ライフサイエンスコーパス: single chain

1 ed in a linear fashion, with the majority as single chains.

2 and functional characterizations of a novel single-chain (120 kDa), multi-domain biotin-dependent ca

3 , consisting of DAP12 fused to the anti-PSCA single-chain Ab fragment scFv(AM1) confers improved cyto

4 ngle-chain BAFF (BBB) and to a lesser extent single-chain ABB, but not APRIL or single-chain BAA, res

5 ing the photoluminescence (PL) from isolated single-chain aggregates and multichain mesoscopic aggreg

6 of photon antibunching contrast compared to single-chain aggregates, implying rather weak interchain

7 bit red-shifted and broadened PL compared to single-chain aggregates.

8 reports in the literature as to whether this single chain amphiphile is in fact bound by LFABP.

9 ssembly and survival of vesicles composed of single chain amphiphiles as model protocell membranes.

10 lipid liposomes (Sterosomes) formulated with single-chain amphiphiles and high content of sterols hav

11 d public receptors observed when compared to single-chain analyses, and a distance-based classifier t

12 by p28/p40 and IL27p28 establish efficacy of single chain and heterodimeric IL-12 family cytokines in

13 e arranged in a linear fashion, primarily as single chains and, to a lesser degree, as branched chain

14 Comparing the single-chain and split ESX ATPases, we reveal difference

15 commercial IL-15 ELISA that detects both the single-chain and the heterodimeric forms of the cytokine

16 nant protein containing a humanized, dimeric single-chain anti-fibroblast growth factor-inducible 14-

17 e second minireview describes application of single chain antibodies (nanobodies) for monitoring and

18 ha-syn::GFP was reduced by immunization with single chain antibodies against alpha-syn.

19 orted earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia viru

20 self-assembled nanorings (CSANs) displaying single chain antibodies can bind to both the CD3 epsilon

21 i mosquitoes expressing m1C3, m4B7, or m2A10 single-chain antibodies (scFvs) have significantly lower

22 rapeutic applications.The therapeutic use of single-chain antibodies (VHHs) is limited by their short

23 Using a panel of single-chain antibodies and a single-chain T-cell recept

24 tely 100 million secreted and membrane-bound single-chain antibodies and identify antibodies that can

25 hile chimeric antigen receptors (CARs) using single-chain antibodies as binding domains are growing i

26 een the antigen and a panel of small, 25 kDa single-chain antibodies at concentrations down to 1 nM.

27 f chimeric antigen receptors (CARs) based on single-chain antibodies for gene immunotherapy of cancer

28 ells expressing tumor-associated antigens by single-chain antibodies fused to a receptor-binding-defi

29 otherapy for HIV-1 using novel CARs based on single-chain antibodies.

30 ing mesothelin-targeted TR3 variants using a single chain antibody (scFv) delivery format (SS-TR3), w

31 stomize the in vivo behavior of an anti-METH single chain antibody (scFv7F9Cys).

32 ant antivenom composed of a few neutralizing single chain antibody fragments (scFvs) that bind to two

33 using three carbohydrate-binding proteins, a single chain antibody, an antigen binding fragment, and

34 on solutions containing a target protein (a single chain antibody, an antigen binding fragment, or a

35 A 27 kDa single chain antibody, which binds to both ligands, serv

36 ced Binding Site (LIBS-MBs) or a nonspecific single-chain antibody (control MBs).

37 o different recombinant reporter proteins, a single-chain antibody (M18 scFv) that contains two disul

38 omplementarity determining regions (CDRs) of single-chain antibody (scAb) fragments is demonstrated.

39 ification, we constructed an anti-annexin IV single-chain antibody (scFv) and an scFv linked to Crry,

40 o biopanning strategy in which a human phage single-chain antibody (scFv) library was injected into h

41 Conjugation to the corona of a single-chain antibody (scFv), which binds to the ligand-

42 We use a single-chain antibody (scFv, specific for activated GPII

43 n order to fulfill this goal, we generated a single-chain antibody (scFv47) from our parental IL13Ral

44 tilizing Herceptin and its derived humanized single-chain antibody (single-chain fragment variable, d

45 A humanized single-chain antibody component in which the variable do

46 ticles of iron oxide (MPIOs) conjugated to a single-chain antibody directed against a ligand-induced

47 cluster of differentiation 3 (CD3)-specific single-chain antibody fragment (scFv), effectively redir

48 sults demonstrate that the topically applied single-chain antibody fragment ESBA105 penetrated into t

49 ding and antigen-binding activity of a human single-chain antibody fragment were simultaneously impro

50 Here we develop single-chain antibody fragments (nanobodies) against tub

51 arting from large phage display libraries of single-chain antibody fragments (scFvs), the three-stage

52 We further demonstrated that single-chain antibody fragments against tumor-specific a

53 assemblies for a monoclonal antibody and its single-chain antibody fragments derivatives.

