ライフサイエンスコーパス: sister chromatid

1 ls necessary for homologous pairing with the sister chromatid.

2 abling SYCP3 to link distant sites along the sister chromatid.

3 on repair), which is based on the homologous sister chromatid.

4 lete replication and faithful segregation of sister chromatids.

5 d transcription take place in the context of sister chromatids.

6 mitotic recombination occurs solely between sister chromatids.

7 es generate mechanical forces that segregate sister chromatids.

8 s that a single cohesin complex entraps both sister chromatids.

9 or centromeres) to mediate cohesion between sister chromatids.

10 elongating spindle physically segregates the sister chromatids.

11 spindle is crucial to achieve segregation of sister chromatids.

12 mal complex proteins, occurs instead between sister chromatids.

13 central core, which may physically separate sister chromatids.

14 and is required to promote bi-orientation of sister chromatids.

15 by proteolytic cleavage to release pairs of sister chromatids.

16 ich directs Cdt1 accumulation on segregating sister chromatids.

17 ndle during mitosis to capture and segregate sister chromatids.

18 on during mitosis depend on cohesion between sister chromatids.

19 lity for global recombination repair between sister chromatids.

20 hromosomes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisia

21 tablishment of proteinaceous bridges between sister chromatids, a function provided by a ring-shaped

22 ggered DSBs, at least in barley, involve the sister chromatid and occur during S or G2 phase of the c

23 and Cyclin B, leading to the dissolution of sister chromatids and anaphase onset [1].

24 e cohesin complex that regulates cohesion of sister chromatids and gene transcription.

25 oci, the cohesion of replicated MUC4 loci on sister chromatids, and their dynamic behaviors during mi

26 chromosome-microtubule attachments even when sister chromatids are correctly bioriented.

27 Sister chromatids are held together by cohesin, a tripar

28 rom Separase-mediated cleavage ensuring that sister chromatids are kept together until their separati

29 leads to anaphase bridge formation (in which sister chromatids are linked by catenated strands of DNA

30 recombination during cell cycle phases when sister chromatids are present.

31 While sister chromatids are segregated from one another in mit

32 Sister chromatids are tethered together by the cohesin c

33 to repair rereplication-associated DSBs, and sister chromatids are used as templates for such HR-medi

34 association of cohesins along the length of sister chromatid arms.

35 logous chromosome is favored over the nearby sister chromatid as a repair template.

36 factors in undamaged cells causes diminished sister chromatid association at centromeric sequences.

37 attern in which both homologs separate their sister chromatids at meiosis I; detect selection for hig

38 egregation at meiosis I but also the fate of sister chromatids at meiosis II.

39 Human sister chromatids at metaphase are primarily linked by c

40 complex, which ensures proper segregation of sister chromatids at mitosis by mediating the interactio

41 al weak H3T3ph signals occur between cohered sister chromatids at prometaphase.

42 During mitosis, duplicated sister chromatids attach to microtubules emanating from

43 Sister chromatid attachment during meiosis II (MII) is m

44 nctional during the S- and G2-phases, when a sister chromatid becomes available.

45 mitosis requires the physical separation of sister chromatids before nuclear envelope reassembly (NE

46 's ability to ensure accurate segregation of sister chromatids, but, as in centromere localization, t

47 3 acetylation locks cohesin rings around the sister chromatids by counteracting an activity associate

48 has been implicated in the alignment of four sister chromatids by forming parallel guanine quadruplex

49 to template switches between homologs versus sister chromatids by using microhomology to prime DNA re

50 ucleate or multinucleate, and the replicated sister chromatids can remain attached and aligned, produ

51 Sister chromatid cohesion (SCC), efficient DNA repair, a

52 3) heterodimeric ATPase, the kleisin subunit sister chromatid cohesion 1 (Scc1) that links the two AT

53 The sister chromatid cohesion 2 and 4 (Scc2-Scc4) complex lo

54 es, cohesin and condensin, are important for sister chromatid cohesion and condensation, respectively

55 alleles are inviable and defective for both sister chromatid cohesion and condensation.

56 essential roles in chromosome condensation, sister chromatid cohesion and DNA repair.

