ライフサイエンスコーパス: sinusoidal endothelial cell

1 me that both C-type lectins are expressed on sinusoidal endothelial cells.

2 othelial cell populations, including hepatic sinusoidal endothelial cells.

3 take of 125I-HA at 37 degrees C by rat liver sinusoidal endothelial cells.

4 oteinase-9 and matrix metalloproteinase-2 by sinusoidal endothelial cells.

5 lymphatic endothelial cells (LECs) and liver sinusoidal endothelial cells.

6 largely restricted to lymph nodes and liver sinusoidal endothelial cells.

7 cription factor 3 (STAT3) in hepatocytes and sinusoidal endothelial cells.

8 ow that in the liver, L-SIGN is expressed by sinusoidal endothelial cells.

9 ed in whole-liver extracts were localized to sinusoidal endothelial cells.

10 ) agonist, increased cAMP levels in cultured sinusoidal endothelial cells.

11 ars very early after injury and derives from sinusoidal endothelial cells.

12 dependent iNOS mRNA induction in Kupffer and sinusoidal endothelial cells.

13 adipocytes, and comprised a minor subset of sinusoidal endothelial cells.

14 only nonparenchymal cells, predominantly in sinusoidal endothelial cells.

15 e week starting with hepatocytes followed by sinusoidal endothelial cells.

16 of circulating leukocytes as well as hepatic sinusoidal endothelial cells.

17 activity in hepatic stellate cells and liver sinusoidal endothelial cells.

18 actor-1 receptors, CXCR7 and CXCR4, in liver sinusoidal endothelial cells.

19 nteractions among rat HSCs, hepatocytes, and sinusoidal endothelial cells.

20 genes encoding pro-IL-1beta and pro-IL-18 in sinusoidal endothelial cells.

21 vascular ectonucleotidase CD39 increased on sinusoidal endothelial cells.

22 ing verified the expression of E-selectin on sinusoidal endothelial cells 4 hours after Gal/ET inject

23 ), hepatic B cells (81.5 +/- 9.3%) and liver sinusoidal endothelial cells (64.6 +/- 13.7%) interacted

24 milarly, selective CXCR7 activation in liver sinusoidal endothelial cells abrogated fibrogenesis.

25 Liver sinusoidal endothelial cell activation and stellate cell

26 tokine release, Kupffer cell activation, and sinusoidal endothelial cell activation.

27 er acute injury, CXCR7 upregulation in liver sinusoidal endothelial cells acts with CXCR4 to induce t

28 Additionally, GIT1 expression was reduced in sinusoidal endothelial cells after liver injury, consist

29 ival, but paradoxically decreased killing of sinusoidal endothelial cells after storage and reperfusi

30 andin E(2), another agent that preconditions sinusoidal endothelial cells against storage/reperfusion

31 d from LPS-stimulated Kupffer cells protects sinusoidal endothelial cells against storage/reperfusion

32 ncreased by 60% +/- 27% over basal values in sinusoidal endothelial cells and 98% +/- 40% in stellate

33 ude the accumulation of gammaDPGA in hepatic sinusoidal endothelial cells and a gammaDPGA clearance r

34 rage involves reperfusion-induced killing of sinusoidal endothelial cells and activation of Kupffer c

35 es exposed to acetaminophen, but not hepatic sinusoidal endothelial cells and biliary epithelial cell

36 eceptor 3 (TLR3)-activated Kupffer and liver sinusoidal endothelial cells and further controlled the

37 f Disse and maintain close interactions with sinusoidal endothelial cells and hepatic epithelial cell

38 Interaction between sinusoidal endothelial cells and hepatocytes is a prereq

39 ersion atomization, to direct genes to liver sinusoidal endothelial cells and hepatocytes, respective

40 with up-regulation of adhesion molecules on sinusoidal endothelial cells and hepatocytes.

41 found that donor hematopoietic cells act on sinusoidal endothelial cells and induce host blood vesse

42 This function was observed in both liver sinusoidal endothelial cells and Kupffer cells even at v

43 ne alkaloid, with reported toxicity in liver sinusoidal endothelial cells and Kupffer cells.

44 marily by ICAM-1 constitutively expressed on sinusoidal endothelial cells and Kupffer cells.

