apodization of two structural parameters: t

32 Upon simultaneous application of an osmotic gradient and the

33 Immunoprecipitation and simultaneous assay by Western blotting using multiplex f

34 Simultaneous assessment of excretory liver and kidney fu

35 etime imaging (FLIm) that enables label-free simultaneous assessment of morphological and biochemical

36 ries of oligomeric proanthocyanidins and the simultaneous assessment of their antioxidant capacity in

37 including reductions in oxidative stress and simultaneous attenuation of ROS-dependent activation of

38 To examine trends in simultaneous benzodiazepine and antidepressant new use a

39 sk shows that freely moving rodents can make simultaneous bilateral tactile discrimination without wh

40 at both neutral and acidic pH, prevents the simultaneous binding of IgG, and reduces circulating IgG

41 Simultaneous binding of SWR to both H2A nucleosome and f

42 nrichment cultures are capable of catalyzing simultaneous biological N and P removal coupled to N2O g

43 ximal anabolic response are achieved only by simultaneous blockade of both receptors.

44 s case contributes to the ongoing efforts of simultaneous BRAF/MEK inhibition as a promising strategy

45 rosslinking immunoprecipitation) to evaluate simultaneous changes in gene expression after imposing a

46 remote-controlled, smart films that undergo simultaneous changes of surface color and morphology upo

47 The capability of simultaneous chemical and topographic imaging of complex

48 This postsynthetic modification resulted in simultaneous chemical delamination and functionalization

49 Solid-phase microextraction and simultaneous chemical-sensory analyses with multidimensi

50 ype of electrospinning collector that allows simultaneous collection and alignment of multiple poly(v

51 om-up assembly of aligned CdS nanowalls by a simultaneous combination of horizontal catalytic vapor-l

52 Simultaneous confocal measurements of cytosolic ([Ca(2+)

53 agen fibrillogenesis using confocal rheology-simultaneous confocal reflectance microscopy, confocal f

54 The simultaneous control of diastereoselectivity and regiose

55 The ability to achieve simultaneous control over the various electromagnetic pr

56 Simultaneous core temperatures were recorded from 1 to 5

57 res in STEC-HUS, aHUS, and secondary HUS are simultaneous damage to endothelial cells, intravascular

58 n on surgical care were developed as part of simultaneous data collection and analysis during qualita

59 The algorithm enables real-time simultaneous deconvolution of O(105) traces of whole-bra

60 reased from 38.3% to 58.4% (P < 0.01) with a simultaneous decrease in that performed by low cumulativ

61 RW presence in the mid-Atlantic region and a simultaneous decrease in the northern Gulf of Maine.

62 Simultaneous deletion of these shadow enhancers in embry

63 g measurements at surfaces using the tip for simultaneous delivery and sensing of the reaction rate.

64 lication stress induced by FANCM deficiency, simultaneous depletion of BLM and FANCM, or of BRCA1 and

65 This phenotype can be rescued by simultaneous depletion of both Satb1 and Satb2, owing to

66 (2017) investigate the dire consequences of simultaneous deregulation of both the Ras and Hippo path

67 ched polymer (PEI) is used for reduction and simultaneous derivation of graphene oxide (GO) to form a

68 hemistry and an RNA internal control for the simultaneous detection and quantification of HEV RNA in

69 H oxidation and GSSG reduction, enabling the simultaneous detection of both species.

70 al polymer named copoly(DMA-NAS-MAPS) to the simultaneous detection of food allergen-specific IgE and

71 Here we demonstrate multiplex and simultaneous detection of four different rare RNA specie

72 A sensitive HPLC-MS/MS method for the simultaneous detection of microbial transglutaminase (TG

73 spectral imaging analysis methods that allow simultaneous detection of multiple bacterial strains at

74 However, current strategies for simultaneous detection of multiple gene fusions are limi

75 Simultaneous detection of single quantum (SQ) and triple

76 Based on this strategy, the simultaneous detection of two tumor markers in single ru

77 lp to identify melanoma biomarkers, allowing simultaneous detection of up to 100 parameters.

