ライフサイエンスコーパス: sinusoid

1 accessible to sporozoites entering the liver sinusoid.

2 rger response than the most effective bar or sinusoid.

3 steatosis and in its development across the sinusoid.

4 the "capillarization" process of the hepatic sinusoid.

5 ncounter the microenvironment of the hepatic sinusoid.

6 toplasmic protrusions (proplatelets) into BM sinusoids.

7 phages (Kupffer cells) that line the hepatic sinusoids.

8 , with fibrin thrombi in some maternal blood sinusoids.

9 bone marrow are found in the parenchyma and sinusoids.

10 ssays that mimic in vivo shear stress in the sinusoids.

11 ortals in the lymphatic endothelium of these sinusoids.

12 f NKT cells results in arrest within hepatic sinusoids.

13 and EGFP(+) platelet-like depositions in the sinusoids.

14 ge intravascular macrophage bed in the liver sinusoids.

15 , leading to the formation of new functional sinusoids.

16 gregation and subsequent entrapment in liver sinusoids.

17 rounded by inflammatory cells in the hepatic sinusoids.

18 s present primarily inside blood vessels and sinusoids.

19 d severe liver hemorrhage and destruction of sinusoids.

20 he endothelium was disrupted in most hepatic sinusoids.

21 e in portal veins, hepatic arteries, and the sinusoids.

22 here to endothelial cells in the bone marrow sinusoids.

23 h vessels are largely derived from the liver sinusoids.

24 56% of portal blood flow bypasses the liver sinusoids.

25 te infiltration in the periportal fields and sinusoids.

26 IgA-secreting cells and have IgA deposits in sinusoids.

27 of transplanted cells that enter the hepatic sinusoids.

28 mulation, primarily within the centrolobular sinusoids.

29 carcinoma (CRC) cells arrest within hepatic sinusoids.

30 liver regeneration during the reformation of sinusoids.

31 gration of primed neutrophils sequestered in sinusoids.

32 ncluding the sequestration of neutrophils in sinusoids.

33 tion to endothelial cells lining the hepatic sinusoids.

34 abnormal vascular architecture, and dilated sinusoids.

35 evels of serum IgA and IgA deposits in liver sinusoids.

36 region, leukocyte adherence, and nonperfused sinusoids.

37 o reticular cells lining and interconnecting sinusoids.

38 njury from significant distances through the sinusoids.

39 and requires deposition of cells in hepatic sinusoids.

40 tes were found in a greater number of distal sinusoids.

41 profoundly contribute to remodeling of liver sinusoids.

42 pendent transmigration of entire MKs into BM sinusoids.

43 patic I/R induced CD4+ T cell recruitment in sinusoids.

44 portal blood flow and pressure within liver sinusoids.

45 t IL-17A(+) T cell subset in the human liver sinusoids.

46 n promoting the development of discontinuous sinusoids.

47 or so-called proplatelets, into bone marrow sinusoids.

48 , respectively, to adhere within the hepatic sinusoids.

49 gulfment of B cells circulating in the liver sinusoids.

50 volving hemorrhagic infiltration via widened sinusoids.

51 d in enlarged hepatocytes and narrowed liver sinusoids.

52 cumulation of malignant cells in the hepatic sinusoids.

53 retention of tumor cells because of narrower sinusoids.

54 e accumulation of leukocytes within enlarged sinusoids.

55 onal zones where arterioles emptied into the sinusoids.

56 eral membrane of hepatocytes adjacent to the sinusoids.

57 dles with rigid probes driven with steps and sinusoids (0.5-500 Hz) and recorded whole-cell responses

58 samine/ET induced neutrophil accumulation in sinusoids (515 +/- 30 neutrophils/50 high power fields)

59 idal endothelial cells (LSEC) which line the sinusoids activate RNase L in response to NS2(H126R) The

60 spose to high infiltration of PMN in hepatic sinusoids after high-dose endotoxin administration were

61 ine hepatocytes are localized in the hepatic sinusoids after surgery and subsequently migrate out of

62 ritic cells; dendritic cells migrated out of sinusoids, after a delay, via the chemokine CX3CL1.