45 ly abundant endocytic receptors expressed by sinusoidal endothelial cells and parenchymal cells in th

46 tive B7-H1 expression on dendritic cells and sinusoidal endothelial cells and promptly induced B7-H1

47 inusoidal leukocyte aggregates and activated sinusoidal endothelial cells, and (3) sustained producti

48 erived APCs including Kupffer cells or liver sinusoidal endothelial cells, and apparently can occur e

49 nts of isolated primary hepatocytes, hepatic sinusoidal endothelial cells, and biliary epithelial cel

50 taline caused depolymerization of F-actin in sinusoidal endothelial cells, and blocking of F-actin de

51 c macrophages, liver-associated lymphocytes, sinusoidal endothelial cells, and hepatic stellate cells

52 inputs, including signals from hepatocytes, sinusoidal endothelial cells, and hepatic stellate cells

53 liver cell types such as progenitors, liver sinusoidal endothelial cells, and hepatic stellate cells

54 ntributions of liver progenitor cells, liver sinusoidal endothelial cells, and hepatic stellate cells

55 stribution in cultured human cholangiocytes, sinusoidal endothelial cells, and hepatocytes revealed t

56 ng expression of eotaxins in hepatocytes and sinusoidal endothelial cells, and induces IL-5 expressio

57 r, CD302 was expressed by hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells.

58 Kupffer cells, liver sinusoidal endothelial cells, and leukocytes express PD-

59 epatic stellate cells, myofibroblasts, liver sinusoidal endothelial cells, and macrophages to illustr

60 gets of VEGF in liver may not be confined to sinusoidal endothelial cells, and that VEGF responses re

61 Liver sinusoidal endothelial cells are a major endogenous sour

62 nisms by which it regulates eNOS activity in sinusoidal endothelial cells are not well understood.

63 tellate cells, and Kupffer cells showed that sinusoidal endothelial cells are the major source of bot

64 Hepatic sinusoidal endothelial cells are unique among endothelia

65 Apoptosis of hepatocytes and sinusoidal endothelial cells, assessed by in situ TUNEL

66 ) maturation and localization to bone marrow sinusoidal endothelial cells (BMECs), stimulating thromb

67 ebrand factor, which is synthesized by liver sinusoidal endothelial cells but not hepatocytes, were u

68 ve (Thy1(+)) oval cells, stellate cells, and sinusoidal endothelial cells but not to hepatocytes.

69 ependent manner and cross-presented by liver sinusoidal endothelial cells, but not dendritic cells, t

70 expression was present in Kupffer cells and sinusoidal endothelial cells, but not in hepatocytes.

71 as detected in whole liver, hepatocytes, and sinusoidal endothelial cells, but not in Kupffer cells.

72 Monocrotaline decreased GSH in sinusoidal endothelial cells, but not in liver homogenat

73 Synthesis of NO in sinusoidal endothelial cells by endothelial nitric-oxide

74 binding was evaluated on primary human liver sinusoidal endothelial cells by flow cytometry and confi

75 prevented the protective preconditioning of sinusoidal endothelial cells by LPS, whereas pretreatmen

76 f the hepatocytes is separated from adjacent sinusoidal endothelial cells by the space of Disse, wher

77 egulation of fibronectin splicing in primary sinusoidal endothelial cells by transfecting a minigene

78 cation of C4d staining in proximity to liver sinusoidal endothelial cell capillarization and stellate

79 tion, constitutive FGFR1 signalling in liver sinusoidal endothelial cells counterbalanced CXCR7-depen

80 Inducible deletion of Cxcr7 in sinusoidal endothelial cells (Cxcr7(iDeltaEC/iDeltaEC))

81 ivation of KCs, inhibited APAP-induced liver sinusoidal endothelial cell damage and improved hepatic

82 lar niche predominantly represented by liver sinusoidal endothelial cells deploys paracrine trophogen

83 In this study, we observed that liver sinusoidal endothelial cells derived from ethanol-fed ra

84 Decreased HGF release by sinusoidal endothelial cells, despite high levels of VEG

85 ransferase, aspartate aminotransferase), and sinusoidal endothelial cell dysfunction (hyaluronic acid

