ライフサイエンスコーパス: single ventricle

1 ge, 13-17 years; 24 girls; 18 with palliated single ventricle).

2 mproved patient outcomes for patients with a single ventricle.

3 eloped for the palliation of children with a single ventricle.

4 m and extends along the entire length of the single ventricle.

5 erm advantage for patients with a functional single ventricle.

6 cal management of patients with a functional single ventricle.

7 intensive care management of patients with a single ventricle.

8 procedures were performed in patients with a single ventricle.

9 <0.001) but not in children with a palliated single ventricle.

10 g HT evaluation in children with a palliated single ventricle.

11 the first years of life among patients with single ventricle.

12 cases of hypoplastic left heart syndrome and single ventricle.

13 tive palliation for patients with functional single ventricles.

14 erformance in young patients with functional single ventricles.

15 s performed in 35 patients with a functional single ventricle (1 week to 12 years old) at various sta

16 T burden was highest in complex CHD, such as single ventricle (22.8%) and d-transposition of the grea

17 Primary diagnosis included single ventricle (36%), d-transposition of the great art

18 .0% (95% confidence interval, 32.6 to 43.5); single ventricle, 56.1% (95% confidence interval, 49.9 t

19 ast decade, as the majority of patients with single ventricle anatomy who have undergone the Fontan o

20 0 feet) were analyzed for patients born with single-ventricle anatomy who would now be of adult age.

21 Of 149 patients with single-ventricle anatomy, 103 underwent the Fontan proce

22 t highest risk are infants with a functional single ventricle and patients with suprasystemic pulmona

23 ot, four with Ebstein's anomaly and two with single ventricle and pulmonary stenosis.

24 She was diagnosed with functional single ventricle and very limited pulmonary blood flow.

25 ties are commonly present in patients with a single ventricle, and detection of these lesions increas

26 ultivariate analysis, weight <4 kg, having a single ventricle, and emergency status were significantl

27 pulmonary atresia intact ventricular septum, single ventricle, and tricuspid atresia born in 1996 to

28 ence of a large ventricular septal defect, a single-ventricle approach to repair should be considered

29 and performance changes occur in functional single ventricles as they progress through staged Fontan

30 d randomized clinical trials in infants with single ventricle CHD and 270 controls from The Cancer Ge

31 Several CNVs likely to be causative of single ventricle CHD were observed, including aberration

32 lack of information, gaps in clinical care, single ventricle complications, and heart failure in the

33 heart surgeries currently performed to treat single-ventricle congenital heart disease.

34 ticles regarding management of newborns with single-ventricle defects have been published during the

35 rience in newborns undergoing palliation for single-ventricle defects, in particular, hypoplastic lef

36 Other single-ventricle defects, transposition of the great art

37 A single ventricle diagnosis (P=0.06), longer postoperativ

38 n coarctation of the aorta, late outcomes in single-ventricle disease, cognitive and psychiatric issu

39 Patients with a single ventricle experience a high rate of brain injury

40 ress test results of all preadolescents with single ventricle Fontan physiology.

41 g improves aerobic capacity in patients with single ventricle Fontan physiology.

42 and predictive value of EOV in patients with single ventricle Fontan physiology.

43 enic CNVs seem to contribute to the cause of single ventricle forms of CHD in >/=10% of cases and are

44 gement strategy for patients with functional single ventricle has evolved to include staging bidirect

45 Infants with functional single ventricle have a high risk of death during the ea

46 Patients with a single ventricle have multiple risk factors for central

47 ; P<0.001) but not in those with a palliated single ventricle (hazard ratio, 1.3; 95% confidence inte

48 ing patient, who had borderline functionally single ventricle heart disease (unbalanced atrioventricu

49 Most candidates have single ventricle heart disease and limited transvenous o

50 ndrome (n = 10) or other forms of functional single-ventricle heart (n = 19).

51 ported to improve outcomes for patients with single-ventricle heart disease during the period between

52 ocus of improving outcomes for patients with single-ventricle heart disease.