57 ns to the axis, plays an independent role in sister chromatid cohesion and double-strand break format

58 ing with DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis a

59 hroughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin str

60 EJ, in addition to its canonical function in sister chromatid cohesion and its recently suggested fun

61 se that spliceosome components contribute to sister chromatid cohesion and mitotic chromosome segrega

62 rates long-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosom

63 to the initial steps of the establishment of sister chromatid cohesion and other chromosomal processe

64 tein complex was discovered for its roles in sister chromatid cohesion and segregation, and the Polyc

65 xhibited defects in chromosomal congression, sister chromatid cohesion and spindle positioning, there

66 rt of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation

67 ng Smc3, but their relative contributions to sister chromatid cohesion are unknown.

68 The abrupt loss of sister chromatid cohesion at anaphase creates a type of

69 ate early S phase DNA replication and robust sister chromatid cohesion at microtubule attachment site

70 ation and live-cell imaging, that persistent sister chromatid cohesion at telomeres triggers a prolon

71 t role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic

72 Sister chromatid cohesion conferred by entrapment of sis

73 essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregatio

74 Initiation of sister chromatid cohesion depends on a separate complex,

75 Sister chromatid cohesion depends on Sororin, a protein

76 Cohesins establish sister chromatid cohesion during S phase and are removed

77 h modify cohesin's Smc3 subunit to establish sister chromatid cohesion during S phase, but differ in

78 In addition to mediating sister chromatid cohesion during the cell cycle, the coh

79 usly that HTP-1/2 prevents premature loss of sister chromatid cohesion during the meiotic divisions b

80 coordinates replication fork progression and sister chromatid cohesion establishment.

81 In the absence of Wapl, sister chromatid cohesion functions well, suggesting tha

82 Timely resolution of sister chromatid cohesion in G2/M is essential for genom

83 -mRNA splicing factors that are required for sister chromatid cohesion in human cells.

84 Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wi

85 depletion of H2A.Z causes precocious loss of sister chromatid cohesion in yeast without loss of Mcd1

86 Sister chromatid cohesion is essential for tension-sensi

87 Sister chromatid cohesion is established during replicat

88 a decrease in securin that ultimately causes sister chromatid cohesion loss.

89 Sister chromatid cohesion mediated by the cohesin comple

90 Sister chromatid cohesion mediated by the cohesin comple

91 The prevailing embrace model for sister chromatid cohesion posits that a single cohesin c

92 pl-Pds5 binding to the cohesin subcomplex of sister chromatid cohesion protein 1 (Scc1) and stromal a

93 During mitosis and meiosis, sister chromatid cohesion resists the pulling forces of

94 te the establishment and two-step release of sister chromatid cohesion that underlies the production

95 g S phase is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome

96 Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell sur

97 hanistic) importance in linking the sites of sister chromatid cohesion to the chromosomal regions tha

98 In addition, defective sister chromatid cohesion was observed in five HNSCC cel

99 mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA l

100 ing XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolis

101 Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for corre

102 It contributes to sister chromatid cohesion, a process mediated by the coh

103 Mitotic chromosome condensation, sister chromatid cohesion, and higher order folding of i

104 n chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA

105 rder chromosome structure, thereby promoting sister chromatid cohesion, chromosome condensation, DNA

106 is a conserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA

107 chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptiona

108 Cohesin plays a critical role in sister chromatid cohesion, double-stranded DNA break rep

109 multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damag

110 In addition to its role in sister chromatid cohesion, genome stability and integrit

111 iotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and

112 lls depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role

113 without premeiotic chromosomal replication, sister chromatid cohesion, synapsis or recombination.

114 Sister chromatid cohesion, which is mediated by the cohe

115 e checkpoint activation and establishment of sister chromatid cohesion.

116 ase activity, is required for Chl1's role in sister chromatid cohesion.

117 assembly, assembly, and the establishment of sister chromatid cohesion.

118 and helicase involved in DNA replication and sister chromatid cohesion.

119 ons in PDS5A or STAG2 resulted in inadequate sister chromatid cohesion.

120 acetylation of cohesin establishes enduring sister chromatid cohesion.

121 nucleosome positioning, gene expression and sister chromatid cohesion.

122 hought to form tripartite rings that mediate sister chromatid cohesion.

123 unction of cohesin distinct from its role in sister chromatid cohesion.

124 t of the cohesin ring, which ensures correct sister chromatid cohesion.

125 pl partakes in a cohesin function outside of sister chromatid cohesion.

126 anochemistry may occur before dissolution of sister chromatid cohesion.

127 function as antagonists to regulate meiotic sister chromatid cohesion.