78 , sensitive and rapid method is proposed for simultaneous determination of 120 various classes of her

79 a range of 0.01-30.0muM and 0.01-25.0muM for simultaneous determination of A and G, with detection li

80 this report, a UPLC-ESI-MS/MS method for the simultaneous determination of aflatoxins, ochratoxin A,

81 anion and cation exchange, which allows the simultaneous determination of analytes with extremely di

82 A new method for simultaneous determination of five bisphenols in canned

83 o validate an analytical method by LC-MS for simultaneous determination of mycotoxins and fungicide r

84 phy-mass spectrometry (GC-MS) method for the simultaneous determination of propane-1,2-diol, butane-2

85 he popular PLUMED library, which enables the simultaneous determination of structure and dynamics of

86 prepared electrode was used in the sensitive simultaneous determination of sunset yellow and tartrazi

87 ction followed by LC-QqQ-MS analysis for the simultaneous determination of the main pentacyclic trite

88 ative proteomics mass spectrometry, allowing simultaneous determination of the steady-state distribut

89 has been evaluated as a microsensor for the simultaneous determination of trace levels of heavy meta

90 ence (ECL) immunoassay was developed for the simultaneous determination of two different tumor marker

91 The present work describes a method for the simultaneous determination of unmodified nucleosides and

92 ordinated regulation of cues that direct the simultaneous development of both peripheral taste organs

93 und that the animals can perform a bilateral simultaneous discrimination without whisking and that th

94 ow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and int

95 Here we describe an optimized protocol for simultaneous dual-channel two-photon fluorescence anisot

96 Here we report simultaneous eddy covariance flux measurements of NOx, C

97 Our simultaneous EEG and fMRI analysis on 21 human subjects

98 Here we use simultaneous EEG-fMRI and computational modelling to ide

99 regression models were used to evaluate the simultaneous effect of risk factors.

100 wth are understood, analyses examining their simultaneous effects are lacking.

101 The simultaneous electroanalytical sensing using BiO-SPEs ex

102 ted, and reliable biosensor for multiple and simultaneous electrochemical analyses in a single device

103 Simultaneous electroencephalography (EEG) and fMRI (EEG/

104 In this study, we performed simultaneous electrophysiology and fast confocal Ca(2+)

105 aphically distinct volcanoes, explaining the simultaneous emergence of double-track volcanism across

106 has demonstrated the unique and unpredicted simultaneous enhancement in toughness and strength with

107 Herein, we report on the simultaneous enhancement of the power and energy densiti

108 PLC and UV-spectrophotometric method for the simultaneous estimation of chlorpyrifos and prophenofos

109 ay device (H2 PAD) is presented that enables simultaneous evaluation of 96 individual H2 production r

110 vel computational imaging technology for the simultaneous evaluation of eight distinct markers, allow

111 es, and it is the first demonstration of the simultaneous evaluation of electrochemical responses fro

112 h-resolution, week-long, time series enabled simultaneous evaluation of ultradian rhythms as well as

113 The simultaneous evolutionary lability and genetic complexit

114 aracterizes the physiological control on the simultaneous exchange of water and carbon dioxide in ter

115 Through the sonochemical method, simultaneous exfoliation of graphite and the reduction o

116 We find a simultaneous expansion of wetland area, driven by the ex

117 underwent hemodynamic exercise testing with simultaneous expired gas analysis to measure oxygen cons

118 We employ simultaneous exposure of Cot molecules and Eu vapor in u

119 Pretreatment with METH, but not simultaneous exposure, significantly increased HIV produ

120 ming of Ig H and L chain expression revealed simultaneous expression of both IgH-mu- and IgL-kappa-ch

121 Using a simultaneous fluorescence-Raman endoscopic system (FRES)

122 Simultaneous fMRI recordings revealed that the same subj

123 using dual-trap optical tweezers and observe simultaneous folding of the nascent polypeptide chain in

124 ment followed by gene amplification, for the simultaneous formation of anomalous CNAs in multiple chr

125 reover, our data provide a framework for the simultaneous formation of multiple cell types by the sam

126 ular frequency and mass, requires use of two simultaneous frequency scans, both linear in mass, and (

127 The overlapping and simultaneous function of multiple silencing mechanisms h

128 Simultaneous functional disruption of both TpnC genes re

129 atropisomeric products, thereby enabling the simultaneous generation of axial and point chirality fro

130 r template-specific primers to allow for the simultaneous generation of high-dimensional sequencing d

131 ssing immune system to treat cancer requires simultaneous generation of tumor-specific CTLs and curta

132 ue cyst formation and size control that show simultaneous growth and size oscillations, we create a m

133 ated to a simultaneous liver-kidney (SLK) or simultaneous heart-kidney (SHK) recipient and the contra

134 and reproductive success over time, using a simultaneous hermaphrodite.

135 s the concept and feasibility for performing simultaneous high-resolution fMRI and TPM imaging at ult

136 Here we integrate simultaneous, high-resolution, tracking of wild baboons

137 re not different from those documented after simultaneous IAT.