54 ity/specificity trade-offs, we have selected single-chain antibody fragments specific for the negativ

55 nscription are decorated specifically by the single-chain antibody HF1 and by the nuclear protein PAR

56 assessed using monoclonal antibody NV23 and single-chain antibody HJT-R3-A9 to identify both virus-l

57 ignated ITEM4-rGel) and a humanized, dimeric single-chain antibody of ITEM-4 fused to rGel (designate

58 d gas-filled MBs were conjugated to either a single-chain antibody specific for activated glycoprotei

59 we have generated immune-challenged chicken single-chain antibody variable-region fragment (scFv) li

60 BNAbs varying in binding sites and generated single-chain-antibody-based CARs.

61 ecreted by Group A Streptococcus (GAS), is a single-chain approximately 47-kDa protein containing thr

62 erature T( *)cr, is related to the protein's single-chain average radius of gyration <Rg>.

63 er extent single-chain ABB, but not APRIL or single-chain BAA, rescued BAFFR-dependent B cell maturat

64 Single-chain BAFF (BBB) and to a lesser extent single-ch

65 s of murine and humanized anti-CD3-anti-PSCA single-chain bispecific Abs.

66 A single chain camelid antibody fragment specific for the

67 rast to wild-type caspase-9, the unprocessed single-chain caspase-9 triple mutant E306A/D315A/D330A (

68 Maturation of the single-chain caspase-9 zymogen through autoproteolytic p

69 ed hydrogel that releases nanoparticles with single-chain CD98 antibodies on their surface (scCD98 fu

70 We report the design and application of single-chain cofactor-free kinases with photoswitchable

71 ion of F-P3EHT leads to an extended rod-like single-chain conformation and hence highly ordered inter

72 ve similarly significant impact on promoting single-chain conformational compactness and phase separa

73 stance 2 orders of magnitude longer than the single-chain contour.

74 In particular, monellin and its single chain derivative (MNEI) are among the sweetest pr

75 mutations of amino acid residues of MNEI, a single chain derivative of the natural sweet protein mon

76 hniques including PEGylation, Fc fusion, and single-chain design.

77 rminus of a single-chain Fv and a bispecific single-chain diabody, respectively.

78 ible, regulated, surface expression of HLA-E single-chain dimers (fused to B2M) or trimers (fused to

79 iples to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nan

80 Using the single-chain due ferri (DFsc) peptide scaffold, the diff

81 tic sublattices built of [FenSe4n+2]infinity single-chain edge-sharing octahedra, coherently embedded

82 himeric subunit protein vaccine (full-length single chain) elicits heterologous protection against si

83 Three versions of a single-chain endonuclease, called Ems26, Ems26+ and Ems2

84 It is a single-chain enzyme in eukaryotes and most bacteria, and

85 The mechanochemical kinetics, single-chain extensibility, toughness and potentially op

86 ystem while also amplifying product yield in single chain-extension experiments and enabling multiple

87 ptides or modified high affinity or bivalent single chain Fab fragments, offering higher specificity

88 ent study, we have developed a novel one-arm single chain Fab heterodimeric bispecific IgG (OAscFab-I

89 ization with one heavy chain consisting of a single chain Fab to prevent wrong pairing of light chain

90 Single chain factor V (fV) circulates as an Mr 330,000 q

91 monomeric gp120 boost, with the full-length single-chain (FLSC) protein.

92 of the two self-assembling motifs results in single-chain folding of the polymer, affording nanometer

93 We previously developed a recombinant single-chain form of a naturally occurring murine hybrid

94 protein revealed a 2.5-fold increase in the single-chain form.

