ライフサイエンスコーパス: single amino acid substitution

1 isomerase VI (Topo VI) A-subunit gene with a single amino acid substitution.

2 a+alpha to 3-alpha structure can occur via a single amino acid substitution.

3 Many of these variants result from a single amino acid substitution.

4 onstitutively active mutants resulted from a single amino acid substitution.

5 n) in which self-assembly was abolished by a single amino acid substitution.

6 tion of the Galpha:RGS protein pair based on single amino acid substitutions.

7 sms) that predicts the functional effects of single amino acid substitutions.

8 er two had nucleotide alterations leading to single amino acid substitutions.

9 peptide-MHC complexes and being sensitive to single amino acid substitutions.

10 enzymes and replicon cells that contain the single amino acid substitutions.

11 in human populations that result in specific single amino acid substitutions.

12 struct a library encoding all 9,595 possible single-amino acid substitutions.

13 a conventional Y/T-shaped antibody through a single amino acid substitution (2G12 I19R) and showed th

14 ELANE mutations were diverse; there were 65 single amino acid substitutions; 61 of these mutations (

15 reconstituted replicon cells containing the single amino acid substitution A156V or A156T.

16 The type of genetic mutation that causes a single amino acid substitution (AAS) in a protein sequen

17 genesis of the predicted helix revealed that single-amino-acid substitutions abolish NSP5 insolubilit

18 n of the SNARE-SNARE interaction caused by a single amino acid substitution adjacent to the SNARE mot

19 find that subunits lacking M4 or containing single amino acid substitutions along an "interacting" f

20 This single amino acid substitution also lies within a second

21 To exploit a single amino-acid substitution among the binding pockets

22 tide-binding characteristics using panels of single amino acid substitution analogs.

23 rary of LLO mutant strains, each harboring a single amino acid substitution and a signature tag, by u

24 Further analysis of the TM domain by single amino acid substitutions and 3-alanine scanning m

25 These alterations range from single-amino-acid substitutions and domain truncations t

26 We now report the effects of additional single-amino-acid substitutions and the effects of delet

27 inhibition by ZPI was impaired 2-3-fold for single amino acid substitutions, and fXIa-144-149A was e

28 ectly capture changes in B(22) values due to single amino acid substitutions, and reveal a new explan

29 A single-amino acid substitution (apoE4[Phe265Ala]) induce

30 es of the TEM and SHV families that arise by single amino acid substitutions are a significant threat

31 many predictors of the functional impact of single amino acid substitutions are publicly available.

32 he N-linked glycosylation site is mutated by single-amino-acid substitution are highly attenuated and

33 CMV capsid protein loop mutants with single-amino-acid substitutions are unable to systemical

34 eby qualifying mutated epitopes that include single amino acid substitutions as effective vaccines.

35 The effect of single amino acid substitutions associated with the Ital

36 Fourteen mutant PanK2 proteins with single amino acid substitutions, associated with either

37 Furthermore, a single amino acid substitution at an invariant leucine i

38 CtBP2 with a single amino acid substitution at Lys-10 (K10R) is predo

39 These LSSmKates differ by a single amino acid substitution at position 160 and exhib

40 A single amino acid substitution at position 170 has expan

41 eptide ligand derived from MBP(85-99) with a single amino acid substitution at position 88 (Val to Ly

42 In this study, we show that a single amino acid substitution at the alpha7 TM2 6' posi

43 A single amino acid substitution at this residue results i

44 n the TEM family of Class A beta-lactamases, single amino acid substitutions at Arg-244 confer resist

45 Single amino acid substitutions at conserved residues we

46 cells containing variant ChrR proteins with single amino acid substitutions at Cys187 or Cys189 exhi

47 We found that Prf variants with single amino acid substitutions at D1416 in the IHD moti

48 ver, our results inform understanding of why single amino acid substitutions at lysine 19 or 49 have

49 approach and generated mutant receptors with single amino acid substitutions at selected positions of

50 find that this specificity can be altered by single amino acid substitutions at several distinct posi