138 tific, Salt Lake City, UT) for the rapid and simultaneous identification (ID) of Staphylococcus aureu

139 This methodology allows simultaneous identification and quantification of sterol

140 Studies estimating the simultaneous impact of environmental variation on both s

141 However, studies on the simultaneous impacts of human-driven environmental alter

142 ascading phosphotransferases that couple the simultaneous import and phosphorylation of a variety of

143 igned multiclonal plastic antibodies through simultaneous imprinting of aflatoxin subtypes B1, B2, G1

144 bolic imaging has increased in recent years, simultaneous in vivo measurement of multiple metabolic e

145 tion after a 10-minute delay) permitted near-simultaneous in vivo microscopy of 2-NBDG and TMRE at th

146 waveguide system can be optimised to enable simultaneous in-situ Raman spectroscopy monitoring of 2D

147 We observed the simultaneous incorporation of up to 12 oligonucleotides

148 agnitudes of these trends are similar to the simultaneous increase in cognitive abilities, at 0.2-0.6

149 A simultaneous increase in up score and decrease in down s

150 ecific regulation of jasmonate biosynthesis; simultaneous induction of synthesis and breakdown of SA;

151 ower the probability of lysogeny compared to simultaneous infections.

152 a time-weighted average of probabilities for simultaneous infections.

153 eric liquid crystal superstructure under the simultaneous influence of an applied electric field and

154 Using simultaneous infrared, optical, x-ray, and radio observa

155 Correspondingly, sestrin deficiency or simultaneous inhibition of all three MAPKs enhanced vacc

156 The simultaneous inhibition of both enzymes appears more pro

157 Simultaneous inhibition of IL-6/8 receptors decreases th

158 Simultaneous inhibition of p300/CBP and Notch has a syne

159 Simultaneous inhibition of Syk and PKC revealed additive

160 This approach enables simultaneous investigation of kinases and phosphorylatio

161 erature superconductor YBa2Cu3O7-X (YBCO) by simultaneous ionic liquid gating and X-ray absorption ex

162 machine perfusion until transplant: 69 with simultaneous kidney transplantation (KT) (at time of LT,

163 6 pancreas transplant patients including 182 simultaneous kidney-pancreas and 84 pancreas alone trans

164 For practical applications, simultaneous large ferroelectric polarization and strong

165 henomena of interest, as demonstrated by our simultaneous live imaging of genomic loci together with

166 ransplants where 1 kidney was allocated to a simultaneous liver-kidney (SLK) or simultaneous heart-ki

167 Simultaneous liver-kidney (SLK) transplantation plays an

168 The device allows the simultaneous loading of cells into 16 separate chambers,

169 With this result, we produced mice that had simultaneous loss of both CM Tln1 and Tln2 and found tha

170 Although simultaneous loss of ey and toy during early eye-antenna

171 However, simultaneous M-cell spikes generated through direct curr

172 c and proteomic analysis in combination with simultaneous manual curation to achieve near complete as

173 ked with whole-animal electrical recordings, simultaneous measurement of behavioural kinematics and f

174 onstrated the ability of the system for near-simultaneous measurement of dopamine release and activit

175 bes offer a low-noise alternative for direct simultaneous measurement of each vector field component.

176 le cell RNA-sequencing (scRNA-seq) can allow simultaneous measurement of TCR sequence and global tran

177 rapid, simple, and multiplex method for the simultaneous measurement of the four DNA bases remains a

178 However, required analytical methods for the simultaneous measurement of tobacco-related toxicants an

179 Voltage clamp fluorometry (VCF) allows simultaneous measurement of voltage sensor movement and

180 Simultaneous measurement using time-resolved absorption

181 ectivity map has never been constructed from simultaneous measurements across the brain.

182 ecute preprogrammed vertical behaviours, the simultaneous measurements at multiple, known locations r

183 dic imaging system that allows real-time and simultaneous measurements of cell growth and protein exp

184 ation by each pathway can be calculated from simultaneous measurements of extracellular acidification

185 Simultaneous measurements of L-type Ca current and intra

186 city, using fluorescence-based analysis, and simultaneous measurements of mitochondrial Ca(2+) handli

187 onfigurations with possibility of performing simultaneous measurements.

188 ng ascorbate during washing, especially with simultaneous mechanical agitation; however, washing in t

189 ystematic repetition of a principal theme in simultaneous melodic lines.