86 significantly attenuated APAP-induced liver sinusoidal endothelial cell dysfunction and ameliorated

87 l cells, we demonstrate that ET-1 binding to sinusoidal endothelial cell ETB receptors led to increas

88 nisms underlying death of cultured rat liver sinusoidal endothelial cells exposed to chemical hypoxia

89 Bone marrow sinusoidal endothelial cells express high levels of Angp

90 ning whether hepatocytes, Kupffer cells, and sinusoidal endothelial cells express mRNA and enzyme act

91 Like human spleen sinusoidal endothelial cells, Flp-In 293 cell lines tran

92 activates eNOS, was substantially reduced in sinusoidal endothelial cells from injured livers.

93 Using sinusoidal endothelial cells from normal or injured live

94 Furthermore, GRK2 expression increased in sinusoidal endothelial cells from portal hypertensive ra

95 tion syndrome are initiated by dehiscence of sinusoidal endothelial cells from the space of Disse.

96 ic acid uptake are reliable markers of liver sinusoidal endothelial cell function and that normal or

97 ar group, suggesting that hepatocyte and not sinusoidal endothelial cell function is adversely affect

98 interleukin-1beta levels as well as impaired sinusoidal endothelial cell function were detected in ac

99 in LPS/RAN-cotreated rats, suggested altered sinusoidal endothelial cell function.

100 Depletion of sinusoidal endothelial cell glutathione (GSH) has been p

101 onine sulfoximine starting day - 2 decreased sinusoidal endothelial cell GSH and attenuated the prote

102 starting day - 1, prevented the decrease in sinusoidal endothelial cell GSH and protected against hi

103 toxicity, at least partially by maintaining sinusoidal endothelial cell GSH levels.

104 nclusion, monocrotaline selectively depletes sinusoidal endothelial cell GSH.

105 cell adhesion and rolling along bone marrow sinusoidal endothelial cells has been defined, and mecha

106 2a-Vegf axis as a prime node in coordinating sinusoidal endothelial cell-hepatocyte crosstalk during

107 ed sulphur colloid to assess the function of sinusoidal endothelial cells, hepatocytes, and Kupffer c

108 In vitro studies of sinusoidal endothelial cells, hepatocytes, stellate cell

109 ICAM-1 and VCAM-1 expression in human liver sinusoidal endothelial cells (HLSECs) and the adhesion o

110 eptor class F, member 1 (SCARF-1) on hepatic sinusoidal endothelial cells (HSEC).

111 cyte differentiation and the role of hepatic sinusoidal endothelial cells (HSECs) in this process are

112 ed extracellular matrices, and human hepatic sinusoidal endothelial cells (HSECs) were quantified in

113 id is a unique vascular bed lined by hepatic sinusoidal endothelial cells (HSECs), a functionally and

114 Sinusoidal endothelial cells in bone marrow have been re

115 study human B-cell migration through hepatic sinusoidal endothelial cells in flow-based adhesion assa

116 IGNR, a human DC-SIGN homologue expressed on sinusoidal endothelial cells in liver and lymph node, al

117 VE-1 is also present in normal hepatic blood sinusoidal endothelial cells in mice and humans.

118 ue inhibitor of metalloproteases confined to sinusoidal endothelial cells in response to myeloid cell

119 iserum showed that DC-SIGNR was expressed on sinusoidal endothelial cells in the liver and on endothe

120 ves lymphocyte transmigration across hepatic sinusoidal endothelial cells in vitro.

121 Because graft failure is linked to sinusoidal endothelial cell injury after storage/reperfu

122 sure to LPS on graft survival in relation to sinusoidal endothelial cell injury after storage/reperfu

123 containing trypan blue for determination of sinusoidal endothelial cell injury by counting trypan bl

124 contrast, LPS-induced hepatocyte and hepatic sinusoidal endothelial cell iNOS expression was signific

125 pecific Notch1 decoys increased sprouting of sinusoidal endothelial cells into micrometastases, there

126 sly showed that apoptosis of hepatocytes and sinusoidal endothelial cells is a critical mechanism of

