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1 alone (apo) and in complex with a nonameric single-stranded RNA.
2 bits growth by sequence-specific cleavage of single-stranded RNA.
3 ding preferences of NPH-II for duplex versus single-stranded RNA.
4 ng others responsible for the recognition of single-stranded RNA.
5 equential packaging of its three segments of single-stranded RNA.
6 esis is potently inhibited by the binding of single-stranded RNA.
7 he respective RNA structures, and amounts of single-stranded RNA.
8 kinase is not activated by and does not bind single-stranded RNA.
9 age large, defined fragments of its genomic, single-stranded RNA.
10 replicative intermediate is represented by a single-stranded RNA.
11 ize the duplex by preferentially binding the single-stranded RNA.
12 ression and/or function of TLR7, a sensor of single-stranded RNA.
13 inding domain confers a general affinity for single-stranded RNA.
14 Argonaute-bound siRNA duplex is converted to single-stranded RNA.
15 dynamic behavior from binding to the random single-stranded RNA.
16 nick and degrade linear as well as circular single-stranded RNA.
17 the Grc3 kinase activity exclusively toward single-stranded RNA.
18 RNA and how this differs from its action on single-stranded RNA.
19 r by preventing the association of Dbp2 with single-stranded RNA.
20 are monomers that induce tight compaction of single-stranded RNA.
21 uble-stranded DNA, type III complexes target single-stranded RNA.
22 disposes of or processes viral and cellular single-stranded RNAs.
23 a segmented genome of eight negative-sense, single-stranded RNAs.
24 gher affinity to SL3 RNA than to double- and single-stranded RNAs.
25 tic Hen1 in their ability to methylate small single-stranded RNAs.
26 f these arises by Piwi-catalysed cleavage of single-stranded RNAs.
27 rimer-independent RNA polymerase activity on single-stranded RNAs.
28 generating double-stranded RNA from specific single-stranded RNAs.
29 ressed the basic physical properties of long single-stranded RNAs.
30 the 5'-phosphate and 3'-hydroxyl termini of single-stranded RNAs.
31 the single-stranded DNA Microviridae and the single-stranded RNA Alloleviviridae, accomplish lysis by
33 xygen species, NOX2 oxidase, is activated by single stranded RNA and DNA viruses in endocytic compart
34 ows direct visualization of the encapsidated single-stranded RNA and coat protein (CP) N-terminal reg
35 rocessive DExH group often translocate along single-stranded RNA and displace paired strands (or prot
36 he pre-steady-state P(i) release kinetics on single-stranded RNA and DNA substrates of different leng
39 rified human PRC2 recognizes G > C,U >> A in single-stranded RNA and has a high affinity for folded g
40 ct sensitivity to pyrimidine-rich regions of single-stranded RNA and is able to process tRNA precurso
41 dered to be linked to the affinity of S1 for single-stranded RNA and its corresponding destabilizatio
42 association was dependent on the presence of single-stranded RNA and mediated by an N-terminal region
43 ts showed that both SUD-C and SUD-MC bind to single-stranded RNA and recognize purine bases more stro
45 and mutational analyses show how it threads single-stranded RNA, and structural features suggest how
46 x binds nucleic acids, with a preference for single-stranded RNA, and the Tex S1 domain is required f
49 itor the in vitro co-assembly of CCMV CP and single-stranded RNA as a function of the strength of CP-
50 ed and characterized two R-plasmid-dependent single-stranded RNA bacteriophages (RPD ssRNA phages), C
52 P L binding were blocked by preannealing the single-stranded RNA bait with miR-122, indicating that t
54 tion motif, domains are the largest class of single-stranded RNA binding domains in the human proteom
59 equence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumi
61 his gene modifier screen identified EndoU, a single-stranded RNA-binding protein of ancient origin, a
63 binding miRNAs function as agonists of these single-stranded RNA-binding TLRs, leading to NF-kappaB s
65 that RNase BN is active on both double- and single-stranded RNA but that duplex RNA is preferred.
68 ed molecular patterns, including double- and single-stranded RNA, by pattern recognition receptors in
69 Top3beta is capable of converting two such single-stranded RNA circles into a double-stranded RNA c
70 olism, we designed an assay by annealing two single-stranded RNA circles with complementary sequences
72 an component has little or no influence over single-stranded RNA cleavage, RI evasion or cytotoxicity
73 response to cytosolic double-stranded RNA or single-stranded RNA containing 5'-triphosphate (5'-ppp).