190 F glutamatergic responses underwent LTD, the simultaneous MF GABAergic responses of stratum lucidum i

191 es intrinsic to chemical exfoliation enables simultaneous modulation of active site density and intri

192 ith the same nonpolar localisation, requires simultaneous modulation of efflux carrier level and pola

193 The model predicted that simultaneous modulation of TGF-beta and matrix metallopr

194 Here, we extend RBT to enable simultaneous monitoring of additional degrees of freedom

195 In a solid tumor mouse model allowing simultaneous monitoring of anti-tumor potency and system

196 nt in BRET measurement paves the way for the simultaneous monitoring of independent biological pathwa

197 ve study for 62 toxic chemicals based on the simultaneous monthly collection of aerosol samples durin

198 s a linear tube that then undergoes multiple simultaneous morphogenetic events to obtain its mature s

199 With numerical simulations, simultaneous multi-band valley dependent edge states and

200 iabetic matched controls were analyzed using simultaneous multicolor immunofluorescence.

201 Analysis of simultaneous multiple patch-clamp recordings from 6068 p

202 induction of IFN-gamma expression; however, simultaneous mutation of three of the mTORC1-dependent s

203 a single-step synthetic route involving the simultaneous nanoparticle formation and functionalizatio

204 Simultaneous narrowband CARS and SFG imaging was faster,

205 nent analysis (PCA) and SFG imaging and (ii) simultaneous narrowband CARS and SFG imaging.

206 We then leveraged the simultaneous nature of the recordings to test several hy

207 Here, we recorded simultaneous neural population activity using multielect

208 zepine new use, and identify determinants of simultaneous new use and long-term benzodiazepine use.

209 t, assess antidepressant treatment length by simultaneous new use status, estimate subsequent long-te

210 essant treatment at 6 months was observed by simultaneous new use status.

211 ed local gradient of NC concentration causes simultaneous nucleation of the two superlattices.

212 dy saccades and smooth movement interact for simultaneous object pursuit and gaze stabilization is no

213 The simultaneous observation of electrons and holes with ext

214 , reveals that this alone cannot explain the simultaneous occurrence of both viral growth outcomes un

215 ptical and electrical effects and/or require simultaneous optical and electrical characterisation, na

216 type phase-change devices that might exploit simultaneous optical and electrical effects and/or requi

217 ring electrophysiological function, allowing simultaneous optical pacing and Vm mapping.

218 ilt optoelectronics probe station capable of simultaneous optical-electrical excitation and simultane

219 multaneous optical-electrical excitation and simultaneous optical-electrical response measurement has

220 nical approach is needed to evaluate whether simultaneous or sequential drug treatment has maximal th

221 However, researchers have rarely run simultaneous or side-by-side tests of whole-body and nos

222 We analyzed recipients of simultaneous pancreas and kidney and pancreas after kidn

223 Out of 1022 simultaneous pancreas and kidney or pancreas after kidne

224 Transplant Network database records for 9916 simultaneous pancreas-kidney transplants (SPKT) performe

225 Importantly, simultaneous patients had more renal vascular thromboses

226 al PET quantitative stability assessment for simultaneous PET scanning during functional MRI studies

227 spective study was carried out for utilizing simultaneous PET/MR imaging for five subjects by using t

228 of (68)Ga-RM2 using a time-of-flight-enabled simultaneous PET/MRI scanner.

229 structured WO3 is a well known catalyst, the simultaneous photocatalytic degradation of organic pollu

230 The simultaneous presence of two recognition sites produces

231 With simultaneous presentation, the measure of WM precision w

232 accines is an attractive methodology for the simultaneous prevention of several infectious diseases i

233 This approach enabled simultaneous printing with multiple printing heads and,

234 The simultaneous pseudo-acetylation of hTau at lysines 163,

235 lationship science is likely to benefit from simultaneous pushes toward both greater integration acro

236 be approach coupled to mass spectrometry for simultaneous quantification and post-translational modif

237 etic peptides for each protein to prompt the simultaneous quantification of >100 peptides from up to

238 me the rapid detection, differentiation, and simultaneous quantification of abrin and its isoforms by

239 technique was developed at 60 degrees C for simultaneous quantification of allyl, 3-butenyl, 4-(meth

240 Multiplexing capabilities for simultaneous quantification of different hIgG1s within t

241 rometry-based methodology was applied to the simultaneous quantification of dozens of protein biomark

242 lvent has been developed and applied for the simultaneous quantification of ferulic acid, umbellifero

243 hniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion p

244 , flexible, and inexpensive approach for the simultaneous quantification of multiple breast cancer re

245 ectroanalytical method was developed for the simultaneous quantification of the dyes indigo carmine (

246 This novel technique allows the simultaneous quantification of the impact that the physi

247 A method for the simultaneous quantitation of seven markers in guarana by

248 om precisely synchronized spiking to broadly simultaneous rate increases, has been subsumed under thi