128 ith distinct sites on chromosomes to mediate sister chromatid cohesion.

129 We suggest that, in the absence of SeqA, the sister-chromatid cohesion 'safety spacer' is destabilize

130 ires coordination between the dissolution of sister-chromatid cohesion and the establishment of prope

131 on at the centromere region until release of sister-chromatid cohesion at the metaphase II/anaphase I

132 physically interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mito

133 has previously been shown to play a role in sister-chromatid cohesion in metazoans.

134 they modify different effectors and regulate sister-chromatid cohesion in opposing ways.

135 Sister-chromatid cohesion is established by Eco1-mediate

136 ilitating the recruitment of kinetochore and sister-chromatid cohesion proteins, both required for co

137 During the cell cycle, sister-chromatid cohesion tethers sister chromatids toge

138 proteins SOLO, SUNN, and ORD is required for sister-chromatid cohesion, localizes to the centromeres

139 Kleisin-like protein and ORD is required for sister-chromatid cohesion, we tested the hypothesis that

140 on, and a stable complex may be required for sister-chromatid cohesion.

141 mosomes to promote chromosome compaction and sister-chromatid cohesion.

142 favoring homologous recombination linked to sister-chromatid cohesion.

143 ional meiosis I division in which replicated sister chromatids comigrate, rather than separate as in

144 r kinetochores during meiosis I may underlie sister chromatid comigration in diverse organisms, but d

145 Thus, kinetochore fusion directs sister chromatid comigration, a conserved feature of mei

146 icated DNA, fully replicated and intertwined sister chromatids--commonly referred to as DNA catenatio

147 ge of centromeric cohesin by separase allows sister chromatids connected to microtubules from opposin

148 cumstantial evidence has linked condensin to sister chromatid decatenation but, because of the diffic

149 s during chromosome segregation by promoting sister chromatid decatenation.

150 n DNA sequence, making recombination between sister chromatids difficult to detect.

151 ls, where they are the consequence of failed sister chromatid disentanglement during chromosome compa

152 lexes ensure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mit

153 This liberates separase triggering sister chromatid disjunction and inactivates cyclin-depe

154 venting cyclin B1 proteolysis at the time of sister chromatid disjunction destabilizes kinetochore-mi

155 Separases are large proteins that mediate sister chromatid disjunction in all eukaryotes.

156 indle assembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes

157 Accurate and efficient separation of sister chromatids during anaphase is critical for faithf

158 n addition, condensin promotes resolution of sister chromatids during anaphase, a function that is co

159 al role in the dissolution of cohesion among sister chromatids during chromosome segregation.

160 x subunit SMC3 to regulate the separation of sister chromatids during mitosis and meiosis.

161 nt (SAC) ensures the accurate segregation of sister chromatids during mitosis.

162 kinase regulates the proper biorientation of sister chromatids during mitosis.

163 al loci required for accurate segregation of sister chromatids during mitosis.

164 ts are essential for faithful segregation of sister chromatids during mitosis.

165 he symmetric tethering of plasmid sisters to sister chromatids embodies the replication-dependent com

166 studies demonstrate that H3T3P distinguishes sister chromatids enriched with distinct pools of H3 in

167 , called Strand-seq, that can be used to map sister chromatid exchange (SCE) events genome-wide in si

168 the simultaneous high-resolution mapping of sister chromatid exchange (SCE), facilitating the study

169 s on UV-induced G1/S checkpoint response and sister chromatid exchange (SCE).

170 s in displaying reduced endogenous levels of sister chromatid exchange (SCE).

171 n, Tet TKO ESCs exhibited increased telomere-sister chromatid exchange and elongated telomeres.

172 centromeric CO-FISH patterns consistent with sister chromatid exchange at the frequency of 5% in prim

173 mutagenic but causes DNA breaks and elevates sister chromatid exchange in mammalian cells.

174 easured interhomolog recombination and intra/sister chromatid exchange in the CUP1 locus.

175 BLM, telomeric circle formation and telomere sister chromatid exchange, both arising out of nucleolyt

176 on can be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations

177 s can occur by replication slippage, unequal sister chromatid exchange, homologous recombination, and

178 ary Pml(C62A/C65A) cells exhibited increased sister-chromatid exchange and chromosome abnormalities.

179 toxicant as well as an effective inducer of sister-chromatid exchange.

