ライフサイエンスコーパス: sirtuin 1

1 effects of resveratrol were mediated through Sirtuin 1.

2 tylated by the stress-responsive deacetylase Sirtuin 1.

3 of the NAD(+)-dependent protein deacetylase sirtuin 1.

4 low AGE diets with increased adiponectin and sirtuin-1.

5 udopeptides that were screened against human sirtuins 1-3 to reveal their in vitro inhibition activit

6 mes (HDAC1-11) and NAD(+)-dependent enzymes (sirtuins 1-7).

7 activity of the NAD(+) dependent deacetylase sirtuin 1, a ChREBP-negative target, were down-regulated

8 ox regulation controls enzymatic activity of sirtuin 1, a mechanism we found to be conserved between

9 w that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie re

10 protective effects have been associated with sirtuin 1 activation by resveratrol, the mechanisms by w

11 ogenesis, by consuming NAD(+) and decreasing Sirtuin 1 activation of the peroxisome proliferator-acti

12 ty-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin grow

13 ylation via maintenance of NAD(+) levels and sirtuin 1 activation.

14 ic ischemia-reperfusion and posttreated with sirtuin 1 activator, SRT1720 (20 mg/kg), or vehicle.

15 to determine the effects of a small molecule sirtuin 1 activator, SRT2104, on inflammation and coagul

16 Indeed, when sirtuin 1 activity was rescued by resveratrol pretreatme

17 Sirtuin 1 also appears to influence lineage/cell-fate de

18 Sirtuin-1 also inhibits cancer metastasis via increasing

19 Id1 deficiency also increased expression of Sirtuin 1 and peroxisome proliferator-activated receptor

20 f stored maternal mRNA transcripts including sirtuin 1 and ubiquitin protein ligase E3a, two genes wi

21 In summary, activation of hepatic AMPK/sirtuin-1 and FGF21/beta-klotho signaling pathways combi

22 3 expression and prevented downregulation of Sirtuin-1 and Foxo3alpha expression in IRPTCs by high gl

23 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3alpha with downregulation of acetylat

24 We observed that both sirtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetyla

25 roblast growth factor 21 (FGF21), targets of sirtuin-1, and beta-klotho, which can acts as a tumor su

26 C apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys.

27 rn blot analysis revealed that caspase-2 and sirtuin 1 are the direct targets of miR-34a.

28 ors, AMP-activated protein kinase (AMPK) and sirtuin-1 are activated.

29 residue in the conserved catalytic region of sirtuin 1 as target for glutaredoxin 2-specific deglutat

30 Pharmacologic stimulation of sirtuin 1 attenuates liver injury after hepatic ischemia

31 on of the anti-inflammatory genes Socs1-3 or sirtuin-1 but reduced levels of IL-1beta + IFN-gamma-ind

32 responses consistent with the activation of sirtuin 1 by a small molecule.

33 Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lys

34 Sirtuin 1 deacetylase (SIRT1) regulates cell ageing and

35 levels by the p300 acetyltransferase and the sirtuin 1 deacetylase controls transcriptional activity,

36 ctivity through a mechanism regulated by the sirtuin 1 deacetylase.

37 resses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha.

38 bined ethanol and LPS-mediated inhibition of sirtuin 1 expression and activity in macrophages.

39 d ADH activity through its direct control of sirtuin 1 expression.

40 ve stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.

41 Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-

42 Sirtuin-1, Foxo3alpha, and catalase expression were sign

43 in mice, and calorie restriction upregulates sirtuin 1 in humans.

44 Molecular analyses identified the role of sirtuin 1 in preventing cell senescence; shed light on t

45 Sirtuin 1 influences gene expression and other cellular

46 Recent work indicates that sirtuin 1 influences growth-factor responses and mainten

47 AMPK/sirtuin-1 inhibit the activity of STAT3 (signal transduc

48 Moreover, miR-217-mediated sirtuin 1 inhibition was accompanied by increased activi

49 Importantly, treating AAV-NT mice with a sirtuin-1 inhibitor markedly reversed many of the observ

50 Sirtuin 1 is an energy-sensing enzyme involved in regula

51 Sirtuin 1 is an energy-sensing enzyme known to modulate

52 ypothesized that pharmacologic activation of sirtuin 1 is protective after hepatic ischemia-reperfusi

53 Sirtuin 1 is required for calorie restriction-induced li

54 We consider recent information on sirtuin 1, its role in aging and metabolism in several s

55 CAF-mediated acetylation and the deacetylase sirtuin-1-mediated deacetylation coexist to maintain CRE

56 histone deacetylase 2 enrichment, but not of sirtuin 1 or sirtuin 2, onto GluA1 and GluA2 gene sequen

57 ochondrial metabolism reorganization through sirtuin 1/peroxisome proliferator-activated receptor gam

58 rations and the AMP-activated protein kinase/sirtuin 1/peroxisome proliferator-activated receptor-gam

59 cade involving AMP-activated protein kinase, sirtuin 1, PGC-1alpha, sirtuin 3, estrogen-related recep

60 heat shock proteins, antioxidant enzymes and sirtuin-1/PGC-1 signalling) are central to the protectiv

61 iption via hnRNP F-responsive element in the Sirtuin-1 promoter.