51 Novel recombinants of Hb S with single amino acid substitutions at the putative axial (r

52 All 741 possible single amino acid substitutions at these sites were test

53 onal interaction of Tetherin with Nef, since single amino acid substitutions at this single position

54 IBMPFD mutants have single amino-acid substitutions at the interface between

55 C-terminal regulatory domain was provided by single-amino-acid substitutions at conserved cysteines (

56 impair the Gal3-Gal80 interaction yielded 12 single-amino-acid substitutions at residues that are pre

57 A single amino acid substitution-based adaptive coevolutio

58 y and genetically characterize in vivo three single amino acid substitutions: beta' E677G, beta V146F

59 Thus, a single amino acid substitution can significantly alter t

60 o fibrillate through the N terminus and that single amino acid substitutions can lead to changes in t

61 f transcripts, the mechanisms by which these single amino acid substitutions change gene expression r

62 a) to study the molecular consequences of 16 single amino acid substitutions, classified as pathogeni

63 jor structural transition can be affected by single amino acid substitutions converging to the "conse

64 This single-amino acid substitution converted a metal-indepen

65 ific peptides were engineered that contained single amino acid substitutions corresponding to missens

66 e OGT but are not fully rescued by OGTs with single amino acid substitutions corresponding to mutatio

67 This simple switch in mechanism by a single amino acid substitution could potentially generat

68 t the infectivity of B virus isolates with a single amino acid substitution (D122N) in the IgV-core o

69 We identified two single amino acid substitutions (D39V and N90A) that sta

70 Single amino acid substitutions defined the critical ami

71 but that neurological disease mapped to the single amino acid substitution Env S159P.

72 To investigate this, a library of single amino-acid substitution epitope variants has been

73 y minor variants comprised from conservative single amino acid substitution events.

74 A single amino acid substitution evolved together with thi

75 study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembr

76 f mutant derivatives of E. coli ACP carrying single amino acid substitutions for their abilities to r

77 udy, we show that mutant p63 proteins with a single amino acid substitution found in EEC syndrome are

78 Indeed, this single amino acid substitution (G-->V) at a residue inva

79 etermine that both mutations are caused by a single amino acid substitution (G297E) in the S2-S3 link

80 e strains carried hly mutations leading to a single amino acid substitution (G299V) or a premature st

81 xic form of diphtheria toxin that contains a single amino acid substitution (G52E).

82 o infection by M13 led to the isolation of a single amino acid substitution, G74S.

83 Each single amino acid substitution (Gly-->Ala at amino acid

84 Disruption of the His-Glu salt bridge by single-amino acid substitutions greatly altered the myr-

85 from the same parental stock and differ by a single amino acid substitution (H1047R) caused by a sing

86 t disruption of the SpoIIQ LytM domain via a single amino acid substitution (H120S) impairs engulfmen

87 y circular dichroism (CD) indicated that the single-amino acid substitutions have little impact on th

88 pes, because of point mutations resulting in single amino acid substitutions, have been described.

89 ransporter (i.e., SERT, slc6a4) that bears a single amino acid substitution, I172M, proximal to the 5

90 , and no infectivity was detectable due to a single amino acid substitution (I516M) near the extreme

91 rgeting event and identified a mutant with a single amino acid substitution (I578F) sufficient to ret

92 2 locus to encode Rec12 proteins each with a single amino acid substitution in a conserved residue.

93 ults demonstrate that a change as small as a single amino acid substitution in a FAD enzyme might res

94 We show that a single amino acid substitution in an abscisic acid-respo

95 s a devastating genetic disorder caused by a single amino acid substitution in beta-globin.

96 A single amino acid substitution in Box-3 of Edmonston MV

97 gle nucleotide change in bvgA resulting in a single amino acid substitution in BvgA.

