ライフサイエンスコーパス: single

1 ng the stained manifold in each stack into a single 2D projection plane, (ii) correcting uneven illum

2 vestigation was a cross-sectional study at a single academic tertiary referral center.

3 ouched and comparable to the activity of the single active units.

4 were identified and compared with those with single admissions (nonrecidivists) from 1997 to 2008.

5 arabine (AraC) represents the most effective single agent treatment for AML.

6 nt kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechani

7 We determined 1,200 mg to be the recommended single-agent dose for future studies in FL and DLBCL, wi

8 Alder and hetero-Diels-Alder reactions via a single ambimodal transition state, and a retro-Claisen r

9 tion of the Galpha:RGS protein pair based on single amino acid substitutions.

10 ant women (26-29 wk of gestation) consumed a single amount of vitamin D (511 IU/d from diet and a cho

11 of ligands by exponential enrichment with a single AMPA receptor target (i.e. GluA1/2R) to isolate R

12 ributes, specifically biological sex, from a single analyte.

13 and the level of information obtained from a single analytical step.

14 e ion trap, we now report the development of single analyzer neutral loss scans in a linear quadrupol

15 this follow-up paper to our previous work on single analyzer precursor ion scans in a linear quadrupo

16 the antiviral and antifibrotic activities of single and dual HBV shRNAs.

17 ompare the capacity of Jagged 1 and Jagged 2 single- and double-deficient DCs to induce AAI.

18 y combining high-resolution multidimensional single- and double-quantum (1)H solid-state NMR spectros

19 , has quantum yields reaching 21% and 11% in single- and double-strands, respectively.

20 was defined as the percentage change between single- and dual-task gait velocities: ([single-task gai

21 kinson's disease compared to controls across single- and multi-site cohorts, and increased over 1 yea

22 ssible the rapid identification of CGRs with single base pair resolution.

23 RNA detection with attomolar sensitivity and single-base mismatch specificity.

24 Relative to a single baseline 24-hour sodium measurement, the use of s

25 direct measurements of phase transitions in single bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphoc

26 and 6 are recruited to the cellulosome via a single-binding mode mechanism with an adaptor scaffoldin

27 C more accurately classified patients with a single blood test into rule-out or rule-in categories: N

28 cific data generated in this study support a single breakpoint for testing trimethoprim-sulfamethoxaz

29 At the timescale of a single burst, conduction delay has a non-monotonic relat

30 In species such as Arabidopsis having a single canonical Galpha, this rate could be affected by

31 lting in the formation of two C-C bonds at a single carbon center bearing a C(sp(3)) organoboron func

32 d from 17 SCCP chain-length standards with a single carbon chain length and variable chlorination lev

33 igenerational cell growth and shape data for single Caulobacter crescentus cells.

34 me and transcriptome profiling (particularly single cell analyses) are providing novel insights into

35 s, machine-learning algorithms achieve blind single cell classification with up to 95% accuracy.

36 ional and mutational pathway assessment of a single cell could be of significant value for dissecting

37 cardiomyocytes and tissue debris producing a single cell suspension that is sorted using magnetic-act

38 o infer the dynamics of differentiation from single cell transcriptomics data and to build predictive

39 Moreover, this single-cell approach provides a better understanding of

40 Microprobe CE-ESI-MS of <0.02% of the single-cell content allowed us to detect approximately 2

41 Single-cell features such as the irregularity of spiking

42 ut immunophenotypic screens with large-scale single-cell gene expression analysis to define the heter

43 The application of single-cell genome sequencing to large cell populations

44 ition, we quantify DMSP incorporation at the single-cell level, with DMSP-degrading bacteria containi

45 pression levels and isoform diversity at the single-cell level.

46 ers evaluate CBCs by making high-dimensional single-cell measurements of size and cytoplasmic and nuc

47 this inherent complexity requires studies at single-cell resolution.