62 ng Nnmt expression or MNAM levels stabilizes sirtuin 1 protein, an effect that is required for their

63 We and others previously demonstrated that sirtuin 1 (SIRT-1) regulates apoptosis and cartilage-spe

64 PKalpha) to total AMPKalpha ratio, decreased sirtuin-1 (Sirt-1) and peroxisomal proliferator-activate

65 han the NAD(+)-dependent histone deacetylase Sirtuin-1 (Sirt-1) are unknown.

66 y decreased levels of the histone deactylase Sirtuin-1 (SirT-1) which has been previously shown to fu

67 that reductions in the cellular deacetylase, sirtuin-1 (SIRT-1), contribute to vascular endothelial d

68 FD-induced mitochondrial dysfunction via the sirtuin-1 (SIRT-1)/ peroxisome proliferator-activated re

69 Here we show that selective knockdown of Sirtuin 1 Sirt1 in hypothalamic Agouti-related peptide-e

70 We show that UnAG rescues sirtuin 1 (SIRT1) activity and superoxide dismutase-2 (S

71 Sirtuin 1 (SIRT1) and its activator resveratrol are emer

72 Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homo

73 ted genes are the anti-lipogenic deacetylase sirtuin 1 (Sirt1) and the anti-lipogenic transcription f

74 factor 1 (HES1) and the protein deacetylase sirtuin 1 (SIRT1) at the Isl1 gene.

75 Whereas sirtuin 1 (SIRT1) can act as a tumor suppressor in some

76 on with sepsis, we report that energy sensor sirtuin 1 (SIRT1) coordinates the epigenetic and bioener

77 und that higher abundance of the deacetylase sirtuin 1 (SIRT1) correlated with lower acetylation occu

78 Heterologous sirtuin 1 (SIRT1) decreased acetylation of Nrf2 as well

79 Sirtuin 1 (SIRT1) depletion in vascular endothelial cell

80 lele showed lower leptin (LEP)(P = 0.03) and sirtuin 1 (SIRT1) expression (P = 0.04).

81 ctivated protein kinase phosphorylation, and sirtuin 1 (SIRT1) expression.

82 strate that the NAD(+)-dependent deacetylase sirtuin 1 (Sirt1) functionally and physically interacts

83 The protein encoded by the sirtuin 1 (Sirt1) gene, which is a mouse homolog of yeas

84 rmacological activation that the deacetylase Sirtuin 1 (SIRT1) has an anti-inflammatory role in a les

85 se of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-ind

86 of the NAD(+)-dependent lysine deacetylase, sirtuin 1 (SIRT1) in fibrogenesis in the cell culture, a

87 omain (p66Shc) and reduced the expression of sirtuin 1 (Sirt1) in mice and humans.

88 We sought to determine the role of sirtuin 1 (SIRT1) in skin barrier function, FLG expressi

89 dinucleotide (NAD(+))-dependent deacetylase sirtuin 1 (SIRT1) in various tissues.

90 on receptor 1 (AGER1) and of survival factor sirtuin 1 (SIRT1) in white adipose tissue (WAT), skeleta

91 Because Sirtuin 1 (SirT1) induces hepatic gluconeogenesis during

92 Sirtuin 1 (SIRT1) is a class III histone deacetylase tha

93 Sirtuin 1 (Sirt1) is a class III histone deacetylase tha

94 The enzyme sirtuin 1 (SIRT1) is a critical regulator of many cellul

95 Sirtuin 1 (Sirt1) is a NAD+-dependent deacetylase that e

96 Sirtuin 1 (SIRT1) is a NAD-dependent deacetylase that is

97 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide

98 Sirtuin 1 (SIRT1) is a nuclear deacetylase that modulate

99 The type III histone deacetylase sirtuin 1 (Sirt1) is a suppressor of both innate and ado

100 Sirtuin 1 (SirT1) is an essential nutrient-sensing histo

101 Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase tha

102 Sirtuin 1 (SIRT1) is involved in both aging and circadia

103 ependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of

104 ximately 7.5 muM) restored the normal TF and sirtuin 1 (SIRT1) levels in MCECs before PGE2 (EC50 appr

105 Sirtuin 1 (SIRT1) NAD(+)-dependent deacetylase regulates

106 Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the pathogenes

107 Sirtuin 1 (SIRT1) plays an important role in preserving

108 region of Brdt protein appeared to separate sirtuin 1 (Sirt1) protein from contact with the chromoce

109 We have previously demonstrated that sirtuin 1 (SIRT1) regulates genes involved in gluconeoge

110 Here, we propose that the nutrient sensor sirtuin 1 (Sirt1) regulates the production of CRH post-t

111 that the stress-responsive genetic regulator sirtuin 1 (Sirt1) selectively augments HIF-2 signaling d