63 in portal vein radicles, as well as in liver sinusoids, albeit integration of cells in the liver pare

64 binding of circulating HCV within the liver sinusoids allowing subsequent transfer of the virus to u

65 lanted hepatocytes immediately entered liver sinusoids, along with attenuation of portal vein radicle

66 During embryonic development, discontinuous sinusoids also allow circulating hematopoietic progenito

67 stimulus sequence, rapidly presented random sinusoids, also produced the same effect, with layer 2/3

68 o showed significant dilatation of the liver sinusoids and an increase in inflammatory cells surround

69 atelets, neutrophils, and lymphocytes within sinusoids and central venules were also observed.

70 stribution of EPHB4 receptors in bone marrow sinusoids and ephrin B2 ligands in hematopoietic cells.

71 om thymic-independent T cells of the hepatic sinusoids and intestinal mucosa.

72 ar cues that control MK polarization towards sinusoids and limit transendothelial crossing to proplat

73 be facilitated by CCL19 and CCL21 on hepatic sinusoids and lymphatics.

74 In particular, extravasation from sinusoids and portal venules (PV) was reduced by 91% and

75 5 mm in diameter by extrinsic compression of sinusoids and portal venules and narrowing caused by adh

76 ear stress were directly measured in hepatic sinusoids and postsinusoidal venules at 2-day intervals

77 al arrest, CD8 TE actively crawl along liver sinusoids and probe sub-sinusoidal hepatocytes for the p

78 -dependent extravasation of neutrophils from sinusoids and reactive oxygen formation.

79 othelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood.

80 PP extensions from the interstitium into BM sinusoids and triggering the subsequent shedding of PPs

81 ctin was selectively up-regulated in hepatic sinusoids and veins where it was necessary for phagocyto

82 BM sinusoids and venules, but not adjacent bone vessels, su

83 ls promote cancer cell adhesion within liver sinusoids and, thereby, influence metastasis.

84 ollagen type IV (highly exposed in the liver sinusoids) and collagen type IV-dependent activation of

85 eukocyte accumulation, number of nonperfused sinusoids, and autofluorescence of reduced nicotinamide

86 initially develop normally together with the sinusoids, and HSPCs home to the resulting niche, but st

87 ormal nodal architecture, collapsed cortical sinusoids, and macrophage accumulation in malformed sinu

88 ncluding plasma exudation, filling of venous sinusoids, and mucosal edema were not induced in these n

89 th leukocyte endothelial adherence, occluded sinusoids, and new vessel formation in vivo.

90 -LDL, Ac-LDL was specifically endocytosed by sinusoids, and Tie2 expression was more pronounced in th

91 LPS-induced structural changes in the liver sinusoid are mediated by an LPS-induced Kupffer cell act

92 Hepatic sinusoids are an environment rich in antigen cross-prese

93 transplantation, hepatocytes entering liver sinusoids are engrafted, whereas cells entrapped in port

94 at control the positioning of B cells in the sinusoids are not understood.

95 These sinusoids arose around locally invasive tumors and were

96 ll progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs).

97 tion of dimethylnitrosamine, repopulated the sinusoid as LSECs and reduced liver injury.

98 pid metabolism is presented which treats the sinusoid as the repeating unit of the liver rather than

99 in targets CD33(+) cells residing in hepatic sinusoids as the mechanism for its hepatic toxicity.

100 ectron microscopy showed the constriction of sinusoids associated with swollen or ruptured mitochondr

101 known as CSPG4)(+) pericytes, distinct from sinusoid-associated leptin receptor (LEPR)(+) cells.

102 M3 intensity changes were approximately sinusoid at low temperatures but became increasingly dis

103 nits in M1 cortex were modulated solely as a sinusoid at the repetition rate of the stimulus for freq

104 panied by ultrastructural changes within the sinusoid at this time.

