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1 le, which are not observable in a mixture of single bases.
3 firmed 15 off-target sites, each harboring a single-base bulge and one to three mismatches to the gui
6 gonaute (TtAgo) ternary complexes containing single-base bulges positioned either within the seed seg
8 igo contained multiple nucleotide changes: a single base change allowing recombinant selection, and s
9 st-transcriptional mechanism that can make a single base change on specific nucleotide sequence in an
11 ntaining complex variation (i.e. more than a single base change), thus making identification of such
13 onfirmed by DNA analysis, which identified a single-base change of cytosine to guanine at the second
14 onucleotides is a strategy aimed at inducing single base changes into the genome, generating a perman
15 single nucleotide polymorphisms (nsSNPs) are single base changes leading to a change to the amino aci
17 sses modifications ranging from thousands of single base changes to megabase-scale path reorganizatio
19 analogues with energetically representative single-base changes (replacements, deletions and inserti
20 ssible amino acid substitutions arising from single-base changes affecting codons 62 and 63 to explor
21 ed technique that delineates the majority of single-base changes, indels, and copy number variants di
22 s laxa, we engineered a cutis laxa mutation (single base deletion) into the human elastin gene contai
23 ss of Y-family polymerases is that they make single-base deletion errors at high frequencies in repet
24 that the interdomain linker also affects the single-base deletion frequency and the mispair extension
26 n the previously estimated mutation rate for single base deletions in homopolymers in the Buchnera ge
29 le base than large deletions, and that these single base deletions were possibly caused by replicatio
30 ral Old World monkeys and apes by frameshift single-base deletions forming premature stop codons.
31 tter property explains how hPolkappa creates single-base deletions in non-repetitive sequences, but d
32 CMS) revealed four molecular variations (two single-base deletions, a nonsense mutation, and a canoni
33 herichia coli DinB polymerase, which creates single-base deletions, prefers to extend slipped DNA sub
34 bilized misalignment mechanism when creating single-base deletions, we find that Dpo4 predominantly u
35 Thus, the tumor-dependent introduction of a single base difference in the miR-376a* sequence dramati
36 ization probe that would enable near-optimal single-base discrimination and perform robustly across d
38 quencing technologies that are less prone to single-base errors should confirm these results by apply
39 single and metagenomic assemblies, including single-base errors, insertions/deletions, genome rearran
40 ide datasets, multiplex-PCR and detection by single-base extension and MALDI-TOF mass spectrometry, i
41 to bind and disrupt nucleosomes containing a single base gap and, because of this property, enhanced
42 racterization of DNMT-mutant ESCs, including single-base genome-wide maps of the targets of these enz
45 nthesis in which a nucleotide specified by a single base in the DNA template is repetitively added to
47 rtion in polymerase active sites could allow single base insertion or deletion mutations to occur, an
50 Not only can maNCB identify m(6)A at the single-base level but it also can quantify the extent of
52 er analysis using expressed region-level and single base-level approaches provides a compromise betwe
54 been considered to monitor hybridization of single base mismatch (SBM) in synthetic oligonucleotides
55 calibration curve of the chMB for detecting single base mismatch and ultraviolet (UV)-induced DNA da
57 ly challenging due to the presence of only a single base mismatch in the middle of the 251 base long
58 s quantitation platform can also distinguish single base mismatch of DNA hybridization and observe th
60 non-complementary target (un-hybridized) and single base mismatch target (named as SMM) hybridized su
61 ed (non-complementary target hybridized) and single base mismatch target hybridized surfaces sensitiv
62 of noncomplementary NA, even to the level of single base mismatch, permanent pore blockade is not see
63 f XPD onto kilobase DNA strands containing a single base mismatch, which is not a specific substrate
65 to relocalize onto DNA strands containing a single base mismatch; EndoIII mutants that are defective
67 Moreover, it has high selectivity against single-base mismatch sequences and can be used directly
69 sensor to study the type and location of the single-base mismatch, as well as the influence of the le
71 es can be reliably quantified with excellent single-base-mismatch differentiation capability by this
72 for the complementary oligonucleotides over single-base-mismatch, two-base-mismatch, and noncompleme
73 n fully complementary, non-complementary and single base mismatched targets, and even between the com
75 ynamic difference between the target and the single-base-mismatched DNA, resulting in a differential
76 chemical sensing system for the detection of single base mismatches (SBMs) using ferrocene-modified D
77 intensity of the complex with DNA containing single base mismatches correlates with the thermodynamic
78 move all non-target nucleic acids, including single base mismatches flanked by adenines or uracils.
