ライフサイエンスコーパス: sinoatrial

1 xpression is observed in the portions of the sinoatrial and atrioventricular junctions that are thoug

2 x30.2, which is most abundantly expressed in sinoatrial and atrioventricular nodal regions of the hea

3 ust expression in the heart, particularly in sinoatrial and atrioventricular nodal regions.

4 distal outflow tract, atrial septum, and in sinoatrial and atrioventricular node.

5 .9 may slow propagation of excitation in the sinoatrial and atrioventricular nodes by shortening the

6 t, unlike ENT1, is virtually absent from the sinoatrial and atrioventricular nodes.

7 electrocardiography or the discovery of the sinoatrial and atrioventricular nodes.

8 , representing a position midway between the sinoatrial and atrioventricular nodes.

9 Much information is encoded in sinoatrial AP waveforms, but both the analysis and the c

10 ntitative analysis and enables comparison of sinoatrial APs by standardizing parameter definitions an

11 parameter that can vary significantly among sinoatrial APs.

12 pisodes of third-degree atrioventricular and sinoatrial block in every NaV1.5-immunized animal, but n

13 pe of unknown origin and atrioventricular or sinoatrial block lasting >10 seconds (average, 17.9+/-6.

14 tantial increases in atrial premature beats, sinoatrial block, and atrioventricular block, accompanie

15 aptation to exercise by modulating intrinsic sinoatrial cell behavior.

16 a2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate

17 tric oxide (NO) synthesized within mammalian sinoatrial cells has been shown to participate in cholin

18 Our ability to generate sinoatrial-compatible spontaneous cardiomyocytes from th

19 The sinoatrial conduction pathways acted as a filter for atr

20 tation waves could enter the SAN through the sinoatrial conduction pathways and overdrive suppress th

21 Ch/Iso modulated filtering properties of the sinoatrial conduction pathways by increasing/decreasing

22 t SAN activation and to identify specialized sinoatrial conduction pathways.

23 xcited via superior, middle, and/or inferior sinoatrial conduction pathways.

24 ged sinoatrial node recovery time, increased sinoatrial conduction time, and recurrent sinus pauses.

25 rial myocardium via superior and/or inferior sinoatrial exit pathways 8.8+/-3.2 mm from the leading p

26 Conduction failure in these sinoatrial exit pathways leads to SAN exit block and is

27 for 2 (or more) narrow superior and inferior sinoatrial exit pathways separated by 12.8+/-4.1 mm.

28 rmal circadian fluctuations and less erratic sinoatrial firing.

29 Both Ca(v)1.2 and Ca(v)1.3 channels mediate sinoatrial L-type currents.

30 pacemaker" current (I(f)) that increases the sinoatrial nodal (SAN) cell membrane diastolic depolariz

31 In wild-type mice, Ang II infusion caused sinoatrial nodal (SAN) cell oxidation by activating NADP

32 Dysregulation of L-type Ca(2+) currents in sinoatrial nodal (SAN) cells causes cardiac arrhythmia.

33 Eleven were found to have an abnormal sinoatrial nodal artery, and 7 of these patients also ha

34 We used a mathematical model of a sinoatrial nodal cell (SAN model) electrically coupled t

35 ted in size to be 3 to 5 times larger than a sinoatrial nodal cell, thus making effective SAN model c

36 ulum (SR) during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal st

37 are crucial for normal pacemaker function of sinoatrial nodal cells (SANC).

38 release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (SANC).

39 spontaneous diastolic depolarization (DD) of sinoatrial nodal cells (SANCs) that triggers recurrent a

40 ing late diastolic depolarization in cardiac sinoatrial nodal cells (SANCs).

41 s) increases the spontaneous beating rate of sinoatrial nodal cells (SANCs); however, the specific li

42 rs (RyRs) during diastolic depolarization of sinoatrial nodal cells augments the terminal depolarizat

43 We determined whether LCRs in rabbit sinoatrial nodal cells require the concurrent membrane d

44 raction) and the spontaneous beating rate of sinoatrial nodal cells were all blunted in RyR2-S2808A+/

45 s in both neonatal atrial myocytes and adult sinoatrial nodal cells.

46 ssociated with ticagrelor were asymptomatic, sinoatrial nodal in origin (66%), and nocturnal.