105 ocytes travel via lung capillaries and liver sinusoids at an extremely rapid rate with the average re

106 s do deliver insulin directly to the hepatic sinusoid because approximately 80% of the insulin is ext

107 square, 0.403 for triangular, and 0.421 for sinusoid), but underestimated the number of cycles requi

108 t that sporozoites are first arrested in the sinusoid by binding to extracellular matrix proteoglycan

109 that circulating CD8 TE arrest within liver sinusoids by docking onto platelets previously adhered t

110 planted cells are rapidly cleared from liver sinusoids by proinflammatory cytokines/chemokines/recept

111 to form are greatly enlarged, pericyte-poor sinusoids, called mother vessels (MV), that originate fr

112 c changes that affect liver function such as sinusoid capillarization or loss of metabolic zonation a

113 Ductular proliferation, metabolic zonation, sinusoid capillarization, and hepatic stellate cell acti

114 ial cell signaling for angiogenesis or liver sinusoid capillarization, the mechanism for initiating t

115 cytes, while reducing the number of perfused sinusoids (capillary no-reflow).

116 portal inflammation, congested or compressed sinusoids, cell atrophy) correlated with leukocyte endot

117 LPS produced ultrastructural changes in the sinusoid characterized by morphological evidence of Kupf

118 large MK preplatelet fragments shed into the sinusoid circulation before terminal proplatelet remodel

119 transmission electron microscopy (TEM) show sinusoid compression resulting from increased hepatic pl

120 ed, small and has: iron deposition; immature sinusoids congested with blood; persistent erythropoieti

121 al of the flow direction without significant sinusoid constriction.

122 ), and significantly decreased the number of sinusoids containing blood flow per microscopic field (6

123 lded as a layered boustrophedon, with planar sinusoids containing interspersed CENP-A-rich and H3-ric

124 d), while 5 (square), 15 (triangle), and 10 (sinusoid) cycles were observed experimentally.

125 -associated pathologic findings (ie, swollen sinusoids, dehydrated cells, and hemorrhagic infiltrate)

126 first 24 h after implantation in the hepatic sinusoid determines its potential to colonize the liver.

127 gration of primed neutrophils sequestered in sinusoids during endotoxemia in vivo.

128 evious work, two anatomically distinct-liver sinusoid endothelial cells (LEC): LEC-1 and LEC-2, have

129 on their relative spatial location along the sinusoid from the portal triad to the central vein.

130 re was well fit by an exponentially decaying sinusoid function with a period of 4.5 A for distances g

131 R, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to

132 nd circulating leukocytes within the hepatic sinusoids have direct access to liver-resident cells, wh

133 ation of blood flow-dependent cell exit from sinusoids improved intrahepatic retention of LSEC to 89

134 by altered diameter of the hepatic veins and sinusoids in Bmpr2(+/-) mice.

135 associated with vascular injury in the liver sinusoids in clinical studies.

136 led leukocytes and the number of nonperfused sinusoids in livers of control and adhesion molecule-def

137 correlates with erythrocyte-filled vascular sinusoids in marrows.

138 In mice it localizes to capillaries and sinusoids in most organs and in lung to larger vessels a

139 s of tonsil tissue, by cells associated with sinusoids in perifollicular areas of spleen tissue, and

140 s postinfection: diffuse spreading along the sinusoids in PIR-B(-/-) mice vs nodular restricted local

141 cells transition from the parenchyma to the sinusoids in the bone marrow of NOD mice and enter the p

142 increase in the number and volume of venous sinusoids in the marrow that was associated with a reduc

143 and Tcf21(+) stromal cells, primarily around sinusoids in the red pulp, while Cxcl12 was expressed by

144 mation in vitro and enhanced HSC coverage of sinusoids in vivo.

145 ose frequency domain magnitude spectrum is a sinusoid increasing in frequency from one waveform to th

146 membrane capacitance (Cm) using two voltage sinusoids indicates that shifts in VpkCm induce Cm chang

147 mechanism by which the destruction of liver sinusoids, induced by the Jo2-mediated co-engagement of

148 f zonated enzyme expression by splitting the sinusoid into periportal to pericentral compartments.

149 caused transformation of discontinuous liver sinusoids into continuous capillaries.