127 The study suggests that the apoptosis of sinusoidal endothelial cells is a pivotal mechanism of p

128 erlying impaired activity of eNOS in injured sinusoidal endothelial cells is defective phosphorylatio

129 thelial cell nitric oxide synthase (eNOS) in sinusoidal endothelial cells is reduced in the injured l

130 o-regenerative angiocrine signals from liver sinusoidal endothelial cells is subverted to promote fib

131 ajor FcgammaRIIB-expressing cell type, liver sinusoidal endothelial cells, is required for both proce

132 es expression of eotaxins in hepatocytes and sinusoidal endothelial cells isolated from wild-type mic

133 Because hepatic sinusoidal endothelial cells kill tumor cells in vitro b

134 A brief period of liver ischemia decreases sinusoidal endothelial cell killing after cold liver sto

135 Ischemic preconditioning decreased sinusoidal endothelial cell killing after storage/reperf

136 or agonist, CGS-21680, and DB-cAMP decreased sinusoidal endothelial cell killing to the same extent a

137 alpha-gal A in several cell types, including sinusoidal endothelial cells, Kupffer cells, and hepatoc

138 Rat liver sinusoidal endothelial cells (LECs) express two hyaluron

139 endocytic hyaluronan (HA) receptor of liver sinusoidal endothelial cells (LECs) is responsible for t

140 Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and for

141 lial cell targeting, we isolated mouse liver sinusoidal endothelial cells (LSEC) and examined cell bi

142 ed LPS in liver became associated with liver sinusoidal endothelial cells (LSEC) and only approximate

143 or (FcgammaRIIb, RIIb) is expressed on liver sinusoidal endothelial cells (LSEC) and that the liver i

144 In this study, we observed that liver sinusoidal endothelial cells (LSEC) derived from ethanol

145 Liver sinusoidal endothelial cells (LSEC) have been reported t

146 that the coculture of hepatocytes with liver sinusoidal endothelial cells (LSEC) significantly increa

147 Priming of CD4(+) T cells by liver sinusoidal endothelial cells (LSEC) supported migration

148 he liver-resident macrophages) and the liver sinusoidal endothelial cells (LSEC) which line the sinus

149 multiple cell types, including hepatocytes, sinusoidal endothelial cells (LSEC), Kupffer cells, and

150 g z-axis resolution, we identified the liver sinusoidal endothelial cells (LSEC), marked by FcgammaRI

151 Interestingly, in liver sinusoidal endothelial cells (LSEC), the cells that form

152 Liver sinusoidal endothelial cells (LSECs) act as a filter bet

153 lining the hepatic sinusoids, such as liver sinusoidal endothelial cells (LSECs) and hepatic stellat

154 mRNA in purified populations of murine liver sinusoidal endothelial cells (LSECs) and hepatocytes, bu

155 We evaluated the kinetics by which rat liver sinusoidal endothelial cells (LSECs) are repopulated in

156 s in hepatocyte growth factor (HGF) in liver sinusoidal endothelial cells (LSECs) are thought to driv

157 Liver sinusoidal endothelial cells (LSECs) are unique organ-re

158 Liver sinusoidal endothelial cells (LSECs) are uniquely differ

159 he association of human platelets with liver sinusoidal endothelial cells (LSECs) by immunohistochemi

160 Here we demonstrate that liver sinusoidal endothelial cells (LSECs) constitute a unique

161 Liver sinusoidal endothelial cells (LSECs) defenestrate and ca

162 Liver sinusoidal endothelial cells (LSECs) differ, both struct

163 Liver sinusoidal endothelial cells (LSECs) have long been note

164 To explore the role of sinusoidal endothelial cells (LSECs) in the adult liver,

165 Liver sinusoidal endothelial cells (LSECs) make up a large pro

166 ifference, the roles of Kupffer cells, liver sinusoidal endothelial cells (LSECs), hepatocytes, scave

167 cterized by loss of differentiation of liver sinusoidal endothelial cells (LSECs), precedes the onset

168 s (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs).

169 igated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).

170 iators of hepatic immune tolerance are liver sinusoidal endothelial cells (LSECs).