74 ne motif to mediate high-affinity binding to single-stranded RNAs containing the transcriptional regu
78 Pase, one of the major enzymes with 3' to 5' single-stranded RNA degradation and processing activitie
80 the HIV-1 genome, which is in the form of a single-stranded RNA enclosed inside a capsid shell, must
83 West Nile virus (WNV), a mosquito-borne, single-stranded RNA flavivirus, causes significant human
85 S1 promotes RNA unwinding by binding to the single-stranded RNA formed transiently during the therma
87 l protocols, one involving direct capture of single-stranded RNA fragments and one involving circular
89 NA copying to proceed, while also protecting single-stranded RNA from Mg(2+)-catalyzed degradation.
90 ifferential scanning calorimetry showed that single-stranded RNA from satellite tobacco mosaic virus
91 nsation and found that ectopic expression of single-stranded RNAs from 1.688(X) repeats enhanced the
92 re critical for reverse transcription of the single-stranded RNA genome into double-stranded DNA.
94 s C, platelets replicated the positive sense single-stranded RNA genome of DENV by up to approximatel
95 talyses a series of reactions to convert the single-stranded RNA genome of HIV into double-stranded D
96 virus particles containing a negative-sense, single-stranded RNA genome packaged within a helical nuc
98 idae family of nonsegmented, negative-sense, single-stranded RNA genome viruses, is a leading cause o
103 ining feature of these viruses is that their single-stranded RNA genomes are of opposite polarity to
104 uses replicate by reverse transcribing their single-stranded RNA genomes into double-stranded DNA usi
108 ase, P4, uses chemical energy to translocate single-stranded RNA genomic precursors into the procapsi
111 iviral immune responses by recognizing viral single-stranded RNA in endosomes, but the biosynthetic p
113 rchange in the average probabilities to form single-stranded RNA in the optimal PPT and branch site l
114 al infections and cleaves cellular and viral single-stranded RNAs, including rRNAs in ribosomes.
116 Moreover, L-RNA complex formation depends on single-stranded RNA, indicating that inter-termini dsRNA
117 the transcription of the relatively flexible single-stranded RNA into a more rigid filamentous struct
120 l functional effects from a seemingly simple single-stranded RNA junction and suggest that junction s
122 with or without a 5'-triphosphate (ppp), by single-stranded RNA marked by a 5'-ppp and by polyuridin
123 e KWKK ((+)NH(3)-Lys-Trp-Lys-Lys-NH(2)) to a single-stranded RNA model, polyuridylate (polyU), by cha
126 As (miRNAs) are small (20-23 nt), non-coding single stranded RNA molecules that act as post-transcrip
129 ion techniques to isolate small, structured, single-stranded RNA molecules known as aptamers that wer
130 (CCMV) is capable of packaging both purified single-stranded RNA molecules of normal composition (com
131 inflammatory condition, is a class of short single-stranded RNA molecules termed microRNAs (miRNAs).
132 MicroRNAs (miRNAs) are naturally occurring single-stranded RNA molecules that post-transcriptionall
133 MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that posttranscriptionally
134 miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene express
135 (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene express
138 amer, whose interaction depended mainly on a single-stranded RNA motif, but not that of the GFP aptam
139 propose a mechanism, we demonstrate that the single-stranded RNA of HIV-1 encodes multiple uridine-ri
140 e junction between the stem and the flanking single-stranded RNA of the pri-miRNA hairpin by DGCR8 fo
141 se H activity that act in concert to convert single-stranded RNA of the viral genome to double-strand
143 es to study 3C alone and in complex with two single-stranded RNA oligonucleotides derived from the or
144 We also present modelling of pyrimidine-rich single-stranded RNA onto the highly conserved surface of
146 e RdRp can initiate de novo from the ends of single-stranded RNA or extend a primed RNA template.