81 to program Cpf1 nucleases are insensitive to single base mismatches, but that many of the other bases
83 sults, such as the greater Cas9 tolerance to single-base mismatches in PAM-distal region than to PAM-
84 he enzymes facilitated the discrimination of single-base mismatches within the recognition or ligatio
86 pots' within the miRNA guide strand at which single base modifications significantly reduce immune st
88 C.I. 1.82 x 10(-10) to 5.23 x 10(-10)) and a single base mutation rate of 2.08 x 10(-10)/site/generat
93 ein VpsT, the LuxR-type regulator VqmA, or a single-base mutation in the hapR promoter that prevents
94 ical assays of BsRppH on RNA substrates with single-base-mutation changes in the first four nucleotid
95 litate, for the first time, the detection of single base mutations in a gene segment and, specificall
97 c diversity of HsDhn3 alleles and effects of single base mutations on the intrinsically disordered st
98 sed to detect and phase up to 82% of de novo single base mutations with a false-positive rate of abou
99 14 mutations, including 5 short indels and 9 single base mutations, and no evidence of larger structu
101 to Cas9 nickase, up to 28% of site-specific single-base mutations are achieved in multiple gene loci
102 onsynonymous germ-line variants, to identify single-base mutations with a high impact on protein stru
103 is used to directly measure the kinetics of single-base nucleotide incorporation into primed DNA tem
106 s significantly slower than the fraying of a single base pair and (ii) initiating branch migration in
107 A changes and propose that the likelihood of single base pair change differs across three orders of m
108 rties by the snake proteins, but rather to a single base pair change in a Hox/Paired box (Pax)-respon
109 In the diminuendo mouse, which carries a single base pair change in the seed region of miR-96, th
111 y an Alu-mediated recombination event, and a single base pair deletion disrupted the ORF of SIGLEC17.
112 of the Rdy phenotype has been described as a single base pair deletion in exon 4 of the CRX gene, thu
114 h-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in
115 strating the ability of our method to detect single base pair differences in DNA specificity of two s
116 ls that the method can resolve as small as a single base pair distance at the extreme vicinity of the
117 NA oligonucleotides has been used to alter a single base pair in a variety of biological systems.
118 a limit of detection of 1nM and can detect a single base pair mismatch between probe and complementar
120 lly relevant concentration levels as well as single base pair mismatch, without requiring complex and
122 nsor was optimized to allow the detection of single base pair mismatched sequences, able to detect as
123 -canonical bases like 2,4-difluorotoluene or single base pair mismatches in the central region of the
125 cus genome purified from yeast identified 14 single base pair missense mutations, one frameshift, one
126 from circulating clades require as few as a single base pair mutation to quantitatively switch their
129 determine distribution of 5-mC and 5-hmC at single base pair resolution at MspI restriction sites.
130 ths of inherited microsatellite alleles with single base pair resolution from short sequence reads is
135 is revealed that instead of unwinding RNA in single base pair steps, Rrp44 accumulates the energy rel
137 ls to engineer mouse strains with reciprocal single base pair substitutions (B6-Cdh23(c.753A>G) and 1
138 cross much of its target site, such that few single base pair substitutions cause a significant decre
139 ndergo ion-induced folding is conferred by a single base pair that follows the conserved A.G pairs, t
141 a purine and often primed transcription on a single base pair to either the terminal or penultimate r
143 d the binding and cleavage properties of all single base pair variant target sites of the canonical L
144 ile most indels at non-coding regions were a single base pair, 3 base pair indels were observed when
150 ing low expression of these putative piRNAs, single-base pair CpG methylation analyses across the gen
151 uggested that these helicases unzip dsNAs in single-base pair increments, consuming one ATP molecule
152 described, which allows for the presence of single-base pair mismatches arising from sequencing erro
153 By profiling genome-wide DNA methylation at single-base pair resolution in thirteen DLBCL diagnosis-
154 most direct evidence thus far that forward, single-base pair stepping of a helicase utilizes the spo
156 at is accessible from the current state by a single base-pair addition/deletion following the Gillesp
157 t signal attenuation upon incorporation of a single base-pair mismatch demonstrates that CT is DNA-me
158 thermore, we extend this approach to perform single base-pair modifications in the TERT promoter; rev
160 discriminate between alleles differing by a single base-pair regardless of the position in the guide
161 d for transcriptome analysis that provides a single base-pair resolution map of transcription start s
162 tprints, high-resolution X-ChIP-seq achieves single base-pair resolution of transcription factor bind
163 eosomes and subnucleosome-sized particles at single base-pair resolution throughout the budding yeast
164 the kinetics of much longer RNA sequences at single base-pair resolution while also allowing for the
165 enabling precise chromosome modifications at single base-pair resolution with an efficiency of >40%,
172 ure into smaller substructures composed of a single base-pair stack, which allows us to leverage exis
173 e, a secondary structure kinetics model with single base-pair steps and a coarse-grained molecular mo
174 ing nucleosomes do not provide the necessary single-base-pair accuracy to determine these positions.