150 These cells translocated from sinusoids into liver plates between 16 and 20 hours afte

151 rms, which are released through the vascular sinusoids into the bloodstream.

152 atic artery was seen circulating through the sinusoids into the central venules.

153 The hepatic sinusoid is a unique vascular bed lined by hepatic sinus

154 ation potential waveforms (square, triangle, sinusoid) is demonstrated.

155 required for vascular homeostasis of hepatic sinusoids; it maintains quiescence and differentiation o

156 Here we report that the amplitude and the sinusoid-like shape of the variability of the light curv

157 led by ingrowth of blood vessels, displaying sinusoid-like structures and stabilized by pericytic cel

158 e to micropattern the self-assembly of liver sinusoid-like structures with micrometer resolution in v

159 Host livers contained large clusters of sinusoids lined by dipeptidyl peptidase IV positive endo

160 clearance by KC during locomotion inside the sinusoid lumen, before crossing the barrier.

161 Most HCT-116-GFP-RFP cells remained in sinusoids near peripheral portal veins.

162 led leukocytes and the number of nonperfused sinusoids (NPS) were monitored (by intravital microscopy

163 assed by vessels similar to the capillarized sinusoids observed in the cirrhotic liver in humans.

164 rem, signals can be decomposed into a sum of sinusoids of different frequencies.

165 Furthermore, neutrophils were observed in sinusoids of enlarged livers and spleens, suggesting tha

166 S. mansoni eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatocyte deat

167 receptor agonist FTY720 emptied the cortical sinusoids of lymphocytes, blocked lymphatic endothelial

168 n the circulation for quiet transport to the sinusoids of spleen and liver where resident macrophages

169 vations that some "proplatelets" form in the sinusoids of the bone marrow before transmigration of in

170 hes an inductive vascular niche in the liver sinusoids of the Id1(-/-) mice, initiating and restoring

171 blood travel via capillaries in the lung or sinusoids of the liver and only 5% migrate to secondary

172 ings consisting of isoluminant red and green sinusoids of the same spatial frequency combined out-of-

173 and a rim of pale cytoplasm infiltrated the sinusoids of the spleen, liver, and bone marrow.

174 transplanted hepatocytes present in hepatic sinusoids or integrated in the parenchyma was greater in

175 of receptor-mediated cell adhesion in liver sinusoids or the manipulation of blood flow-dependent ce

176 This sinusoid pattern is more pronounced at higher latitudes

177 Electric fields were generated by sinusoid patterns at slow frequency (0.8, 1.25 or 1.7 Hz

178 After cell transplantation in hepatic sinusoids, perturbations in hepatic microcirculation alo

179 d receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind

180 of capillaries, high endothelial venule, and sinusoids produced abundant gp-Fy.

181 cies (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive

182 Sinusoids rapidly re-endothelialize within 48 hours of t

183 eneralized estimating equations, 4-parameter sinusoid regression, and generalized linear models were

184 to I/R and smaller increments in nonperfused sinusoids, relative to C57B1 mice.

185 t T cell accumulation in lymph node cortical sinusoids required intrinsic S1P1 expression and was ant

186 forces exist in high endothelial venules and sinusoids, respectively.

187 ncreased deposition of transplanted cells in sinusoids resulted in greater cell engraftment.

188 HL shows a sinusoid seasonal incidence pattern (p < 0.001).

189 of blood into bone marrow compartments, and sinusoids serve as a conduit to the bloodstream and as n

190 ransplanted hepatocytes entering the hepatic sinusoids showed superior survival.

191 ction in close association with bone VEC and sinusoids, signals mediating their interactions are not

192 s of T cells approached and engaged cortical sinusoids similarly in the presence or absence of FTY720

193 Stromal cells lining the hepatic sinusoids, such as liver sinusoidal endothelial cells (L

194 ce was associated with reduced numbers in BM sinusoids, suggesting a role for S1P in BM egress.

195 thelial cells (LEC-1) located in the hepatic sinusoids support in vitro megakaryocytopoiesis from mur

196 re that neutrophils accumulated in the liver sinusoids suppress cytokine and chemokine mRNA expressio

197 al dominant disorder characterized by venous sinusoids that predispose to intracranial hemorrhage.