47 uses, which were predominantly asymptomatic, sinoatrial nodal in origin, and nocturnal and occurred m

48 Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANCs) are the proxima

49 e of diastolic depolarization (DD) in rabbit sinoatrial nodal pacemaker cells (SANCs) generate an inw

50 Thus, the biological clock of sinoatrial nodal pacemaker cells, like that of many othe

51 lectively inhibits the funny current (If) in sinoatrial nodal tissue, resulting in a decrease in the

52 ine in situ detection of connexins in rabbit sinoatrial node (a tissue that is particularly rich in f

53 ted in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4).

54 canine AVJ preparations that did not contain sinoatrial node (n = 10).

55 d indices of sympathovagal modulation of the sinoatrial node (ratio of low-frequency to high-frequenc

56 tructive heart surgery include injury of the sinoatrial node (SAN) and atrioventricular node (AVN), r

57 highly expressed in embryonic myocardium and sinoatrial node (SAN) and is required for cardiac automa

58 Experiments were performed on sinoatrial node (SAN) and latent atrial pacemaker (LAP)

59 Numerous studies implicate the sinoatrial node (SAN) as a participant in atrial arrhyth

60 ane voltage and Ca2+ clocks jointly regulate sinoatrial node (SAN) automaticity.

61 te the activation within the human or canine sinoatrial node (SAN) because they are intramural struct

62 rucial regulatory role in the development of sinoatrial node (SAN) by repressing the expression of Nk

63 olecular and functional properties of native sinoatrial node (SAN) cardiomyocytes.

64 In sinoatrial node (SAN) cells, electrogenic sodium-calcium

65 t these sites and how this relates to normal sinoatrial node (SAN) development remain uncharacterized

66 Although sinoatrial node (SAN) dysfunction is a hallmark of human

67 polymorphic ventricular tachycardia manifest sinoatrial node (SAN) dysfunction, the mechanisms of whi

68 primary pacemaker area of the intact rabbit sinoatrial node (SAN) exhibits robust positive labeling

69 d by Ras-related small G proteins, regulates sinoatrial node (SAN) ion channel activity through a mec

70 ght to confirm our hypothesis that the human sinoatrial node (SAN) is functionally insulated from the

71 The sinoatrial node (SAN) maintains a rhythmic heartbeat; th

72 her their presence nor their contribution to sinoatrial node (SAN) pacemaker activity has been invest

73 ated in controlling automaticity in isolated sinoatrial node (SAN) pacemaker cells, but the potential

74 in embryonic heart, but their role in adult sinoatrial node (SAN) pacemaking is uncertain.

75 rough K(+) channels are essential for proper sinoatrial node (SAN) pacemaking, but the influence of i

76 ated current, If, plays an important role in sinoatrial node (SAN) pacemaking.

77 ces in cardiomyocyte automaticity permit the sinoatrial node (SAN) to function as the leading cardiac

78 Dysfunction of pacemaker activity in the sinoatrial node (SAN) underlies "sick sinus" syndrome (S

79 The heartbeat originates within the sinoatrial node (SAN), a small structure containing <10,

80 pecialized cardiomyocytes located within the sinoatrial node (SAN), and is responsible for originatin

81 The sinoatrial node (SAN), functionally known as the pacemak

82 Reentrant arrhythmias involving the sinoatrial node (SAN), namely SAN reentry, remain one of

83 ify ion channel transcripts expressed in the sinoatrial node (SAN), the pacemaker of the heart.

84 situ studies indicated that Pitx2 suppresses sinoatrial node (SAN)-specific gene expression, includin

85 ia and ventricles, there is no model for the sinoatrial node (SAN).

86 R) modulates the spontaneous activity of the sinoatrial node (SAN).

87 by specialized cardiomyocytes located in the sinoatrial node (SAN).

88 te (HR) by inhibiting pacemaker cells in the sinoatrial node (SAN).

89 bx18 give rise to the heart's pacemaker, the sinoatrial node (SAN).

90 of this is the use of optical mapping in the sinoatrial node (SAN): when microelectrode and optical r

91 dly rectifying K+ (GIRK or KACh) channels of sinoatrial node and atria play a major role in beat-to-b

92 shown at birth to be present throughout the sinoatrial node and atrial muscle, however, at one month

93 ls is required for proper hearing as well as sinoatrial node and brain function.

94 ty of cell types and distribution within the sinoatrial node and cell-cell interactions add complexit

95 ntify Islet-1 as a novel marker of the adult sinoatrial node and do not provide evidence for Islet-1(

96 izes the leading pacemaker region within the sinoatrial node and hence is crucial for stable heart ra

97 the HCN1 protein is highly expressed in the sinoatrial node and is colocalized with HCN4, the main s

98 ardiac myocytes and specialized cells in the sinoatrial node and the conduction system.