180 c mitotic recombination, a high frequency of sister chromatid exchanges and double strand DNA breaks,

181 RECQ5 is significant in suppressing sister chromatid exchanges during homologous recombinati

182 Positional coincidence of >81% of sister chromatid exchanges with target loci is unprecede

183 Sister chromatid exchanges, a surrogate measure of iHR,

184 cause in its absence cells display increased sister chromatid exchanges, replication origin firing an

185 d telomere shortening, elevation of telomere sister-chromatid exchanges and increased aphidicolin-ind

186 hugoshin) mutants during meiosis II when the sister chromatids exhibit random distribution.

187 me that removes catenanes persisting between sister chromatids following DNA replication.

188 Cohesin stably holds together the sister chromatids from S phase until mitosis.

189 It is currently unknown how sister chromatid fusion is produced from a mitotic break

190 nd exchange with the homolog rather than the sister chromatid (homolog bias).

191 Depletion of SA2 but not SA1 decreased sister chromatid homologous recombination repair and aff

192 owing the reproducibility of banding between sister chromatids, homologue pairs and from one metaphas

193 ys, including homologous recombination (HR), sister chromatid HR, resolution of branched HR intermedi

194 lexes are thought to bind by encircling both sister chromatids in a topological embrace.

195 ex-is essential for efficient segregation of sister chromatids in eukaryotes [1-4].

196 also provide crucial links between pairs of sister chromatids in eukaryotic meiosis.

197 sess the resection needed for repair between sister chromatids in G-2 arrested cells of random, radia

198 otubule attachment/centromere, and co-orient sister chromatids in meiosis I in Saccharomyces cerevisi

199 hich condensin complexes compact and resolve sister chromatids in mitosis and by which cohesin genera

200 e (a protease required for the separation of sister chromatids in mitosis and meiosis).

201 oint system prevents premature separation of sister chromatids in mitosis and thus ensures the fideli

202 oint system prevents premature separation of sister chromatids in mitosis and thus ensures the fideli

203 that, despite a loss in centromere cohesion, sister chromatids in STAG2 mutant tumor cells maintain c

204 al genome fails to condense and resolve into sister chromatids in synchrony with the maternal genome.

205 TB plasmid sisters are tightly correlated to sister chromatids in the extents of co-segregation as we

206 mes in the first division and segregation of sister chromatids in the second division.

207 nable to support stable bipolar alignment of sister chromatids, indicating failure of kinetochore-mic

208 This may reflect that cohesin-mediated sister chromatid interactions are sufficient for double-

209 ion, topoisomerase II (topo II) must resolve sister chromatid intertwines (SCI) formed during deoxynu

210 These mitotic sister chromatid intertwines (SCIs) can be found as; sho

211 Sister chromatid intertwines (SCIs), or catenanes, are t

212 l regions as circular "loop outs" to convert sister chromatid intertwines into catenated circles.

213 ompanied by drastic changes in the degree of sister chromatid intertwines.

214 le-strand break (DSB) repair pathways when a sister chromatid is not available.

215 sation and NER until effective separation of sister chromatids is achieved.

216 The establishment of tension between sister chromatids is essential for quenching a checkpoin

217 Homologous recombination involving sister chromatids is the most accurate, and thus most fr

218 ge effect." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically

219 he SAC coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle wit

220 mmonly referred to as DNA catenation--and as sister chromatid linkages generated by homologous recomb

221 This requires that sister chromatids maintain cohesion at the centromere as

222 Depending on the system, sister chromatids may display either of two distinct beh

223 Cohesion between sister chromatids, mediated by the chromosomal cohesin c

224 During mitosis, sister chromatids must be faithfully segregated to ensur

225 ate chromosome segregation, cohesion between sister chromatids must be released in a controlled manne

226 ICRF-193-treated PICH(-/-) cells undergo sister chromatid non-disjunction in anaphase, and freque

227 on of a phosphomimetic Yen1 mutant increased sister chromatid nondisjunction.