95 ts for open promoter complex formation using single-chain forms of bEBP lacking the full complement o

96 To overcome this problem, we fused TM with a single chain fragment (scFv) of an antibody targeted to

97 resents the crystal structure of two chicken single chain fragment variable (scFv) antibodies generat

98 s work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the

99 A novel single chain fragment variable (scFv) fragment was gener

100 binant antibody library was used to obtain a single chain fragment variable (scFv, designated 2B4) to

101 mmunological characterization of a monomeric single-chain fragment (ScFv) of human origin specific fo

102 A synthetic gene coding for a single-chain fragment (ScFv) specific for the major timo

103 Recently, a single-chain fragment antigen binding (Fab) (scFab) form

104 on of a generic anti-immunocomplex (anti-IC) single-chain fragment of antibody variable domain (scFv)

105 A single-chain fragment variable (scFv) recognizing beta2-

106 ting of the ectodomain of B7-H6 and the CD20 single-chain fragment variable 7D8 was generated to mimi

107 Immunoadhesin (single-chain fragment variable [scFv]-Fc) forms of IgGs

108 orable binding to FcRn was maintained when a single-chain fragment variable antibody was genetically

109 scribe, to our knowledge, the first anti-NCL single-chain fragment variable displaying antineoplastic

110 ntially combine the high display levels of a single-chain fragment variable with the high stability o

111 to segregate light chains, or utilize scFv (single-chain fragment variable)-Fc fusion.

112 its derived humanized single-chain antibody (single-chain fragment variable, designated 4D5), we gene

113 play technology, we engineered a fully human single-chain fragment variable, named 4LB5.

114 allergic encephalomyelitis (EAE), we created single-chain fragment variables (scFv) specific for DEC2

115 pecially engineered anti-h-FABP and anti-MPO single-chain fragment variables (scFv) were immobilized

116 Anti-METH IgGs and single chain fragments (scFvs) have shown efficacy in pr

117 )-1 stimulate each other's binding, we fused single-chain fragments (scFv) of paired anti-mouse PECAM

118 fferential cell screening of a yeast-display single-chain fragments variable (scFv) library derived f

119 s conventional alphabeta heterodimers, or as single-chain fragments variable constructs linked to CD3

120 xes whereas CARs typically use an Ab-derived single-chain fragments variable that recognizes cancer-a

121 e cells, we developed a genetically encoded, single-chain FRET-based biosensor for Rac2.

122 al models of common biosensor architectures (single-chain FRET-based biosensors), which include both

123 Single-chain fusion proteins comprised of GM-CSF and neu

124 By displaying the humanized 8H9 single chain Fv (scFv) on the surface of yeast, the affi

125 ragments, such as diabodies, minibodies, and single-chain Fv (scFv) -Fc, have been successfully emplo

126 g ephrinB2 activity, 2 highly specific human single-chain Fv (scFv) Ab fragments against ephrinB2 wer

127 its natural substrate-binding domain with a single-chain Fv (scFv) intrabody or a fibronectin type I

128 Fully-human single-chain Fv (scFv) proteins are key potential buildi

129 residues, were fused to the C terminus of a single-chain Fv and a bispecific single-chain diabody, r

130 Single-chain Fv antibodies (scFvs), expressed as intrabo

131 The C4 single-chain Fv antibody (scFv) binds to the first 17 re

132 ialdehyde (MDA)-lysine epitopes or the human single-chain Fv antibody fragment IK17 targeted to MDA-l

133 oducing varying levels of recombinant VHH or single-chain Fv antibody fragments fused to the human im

134 The binding affinity of a model single-chain Fv antibody was optimized by using ALV disp

135 We show that a single-chain Fv fragment (scFv) of a previously reported

136 t versatile biosensing elements are antibody single-chain Fv fragments (scFv), antibody fragment-anti

137 The CD4BD(core) peptide was recognized by single-chain Fv fragments from noninfected humans with l

138 with the corresponding V(H)3-family FRs from single-chain Fv JL427 improved the CD4BD(core) peptide-b

139 the framework region (FR) of a V(H)4-family single-chain Fv with the corresponding V(H)3-family FRs

140 response maps that track changes across each single chain-Fv fragment, thus providing valuable insigh

141 Across a set of six single chain-Fv fragments of the anti-lymphotoxin-beta r

142 To test the hypothesis that single-chain FXII expresses activity that could initiate

143 ct activation in which activity intrinsic to single-chain FXII initiates alphaFXIIa and alpha-kallikr

144 Plasminogen is a 92-kDa single chain glycoprotein that circulates in plasma as a

145 sultant linked gp120-gp41 constructs, termed single-chain gp140 (sc-gp140), exhibited different level

146 spatially close and can be linked to create single-chain homo- or hetero-ligands of defined stoichio

147 nts for fusion of domains extracted from six single-chain I-OnuI family LHEs, spanning 40-70% amino a

148 trinsic immunoregulatory activities of other single chain IL-12 subunits might be exploited to treat

149 kinetics and in vivo bioactivity superior to single chain IL-15.