98 During recent evolution, a single amino acid substitution in DOES NOT MAKE INFECTIO

99 s with the disease phenotype that produces a single amino acid substitution in eukaryotic elongation

100 We isolated an fbp allele encoding a single amino acid substitution in FBPase (S123F), which

101 One virus had a single amino acid substitution in Gc.

102 Single amino acid substitution in Gli2 putative binding

103 Here, we report that a single amino acid substitution in Insig-2, Insig-2(L210A

104 A single amino acid substitution in MgtC that prevents bin

105 he Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROT

106 za B/Yamanashi/166/1998 viruses containing a single amino acid substitution in NA generated by revers

107 These results suggest that a single amino acid substitution in Npt2a can lead to impr

108 Both mutations cause a single amino acid substitution in one OPR repeat.

109 om the mouse genome, T(FC) and T(Fspa), to a single amino acid substitution in ORF1p, D159H.

110 On the other hand, a mutant with a single amino acid substitution in PHD2 within the full-l

111 Such ability was restored by a single amino acid substitution in position 186 (K186E) t

112 We show that a single amino acid substitution in Sin (I100T) is suffici

113 A single amino acid substitution in that domain abolished

114 relative to SCO 1441 and 2687 results from a single amino acid substitution in the active site of the

115 A single amino acid substitution in the active site of the

116 Recently, we showed that a single amino acid substitution in the alcohol binding po

117 analysis of VSIV-6.8 revealed that it had a single amino acid substitution in the amino-terminal reg

118 Our findings show that a single amino acid substitution in the C terminus, which

119 We have identified a single amino acid substitution in the Caulobacter struct

120 rature-sensitive mutant alp5-1134 contains a single amino acid substitution in the conserved C-termin

121 ant of zebrafish Abcc4 was identified with a single amino acid substitution in the cytoplasmic loop T

122 tetraploid wheat accessions revealed that a single amino acid substitution in the DNA-binding domain

123 in vitro evolution also revealed that just a single amino acid substitution in the envelope can confe

124 We investigated the role of a single amino acid substitution in the hemagglutinin clea

125 Twelve selection steps, each resulting in a single amino acid substitution in the hemagglutinin glob

126 We previously reported a single amino acid substitution in the highly conserved T

127 Taken together, the study demonstrates how a single amino acid substitution in the histidine kinase r

128 e HCMV BACs, a recombinant virus (RV) with a single amino acid substitution in the IE86 protein was i

129 The Ins2(Akita) mutation results in a single amino acid substitution in the insulin 2 gene tha

130 fied Snf1 alpha subunit with a conservative, single amino acid substitution in the kinase domain is p

131 Expression of a DnaA protein that contains a single amino acid substitution in the membrane-binding d

132 Here we report that a single amino acid substitution in the mumps virus V prot

133 be reengineered in both TRPV1 orthologs by a single amino acid substitution in the N-terminal ankyrin

134 deficient mutant form of XPF that contains a single amino acid substitution in the N-terminus of XPF

135 Thus, a single amino acid substitution in the regulatory domain

136 rected mutagenesis, it was determined that a single amino acid substitution in the TOPRIM domain chan

137 nteracts with the mTOR-Raptor complex, and a single amino acid substitution in the TOS (TOR signaling

138 that Candid1 is attenuated in mice through a single amino acid substitution in the transmembrane doma

139 In addition, a single amino acid substitution in the VLY undecapeptide

140 notype observed in IOSCA, a result of only a single amino acid substitution in Twinkle and Twinky, su

141 Finally, a single amino acid substitution in VieA that increases th

142 rrestin recruitment, by different effects of single amino acid substitutions in ACKR3 on arrestin in

143 V) peptide/HLA-A*02 Ag complex characterized single amino acid substitutions in both TCRs that enhanc

144 Thus, single amino acid substitutions in CRV of L protein that

145 The screen resulted in seven different single amino acid substitutions in cytochrome b renderin

146 We use single amino acid substitutions in DAXX that abrogate fo

147 Surprisingly, we found single amino acid substitutions in DsbG that were able t

148 est this idea, we generated transposons with single amino acid substitutions in highly conserved resi

149 de and N-acetyl-VWYIK-amide corresponding to single amino acid substitutions in LWYIK, a segment foun

150 H77 NS4B proteins yielded mutants containing single amino acid substitutions in NS3 and NS4A.

151 Single amino acid substitutions in p97 have been linked

152 Eighteen single amino acid substitutions in phage P22 coat protei

153 int mutations in their genomes, which led to single amino acid substitutions in proteins of interest.