48 ling the transcriptomes of individual cells, single-cell RNA sequencing provides unparalleled resolut

49 study, we combine novel mouse reporters and single-cell RNA sequencing to reveal the heterogeneity i

50 Using single-cell RNA-Seq and multiplexed in situ hybridizatio

51 tal tumors and their microenvironments using single-cell RNA-seq from 11 primary colorectal tumors an

52 Technical advances in single-cell sequencing data and their application to gre

53 iple times in individual tumors for 11 of 12 single-cell sequencing data sets from a variety of human

54 More generally, a new wave of quantitative single-cell studies has begun to elucidate how signaling

55 , RNA-seq, ChIP-seq, targeted sequencing and single-cell whole-genome sequencing, with a minimal requ

56 sters, incapable of separating clusters from single cells and/or cause cluster damage or dissociation

57 indered by technical challenges in isolating single cells during genome preparation.

58 ork for understanding resistance dynamics in single cells.

59 e care intervention (UC + PAL) (n = 75) at a single center.

60 t Database and a nested cohort analysis of a single center.

61 A single-center cohort of patients undergoing coronary or

62 METHODS AND A single-center continuous flow-LVAD database (n=354) was

63 Retrospective single-center study of all LT since the start of DCD pro

64 lecular imaging in oncology have been small, single-center trials.

65 tely 100 million secreted and membrane-bound single-chain antibodies and identify antibodies that can

66 We report the design and application of single-chain cofactor-free kinases with photoswitchable

67 y two landmark genes are designed to share a single channel.

68 By using single-channel current recording, we define discrete ass

69 In the presence of tRNA, blocking events of single-channel currents through the pore formed by recom

70 e receptors distinguish ACh and Cho, we used single-channel electrophysiology to measure resting affi

71 llular heterogeneity in tumors and analyzing single circulating tumor cells.

72 cal species 1,2,4,7-cyclooctatetraenyl via a single-collision event and opens up a versatile, unconve

73 New single-component effector CRISPR systems are emerging fr

74 ch many are yet unidentified) rather than by single compounds.

75 This single comprehensive WGS assay has replaced seven molecu

76 Using a single-copy assay, we measured HIV-1 RNA levels in CSF a

77 affinity purification of a sequence-specific single-copy endogenous chromosomal locus containing a DN

78 We propose that co-option of single-copy genes may be a common but relatively underst

79 Because some of the best single correlations with severity (Scoring of AD, or SCO

80 A 66% spin polarization of the BZA single crystal was obtained by Andreev reflection spectr

81 , zero-field (57)Fe Mossbauer, magnetometry, single crystal X-ray diffraction, XAS, and EXAFS for 6.

82 by atomic-resolution scanning TEM (STEM) and single-crystal diffraction using synchrotron radiation.

83 questions, we have studied the behaviour of single-crystal La2-xSrxCuO4 films through which an elect

84 ng to elucidate the delithiation dynamics of single-crystal lithium iron phosphate microrods with lon

85 Electrochemical etching is used to slice off single-crystalline AlGaN/GaN layers while preserving the

86 The single crystals of tetragonal structure are easy to clea

87 lf-diffusion coefficients in natural olivine single crystals that were determined at upper mantle con

88 ading to the emergence of lipid bicontinuous single crystals with unprecedented swelling capacity.

89 ensive, limiting their application to small, single data sets.

90 Effect estimates based on a single day of exposure may underestimate true effects fo

91 crolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone

92 ic response and electroluminescence within a single device.

93 olume droplets with pinpoint accuracy into a single diatom frustule with dimension around 30micromx7m

94 e of heterogeneity, AD is still considered a single disease and usually treated according to the "one

95 tion of mature blood cells is derived from a single dominant hematopoietic stem cell lineage.

96 on mode), including 70 known metabolites, in single dorsal and ventral cells in 8-to-32-cell embryos.

97 A single dose of 5 x 10(12) or 2 x 10(13) genome copies of

98 ng to primary care with acute sore throat, a single dose of oral dexamethasone compared with placebo

99 andard influenza vaccination consisting of a single dose.