150 Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Ra

151 IL-15Ralpha heterodimer in vivo, whereas the single-chain IL-15 is poorly secreted and unstable.

152 tion not only rationalizes the inactivity of single-chain insulin (SCI) analogs (in which the A and B

153 nd stability of such an analog, a 57-residue single-chain insulin (SCI) with multiple acidic substitu

154 t high-fidelity reporting is possible when a single-chain intermolecular biosensor is used that canno

155 A single-chain intramolecular quadruplex has been straight

156 apasin binding to the core TM domain of TAP1 single chains is mysterious because this interaction is

157 As new single-chain LAGLIDADG nuclease scaffolds are identified

158 nd Sn atoms within individual {M}(n)Se(4n+2) single chain leading to quasi isolated {MnSe(6)} octahed

159 We observe that this polymer structure of a single chain linked to itself interacts differently with

160 have assembled from fatty acids and related single-chain lipids available in the prebiotic environme

161 b(valpn)Cu](3+) dinuclear cations produced a single-chain magnet (SCM) involving stacking interaction

162 nge magnetic ordering below 5.1 K as well as single-chain magnetic behavior at lower temperatures wit

163 L = pyetNO (1), tvpNO (2)] and consisting of single-chain magnets connected through organic ligands (

164 rection in the design of single-molecule and single-chain magnets.

165 d slow magnetic relaxation characteristic of single-chain magnets.

166 ical assembly of a query (in addition to the single chain), mapping of the conservation grades onto 2

167 Self-assemblies of equimolar double and single chain mixed ionic surfactants, with increasing nu

168 umatin and, together with the Y65R mutant of single chain monellin, one of the two sweetest proteins

169 the TSE in a beta-sandwich (I27) protein and single-chain monellin as the denaturant concentration is

170 antigen binding domains (VHH) of five unique single-chain monoclonal antibodies that differ in their

171 aryotic Cu-ATPases, ATP7B is assumed to be a single-chain monomer.

172 ivation by Pd(OAc)2 is demonstrated as a new single-chain nanoparticle (SCNP) folding process, enabli

173 rein, we introduce the first approach to map single-chain nanoparticle (SCNP) folding via high-resolu

174 al single rings, complex multi-ring systems, single chain nanoparticles, tadpoles, dumbbells and hair

175 characterization of platinum(II)-crosslinked single-chain nanoparticles (Pt(II) -SCNPs) to demonstrat

176 These compartmentalized single-chain objects were prepared by performing success

177 ructures could be efficiently compacted into single-chain objects.

178 sider multicellular structures composed of a single chain of cells as well as a chain of cells with a

179 diction of the micromechanical behavior of a single chain of cyclopropanated polybutadiene, which is

180 The second model consists of single chains of corner-sharing FeO6 octahedra being bri

181 2M, using the ALT-803 scaffold fused to four single chains of the tumor-targeting monoclonal antibody

182 gh thermal motions cause an evolution of the single chain orbital energies.

183 Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan de

184 uble-compaction occurred and that the formed single-chain particles contain distinct cross-linked sub

185 We describe single-chain polymer nanoparticles (SCNPs) possessing in

186 polymer with a cylindrical brush block and a single-chain polymeric nanoparticle block folded due to

187 Single-chain polymeric nanoparticles (SCPNs) are intrigu

188 cule force spectroscopy (SMFS) is applied to single-chain polymeric nanoparticles (SCPNs) to acquire

189 mplementary association motifs and fold into single-chain polymeric nanoparticles (SCPNs) via orthogo

190 The 63-kDa single-chain precursor protein localizes to pre-lysosoma

191 VIII (FVIII) is predominantly expressed as a single-chain protein and exhibits greater stability afte

192 We produced and characterized >20 single-chain protein cages in three shapes-tetrahedron,

193 This work reports the first example of a single-chain protein computationally designed to contain

194 we present an approach to rationally design single-chain protein constructs that mimic the NHR coile

195 S neurons, but not glia, express SorCS2 as a single-chain protein that is essential for proBDNF-induc

196 This study analysed one such single-chain protein, TstI.

197 cterize a hypothetical approximately 100 kDa single-chain protein, YonO, encoded by the SPbeta propha

198 nd gmrD genes are fused together to encode a single-chain protein.