154 thogens, naturally occurring APLs containing single amino acid substitutions in putative TCR contact

155 strains of Pseudomonas butanovora containing single amino acid substitutions in the alpha-subunit of

156 Single amino acid substitutions in the C-terminal membra

157 ty, amphipathicity, and helicity (induced by single amino acid substitutions in the center of the pol

158 Here, we examined the ability of single amino acid substitutions in the conserved 17-amin

159 hyl ester (AME), blocks HIV-1 entry and that single amino acid substitutions in the cytoplasmic tail

160 e multifocal leukoencephalopathy (PML) carry single amino acid substitutions in the domain of the VP1

161 two most common mutations correspond to two single amino acid substitutions in the hMYH protein: Y16

162 inant HSV-expressing mutant forms of gB with single amino acid substitutions in the hydrophobic "fusi

163 ctivation or inactivation by introduction of single amino acid substitutions in the transmembrane dom

164 ibrillar collagens play a critical role, and single amino acid substitutions in these proteins lead t

165 Here, we identified single amino acid substitutions in Vps13 (vacuolar prote

166 We demonstrate that a single amino-acid substitution in a banana lectin, repla

167 two brothers with classical ASD who carry a single amino-acid substitution in NL4 (R87W).

168 and dilated cardiomyopathy that result from single amino-acid substitutions in one of several of the

169 Single amino-acid substitutions in the G-helix interface

170 se pedigrees was associated with a series of single amino-acid substitutions in the intramembrane dom

171 ies of CMY-32, a class C enzyme possessing a single-amino acid substitution in the Omega loop (Gly214

172 The disruption of these factors by a single-amino-acid substitution in a polymerase protein o

173 A single-amino-acid substitution in Kar9p, L304P disrupted

174 In one case, a single-amino-acid substitution in the fusion peptide of

175 Single-amino-acid substitutions in chimeric PrP transgen

176 Using a coprecipitation-based assay, seven single-amino-acid substitutions in HeV G were identified

177 Single-amino-acid substitutions in the beta-barrel domai

178 d through the isolation of loss-of-function, single-amino-acid substitutions in the conserved peripla

179 for this difference were initiated by making single-amino-acid substitutions in the hydroxylase alpha

180 replication, recombinant viruses containing single-amino-acid substitutions in the N protein were re

181 We show that certain single-amino-acid substitutions in the prion protein Sup

182 Interestingly, we have observed that several single-amino-acid substitutions in this highly conserved

183 combinant viruses encoding ns2 proteins with single-amino-acid substitutions in, or adjacent to, thes

184 Single amino acid substitutions indicated that phosphory

185 Here, we introduce single amino acid substitutions into factor B that precl

186 del, and to this end introduced all possible single amino acid substitutions into the S-switch region

187 Most single amino acid substitutions involving charged and po

188 seems to be intrinsically restricted, and a single amino acid substitution is sufficient to drastica

189 ression, but this activity was restored by a single amino acid substitution (K186E), which was respon

190 ity of both ALA1 and ALA2 was abolished by a single amino acid substitution known to inactivate the f

191 urface for guanosine triphosphate-bound Ras, single amino acid substitutions known to abolish the AF6

192 Single amino acid substitutions (L255A or I256A) had a m

193 changes in thin filament structure caused by single amino acid substitutions lead to differences in t

194 Besides single-amino-acid substitutions, Lhr orthologs differ by

195 ts of BamD depletion were partly reversed by single-amino-acid substitutions mapping within the beta-

196 the center of its dimer interface through a single amino acid substitution (MIP-1beta-A10C).