198 VVRs were also produced by single sinusoids that transiently increased BP and HR, by 70-90

199 tress, occurring in proximity to nonperfused sinusoids, that may contribute to liver injury.

200 lexity of studying individual regions of the sinusoid, the causes of this zone specificity and its im

201 induces neutrophil sequestration in hepatic sinusoids, the activation of proinflammatory transcripti

202 tocytes and endothelial cells lining hepatic sinusoids, the adrenal glands, and the ovary hydrolyzes

203 s accompany the formation of the caudal vein sinusoids, the other main component of the CHT niche, an

204 sence shows high protein expression in liver sinusoids, the venous sinuses of the red pulp in spleen,

205 eveal that when immature B cells are near BM sinusoids their motility is reduced, their morphology is

206 transplanted islets delivered to the hepatic sinusoids (therefore effectively restoring a portal mode

207 nd immature B cells entering and crawling in sinusoids; these immature B cells were displaced by CB2

208 e intestine, and in distinctive, thin-walled sinusoids this mixture passes over a large macrophage po

209 cession was fitted with a single-mode damped sinusoid to extract the Gilbert damping parameter.

210 enetrate cell barriers in the skin and liver sinusoid to reach their target cell, the hepatocyte, whe

211 ransmigration of leukocytes from the hepatic sinusoid to sites of tissue damage during the inflammato

212 ng the temporal information of low-frequency sinusoids to locations in the cochlea tuned to high freq

213 ategies to deposit cells into distal hepatic sinusoids, to disrupt sinusoidal endothelium for facilit

214 eye or ear, efficiency for detecting a short sinusoid (tone or grating) with few features is a substa

215 ophils relevant for the injury accumulate in sinusoids, transmigrate, and adhere to hepatocytes.

216 om the adult endothelium also led to dilated sinusoids, vascular shunts, and necrosis, albeit milder

217 e in the bone marrow redistributed away from sinusoid vessels.

218 ron-microscopic examination of the rat liver sinusoid was performed in this study after in vivo treat

219 In addition, early adhesion within liver sinusoids was inhibited in the absence of neutrophils an

220 etic aplasia and erythrocyte-filled vascular sinusoids were apparent in marrows.

221 labeled leukocytes and number of nonperfused sinusoids were monitored by intravital microscopy in liv

222 f sinusoidal lining cells and destruction of sinusoids were observed, consistent with the characteris

223 resembled arterioles and bypassed the normal sinusoids were observed.

224 The numbers of perfused sinusoids were significantly reduced at each time point.

225 The liver sinusoids were the only capillaries in which EPCR was ex

226 phi, between the force and tip displacement sinusoids, were measured in the frequency range f ~ 0.2-

227 resistance to blood flow through the hepatic sinusoids when portal hypertension occurs in the absence

228 gely expressed on endothelial cells in liver sinusoids, whereas DC-SIGN is expressed on dendritic cel

229 e increased transplanted cell entry in liver sinusoids, whereas labetalol, nifedipine, CGRP, and gluc

230 n terms of idealized oscillators (modeled as sinusoids), which differ from biological oscillators in

231 They are located in hepatic sinusoid, which allows them to remove foreign materials,

232 For example, in the liver, discontinuous sinusoids, which are fenestrated capillaries with interc

233 ells are also involved in the contraction of sinusoids, which leads to increased intrahepatic pressur

234 cted 2 (square), 3 (triangle), and 5 cycles (sinusoid), while 5 (square), 15 (triangle), and 10 (sinu

235 e chair and video image always resulted in a sinusoid with a peak velocity of 50 degrees /s.

236 Coating of cells or of liver sinusoids with natural collagen, natural laminin, or an

237 The fit of sinusoids with the 3.6 residues per turn period of ideal

238 tly after deposition of hepatocytes in liver sinusoids, with clearance of a significant fraction of t

239 s are best described as harmonically related sinusoids, with periods of approximately 1,000, 500 and

240 /N629D yolk sac vessels and aorta consist of sinusoids without normal arborization.