100 Subjects received single doses of dofetilide, quinidine, ranolazine, and p

101 tive tract and peripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (S

102 rdings in the peripheral primate retina with single-electrode and several types of multi-electrode st

103 This Single Electron Pair Distribution Analysis (SEPDA) revea

104 sible than other possible mechanisms such as single electron transfer, halogen atom transfer, and sig

105 harness reactive radicals through discrete, single-electron transfer (SET) events.

106 LA-ICP-MS analyses of glacier ice involved a single element per ablation pass or spot.

107 ding short-term surveillance that focuses on single epidemics and acutely ill individuals, the subtle

108 advanced informatics or can only be used in single experimental models.

109 glycans are all detected and identified in a single experimental procedure.

110 Although no single feature defines EoE, a constellation of compatibl

111 roaches can match multiple identities with a single feature.

112 nd characterization of electron bunches with single femtosecond or attosecond durations.

113 reactions: the microscale model represents a single fiber cross-section; the macroscale model represe

114 From whole organ to single fibre levels, experimental demands and hardware r

115 The same comparisons in men, based on a single food frequency questionnaire, displayed hazard ra

116 ors with large dynamic ranges by employing a single FP-cassette, named GO-(Green-Orange) Matryoshka.

117 (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant

118 multielectrode recordings to investigate how single GC neurons respond to intraorally delivered tasta

119 Single gene tests to predict whether cancers respond to

120 haromyces pombe Germinating spores develop a single germ tube that emerges from the outer spore wall

121 ts, for the first time, the integration on a single glass substrate of different thin film technologi

122 To examine this issue, we used single glomerular stimulation in mouse olfactory bulb sl

123 Patients and Methods A prospective, single-group, observational study design was used to tes

124 pproximately 27 nm localization precision at single hippocampal synapses under physiological conditio

125 nterneurons are often treated in models as a single homogenous population, despite previous descripti

126 Therefore, the selective conversion of a single hydroxyl group in natural products into a ketone

127 A single immunization of rhesus macaques elicited a rapid

128 uncharacterized transmembrane protein with a single immunoglobulin (Ig) domain, instructs the distinc

129 r immune microenvironments co-exist within a single individual and may explain in part the heterogene

130 n of PM2.5 is comparable in magnitude to any single individual- or neighborhood-level factor.

131 studied as populations but the behaviour of single, individual cells can have important consequences

132 Firstly, a single inductive coil is placed on the top of a melting

133 went AVR (AVR+ARE, n=1854; AVR, n=5185) at a single institution.

134 nts from January 1 to December 31, 2013 at a single institution.

135 In a single-institution cohort, these results suggest that NA

136 d through cooperative groups, consortia, and single institutions.

137 Following a single intranasal inoculation, both animal species shed

138 patients (6 PC, 2 BC, and 2 UBC) received a single intravenous dose of (68)Ga-NOTA-AE105 (154 +/- 59

139 gRNA) and mRNA encoding Cas9, we show that a single intravenous injection into mice induces >80% edit

140 eliably predict the functional importance of single isolated UMCs across the genome, which is usually

141 To do so, we laser-ablate single k-fibers at different spindle locations and in di

142 ts, (iii) stitching the mosaic planes into a single, large 2D image and (iv) adjusting the contrast.

143 the energy spectra of electrons emitted from single layer graphene as a result of the decay of deep h

144 from larger iodine clusters deviates from a single layer structure; instead, a bi-layer structure qu

145 ventional superconductivity was predicted in single-layer graphene (SLG), with the electrons pairing

146 Especially, single-layer tungsten disulfides (WS2) is a direct band

147 lateral internal thoracic artery (BITA) over single left internal thoracic artery (SITA).

148 rally, we demonstrate a mechanism by which a single lesion can cause a complex neuropsychiatric syndr

149 o, including both small- and long-RNAs, in a single library preparation step.