228 ted by a chromothripsis event involving both sister chromatids of the Robertsonian chromosome, a nove

229 During hermaphrodite spermatogenesis, the sister chromatids of the X chromosomes separate during m

230 h single-chromosome resolution and show that sister chromatids of X and Y chromosomes, but not autoso

231 generated the triplication occurred between sister chromatids on the duplication-bearing chromosome

232 paired by homologous recombination using the sister chromatid or the homologous chromosome (homolog)

233 the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalent

234 olliday junctions (HJs) that physically link sister chromatids or homologous chromosomes are formed a

235 Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad2

236 eiotic-specific cohesin member, required for sister chromatid pairing and for preventing telomere sho

237 t (SAC) delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while

238 It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and tha

239 When sister chromatid pairs become bioriented, the E3 ligase

240 ng chromosomes once each cell cycle produces sister chromatid pairs, which separate accurately at ana

241 The cohesion of replicated sister chromatids promotes chromosome biorientation, gen

242 talled replication forks may be processed by sister chromatid recombination (SCR), generating error-f

243 inating the extended repair synthesis during sister chromatid recombination (SCR).

244 The rate of intra/sister chromatid recombination exceeded the rate of inte

245 ation in rate of both interhomolog and intra/sister chromatid recombination in the CUP1 array; recomb

246 Despite its importance, sister chromatid recombination is not easily studied bec

247 CAG repeat stability and promote gap-induced sister chromatid recombination.

248 und centromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pe

249 Sister chromatid resolution during mitosis required the

250 omologs segregate to opposite poles; and (3) sister chromatids segregate to opposite poles.

251 romoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis.

252 promoting complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and the establ

253 APC/C, controlling sister chromatid segregation, cytokinesis, and the estab

254 rt of a response mechanism ensuring accurate sister chromatid segregation.

255 ts and H2AThr133ph on maize lines containing sister chromatids separate precociously in anaphase I re

256 er-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant

257 s induced bone marrow aplasia with premature sister chromatid separation and revealed an absolute req

258 Hos1 depletion significantly delayed sister chromatid separation and segregation.

259 erference-mediated knockdown of SENP1 delays sister chromatid separation at metaphase, whereas SENP2

260 Removal of cohesin is necessary for sister chromatid separation during anaphase, and this is

261 Precise control of sister chromatid separation during mitosis is pivotal to

262 proteins) is critically important for proper sister chromatid separation during mitosis.

263 s a crucial role in regulating the timing of sister chromatid separation during mitosis.

264 catenation is resolved, permitting complete sister chromatid separation in the ensuing anaphase.

265 Crucially, sister chromatid separation must be delayed until all th

266 SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are at

267 Coupling sister chromatid separation with subsequent exit from mi

268 olved during and following S-phase, aided by sister chromatid separation.

269 itylates securin for proteolysis, triggering sister chromatid separation.

270 spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy.

271 gulation through its prevention of premature sister-chromatid separation and the formation of DNA loo

272 ent of attachment monitoring mechanisms when sister chromatids split and tension is lost at anaphase

273 required both for the tethering together of sister chromatids (termed cohesion) and subsequent conde

274 break hotspots form more frequently between sister chromatids than between homologs, but a novel spe

275 Sister chromatids that arrested with a lateral attachmen

276 ggesting that it controls the segregation of sister chromatids through heterochromatin modification.

277 The cohesin complex embraces sister chromatids throughout interphase, but during mito

278 me segregation requires centromeres on every sister chromatid to correctly form and attach the microt

279 points in the cell cycle when the lack of a sister chromatid to serve as a homologous template preve

280 forms a ring-shaped structure that embraces sister chromatids to promote their cohesion.

281 two-step removal of cohesin is required for sister chromatids to separate.

282 plexes that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called

283 chores are large protein complexes that link sister chromatids to the spindle and transduce microtubu

284 The latter then cleaves cohesin holding sister chromatids together [2].

285 The ability of cohesin to tether sister chromatids together depends on acetylation of its

286 rnover to one capable of tenaciously holding sister chromatids together for extended periods of time,

287 ell cycle, sister-chromatid cohesion tethers sister chromatids together from S phase to the metaphase

288 The cohesin ring holds newly replicated sister chromatids together until their separation at ana

289 rase-mediated cleavage, in order to maintain sister chromatids together until their separation in mei

290 oval of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I

291 identified through its major role in holding sister chromatids together.

292 ecruitment of high levels of cohesin to link sister chromatids together.

293 e assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to

294 ated dimerization, but recombination between sister chromatids was largely unaffected.

295 Finally, an abnormal separation of sister chromatids was observed upon INO80 downregulation

296 mitosis requires the physical separation of sister chromatids which depends on correct position of m

297 The unpaired X precociously separates into sister chromatids, which co-segregate with the autosome

298 Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromoso

299 mitotic fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph

300 e not consistent with cohesin embracing both sister chromatids within silent chromatin domains.