99 els of MiRP1 and HCN subunits in the cardiac sinoatrial node and the contribution of pacemaker channe

100 The sinoatrial node and the ventricle of the heart receive s

101 ) hearts the focus ultimately shifted to the sinoatrial node at a very prolonged cycle length (initia

102 t density contributes to the acceleration of sinoatrial node automaticity and explains, in part, the

103 Sinoatrial node automaticity was slowed in treated group

104 recorded from isolated papillary muscle and sinoatrial node by microelectrode techniques.

105 current appearing in the Noble model of the sinoatrial node cell in the mammalian heart.

106 r evaluated in rabbit isolated patch-clamped sinoatrial node cells (n = 21), where we found that 5 mu

107 Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-medi

108 neath the cell plasma membrane (subspace) of sinoatrial node cells (SANCs) occurring during diastolic

109 ct in concert with ion channels to confer on sinoatrial node cells (SANCs) their status of dominance

110 roughly periodic LCRs in depolarized rabbit sinoatrial node cells (SANCs).

111 caffeine (2-4 mM) to isolated single rabbit sinoatrial node cells acutely reduces their spontaneous

112 geneity of the electrical activity of single sinoatrial node cells as well as that of the intact sino

113 Spontaneous action potentials of sinoatrial node cells from pregnant mice exhibited highe

114 The electrical activity of sinoatrial node cells is heterogeneous.

115 intracellular cAMP levels were unchanged in sinoatrial node cells of pregnant mice.

116 In sinoatrial node cells of the heart, beating rate is cont

117 ted inward current similar to the If seen in sinoatrial node cells of the heart.

118 (as measured by cell capacitance) of rabbit sinoatrial node cells was investigated using the whole-c

119 n of pacemaker mechanisms in single isolated sinoatrial node cells, explanted beating sinoatrial node

120 on of spontaneous action potential firing in sinoatrial node cells.

121 ergically stimulated ion channels in cardiac sinoatrial node cells.

122 .0 pA/pF; P, -28.6+/-2.9 pA/pF; P=0.0002) in sinoatrial node cells.

123 the slope of the diastolic depolarization of sinoatrial node cells.

124 ysis that Cx43 protein expression within the sinoatrial node decreased with age; however, the express

125 uch as Shox2 and Tbx3, that are required for sinoatrial node development.

126 r conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and

127 Sinoatrial node dysfunction associated with CPVT may inc

128 Clinical studies have shown that sinoatrial node dysfunction occurs at the highest incide

129 hmias: sinus pauses and bradycardia indicate sinoatrial node dysfunction, whereas preexcitation and a

130 ation and miR-106b-25 heterozygosity develop sinoatrial node dysfunction.

131 P maps during normal atrial excitation (i.e. sinoatrial node excitation) were compared to those obser

132 h-frequency ratio [P=0.03]) and less erratic sinoatrial node firing (eg, lower Poincare ratio [P=0.02

133 The age-dependent reduction in sinoatrial node function was not associated with changes

134 vagal activity, baroreceptor responses, and sinoatrial node function.

135 x2 regulates microRNAs (miRs) to repress the sinoatrial node genetic program.

136 onic parasympathetic neurons innervating the sinoatrial node in control and HF dogs (both, n=8).

137 beta-adrenergic receptor stimulation of the sinoatrial node in intact dogs is markedly blunted when

138 h incidence of bradycardia suggests possible sinoatrial node involvement.

139 y definition, that pacemaker function of the sinoatrial node is compromised during aging.

140 The sinoatrial node is the main impulse-generating tissue in

141 ectrical signal is known to originate in the sinoatrial node myocyte, but exactly what role Ca plays

142 ow that depressed excitability of individual sinoatrial node myocytes (SAMs) contributes to reduction

143 Sinoatrial node myocytes act as cardiac pacemaker cells

144 +) cells in the right atrium coexpressed the sinoatrial node pacemaker cell marker HCN4.

145 ted sinoatrial node cells, explanted beating sinoatrial node preparation, telemetric in vivo electroc

146 nitiates early in development, represses the sinoatrial node program and pacemaker activity on the le

147 by bradycardia, sinus dysrhythmia, prolonged sinoatrial node recovery time, increased sinoatrial cond

148 We developed a computational model of the sinoatrial node that showed that a loss of SAN cells bel

149 coupling was investigated by dye transfer in sinoatrial node tissue explants.