150 ions based on transcriptome profiling of 144 single LNCaP prostate cancer cells treated or untreated

151 d in situ hybridization, we show here that a single marker, Neuromedin B mRNA (Nmb), identifies RTN n

152 function of mean expression collapse onto a single master curve independent of the strength and numb

153 mear, and the resulting variance in unbiased single measurements depends on this smear parameter.

154 ection with phase shifters-are included in a single metal layer.

155 ental CMV-based vaccine vectors expressing a single MHC class I-restricted high-avidity epitope provi

156 geted knockdown of the GLP-1 receptor in the single-minded 1 neurons, we show dependence of paraventr

157 Mice with single-minded 1-mediated Glp1r knockdown had reduced hyp

158 work in Drosophila shows that mutation of a single miRNA locus (miR-iab4/iab8) affects the capacity

159 ser frequency content between multi-mode and single mode operation.

160 (EMA), which uses a pioneering hybrid quasi-single model approach.

161 most reports based on >1000 measurements for single molecule break junctions.

162 ometer particles broadly used to investigate single molecule dynamics in vitro.

163 Using the telomere-specific single-molecule analysis of replicated DNA technique, we

164 resonance energy transfer (FRET) to resolve single-molecule association dynamics at up to millimolar

165 eled ribosome-nascent chain libraries enable single-molecule co-localization of genotypes with phenot

166 directed evolution of proteins with designer single-molecule conformational phenotypes of interest.

167 However, as single-molecule drugs or synergistic mixtures, these rem

168 structural integrity is necessary to observe single-molecule fluorescence of GFP.

169 Here, using single-molecule fluorescence resonance energy transfer i

170 The Editors' Pick by Echelman et al. applied single-molecule force spectroscopy to show that an adhes

171 weezers, infrared evanescent scattering, and single-molecule FRET imaging, providing real-time multip

172 Our real-time single-molecule imaging data demonstrate that TFIID alon

173 We show that this can be used to perform single-molecule localization microscopy (SMLM) on cells

174 cer, much in the spirit of recent works with single-molecule magnets.

175 lative SRM to materials characterization and single-molecule reactions.

176 lution map of 6mA in Tetrahymena by applying single-molecule real-time (SMRT) sequencing.

177 We exploited the capacity of single-molecule real-time sequencing technology to deter

178 phenotypes, are well suited for multiplexed single-molecule screening of protein libraries, and shou

179 omyces finnis were assembled with long-read, single-molecule technology.

180 approach can potentially be developed into a single-molecule toolbox to investigate the biophysical m

181 Single-molecule-based super-resolution microscopy offers

182 nsecutive versus alternate days and given as single morning doses versus twice-daily split dosing.

183 e an average of planned actions but rather a single movement that optimizes motor costs.

184 ay to assess the ex vivo drug sensitivity of single multiple myeloma cells based on measuring their m

185 at the mass and collisional cross-section of single multiply charged ions can be obtained from these

186 ndividual muscle fibres, the contribution of single muscle fibre adaptations to ageing-induced atroph

187 in eol1 clf double mutants compared with clf single mutants.

188 Whole exome sequencing identified a single mutation in SLC30A9 within this locus, segregatin

189 No single mutation occurred in all four tumors or in all st

190 The single-nephron GFR did not vary significantly according

191 ical basis of conscious volition down to the single-neuron level.

192 clear and whole cell transcriptomes in mouse single neurons and provided a normalization strategy to

193 Spiking patterns of single neurons in both core and shell subregions during

194 y done by measuring electrical activity from single neurons in experimental sessions.

195 sing two probes, more than 700 well-isolated single neurons were recorded simultaneously from five br

196 n and propagation of action potential within single neurons, and validate the imaging technique with

197 We show that a combination of single nicks in the target gene and donor plasmid (SNGD)

198 ficant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (

199 TB-DzT combines a multiplex PCR with single nucleotide polymorphism (SNP) detection using hig

200 This mutation- and single nucleotide polymorphism-independent method could

201 In total, 24,710 high-quality Single Nucleotide Polymorphisms (SNP) were identified.

202 ed an association between IA development and single nucleotide polymorphisms (SNPs), but many SNPs ha

203 A polygenic risk score (PRS) composed of single nucleotide polymorphisms from the pathway most co

204 Single nucleotide polymorphisms within the prion protein

205 Here, we present a genome-wide analysis of single-nucleotide polymorphism (SNP) data for Spanish te

206 We identified an atherosclerosis-associated single-nucleotide polymorphism (SNP) located in the intr

207 ozygous, or homozygous for the TSLPrs1898671 single-nucleotide polymorphism.