197 rveying the effectiveness of virtually every single amino acid substitution mutant of 27L to activate

198 We engineered a collection of single amino acid substitution mutants at residues (A370

199 Single amino acid substitution mutants with changes at Q

200 Revertants of single-amino-acid substitution mutants were obtained tha

201 idues essential for activity, a series of 46 single-amino-acid-substitution mutants were examined for

202 Furthermore, a single amino acid substitution, N195D, in HTLV-1 SU (Ach

203 nique A22-resistant Caulobacter strains with single amino acid substitutions near the nucleotide bind

204 A survey of single amino acid substitutions near the polymerase acti

205 We show that single amino acid substitutions near the receptor bindin

206 uced amino acid sequence analyses revealed a single amino acid substitution of Ala to Thr at position

207 A single amino acid substitution of IKZF3 conferred resist

208 ago, beta4Gal-T1 appeared as a result of the single amino acid substitution of Tyr or Phe for Leu or

209 mapping information as a guide to introduce single amino acid substitutions of nine different residu

210 In contrast, GP64 proteins with single amino acid substitutions of residues 153 and 156

211 We studied the consequences of single amino acid substitutions of the only 2 lysine res

212 Surprisingly, single amino acid substitutions of these positions do no

213 Accurate predictive models for the impact of single amino acid substitutions on protein stability pro

214 n another in order to monitor the effects of single amino acid substitutions on sigma32 activity.

215 These findings highlight (i) the impact of single-amino acid substitutions on protein evolution in

216 x1/AML1 subnuclear localization, either by a single amino acid substitution or by a chromosomal trans

217 One mutant Mam2[P261L] contained a single-amino-acid substitution (Pro261 to Leu) within a

218 Of the nine amino acids, two single-amino-acid substitutions, Q374R and I412V, restor

219 t that alterations of single base-pairs or a single amino acid substitution (R112A) can induce strand

220 4) with a bleeding diathesis attributed to a single amino acid substitution (R216Q) in the N-terminal

221 A single amino acid substitution, R222A, disrupts the stro

222 e prevailing PIP(2) concentration, we made a single amino acid substitution (R228Q), which reduced th

223 We found that a single amino acid substitution (R441A) in the full-lengt

224 Several polymorphisms of Ogg1, including the single amino-acid substitutions R46Q, R131Q and R154H, a

225 We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacter

226 Here, we analysed the effect of a single amino-acid substitution (R704C) that targets a co

227 at case, the loss of toxicity was due to the single amino acid substitution, R99C.

228 dard methods can be laborious and only allow single amino acid substitution, respectively.

229 ructose 6-P-specific enzyme was started by a single amino acid substitution resulting in negative sel

230 These results indicate that a single amino acid substitution results in functional div

231 pic analysis of the two iNK TCR types with a single amino acid substitution revealed that the stainin

232 phenotype of F-S MLV can be attributed to a single amino acid substitution (S84A) in the VRA region

233 between these two clusters tolerated radical single amino acid substitutions; short deletions in that

234 he divL and cckA suppressor alleles all have single amino acid substitutions, some of which confer a

235 Single-amino acid substitution studies of d-Nal(2')(7)-A

236 ility-shift assays, for HucR mutants bearing single amino acid substitutions suggests the importance

237 Nevertheless, by a single amino acid substitution, synaptobrevin can be dri

238 A single amino acid substitution, T290K, in the R1 agonist

239 A single amino acid substitution that abolishes the USP ac

240 A single amino acid substitution that abrogates intranucle

241 iosynthetic enzyme from IPMDH results from a single amino acid substitution that alters substrate spe

242 isolation of FkpA-DsbA mutants containing a single amino acid substitution that changed the active s

243 Remarkably, a single amino acid substitution that compromises Sen1 fun

244 t PrP mutants were designed to contain every single amino acid substitution that distinguishes rabbit

245 286A) and fHbp(E313A), which each contains a single amino acid substitution that leads to a marked re

246 accumulation is most likely attributed to a single amino acid substitution that leads to different O

247 se inhibitor 1A (SERPINA1) gene leading to a single amino acid substitution that results in an unfold

248 tability and folding appear to result from a single amino acid substitution that stabilizes a helix b