175 This patient carries a homozygous, germline, single-base-pair deletion in FASLG exon 1, leading to a
177 etection, with the capabilty to discriminate single-base-pair mismatched DNA mutation (single nucleot
181 ng tool for genome-editing DNA in cells with single-base-pair precision, which allows novel in vitro
182 cis-regulatory binding sites (footprints) at single-base-pair resolution to compare binding sites and
183 made it possible to decode DNA methylomes at single-base-pair resolution under various physiological
185 ndividual DNA-binding proteins (for example, single-base-pair stepping of DNA translocases) along wit
189 of selected novel dinB alleles, generated by single-base-pair substitutions in the dnaE915 strain, in
190 the toxT promoter, promoter derivatives with single-base-pair transversions spanning the ToxR-footpri
191 toolbox at three length scales, ranging from single base pairs to megabase-scale chromosomal domains,
195 technology to define TOP2 cleavage sites at single-base precision, and use the technology to charact
199 quantify expression of nearly 10,000 TSS at single base resolution by Capp-Switch sequencing, which
200 ability to detect DNA modification sites at single base resolution could significantly advance studi
201 across flowering plant species, we compared single base resolution DNA methylomes of 34 diverse angi
202 of AmpSeq-SSR were nearly 100 and 94% with a single base resolution for homozygous and heterozygous s
204 mC levels can be computationally inferred at single base resolution using sequencing or array data fr
205 me showing differential expression signal at single base resolution without relying on existing annot
206 nsive methylomes of two H. pylori strains at single base resolution, using Single Molecule Real-Time
213 to determine cytosine methylation states at single-base resolution across entire genomes and populat
216 alyses of human and mouse methylomic data at single-base resolution confirm that sloping shores are u
217 nary rates against experimentally determined single-base resolution DNA methylation data derived from
218 le stochastic simulation tool that generates single-base resolution DNA methylation data genome-wide.
219 rack, an efficient mechanism for visualizing single-base resolution DNA methylation data on a genome
222 nce genome assemblies and methods to profile single-base resolution DNA methylation states, DNA methy
223 pproaches for locating alkylation adducts at single-base resolution in DNA could enable new technolog
225 whole-genome profiles of DNA methylation at single-base resolution in five human iPSC lines, along w
227 cificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex
228 A methylation and hydroxymethylation maps at single-base resolution in human normal liver and lung as
229 equencing to evaluate the mutational load at single-base resolution in individual gene-corrected huma
230 ytosine (5hmC) and 5-formylcytosine (5fC) at single-base resolution is important to understand their
232 ylation (gbM) within exons, we have gathered single-base resolution methylome data that span the phyl
234 Herein, we obtained the DNA methylomes at single-base resolution of Madin-Darby canine kidney cell
235 n electrophoresis ("micelle-ELFSE") provides single-base resolution of Sanger sequencing products up
239 how a much-conserved synteny, whereas at the single-base resolution there are considerable species di
240 7 DNAP at the replication fork junction with single-base resolution to create a structural model that
242 epigenetic modification that is studied at a single-base resolution with bisulfite treatment followed
244 ncing (TAB-seq), which can identify 5-hmC at single-base resolution, as well as determine its abundan
245 quantitative method to decode 5fC in DNA at single-base resolution, based on a selective chemical re
246 rate methylome maps for four sample types at single-base resolution, identify a link between DNA meth
248 egrees of protein-induced perturbations with single-base resolution, where the largest changes occur
259 he unbiased study of RNA epigenome at a near single-base resolution; however, unique features of this
261 s a part of a software suite for genome-wide single base-resolution methylation data analysis that su
262 and non-CpG cytosine methylation analysis at single base-resolution using high-throughput locus-speci
263 , and primordial germ cell (PGC), as well as single-base-resolution maps of oxidized cytosine bases f
267 ual specificity of the T-box is allowed by a single base shift on the SL from one overlapping codon t
269 reduced infectivity of CM972 and detected a single base substitution in TC_0236 in CM3.1 that may be
272 pair missense mutations, one frameshift, one single base substitution to a stop codon and one dinucle
274 spectrum in which T-->C is the most frequent single-base substitution and differs significantly from
275 is and candidate genes for causing the major single-base substitution in cancer-associated DNA mutati
278 m the remains and one living relative, and a single-base substitution when compared with a second rel
281 ecular spectrum of fast-neutron (FN)-induced single base substitutions differed substantially from th
282 ted diseases have been found to be caused by single base substitutions, small insertions or deletions
284 y of disease-associated mutations constitute single-base substitutions and short deletions and/or ins
285 facilitate the high-fidelity introduction of single-base substitutions via HDR following co-delivery
286 nts, enabling isolation of mutant lines with single-base substitutions without antibiotic selection.
287 eosarcomas exhibit a specific combination of single-base substitutions, LOH, or large-scale genome in
288 ls, approximately 70% of mutations comprised single-base substitutions, mostly at G.C base-pairs, wit
290 a 'molecular tuning' effect with respect to single-base termination and improved nucleotide fidelity
291 cular tuning of enzymatic properties such as single-base termination and improved nucleotide selectiv
292 characterized with respect to incorporation, single-base termination, nucleotide selectivity and phot
293 In addition, we found that FNs induced more single base than large deletions, and that these single
296 comW bypass mutations and mapped them to 10 single-base transitions, all within rpoD, encoding the p
297 omain motions of NS3 helicase and reproduced single-base translocation of NS3 helicase along ssDNA in
300 ysis is highly suitable for the detection of single-base variants and small insertions or deletions.
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