ライフサイエンスコーパス: single base substitution

1 p to 30 nucleotides in length differing by a single base substitution.

2 train-specific genetic polymorphism due to a single base substitution.

3 d by site-directed mutagenesis, usually by a single-base substitution.

4 ines have been developed for the analysis of single base substitutions.

5 sible amino acid changes that can arise from single base substitutions.

6 kely to be due to both inherited and somatic single base substitutions.

7 ines have been developed for the analysis of single base substitutions.

8 ines have been developed for the analysis of single base substitutions.

9 rtiary interactions in a group I ribozyme by single-base substitutions.

10 titutions, whereas 10.0% showed semitargeted single-base substitutions.

11 including a three-nucleotide deletion and 12 single-base substitutions.

12 All mutations were single base substitutions, 10 were missense and 5 were s

13 mutations were identified in 25 patients (23 single-base substitutions, 3 deletions, 1 duplication).

14 Also, the level of semitargeted single-base substitutions 5' to the lesion was increased

15 Bidirectional sequencing identified the single-base substitution +57C>T in miR-184.

16 molysis bullosa simplex patient with a novel single base substitution (A-->T1414) that changes the ly

17 th an increased mutagenic frequency for both single base substitutions and deletions compared with un

18 spectrum in which T-->C is the most frequent single-base substitution and differs significantly from

19 silon synthesizes DNA accurately, generating single-base substitutions and deletions at average error

20 of the induced psoralen-pcPNA mutations were single-base substitutions and deletions at the predicted

21 C of the human factor IX gene and 100% of 42 single-base substitutions and one microdeletion present

22 y of disease-associated mutations constitute single-base substitutions and short deletions and/or ins

23 nt can detect 10 of the 12 types of possible single-base substitutions; and (ii) the SSCP component i

24 Inherited, single-base substitutions are found at only two position

25 odel mutant DNA fragments, each containing a single base substitution, are achieved using both single

26 start: the binding of Fis is suppressed by a single base substitution at position -146.

27 DNA site for Fis: binding is suppressed by a single base substitution at position -99.

28 B cells of C3H/HeJ mice reveals a consistent single base substitution at position 870, where a thymid

29 A single base substitution at the stop codon of this gene

30 The results revealed that either a single base substitution at the TA step or in the adjace

31 in certain sequence contexts, and generates single base substitutions at an average rate of 2.4 x 10

32 Single base substitutions at the G:C base pairs were the

33 Single-base substitutions at G/C pairs were the predomin

34 this observation by generating all possible single-base substitutions at positions 43, 44, and 45 of

35 9-base PCR product enables identification of single base substitutions by direct molecular weight det

36 Analysis of more than 1500 single-base substitutions by human pol eta indicates tha

37 In addition: (i) single base substitutions caused discontinuous distribut

38 ce specificity of HilC and HilD, a series of single base substitutions changing each position in a DN

39 Single base substitutions comprised 86% of the N-OH-AABP

40 yzed where mass differences corresponding to single base substitutions could be accurately assigned.

41 We observed divergent spectra of single base substitutions derived from general and induc

42 ecular spectrum of fast-neutron (FN)-induced single base substitutions differed substantially from th

43 This fact, combined with the high rate of single base substitution errors and complex mutations ob

44 A single base substitution (G to A) in the promoter region

45 vo (that is, newly arisen and not inherited) single-base substitution, G608G(GGC > GGT), within exon

46 DNA molecules differing by as little as a single-base substitution have traditionally been disting

47 spectively, and a nonsense mutation due to a single base substitution in exon 4.

48 A single base substitution in SMN2, c.859G>C,, was identif

49 reduced infectivity of CM972 and detected a single base substitution in TC_0236 in CM3.1 that may be

50 inct by flaA PCR-RFLP but differed only by a single base substitution in the 582-bp region.

51 cted individuals showed heterozygosity for a single base substitution in the apoAII stop codon.