249 We identified single amino acid substitutions that are likely responsi

250 Single amino acid substitutions that conferred drug resi

251 We identified nine single amino acid substitutions that could not complemen

252 ied a novel yeast genetic screen to identity single amino acid substitutions that interfered with M3R

253 Two single amino acid substitutions that reduced and abolish

254 ance (SPR) analyses of constructs containing single amino acid substitutions that these conserved res

255 esynaptic LTP at mossy-fiber synapses, and a single amino-acid substitution that blocks the cAMP-depe

256 man tumor suppressor protein p53 to identify single amino-acid substitutions that can restore activit

257 in the complexin-1 C terminus identified two single amino-acid substitutions that impaired clamping w

258 We previously isolated a panel of single-amino-acid substitutions that confer resistance t

259 ounds of selection repeatedly identified six single-amino-acid substitutions that independently confe

260 t mice and (2) Syt12 knockin mice carrying a single amino-acid substitution [the serine-97-to-alanine

261 of site-specific mutant HAs indicate that a single amino acid substitution, Thr-30 --> Ser, influenc

262 Single amino acid substitutions to benenodin-1 generate

263 Using a panel of L proteins with single-amino-acid substitutions to residues universally

264 cesses could be distinguished, however, by a single-amino acid substitution (Tyr(310) --> Ala), which

265 Here we show that a naturally occurring single amino acid substitution (tyrosine to cysteine) at

266 lpha-tubulin Atb2 (atb2-983) that contains a single amino acid substitution (V260I).

267 A single amino acid substitution, W102G, in the MLV envelo

268 For example, a single amino acid substitution (W424G) in the active sit

269 the pathogenesis of demyelinating disease, a single amino acid substitution was introduced into the p

270 We determined that a single amino acid substitution was likely responsible fo

271 From a set of 26 unique single amino acid substitutions, we characterized mutati

272 A number of single amino acid substitutions were identified that equ

273 ction map for disease mutations, 52 selected single amino acid substitutions were introduced into GCa

274 Single amino acid substitutions were introduced into the

275 Single amino acid substitutions were made in each of the

276 Next, single amino acid substitutions were made in StxB1 to mi

277 erent GIGYF2 missense mutations resulting in single amino acid substitutions were present in 12 unrel

278 eles of wspR, each encoding a protein with a single amino acid substitution, were generated by mutage

279 Nineteen mutants, each with a single amino acid substitution, were isolated and displa

280 s sequence variants in LMNA, which result in single amino-acid substitutions, were identified in pati

281 ified 22 mutants with mutations resulting in single amino acid substitutions which cause a variety of

282 The mutations primarily result in single amino acid substitutions, with >85% of the mutati

283 A peptide with a single amino acid substitution within R3614-3643 (L3624D

284 iously isolated sonB1, a mutation encoding a single amino acid substitution within the Aspergillus ni

285 Resistance to C1 was conferred by a single amino acid substitution within the compound-bindi

286 single point mutation gives rise to a unique single amino acid substitution within the motor domain.

287 Genome-wide sequencing indicated that a single amino acid substitution within the ppMan-dependen

288 xtended adenovirus binding surface, since no single amino acid substitution within these areas elimin

289 M) were calculated for nearly every possible single amino acid substitution within this fragment.

290 Importantly, single amino acid substitutions within a region of Rtf1

291 binant viruses expressing GP64 proteins with single amino acid substitutions within amino acids 120 t

292 The mutations included six single amino acid substitutions within an amino-terminal

293 eric toxins and mutant toxins that contained single amino acid substitutions within the catalytic sit

294 Single amino acid substitutions within the dynamic pre-S

295 Since several mutants harboring single amino acid substitutions within the E2 transactiv

296 Indeed, a panel of five single amino acid substitutions within the region from a

297 aromatic-rich loop using RecQ variants with single amino acid substitutions within the segment.

298 Single amino acid substitutions within this N-terminal d

299 ystematic study of the structural effects of single-amino acid substitutions within the hydrophobic c

300 itope escape variants that could manifest as single amino-acid substitutions would not emerge by esca