53 cedure for the palliation of patients with a single-ventricle heart, there have been very few reports

54 Advances in the care of children with single ventricle hearts have resulted in remarkably impr

55 Surgical strategies for patients with single ventricle include intermediate staging or early F

56 This review suggests that the diagnosis of single ventricle, initiation of ECMO in the operating ro

57 factors: age, ventricular morphology (right single ventricle, left single ventricle [RV/LV]), fenest

58 (MBT) shunt, the first palliative stage for single-ventricle lesions with systemic outflow obstructi

59 ren who had undergone Fontan corrections for single-ventricle lesions.

60 icular repair and which are better served by single ventricle management.

61 The long-term outcome of single-ventricle management in these patients is not kno

62 n young pediatric patients with a functional single ventricle, matrix-array 3DE measurements of mass

63 entricular septal defect (n=3), functionally single ventricle (n=3) and ventricular septal defect wit

64 Long-term single-ventricle outcomes among neonatal survivors of th

65 perioperative implications of the stages of single ventricle palliation is critical.

66 proposed as a means of improving outcomes of single ventricle palliation.

67 diameter was pre-specified for patients with single ventricle palliation.

68 tients with LH hypoplasia who have undergone single-ventricle palliation (SVP).

69 the entire population of newborns undergoing single-ventricle palliation are unclear.

70 In infants requiring 3-stage single-ventricle palliation for hypoplastic left heart s

71 urgical management consisted of a functional single-ventricle palliation in 38 patients (83%) and biv

72 Failed single-ventricle palliation is a growing indication for

73 nd of a spectrum of LV hypoplasia, mandating single-ventricle palliation or cardiac transplantation.

74 nital heart surgery, especially after failed single-ventricle palliation, is presenting new obstacles

75 e Fontan is typically not the final stage of single-ventricle palliation.

76 All 134 patients had a form of single ventricle pathological anatomy.

77 articular interest, conduit reoperations and single ventricle pathway modifications are still an art

78 ne arrhythmic death related to asystole in a single ventricle patient.

79 ary collateral (SPC) flow occurs commonly in single ventricle patients after superior cavo-pulmonary

80 lmonary arterial collateral (SPC) vessels in single ventricle patients are poorly understood.

81 Single ventricle patients not requiring an intervention

82 tment with phosphodiesterase-5 inhibitors in single ventricle patients with heart failure, including

83 on is routinely used as a diagnostic tool in single ventricle patients with superior cavopulmonary co

84 rends toward worse outcomes were observed in single ventricle patients, biventricular patients with l

85 ion of VADs in complex circulations, such as single ventricle patients, remains infrequent and is ass

86 inition 1, 86% for definition 2, and 75% for single ventricle patients.

87 edback mechanisms, 12 intubated, ventilated, single-ventricle patients in SCPC physiology (age 2.2+/-

88 the total cavopulmonary connection (TCPC) in single-ventricle patients undergoing Fontan can be calcu

89 In single-ventricle patients, a staged approach is employed

90 The most common diagnosis was single ventricle physiology (52%), 9 palliated by Fontan

91 Single ventricle physiology and failure to separate from

92 Newborns with prenatal diagnosis of single ventricle physiology and transposition of the gre

93 Current approaches to single ventricle physiology as well as areas of controve

94 T FINDINGS: Infants following palliation for single ventricle physiology have persistent growth failu

95 livery of adequate nutrition in infants with single ventricle physiology is essential to improve outc

96 ents undergoing cavopulmonary palliation for single ventricle physiology may be impacted by living at

97 e whether pathogenic CNVs among infants with single ventricle physiology were associated with inferio

98 with transposition of the great arteries and single ventricle physiology were included in this analys

99 atrial septal defects, tetralogy of Fallot, single ventricle physiology, and following cardiac trans

100 heart malformations are those with so-called single ventricle physiology, in which there is only one

101 ndergoing Fontan procedures as palliation of single ventricle physiology, the addition of a fenestrat

102 ansposition of the great arteries and 57 had single ventricle physiology.

103 heart disease, and 80% of these patients had single ventricle physiology.

104 n patients with systemic right ventricles or single ventricle physiology.

105 espiratory support; 4) expanding research of single ventricle physiology; 5) advances in the treatmen

106 In particular, all patients with single- ventricle physiology currently undergo diagnosti

107 (hazard ratio, 3.66; 95% CI, 2.26-5.92) and single-ventricle physiology (hazard ratio, 1.98; 95% CI,

108 erformance in children and young adults with single-ventricle physiology after the Fontan operation.