52 nsfected 3T3-L1 cells demonstrated that this single base substitution in the putative E2 box signific

53 nal significance of the G24 residue, we made single base substitutions in SRP RNA at this position an

54 Single base substitutions in the -10 hexamer, but not in

55 ated by the effects of several deletions and single base substitutions in the nir promoter upstream s

56 is and candidate genes for causing the major single-base substitution in cancer-associated DNA mutati

57 Deep sequencing identified a single-base substitution in guanylate cyclase 2D, membra

58 Bi-ddF detected 100% of 28 single-base substitutions in a 494 bp segment containing

59 We have accumulated over 20 single-base substitutions in T. thermophilus 16S and 23S

60 The remaining seven mutations (58%) were single-base substitutions in the coding (ND1, ND4, ND5,

61 Single-base substitutions in the fnr and resA promoters

62 We identified 7 different single-base substitutions in the gene (ELA2) encoding ne

63 ting the next correct nucleotide, generating single-base substitutions in the process.

64 Because single-base substitutions in the UhpA-binding region had

65 16 alterations of 36% (nine deletions, three single base substitutions, including one polymorphism).

66 B that can result in the Rif(r) phenotype by single-base substitution is more limited than in certain

67 , such as an ethyl-methane sulfonate derived single base substitutions, is limited by array coverage

68 The most common OI mutations are single base substitutions leading to replacement of Gly

69 eosarcomas exhibit a specific combination of single-base substitutions, LOH, or large-scale genome in

70 poB gene of this clinical isolate revealed a single base substitution, most likely a silent point mut

71 ls, approximately 70% of mutations comprised single-base substitutions, mostly at G.C base-pairs, wit

72 Two single base substitution mutations discovered in the ORF

73 Single base substitution mutations in codons 248 and 273

74 the RY box region has been used to show that single-base substitutions of A(r)G either 23 or 19 bp 5'

75 Similar binding studies with single-base substitutions on d(TGTCATTG) further reveal

76 g of the entire 2.2-Mb interval identified 2 single-base substitutions, one in an intergenic region a

77 s as well as all mismatches, including three single-base substitutions, one microdeletion, one microi

78 Each mutational lesion (single base substitution or deletion) extended the fabK

79 eference strain emm sequences as a result of single base substitutions or other alterations likely to

80 g on transcription conditions, AID can cause single-base substitutions or MCMs.

81 hexanucleotide and its variants derived by a single base substitution, particularly A --> G and T -->

82 however, have indicated that, in addition to single-base substitutions, Polkappa generates single-bas

83 Finally, we identified a common, silent, single-base substitution polymorphism in the 5HT3R gene

84 e TGF-beta1 gene promoter has identified two single base substitution polymorphisms.

85 The sequence of Cytinus showed 121 single base substitutions relative to Nicotiana (8% of t

86 Single base substitutions (SBSs) and insertions/deletion

87 ecificity followed by those complementary to single base substitutions, single base deletions and sin

88 ted diseases have been found to be caused by single base substitutions, small insertions or deletions

89 However, we found a higher frequency of single base substitution than deletion mutations.

90 nscription and growth properties contained a single base substitution that increased the M gene end U

91 activation segment of the kinase domain as a single-base substitution that converts a valine to gluta

92 Family 1 had a single-base substitution that led to the replacement of

93 The mutation responsible is a single-base substitution that produces truncation of the

94 embly of 3HT and 5HT complexes is blocked by single-base substitutions that disrupt individual interm

95 an airway epithelial cells and indicate that single base substitution (the silent mutation giving ris

96 pair missense mutations, one frameshift, one single base substitution to a stop codon and one dinucle

97 facilitate the high-fidelity introduction of single-base substitutions via HDR following co-delivery

98 A single base substitution was detected in spl11, which re

99 of intron-gain alleles with that for derived single-base substitutions, we also provide evidence that

100 When the mobilities of 46 single base substitutions were characterized, the distri

101 Single base substitutions were introduced into the P loo

102 changes in electrophoretic mobilities due to single base substitutions were measured for single-stran

103 However, we report that two-thirds of single base substitutions were tolerated without loss of

104 m the remains and one living relative, and a single-base substitution when compared with a second rel

105 HD domain mutations that we identified were single-base substitutions, whereas all of the PEST domai

106 the exon-skipping mutations that are due to single base substitutions, which we have identified in 2

107 The d4-95 and d4-96 alleles are single base substitutions, while d4-662 (previously pawn

108 comparison between two cDNAs, differing by a single base substitution within the 3'-untranslated regi

109 recA operator mutants, we found that several single base substitutions within the 14 bp recA operator

110 Single-base substitutions within the 10-bp core sequence

111 nts, enabling isolation of mutant lines with single-base substitutions without antibiotic selection.