208 ed to select the most potentially associated single-nucleotide polymorphisms (SNPs), whereas the mark

209 od to compare allele read fractions at known single-nucleotide polymorphisms, considering depth-depen

210 environments and genotyped with 2.5 million single-nucleotide polymorphisms.

211 geny by typing with microsatellites and 9230 single-nucleotide polymorphisms.

212 base editors to knock out genes by changing single nucleotides to create stop codons.

213 Using quantum point contact measurements on single nucleotides within DNA macromolecules, we demonst

214 y tract infection rates, between those using single or multi-use catheters.

215 he high output voltage of TENGs can generate single- or alternating-polarity ion pulses, and is ideal

216 lusion The only difference between using the single- or double-needle procedure when performing US-gu

217 Single oral dose of 10 mg of dexamethasone (n = 293) or

218 , 61.7 years +/- 13.8) were recruited from a single osteoporosis center.

219 By employing a single parameter, DeltaC1/2%, we compared relative chang

220 By analysing more than 18,000 single parasite transcriptomes from a conditional AP2-G

221 pectrometers (SPMSs), which generate in situ single particle composition data, are excellent tools fo

222 Single particle mass spectrometers (SPMSs), which genera

223 dths are dominated (73-83%) by the intrinsic single particle spectral broadening, as observed using s

224 in-focus data acquisition method for cryo-EM single-particle analysis with the Volta phase plate.

225 tural analyses of antigen-antibody complexes.Single-particle electron cryomicroscopy (cryoEM) can cir

226 Furthermore, single-particle EM analysis revealed, for the first time

227 s, fPlas-gold nanoparticles appear mostly as single particles and they cluster during the vesicular t

228 representation electoral rules mean that no single party controls a majority of seats in the legisla

229 luent, which was not readily possible in the single-pass operation.

230 nhard nebulizer in combination with a heated single-pass spray chamber, and a rotary injection valve,

231 via computational analysis, time-correlated single photon counting studies, and transient absorption

232 al TSL and dox distribution were analyzed by single-photon emission computed tomography (SPECT)/compu

233 m defects are an emerging class of synthetic single-photon emitters that hold vast potential for near

234 c contrast-enhanced MR images, consisting of single-plane (axial) structural imaging (T2-weighted tur

235 mic and genomic analysis at the level of one single plant cell type, the root hair cell, and between

236 We identified single-point mutations in the Fc domain (e.g., E345K or

237 ompletely abolished the generation of CD8(+) single-positive thymocytes.

238 A single pot dipolar cycloaddition reaction/Cope eliminati

239 All tumors were treated in a single procedure using the 4C or Perfexion Gamma Knife.

240 ed to understand how a polymer composed of a single protein can switch between different supercoiled

241 ptional profiling experiments show that this single protein is implicated in the regulation of MAP ki

242 bination of at least two reaction steps in a single reaction vessel without isolation of the intermed

243 ne the sequence of complete JCPyV genomes in single reads.

244 s of cell behavior are coordinated through a single receptor is not known.

245 Our results suggest the potential of using a single receptor target to develop RNA aptamers with dual

246 rd of 54 detected annihilation events from a single release of the trapped anti-atoms accumulated fro

247 to early Oligocene, and does not represent a single response to a rapid decline in atmospheric pCO2 a

248 Eu(3+)'s and Sm(3+)'s action was tested on single RyR1 channels reconstituted into planar lipid bil

249 genomic features can not be addressed with a single SAG.