109 PL through the TCPC may play a role in single-ventricle physiology and is a function of cardiac

110 odynamically detrimental in circumstances of single-ventricle physiology and should be used with caut

111 zation is standard practice in patients with single-ventricle physiology before bidirectional Glenn a

112 First, the standard model of single-ventricle physiology can be reexpressed in a form

113 In neonatal lambs with single-ventricle physiology created in utero, epinephrin

114 The lack of animal models of single-ventricle physiology has hindered the understandi

115 Children and young adults with single-ventricle physiology have abnormal exercise capac

116 Infants with single-ventricle physiology have poor growth and are at

117 Bone marrow transplant recipients and single-ventricle physiology have the poorest outcomes.

118 Administration of enalapril to infants with single-ventricle physiology in the first year of life di

119 Single-ventricle physiology is characterized by parallel

120 ouble-blind trial involving 230 infants with single-ventricle physiology randomized to receive enalap

121 Five-year survival for single-ventricle physiology was 47.2% (95% CI, 34.3-59.1

122 A reproducible fetal animal model of single-ventricle physiology was created to examine the e

123 Of 110 neonates with functionally single-ventricle physiology who underwent stage I pallia

124 volumes and mass in pediatric patients with single-ventricle physiology would aid clinical managemen

125 lnerability indicators, renal insufficiency, single-ventricle physiology, and coagulation disorder.

126 ly fatal disorder occurring in children with single-ventricle physiology, and other diseases, as well

127 rdization: patient age, renal insufficiency, single-ventricle physiology, procedure-type risk group,

128 osition of the great arteries and 12 who had single-ventricle physiology--with the use of magnetic re

129 ion of complex congenital heart disease with single-ventricle physiology.

130 the goal in the management of patients with single-ventricle physiology.

131 doses in the resuscitation of patients with single-ventricle physiology.

132 ll enable better management of patients with single-ventricle physiology.

133 l after surgical palliation in children with single-ventricle physiology.

134 is a successful palliation for children with single-ventricle physiology; however, many will eventual

135 ted the most from this progress has been the single-ventricle population.

136 The Pediatric Heart Network's (PHN) single ventricle reconstruction (SVR) trial compared shu

137 The Pediatric Heart Network's Single Ventricle Reconstruction (SVR) trial randomized i

138 The Single Ventricle Reconstruction (SVR) trial randomized s

139 In the Single Ventricle Reconstruction (SVR) trial, 1-year tran

140 e physiologic requirements for success after single ventricle reconstruction has resulted in dramatic

141 As the Single Ventricle Reconstruction study was based on the i

142 Since 2010, the Single Ventricle Reconstruction trial has matured and ha

143 Examining the available data in light of the Single Ventricle Reconstruction trial is insightful as f

144 In the Single Ventricle Reconstruction trial of the Norwood pro

145 and Blood Institute Pediatric Heart Network Single Ventricle Reconstruction Trial public data set wa

146 The multi-institutional Single Ventricle Reconstruction trial randomly assigned

147 multi-institutional Pediatric Heart Network Single-Ventricle Reconstruction Trial, interstage mortal

148 epair (closure of septal defects) instead of single-ventricle repair (Norwood palliation and Fontan o

149 Infants with single ventricle require staged cardiac surgery, with st

150 lar morphology (right single ventricle, left single ventricle [RV/LV]), fenestration open (FO) or clo

151 Patients with single-ventricle, shunt-dependent physiology are at incr

152 ations for surgical palliation of functional single ventricle since the initial report by Fontan and

153 tality rate and an increase in the number of single-ventricle survivors.

154 dies in zebrafish, a lower vertebrate with a single ventricle, that latent TGF-beta binding protein 3

155 monary artery shunt alone in patients with a single ventricle to facilitate ventricular volume unload

156 e 5-year survival in infants with functional single ventricle, to define factors associated with surv

157 nts (median age, 7 months) with a functional single ventricle undergoing CMR under general anesthesia

158 ional echocardiography (3DE) measurements of single-ventricle volumes, mass, and ejection fraction wi

159 Single ventricle was the pretransplantation diagnosis fo

160 Patients who had a single ventricle, weight <4 kg, or who underwent an emer

161 Patients with a single ventricle were studied with magnetic resonance im

162 Preadolescents with single ventricle who undergo volume unloading surgery at