199 These single-chain proteins bound to synthetic CHR peptides wi

200 ype ISP restriction-modification enzymes are single-chain proteins comprising an Mrr-family nuclease,

201 een classified as type 1 RIPs, consisting of single-chain proteins, and type 2 RIPs, consisting of an

202 Organoclays synthesized from single chain quaternary ammonium cations (QAC) ((CH(3))(

203 ade significant improvements to our existing single-chain Rac1 biosensor.

204 Here, we describe the development of a single-chain rare-cleaving nuclease architecture, which

205 ns from cyclin B en bloc, proceeding until a single chain remains.

206 l radiopharmaceutical based on a recombinant single-chain (sc) derivative of VEGF, in orthotopic brea

207 Several single-chain (scFv) antibodies, derived from an affinity

208 tificial heteropolymers the control over the single chain self-assembling properties does not reach t

209 Overexpression of the single-chain SPT fusion protein under the control of a t

210 s individual subunits or as a heterotrimeric single-chain SPT fusion protein.

211 We infer from single-chain studies that for complete PspF inhibition t

212 ing a panel of single-chain antibodies and a single-chain T-cell receptor (collectively termed scFvs)

213 To mitigate this problem, we used a single-chain tandem dimer of MCP (tdMCP) that significan

214 uded a high-affinity, MART-1/HLA-A2-specific single-chain TCR and two other high-affinity TCRs that a

215 This review covers the recent advances in single chain technology for the construction of soft nan

216 s through the full development of so-called "single chain technology".

217 e the expected, long-term valuable output of single chain technology.

218 ion, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF

219 ter system to measure translocation by an AB single-chain toxin in intact cells.

220 The single-chain toxins TcdA and TcdB are the main virulence

221 amino-terminal extended peptide MHC class I single-chain trimer (AT-SCT), which preferentially promo

222 tinguish between these pathways, we designed single-chain trimer (SCT) peptide-MHC class I complexes

223 e with inducible MHC class I consisting of a single-chain trimer (SCT), ovalbumin peptide-beta2 micro

224 ath compared with native nonamer MHC class I single-chain trimer (SCT)-activated T cells.

225 inal extended decamer peptide expressed as a single-chain trimer, the amino-terminal extended peptide

226 Furthermore, we demonstrate that all single-chain TTLLs with known glutamylase activity utili

227 Intranuclear single-chain uPA binds directly to and interferes with t

228 Here we report that wild type single-chain uPA, but not uPA variants incapable of nucl

229 We fused single-chain urokinase plasminogen activator (scuPA) to

230 G221S variants displayed moderately reduced single-chain urokinase-type plasminogen activator activa

231 The G221E variant failed to activate the single-chain urokinase-type plasminogen activator, and t

232 gs algorithm that allows for parallelizing a single chain using existing MCMC methods.

233 distinct, high affinity antibody fragments (single chain variable and antigen-binding (Fab) fragment

234 We report the molecular design of a single chain variable antibody fragment (scFv) that bind

235 in both free anti-IL-1beta Fab and anti-IL-6 single chain variable exist in multiple conformations, w

236 ls were genetically modified to display both single chain variable fragment (scFv) antibodies and gol

237 Recombinant HSV-1 containing the ch14.18 single chain variable fragment (scFv) at the N-terminus

238 The VEGF binding domain consists of a single chain variable fragment (scFv) based on ranibizum

239 tom Pinnularia sp. and functionalized with a single chain variable fragment (scFv) derived from an an

240 We constructed a phage recombinant single chain variable fragment (scFv) library with a div

241 e, we report the crystal structure of mAb735 single chain variable fragment (scFv735) in complex with

242 We have generated five dual-specific single chain variable fragments (scFv) that neutralize t

243 gy were used to construct stable recombinant single chain variable fragments (ScFvs) representing the

244 Phl p 1 using allergen-specific IgE-derived single-chain variable Ab fragments (IgE-ScFvs) isolated

245 III, the specificity was also tested using a single-chain variable antibody fragment directed against

246 riable fragment (muscFv1E4), and a humanized single-chain variable fragment (huscFv1E4) retained the

247 agment of 1E4 (Fab1E4), a recombinant murine single-chain variable fragment (muscFv1E4), and a humani

248 eptide (Asp-Tyr-Lys-Asp) were grafted onto a single-chain variable fragment (scFv) acceptor framework

249 igands of choice, such as anti-Her2 antibody single-chain variable fragment (scFv) and luteinizing ho