171 Morphological and functional changes to sinusoidal endothelial cells mediated by soluble factors

172 Surprisingly, Kupffer cells, but also liver sinusoidal endothelial cells, mounted responses to rAAV,

173 of steatotic liver isografts via preventing sinusoidal endothelial cell necrapoptosis and consequent

174 on after transplantation induces significant sinusoidal endothelial cell necrapoptosis in steatotic Z

175 cal abnormalities have been described in the sinusoidal endothelial cells of cirrhotic livers, but th

176 Sinusoidal endothelial cells of human liver, lymph node,

177 E, 315- and 190-kDa, are highly expressed in sinusoidal endothelial cells of liver, lymph node, and s

178 RE isoforms (190 and 315 kDa) are present in sinusoidal endothelial cells of liver, spleen, and lymph

179 We conclude that HARE in the sinusoidal endothelial cells of lymph nodes and liver li

180 s membrane proteins, are highly expressed in sinusoidal endothelial cells of lymph nodes, liver, and

181 found as two isoforms (315- and 190-kDa) in sinusoidal endothelial cells of the liver, lymph node, a

182 5- and approximately 300-kDa HARE species in sinusoidal endothelial cells of the liver, spleen, and l

183 plenic macrophages and the Kupffer cells and sinusoidal endothelial cells of the liver.

184 was observed, without evident effects on the sinusoidal endothelial cell or on the hepatocyte.

185 loid cell recruitment more than either liver sinusoidal endothelial cells or Kupffer cells.

186 that targeting a heterologous NOS isoform to sinusoidal endothelial cells or other perisinusoidal cel

187 porcine aortic, femoral arterial, and liver sinusoidal endothelial cells (PAEC/PFAEC/PLSEC).

188 e liver injury, where it has been shown that sinusoidal endothelial cells produce EIIIA-fibronectin.

189 HSCs, hepatocytes, and sinusoidal endothelial cells produced and secreted fibro

190 fter liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) r

191 was presented that bone marrow (BM)-derived Sinusoidal endothelial cell PROgenitor Cells (sprocs) pl

192 s well as the kinetics of hepatocellular and sinusoidal endothelial cell proliferation, were assessed

193 e to the coordination between hepatocyte and sinusoidal endothelial cell proliferation.

194 this study, we investigated the mechanism of sinusoidal endothelial cell protection after ischemic pr

195 r pathway coupled to increased cAMP mediates sinusoidal endothelial cell protection by ischemic preco

196 Sleeping Beauty transposon targeted to liver sinusoidal endothelial cells provided long-term expressi

197 rses of the recovery suggest that successful sinusoidal endothelial cell recovery may depend upon pri

198 To determine whether sinusoidal endothelial cells released MMPs when placed i

199 stellate cells and CD34 expression by liver sinusoidal endothelial cells remained stable, consistent

200 re expressed in the liver by parenchymal and sinusoidal endothelial cells, respectively.

201 cts of the vascular ectonucleotidase CD39 on sinusoidal endothelial cell responses following partial

202 roduction of cytokines and free radicals and sinusoidal endothelial cell (SEC) activation, may contri

203 Sinusoidal endothelial cell (SEC) apoptosis is a central

204 the liver followed by reperfusion results in sinusoidal endothelial cell (SEC) apoptosis.

205 gnificant vascular remodeling with increased sinusoidal endothelial cell (SEC) capillarization, vascu

206 Sinusoidal endothelial cell (SEC) function and permeabil

207 milar effects of GdCl3 on one of the hepatic sinusoidal endothelial cell (SEC) functions, i.e., hyalu

208 donor prodrug, restored NO levels, preserved sinusoidal endothelial cell (SEC) integrity and sinusoid

209 Sinusoidal endothelial cell (SEC) porosities were compar

210 patocyte division has mostly subsided, while sinusoidal endothelial cell (SEC) proliferation is initi

211 Sinusoidal endothelial cells (SEC) are a target of CI/WR

212 gested that more than 50% of hepatocytes and sinusoidal endothelial cells (SEC) are undergoing apopto

213 bazine showed selective in vitro toxicity to sinusoidal endothelial cells (SEC) compared with hepatoc

214 O is examined in further detail by isolating sinusoidal endothelial cells (SEC) from the rat liver.

215 ity on the cellular events that occur in rat sinusoidal endothelial cells (SEC) in the cold.

