ライフサイエンスコーパス: single nucleotide substitution

1 U) by the insertion of a nucleotide and by a single nucleotide substitution.

2 dels the change in enhancer signature upon a single nucleotide substitution.

3 of the parent Y942H virus, which possessed a single nucleotide substitution.

4 differentiate a spurious target containing a single-nucleotide substitution.

5 -gamma), and interleukin 10 (IL-10) based on single nucleotide substitutions.

6 with the germ-line sequences with only four single nucleotide substitutions.

7 on/duplication of these elements rather than single nucleotide substitutions.

8 , reagentless, room-temperature detection of single nucleotide substitutions.

9 acid changes leading to escape resulted from single nucleotide substitutions.

10 rted in mouse and human and to date, all are single nucleotide substitutions.

11 and a noticeable capability to discriminate single-nucleotide substitutions.

12 equences, and thus prevents viral escape via single-nucleotide substitutions.

13 among LDSIs of a strain were associated with single-nucleotide substitutions.

14 e sequence, of which 9726 were nonsynonymous single-nucleotide substitutions.

15 used frequency-validated SNPs resulting from single-nucleotide substitutions.

16 revealed seven rare and private heterozygous single nucleotide substitutions (4% of individuals).

17 ion, a 1 bp deletion, a 13 bp deletion and a single nucleotide substitution affecting a donor splice

18 proximately 3%, more than half of which were single nucleotide substitutions affecting a basic clamp-

19 -scale analysis of lineage-specific rates of single-nucleotide substitutions among hominoids.

20 of these codon mutations was generated by a single nucleotide substitution and therefore had the pot

21 Of these, 79 were single nucleotide substitutions and 9 sites involved ins

22 data show that Jun-Fos heterodimer tolerates single nucleotide substitutions and binds to TGACTCA var

23 In a test of selectivity, single nucleotide substitutions and deletions could succ

24 er filtering, >2000 rare variants (including single nucleotide substitutions and indels) were shared

25 f 25mer probes complementary to all possible single nucleotide substitutions and insertions, and one

26 Single nucleotide substitutions and unique insertions/de

27 Single-nucleotide substitutions and small in-frame inser

28 As expected, single-nucleotide substitutions and small indels occur f

29 Single nucleotide substitutions are 10 times more freque

30 ough oligonucleotide probes complementary to single nucleotide substitutions are commonly used in mic

31 but instead is organized in such a way that single nucleotide substitutions are more likely to resul

32 Single-nucleotide substitutions are a defining character

33 Non-templated, single-nucleotide substitutions are incorporated at high

34 A single nucleotide substitution at codon 249, predicting

35 Patients with FBD have a single nucleotide substitution at codon 267 in the BRI2

36 Single nucleotide substitution at six of eight positions

37 In most of these cases we observed a single nucleotide substitution at the middle position of

38 d oligodeoxyribonucleotide and distinguishes single nucleotide substitutions at any position of a 20-

39 m switching results from the introduction of single nucleotide substitutions at defined locations in

40 g of the promoter activity revealed that two single nucleotide substitutions at positions -331 and -1

41 me of an organism arises from such events as single nucleotide substitutions at the DNA level, differ

42 Mutation screening of KERA revealed a novel single-nucleotide substitution at codon 215, which resul

43 ges did not reduce tR1 function, 11 specific single-nucleotide substitutions at eight positions inter

44 showed that the mutations were predominantly single-nucleotide substitutions broadly distributed with

45 tically detects the presence of heterozygous single nucleotide substitutions by fluorescencebased seq

46 rations (e.g., insertions and deletions) and single-nucleotide substitutions by comparing the followi

47 Recent research has illustrated that even a single nucleotide substitution can alter the selective b

48 ncing showed that the defect was linked to a single nucleotide substitution causing an amino acid cha

49 -infectious isolates bosR allele contained a single nucleotide substitution, converting an arginine t

50 We set out to understand how a single nucleotide substitution could cause such a dramat

51 y, these assays identified a site at which a single nucleotide substitution could distinctly impact p

52 Twenty-one constructs with single nucleotide substitutions covering all 15 position

53 A single nucleotide substitution creates an oligo-adenine

54 We report the most common single-nucleotide substitution/deletion mutations in fav

55 t into connected components that represented single nucleotide substitution events revealed a network

56 Genotyping for the single nucleotide substitution (G to A) at position 61 i

57 We identified a single nucleotide substitution (G to A) at position 61 o

58 We found a single nucleotide substitution (G1238T) that results in

59 the second leucine rich repeat, the other, a single nucleotide substitution (G2078 --> A) for the try

60 The truncation is caused by a single nucleotide substitution in a splice donor, leadin

61 f different dimorphic polymorphisms based on single nucleotide substitution in chronic HCV patients (

62 f pairs apparently resulted from a concerted single nucleotide substitution in each pairing oligonucl

63 Molecular genetic studies revealed a single nucleotide substitution in SCN5A exon 28 that cau

64 the photorespiratory sat mutants revealed a single nucleotide substitution in the AGT1 gene from the

65 out a family history of uveal melanoma had a single nucleotide substitution in the conserved splice d

66 These data are strong evidence that the single nucleotide substitution in the fa allele of Lepr

67 These data demonstrate that single nucleotide substitution in the human genome is fe

68 ns in stem-loop III allow snRNP formation, a single nucleotide substitution in the loop prevents tran

69 inal (Rld1-O) mutation, which results from a single nucleotide substitution in the miRNA166 complemen

70 site reversion to Tyr, Trp, Phe, or His by a single nucleotide substitution in the original mutant co

71 n of the duck hepatitis B virus that bears a single nucleotide substitution in the pre-S envelope pro

72 d mutant clones containing either SGD with a single nucleotide substitution in the R(144) codon or do

73 ied the gene, ORF 54, which was altered by a single nucleotide substitution in tsN1054.