250 Single-chain variable fragment (scFv) antibodies increas

251 CAR) in which targeting was achieved using a single-chain variable fragment (scFv) derived from the 5

252 fically target NCT and expressed them in the single-chain variable fragment (scFv) format in mammalia

253 how genetic fusion of a short peptide or an single-chain variable fragment (scFv) fragment to human

254 Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins ca

255 b) was constructed by inserting an anti-Her2 single-chain variable fragment (ScFv) into an anti-CD3 F

256 A single-chain variable fragment (scFv) intrabody was gene

257 tructed a rationally designed, fully defined single-chain variable fragment (scFv) library and analys

258 A 3H3 single-chain variable fragment (scFv) retained the bindi

259 strated by evolution of an anti-Fas receptor single-chain variable fragment (scFv) that was improved

260 ovement relative to that of the parental 80R single-chain variable fragment (scFv).

261 ngly, comparison of the Ag-free structure of single-chain variable fragment 2D10 with those bound to

262 Engineered single-chain variable fragment antibodies (scFv) are muc

263 previously designed a fusion protein of TM [single-chain variable fragment antibody (scFv)/TM] targe

264 Anti-FvTox1 single-chain variable fragment antibody expressed in tra

265 MA(+)TACI(-) and BCMA(-)TACI(+) cells, and a single-chain variable fragment CAR targeting BCMA alone

266 of nonspecific antibodies from two synthetic single-chain variable fragment libraries expressed on th

267 Previously discovered from a synthetic single-chain variable fragment library, S4 is also a hig

268 targeting protein Ags to B cells via a CD19 single-chain variable fragment miniAb.

269 ic CAR in which a CD4 segment is linked to a single-chain variable fragment of the 17b human monoclon

270 random mutagenesis and DNA shuffling of the single-chain variable fragment of the neutralizing antib

271 strategy on whole P. aeruginosa cells using single-chain variable fragment phage libraries derived f

272 xpress a CD19-CAR incorporating an anti-CD19 single-chain variable fragment plus TCR zeta and CD28 si

273 brary representing a highly diverse array of single-chain variable fragment sequences was first desig

274 We have used Phage Display to select scFv (single-chain variable fragment) clones from a combinator

275 etected when an anti-EGFR antibody (425 Snap single-chain variable fragment) that allows for dimeriza

276 receptors (CARs) containing a CD123-specific single-chain variable fragment, in combination with a CD

277 rein, we report on newly developed nanoyeast single-chain variable fragments (NYscFv) as an attractiv

278 used phage display techniques to identify 53 single-chain variable fragments (scFvs) after three roun

279 ed for the therapeutic effect, we engineered single-chain variable fragments (scFvs) derived from HJ8

280 ion, a functional screening strategy selects single-chain variable fragments (scFvs) directly for the

281 We here describe an approach to identify single-chain variable fragments (scFvs) specific for mut

282 We generated two single-chain variable fragments (scFvs) that recognize d

283 tives, such as antibody fragments (Fabs) and single-chain variable fragments (scFvs), are now being u

284 These binding proteins are based on antibody single-chain variable fragments and activate fluorogenic

285 It consists of 2 single-chain variable fragments specific for CD19 presen

286 rated with CdSe quantum dots and recombinant single-chain variable fragments towards MSLN, is used to

287 V3 loop, we generated 20 variants of KD-247 single-chain variable fragments with mutations in the an

288 red by antigen-independent clustering of CAR single-chain variable fragments, can induce early exhaus

289 Using single-chain variable fragments, we tested antibody resi

290 ates MG to a similar extent as FAPs based on single-chain variable fragments.

291 of recombinant immunotoxins containing mouse single-chain variable regions fused with a Pseudomonas t

292 ucture of influenza-virus hemagglutinin (HA):single-chain variable-domain fragment complexes, by stud

293 In particular, smaller, single-chain-variable antibody fragments (scFv's) are at

294 ntial receptor-binding site in an engineered single-chain variant of LTalpha1beta2 reveal the high-af

295 ally active mutants of scVEGF (an engineered single-chain version of pan-receptor VEGF-A with an N-te

296 e of subunit communication in a reengineered single-chain version of the homodimeric transcription fa

297 e generated a chimeric prodrug composed of a single-chain version of the variable region of an anti-a

298 lowed for the intramolecular crosslinking of single chains via the addition of [Pt(1,5-cyclooctadiene

299 However, single chains were often shared between patients and use

300 d backbones manifest HRTEM and AFM images of single-chain-wrapped SWNTs that reveal significant prefe