250 UV-LED device fabricated and showed a strong single sharp electroluminescence (EL) peak at 325 nm and

251 ignals concerning the light environment by a single sigma factor to regulate chloroplast transcriptio

252 g holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD and

253 Single site randomized control trial, 3 groupsx4 time po

254 Parkinson's disease but not in controls at a single site.

255 A single-sized CdSe quantum dot (3.0 +/- 0.2 nm) can repla

256 second spin-orbit torque pulses can generate single skyrmions at custom-defined positions in a magnet

257 gh Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus

258 able prodrugs/donors that directly deliver a single species, including hydrogen sulfide, perthiol, an

259 io-electrochemical device for spontaneous or single step conversion of biomass into electricity, base

260 around the world will be consolidated into a single strain by "endoreduplication intercross." Chemica

261 olidation of 16 synthetic chromosomes into a single strain.

262 h-resolution capillary electrophoresis-based single-strand conformation polymorphism (CE-SSCP).

263 ion of U:G mismatches is translated into the single-strand nick required for error-prone synthesis is

264 Single-stranded DNA (ssDNA) is notable for its interacti

265 Single-stranded DNA oligonucleotides have unique, and in

266 sively copied, and regenerated by release of single-stranded product DNA.

267 ssential host factor for many positive-sense single-stranded RNA (+RNA) viruses including human patho

268 Here, we created site-specifically modified single-stranded vectors for replication in primate (COS7

269 simultaneously and cause damages that exceed single stresses.

270 ly able to merge the neighboring TADs into a single structure.

271 Herein, we report the error rates of three single-subunit RNAPs measured from the catalytic efficie

272 phenomenon of quantum wave mixing (QWM) on a single superconducting artificial atom.

273 ave been proposed for oxidation reactions on single supported atom.

274 male-to-female conversion, whereas loss of a single suppressor of female development drives male-to-h

275 that make it possible to track the masses of single suspended cells and adherent cells.

276 een single- and dual-task gait velocities: ([single-task gait velocity - dual-task gait velocity]/ si

277 sk gait velocity - dual-task gait velocity]/ single-task gait velocity) x 100.

278 ith an alpha-l-arabinofuranosidase, removing single terminally-linked arabinose residues, decreased t

279 d, phase 3 trial, we recruited patients at a single tertiary cancer centre in the USA.

280 microbiome studies have primarily focused on single time points or a few individuals.

281 Forty single-tooth dental implants inserted after placement of

282 p to six genes by expressing 12 gRNAs from a single transcript.

283 LA detection from single transcriptomic study, however, is often unstable

284 tions of longitudinal modes in lasers with a single transverse mode.

285 cortex, with robust effects at the level of single trials.

286 ffect of E6APC820A on wild-type activity and single-turnover pulse-chase kinetics.

287 hree sequential, independent cohorts, from a single U.S. health system, through their hospitalization

288 challenging, as multiple modifications on a single ubiquitin preclude the use of standard bottom-up

289 light microscopy, or electron micrographs of single ultrathin sections imaged by transmission electro

290 Thus, RNA synthesis by even a single, uncoated particle can initiate infection in a ce

291 We intraoperatively recorded single unit activity in ten patients with PD who perform

292 visual cortex of adult rats while recording single unit and population activity, we demonstrate that

293 he type of prosthetic restoration needed: 1) single unit porcelain-fused-to-metal (PFM) crowns (SCs)

294 ith allele-level HLA matching who received a single unit umbilical cord blood transplantation for non

295 atients receiving combination haploidentical single-unit cord blood transplants, we have added 4 Gy T

296 From these, three single-variants I189H, A282P, D143K were found to be mor

297 ldren got 3 or more injectable vaccines in a single visit reported being only comfortable with 1 or 2

298 ortable with 1 or 2 injectable vaccines in a single visit.

299 Here we use fMRI to relate changes in single voxel receptive fields (vRFs) to changes in popul

300 Single-walled carbon nanotubes (SWCNTs) have been incorp