112 ulation and Th2 inflammation and blockers of sirtuin 1 (Sirt1) to define its roles in these responses

113 d the target of DLA, the binding affinity of Sirtuin 1 (SIRT1) to DLA and DLA derivatives with replac

114 Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its associati

115 Sirtuin 1 (Sirt1), a class III histone/protein deacetyla

116 We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-dependen

117 ed activation of KRAS and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silenc

118 Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feat

119 The NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1), a key regulator of mammalian metaboli

120 We now report that overexpression of sirtuin 1 (Sirt1), a mediator of the beneficial metaboli

121 e their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylas

122 the JCI includes studies demonstrating that sirtuin 1 (Sirt1), a NAD+-dependent deacetylase, slows r

123 Anti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deac

124 We demonstrate that Sirtuin 1 (Sirt1), a redox-sensing deacetylase, selectiv

125 In this study, we report that sirtuin 1 (Sirt1), a type III histone deacetylase, negat

126 Sirtuin 1 (SIRT1), an NAD(+)-dependent deacetylase, has

127 Sirtuin 1 (SIRT1), an NAD(+)-dependent protein deacetyla

128 Sirtuin 1 (SIRT1), an NAD-dependent deacetylase, partici

129 A "longevity " gene, sirtuin 1 (SIRT1), can attenuate age-dependent induction

130 ylation of histone deacetylase 2 (HDAC2) and Sirtuin 1 (SIRT1), deacetylases that participate, respec

131 Recently, the mammalian ortholog of Sir2, sirtuin 1 (Sirt1), has been identified as a potential tr

132 The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exe

133 se p300 and the nutrient-sensing deacetylase sirtuin 1 (SIRT1), maintains energy balance in mice thro

134 itis (EAE) with resveratrol, an activator of sirtuin 1 (SIRT1), reduces disease severity.

135 n of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), resulting in enhanced mitochondrial o

136 iovascular risk factors on the expression of sirtuin 1 (SIRT1), SIPS, and apoptosis, and we documente

137 cers of fatty acid beta-oxidation, including sirtuin 1 (SIRT1), sirtuin 3 (SIRT3), and Nrf-1.

138 t from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated pr

139 Sirtuin 1 (SIRT1), the founding member of Class III hist

140 Sirtuin 1 (SIRT1), the most conserved mammalian oxidized

141 lation of memory-associated genes, including Sirtuin 1 (Sirt1), within the hippocampus, and thus offe

142 depends on NAD(+) activation of deacetylase sirtuin 1 (SirT1).

143 tion reaction is reversed by the deacetylase sirtuin 1 (SIRT1).

144 gulation of the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1).

145 dinucleotide (NAD(+))-dependent deacetylase Sirtuin 1 (Sirt1).

146 oxidase 2 (NOX2); and the down-regulation of Sirtuin 1 (Sirt1)/Timp3 pathways mediate fibrogenic acti

147 Using this continuous assay with sirtuin-1 (Sirt1) and the ADP-ribosyl cyclase CD38, the

148 We focused on sirtuin-1 (SIRT1) deacetylase due to its involvement in

149 oxisome proliferator-activated receptor- and sirtuin-1 (SIRT1) expression, with consequent increased

150 The NAD(+)-dependent protein deacetylase Sirtuin-1 (Sirt1) has been implicated in carcinogenesis

151 Sirtuin-1 (SIRT1) is an NAD-dependent deacetylase posses

152 ducer, its role in OLT and interactions with sirtuin-1 (SIRT1), a key autophagy regulator, have not b

153 Sirtuin-1 (SirT1), a member of the NAD(+)-dependent clas

154 ion by adropin may be mediated by inhibiting Sirtuin-1 (SIRT1), a PGC-1alpha deacetylase.

155 certain HDACs, especially HDAC6, HDAC9, and Sirtuin-1 (Sirt1), can augment Treg suppressive potency

156 Sirtuin-1 (SIRT1), NAD(+)-dependent deacetylase, has bee

157 otein-cytochrome-C-oxidase subunit-2 (COX2), sirtuin-1 (SIRT1), peroxisome-proliferator-activated-rec

158 ation of cytoprotective heme oxygenase-1 and sirtuin-1 (SIRT1).

159 and SIRT1 and the deacetylation of FOXO1 by Sirtuin-1 (SIRT1).

160 pendent class III histone deactelyase (HDAC) sirtuin-1 (SIRT1).

161 Transfection of Sirtuin-1 small interfering RNA prevented hnRNP F stimul

162 hnRNP F stimulated Sirtuin-1 transcription via hnRNP F-responsive element i

163 However, sirtuin 1 was downregulated and so the accumulation of N

164 We hypothesized that stimulating Sirtuin 1 would increase mitochondrial biogenesis thereb