150 RNA sequencing on sinoatrial node tissue lacking Islet-1 established that

151 pecifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting o

152 en by an electrical impulse generated in the sinoatrial node to propagate from atria to ventricles.

153 uction system, extending proximally from the sinoatrial node to the distal Purkinje fibers.

154 ional computerized numerical modeling of the sinoatrial node was conducted to validate the theoretica

155 s is controversial despite the fact that the sinoatrial node was discovered over 100 years ago.

156 Given that other biological (e.g., sinoatrial node) and artificial systems display phase-lo

157 within regions of the heart that become the sinoatrial node, atrioventricular node, and bundle of Hi

158 opagation of the action potential across the sinoatrial node, from the initiation point to the crista

159 [Ca(2+)]i release and Ca(2+) handling in the sinoatrial node, impaired pacemaker activity and symptom

160 During failure of the sinoatrial node, the heart can be driven by an atriovent

161 Passing the sinoatrial node, the P-wave developed an initial positiv

162 ession and network analysis identified novel sinoatrial node-enriched genes and predicted that the tr

163 The AVJ is a primary backup pacemaker to the sinoatrial node.

164 may mask intrinsic fractal behaviour of the sinoatrial node.

165 unction, with initial, larger effects on the sinoatrial node.

166 and peripheral cells that make up the native sinoatrial node.

167 right atrial foci, especially those near the sinoatrial node.

168 e wall, corresponding to the location of the sinoatrial node.

169 otein was not expressed in the centre of the sinoatrial node.

170 lowering agent that acts specifically on the sinoatrial node.

171 of ionic currents in pacemaker cells of the sinoatrial node.

172 ial node cells as well as that of the intact sinoatrial node.

173 It also is present in areas within the sinoatrial node.

174 adycardia, consistent with AC9 expression in sinoatrial node.

175 nscriptional regulator within the developing sinoatrial node.

176 properties of pacemaker myocytes in the aged sinoatrial node.

177 sistently Islet-1 mRNA was detected in human sinoatrial node.

178 er-law behavior comparable to those of human sinoatrial node.

179 in isolated guinea pig spontaneously beating sinoatrial node/atrial preparations.

180 A single isolated sinoatrial pacemaker cell presents intrinsic interbeat i

181 quency of pacemaker potentials from isolated sinoatrial pacemaker cells in the presence of endogenous

182 ffect of current fluctuations on the IBIs of sinoatrial pacemaker cells.

183 node and is colocalized with HCN4, the main sinoatrial pacemaker channel isoform.

184 which organized activation emanated from the sinoatrial pacemaker region.

185 ined how these properties of Ca(v)1.3 affect sinoatrial pacemaking in a mathematical model.

186 right vagosympathetic trunks innervated the sinoatrial plexus proximal to their entry into the heart

187 were contacted by fiber varicosities in the sinoatrial plexus than in the atrioventricular plexus af

188 The pacemaker converges to the sinoatrial region during development and comprises fewer

189 oepicardium, which develops posterior to the sinoatrial region of the looping-stage heart.

190 The arrhythmia included sinoatrial (SA) block, sinus arrest, 2 degrees and 3 deg

191 Sinoatrial (SA) nodal cells were identified in cardiac t

192 e Ca(v)1.3 (alpha(1D)) Ca(2+) channel in the sinoatrial (SA) node by using Ca(v)1.3 Ca(2+) channel-de

193 from the spontaneous rhythmic excitation of sinoatrial (SA) node cells.

194 on entry through L-type Ca2+ channels in the sinoatrial (SA) node contributes to pacemaker activity,

195 ontaneous activity of pacemaker cells in the sinoatrial (SA) node controls heart rate under normal ph

196 retation (mosaic model) of the makeup of the sinoatrial (SA) node has been proposed to explain the ch

197 on enzymatically isolated myocytes from the sinoatrial (SA) node, right and left atria, right and le

198 nt in the myocytes of the ventricles and the sinoatrial (SA) node.

199 x5 expression is restricted to the posterior sinoatrial segments of the heart, consistent with the ti

200 ed at the venous pole in a plexus around the sinoatrial valve; mean total number of cells was 197 +/-

201 d channel 4, were located in the base of the sinoatrial valves, and this region was densely innervate

202 located in a ganglionated plexus around the sinoatrial valves.