216 Platelet adhesion to hepatic sinusoidal endothelial cells (SEC) is a major mechanism

217 We hypothesize that capillarization of sinusoidal endothelial cells (SEC) is permissive for hep

218 hat cause HVOD initially causing HVOD target sinusoidal endothelial cells (SEC) perhaps via profound

219 Sinusoidal endothelial cells (SEC) showed evidence of ap

220 HIR-induced apoptosis of hepatic sinusoidal endothelial cells (SEC) within 6 hours of HIR

221 ticles contain Hh ligands that alter hepatic sinusoidal endothelial cells (SEC).

222 In vitro, human hepatic sinusoidal endothelial cells secreted IFN-inducible prot

223 on ET-1-mediated eNOS activation in hepatic sinusoidal endothelial cells (SECs) and to investigate t

224 To test the hypothesis that fenestrated sinusoidal endothelial cells (SECs) are crucial for this

225 Liver sinusoidal endothelial cells (SECs) are generally refrac

226 Because CRCs contact sinusoidal endothelial cells (SECs) during implantation,

227 Damage to hepatic sinusoidal endothelial cells (SECs) initiates sinusoidal

228 HSCs and sinusoidal endothelial cells (SECs) reside in close prox

229 eNOS interactor, regulates eNOS activity in sinusoidal endothelial cells (SECs) via its interaction

230 ured in isolated hepatocytes, Kupffer cells, sinusoidal endothelial cells (SECs), and hepatic stellat

231 ted in marked pathologic remodeling in liver sinusoidal endothelial cells (SECs), including SEC defen

232 nd activated stellate and Kupffer cells, and sinusoidal endothelial cells (SECs).

233 matrix metalloproteinases (MMPs) by hepatic sinusoidal endothelial cells (SECs).

234 NOS), this isoform has not been described in sinusoidal endothelial cells (SECs).

235 These experiments showed that liver sinusoidal endothelial cells selectively suppress the ex

236 s of nonhematopoietic liver cells, including sinusoidal endothelial cells, stellate cells located in

237 the neuronal NOS gene (nNOS) targeted liver sinusoidal endothelial cells, stellate cells, and hepato

238 that divergent angiocrine signals from liver sinusoidal endothelial cells stimulate regeneration afte

239 ression shifted angiocrine response of liver sinusoidal endothelial cells, stimulating proliferation

240 Supernatants of isolated rat sinusoidal endothelial cells stored in the cold containe

241 veral microenvironmental regulators of liver sinusoidal endothelial cells that prolong their phenotyp

242 Liver sinusoidal endothelial cells, the origin of liver tumor

243 fter BM suppression supports the assembly of sinusoidal endothelial cells, thereby promoting reconsti

244 id not affect the susceptibility of cultured sinusoidal endothelial cells to Jo2-induced apoptosis.

245 as pretreatment with dimethyl PGE2 protected sinusoidal endothelial cells to the same extent as LPS.

246 timulates cytokine production in neighboring sinusoidal endothelial cells via Tlr9 and the Nalp3 infl

247 um could be replaced with transplanted liver sinusoidal endothelial cells, we developed an animal mod

248 Unlike capsular polysaccharides, the hepatic sinusoidal endothelial cells were also sites for gammaDP

249 eukin-1beta on GMP-140 expression in primary sinusoidal endothelial cells were analyzed.

250 In vivo function of hepatocytes and sinusoidal endothelial cells were evaluated by indocyani

251 al changes that permit the dehiscence of the sinusoidal endothelial cells were investigated.

252 In spleen, macrophages and sinusoidal endothelial cells were positive, whereas in l

253 taline causes depolymerization of F-actin in sinusoidal endothelial cells, which leads to increased e

254 that TIPS pseudointima are lined by hepatic sinusoidal endothelial cells, which stimulate pseudointi

255 y affected viability of hepatic stellate and sinusoidal endothelial cells, which was reversed by CPA

256 d preservation/reperfusion primarily affects sinusoidal endothelial cells, while hepatocytes are thou

257 Coculture of hepatocytes or sinusoidal endothelial cells with HSCs increased the lev