249 from Spirulina platensis in free solution by simultaneous readout of their brightness, fluorescence a

250 Despite the rapid progress in this area, simultaneous realization of reconfigurability, high effi

251 ses as a function of temperature through the simultaneous recording of images, quantitative color cha

252 Double-sided VSD imaging enabled simultaneous recording of membrane potential events from

253 We used simultaneous recordings from multiple neurons in the hip

254 Simultaneous recordings of neurons in singing finches re

255 The strategy involved the simultaneous reduction of RhCl3 and graphene oxide with

256 However, because of simultaneous regrowth, the net contribution of deforesta

257 Simultaneous regulation of polyamine metabolism and miR-

258 gh combinatorial interrogation, we find that simultaneous repression of multiple weak constituents ca

259 A simultaneous residue analysis method is validated using

260 trics are conical spin spiral magnets with a simultaneous reversal of magnetization and electric pola

261 these Grp(+) neurons generated rarely seen, simultaneous robust pain and itch responses that were in

262 hannel scanning probe nanopipet that enables simultaneous scanning ion conductance microscopy (SICM)

263 y of the GE SIGNA PET/MR was examined during simultaneous scanning of aggressive MR pulse sequences.

264 Normalized sensitivity was stable during simultaneous scanning within 0.3%.

265 Simultaneous scans can also be performed.

266 illiwatts per square metre per gel cell upon simultaneous, self-registered mechanical contact activat

267 compensate for unimodal noise by relying on simultaneous sensory input from another modality.

268 electrophoresis, we perform 100s to 1000s of simultaneous separations of endogenous proteins.

269 cations of inherited variants detected using simultaneous sequencing of the tumor and normal tissue (

270 n increase in intra-aggregate porosity and a simultaneous shift toward greater accumulation of pore s

271 Utilizing a barcoding method that allows a simultaneous single-cell analysis of the tumor, non-invo

272 propose tunable resistive pulse sensing for simultaneous size and surface charge measurements on a p

273 an be readily multiplexed as demonstrated by simultaneous small molecule activation from two independ

274 We used newly developed, high-speed, simultaneous sodium and calcium imaging to examine ion d

275 ended vena cava thrombosis; in 2 patients, a simultaneous sternotomy was performed for resection of b

276 deling neural activity as driven by multiple simultaneous stimulus features rather than intrinsic neu

277 gene expression reprogramming, which permits simultaneous stress sensing and proteostasis.

278 ys a key role in IAPP self-assembly, whereas simultaneous substitution of four aromatic/hydrophobic r

279 ensing platforms that operate using multiple simultaneous superimposable signals.

280 Surprisingly, the number of simultaneous synaptic joints decreases rapidly after sat

281 in sodium chloride solution are analysed by simultaneous synchrotron small-angle X-ray scattering an

282 st to report novel mechanistic insights into simultaneous targeting of receptor-mediated proliferatio

283 a theoretically informed model that enables simultaneous testing of different pathways to incident a

284 -spot diagnosis and even the possibility for simultaneous therapy of diseases caused by bacterial inf

285 nsation mechanism can be utilized to achieve simultaneous thermal robustness and high coercivity in r

286 ior of resveratrol was investigated by using simultaneous thermogravimetry and differential scanning

287 RNA sequencing, Tradict may therefore enable simultaneous transcriptome-wide screening and mechanisti

288 slate into protein production, and therefore simultaneous transcripts and protein measurement are ess

289 opagating electromagnetic wave, allowing for simultaneous transmission and receiving of signals throu

290 bsequent to the chemotherapeutic paclitaxel; simultaneous treatment more effectively suppressed tumor

291 A insertion were insensitive to AtRALF1, and simultaneous treatment with both AtRALF1 and CML38 prote

292 ls exceeding 1 muT, lifetimes up to 6 s, and simultaneous two-mode detection, consisting of a high-se

293 gold-containing nanocomposite structures by simultaneous two-photon polymerisation and photoreductio

294 nefits of integrative taxonomy, particularly simultaneous use of molecular/geographical tools, as a p

295 Simultaneous viral delivery of the inhibitory SNAG-mGluR

296 we report an approach that allows for rapid, simultaneous visualisation of calcified bone tissue and

297 Live cell imaging enabled simultaneous visualization of the interaction of control

298 ratios after 1500 ms exposures to groups of simultaneous voices.

299 cation of graphite paste electrode (GPE) for simultaneous voltammetric determination of 4-Amino Pheno

300 The recent introduction of simultaneous whole-body PET/MR scanners has enabled new