74 Somatic hypermutation introduces multiple single nucleotide substitutions in and around the rearra

75 ice established two obese pedigrees in which single nucleotide substitutions in Mc4r and Sim1 genes w

76 Three of these polymorphisms are due to single nucleotide substitutions in the alpha-spectrin ge

77 cient bacterium to identify four independent single nucleotide substitutions in the alsK and nanK gen

78 em of the poliovirus cre and was reversed by single nucleotide substitutions in the stem as well as t

79 The majority (86%) of single nucleotide substitutions in this sequence exert s

80 (SOLiD 3 ECC) for their ability to identify single nucleotide substitutions in whole genome sequence

81 The fourth was a single-nucleotide substitution in intron 2, 11 bp upstre

82 c organization contribute to the patterns of single-nucleotide substitution in normal and cancer geno

83 A single-nucleotide substitution in the intronic region th

84 ids was constructed containing predominantly single-nucleotide substitutions in a 24 nt region previo

85 more stable than the READY state, as several single-nucleotide substitutions in a hypervariable regio

86 Many single-nucleotide substitutions in cancer genomes arise

87 Here, we report measurements of random single-nucleotide substitutions in normal and neoplastic

88 Single-nucleotide substitutions in the 6x octamer that a

89 ndependent human selections of four distinct single-nucleotide substitutions in the GmTfl1 gene, each

90 characterize viruses harboring all remaining single-nucleotide substitutions in the pentaloop of MHV

91 Twelve single-nucleotide substitutions in the rpoB gene were de

92 B40-BAC4 and FIX (but not TR) were mapped to single-nucleotide substitutions in UL128L.

93 human genome have been identified, including single nucleotide substitutions, insertion and deletion,

94 Furthermore, we demonstrated that single nucleotide substitutions into the coding region o

95 oach to quantify the effects of all possible single-nucleotide substitutions introduced into importan

96 determined that the frequency of intergenic single-nucleotide substitution is significantly higher i

97 be changed by random mutagenesis and that a single-nucleotide substitution is sufficient to change t

98 ypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic in

99 Two single-nucleotide substitution mutants (comX::T162C; com

100 A single nucleotide substitution of thymidine to guanine (

101 With both kinetic studies and single nucleotide substitutions of target and guide nucl

102 uration can be altered as a consequence of a single-nucleotide substitution on the target.

103 A mouse transgenic assay shows that these single nucleotide substitutions operate as gain-of-funct

104 All of these alleles are characterized by single nucleotide substitutions or deletions leading to

105 hibited the mutation rate of >/=1.3 x 10(-8) single nucleotide substitutions per site per generation,

106 propose that, in addition to recombination, single nucleotide substitutions played an important role

107 Two single nucleotide substitutions present in the SM sequen

108 Furthermore, single nucleotide substitution probes displayed the most

109 In personal genomes, the single-nucleotide substitution rate is higher near sites

110 resolution site (trs), CCGGT/CG, contains a single nucleotide substitution relative to the AAV(2) tr

111 Whereas rates of single-nucleotide substitution remain relatively constan

112 isolated from normal cell types contained a single nucleotide substitution, resulting in an amino ac

113 Single nucleotide substitutions reveal that, in contrast

114 Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the human GC

115 P detection method has been validated on all single-nucleotide substitution scenarios in three synthe

116 quences for quality and number of reads, all single-nucleotide substitutions, small insertion and del

117 m of human genome variation: novel and known single-nucleotide substitutions (SNP/SNV), short inserti

118 However, the origin of single-nucleotide substitutions (SNS) in nonfamilial can

119 ations are typical SHM consisting largely of single nucleotide substitutions targeted to hotspots.

120 e from an ancestral molecule was caused by a single nucleotide substitution that occurred after the c

121 Interestingly, certain single nucleotide substitutions that impacted Pot1pN bin

122 All five far1 alleles isolated have single nucleotide substitutions that introduce stop codo

123 he nonlytic plaque phenotype resulted from a single-nucleotide substitution that shifted a tyrosine r

124 of these enhancers evolved through multiple single-nucleotide substitutions that altered both the ti

125 o acid substitutions in HIV-1 RT; however, a single nucleotide substitution (thymine to cytosine) was

126 human brain evolution span a wide range from single-nucleotide substitutions to large-scale structura

127 We also describe eight noncoding single-nucleotide substitutions, two of which are presen

128 Single-nucleotide substitution type rates are significan

129 ne mutational categories on the basis of the single-nucleotide substitution type.

130 A single nucleotide substitution was detected in the GUSB

131 udogene-derived mutation rates for different single nucleotide substitutions we have estimated, for t

132 cleotides required for function, a series of single nucleotide substitutions were introduced in the F

133 Single nucleotide substitutions were made in the core he

134 ected a gacA mutant of Pf-5 that contained a single nucleotide substitution within a predicted alpha-

135 Single nucleotide substitutions within protein coding re