147 8 may be activated by their native ligands, single-stranded RNA, or by small molecules of the imidaz
148 ther TLRs (poly(I.C), flagellin, loxoribine, single-stranded RNA, or CpG DNA) in macrophages and HEK-
149 viruses distantly related to members of the single-stranded RNA picorna-like virus superfamily were
152 ependent RNA endonuclease activity targeting single-stranded RNA regions and demonstrate the function
153 ome, we accurately and simultaneously mapped single-stranded RNA regions in multiple ncRNAs with know
157 ur NMR spectroscopic investigations on short single-stranded RNA revealed a strong preference for C2'
158 ssential host factor for many positive-sense single-stranded RNA (+RNA) viruses including human patho
160 A virus (IAV) genomes are composed of eight single-stranded RNA segments that are coated by viral nu
161 6) and identified two conserved, putatively single-stranded RNA segments, upstream of S1 (nt 2 and 3
163 s of Mss116p in complex with ATP analogs and single-stranded RNA show that the helicase core induces
165 Higher ratios of HCV double-stranded to single-stranded RNA (ssRNA) correlated positively with I
166 est Nile virus (WNV), a mosquito-transmitted single-stranded RNA (ssRNA) flavivirus, causes human dis
167 show that topological structures containing single-stranded RNA (ssRNA) free of strong base pairing
169 ata from a competition assay between SLA and single-stranded RNA (ssRNA) indicate that SLA competes w
170 ndicates that small phages, particularly the single-stranded RNA (ssRNA) leviviruses, have a previous
171 All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide protein
172 A ligase to capture various short 20-24 base single-stranded RNA (ssRNA) oligonucleotides from a targ
174 The recent discovery of the positive-sense single-stranded RNA (ssRNA) Orsay virus (OV) as a natura
175 ose genome is packaged sequentially as three single-stranded RNA (ssRNA) segments into an icosahedral
176 ) binds with 20nM dissociation constant to a single-stranded RNA (ssRNA) sequence adjacent to the bra
177 d protein structures are the active sites of single-stranded RNA (ssRNA) synthesis; (v) at late times
178 e show that Cas9 binds with high affinity to single-stranded RNA (ssRNA) targets matching the Cas9-as
180 ed rotavirus double-layer particles, nascent single-stranded RNA (ssRNA) transcripts (termed in vitro
181 ontal gene transfer may have occurred from a single-stranded RNA (ssRNA) virus (hypovirus) to a dsRNA
182 ly for adenoviruses, which resembles that of single-stranded RNA (ssRNA) viruses but differs from the
186 h pump their genome into a preformed capsid, single-stranded RNA (ssRNA) viruses, such as bacteriopha
188 en the rates of double-stranded DNA (dsDNA), single-stranded RNA (ssRNA), and ssDNA/reverse-transcrib
189 recognizes guanosine- and uridine-rich viral single-stranded RNA (ssRNA), including influenza virus s
190 zyme Argonaute 2 (hAgo2) and Cryptosporidium single-stranded RNA (ssRNA), we induced specific slicing
191 x measures either ~22 nt from the upper stem-single-stranded RNA (ssRNA, terminal loop) junction or ~
192 ruses, especially those with positive-sense, single-stranded RNA (+ssRNA) genomes, are abundant in tr
193 important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially
195 CCHF) virus is a tick-borne, negative-sense, single-stranded RNA [ssRNA(-)] nairovirus that produces
196 sent in all three pathogenic positive-sense, single-stranded RNA [(+)ssRNA] virus families which carr
197 cinating features of these highly structured single stranded RNAs (ssRNAs) with emphasis on their pre
199 Chemical shift changes upon the addition of single-stranded RNAs (ssRNAs) identified a group of resi
200 bstantially higher affinity as compared with single-stranded RNA structures unless they contain a 5'-
201 w that Rho unidirectionally translocates the single-stranded RNA substrate via a population shift of
203 minus resemble those seen in the presence of single-stranded RNA suggesting similarities in binding.
204 signaling induced by NOD2 over-expression or single stranded RNA, suggesting specificity for the MDP-
205 Ape1 was found to cleave AP-site-containing single-stranded RNA, suggesting a novel "cleansing" func
206 strand scission in double-stranded RNA over single-stranded RNA suggests that this chemistry may be
207 lex RNA regardless of the orientation of the single-stranded RNA tail, it preferred a 5' to 3' polari
208 e CRISPR RNA and can be programmed to cleave single-stranded RNA targets carrying complementary proto
209 a unique biochemical activity: the use of a single-stranded RNA template for the synthesis of single
210 es the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3' untransl
213 )-fold smaller ribonuclease activity against single-stranded RNA than do the restrictocin homologues,
215 roRNAs (miRNAs) are small approximately 22nt single stranded RNAs that negatively regulate protein ex
219 NAs (miRNAs) are 19 to 25nt non-coding small single-stranded RNAs that negatively regulate gene expre
221 unusually long, high-affinity interface with single-stranded RNA, that this interface provides a func
222 e also show that TRBP can bind 21-nucleotide single-stranded RNAs, though with far lower affinity tha
223 lex dynamics associated with transition of a single stranded RNA to its secondary and tertiary struct
224 capsidation and reverse transcription from a single-stranded RNA to a double-stranded DNA through the
225 MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via co
226 ay represent a conserved scaffold that binds single-stranded RNA to regulate transcription in both eu
228 ed by the complementary association of three single-stranded RNA units, was optimized for improved ge
229 with 10-bp RNA-RNA duplexes and was aided by single-stranded RNA upstream of the duplex but was signi
230 he strength of attraction between CP and the single-stranded RNA viral genome is controlled by ionic
235 arainfluenza virus (PIV) is a negative-sense single-stranded RNA virus in the Paramyxoviridae family.
236 xin (EMR) family have been shown to modulate single-stranded RNA virus infection through regulating s
237 netics and mechanisms of inactivation of the single-stranded RNA virus MS2 under temperature, pH and
238 ect experimental evidence that assembly of a single-stranded RNA virus occurs via a packaging signal-
239 amyxovirus type 1 (APMV-1), a negative-sense single-stranded RNA virus of the genus Avulavirus, famil
240 ry syncytial virus (RSV) is a negative-sense single-stranded RNA virus responsible for lower respirat
241 ry syncytial virus (RSV) is a negative-sense single-stranded RNA virus responsible for lower respirat
242 Human respiratory syncytial virus (RSV) is a single-stranded RNA virus that causes acute, and occasio
244 d the RNA content of a purified nonenveloped single-stranded RNA virus, flock house virus (FHV).
249 or the replication of various positive-sense single stranded RNA viruses, which hijack this cellular
251 r mechanisms controlling genome packaging by single-stranded RNA viruses are still largely unknown.
253 n is a common strategy among positive-sense, single-stranded RNA viruses for bypassing the host cell
255 he members of this family of positive-sense, single-stranded RNA viruses have limited coding capacity
257 potentially profound implications for other single-stranded RNA viruses known to have RNA PSs, inclu
258 that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negati
263 eny, experimental evidence on positive sense single-stranded RNA viruses suggests that the CP also re
264 ain evolutionary dynamics closer to those of single-stranded RNA viruses than to those of double-stra
265 y of enveloped, negative-sense, nonsegmented single-stranded RNA viruses that account for a significa
266 s (HAstVs) are nonenveloped, positive-sense, single-stranded RNA viruses that are a leading cause of
270 stroviruses are nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal
272 link between platelets and their response to single-stranded RNA viruses that involves activation of
274 a large family of enveloped, negative-sense, single-stranded RNA viruses with significant economic an
275 double-stranded RNA viruses, positive-sense single-stranded RNA viruses, and the reverse-transcribin
276 hibit the replication of many negative-sense single-stranded RNA viruses, as well as double-stranded
277 We found that during sickness behavior, single-stranded RNA viruses, double-stranded RNA ligands
279 Alphavirus consists of a group of enveloped, single-stranded RNA viruses, many of which are transmitt
280 ation of selected nonenveloped and enveloped single-stranded RNA viruses, retroviruses, bacteriophage
281 ve roles of viral genomes in the assembly of single-stranded RNA viruses, we have developed a new ana
289 small, spherical, enveloped, positive-sense, single-stranded, RNA viruses responsible for considerabl
290 efective in signaling with triphosphorylated single-stranded RNAs were perfectly capable of signaling
291 structural homology, wild-type MAB21L2 bound single-stranded RNA, whereas this activity was lost in a
293 roaches for estimating hydrodynamic radii of single-stranded RNAs, which use generic RNA structure pr
295 c SAMHD1 was found to bind preferentially to single-stranded RNA, while the tetrameric form required
296 receptors (RLRs), RIG-I and MDA5, recognize single-stranded RNA with 5' triphosphates and double-str
298 The influenza virus genome is an 8-segment single-stranded RNA with high potential for in situ reco
300 It displays unusual specificity in vitro for single-stranded RNAs with at least one adenosine at the
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