ライフサイエンスコーパス: sister chromatid cohesion

1 As are entrapped, and thereby held together (sister chromatid cohesion).

2 e checkpoint activation and establishment of sister chromatid cohesion.

3 direct role for H2A.Z in the maintenance of sister chromatid cohesion.

4 d despite a drop of tension after removal of sister chromatid cohesion.

5 s on the timely establishment and removal of sister chromatid cohesion.

6 sociation with the replication fork promotes sister chromatid cohesion.

7 ntally by separase-independent resolution of sister chromatid cohesion.

8 interactions can, with time, rupture normal sister chromatid cohesion.

9 cohesin at DNA breaks and thereby promoting sister chromatid cohesion.

10 ich is crucial for the timely dissolution of sister chromatid cohesion.

11 omplex is critical to its ability to mediate sister chromatid cohesion.

12 oth DNA replication and the establishment of sister chromatid cohesion.

13 tionarily conserved cohesin complex mediates sister chromatid cohesion.

14 subunit Smc3 to promote the establishment of sister chromatid cohesion.

15 n on chromosomes and cause lethal defects in sister chromatid cohesion.

16 nzymatic activity is regulated to facilitate sister chromatid cohesion.

17 cetylation contributes to the maintenance of sister chromatid cohesion.

18 yeast that is required for the formation of sister chromatid cohesion.

19 st acetylation of cohesin's SMC3 subunit and sister chromatid cohesion.

20 ransferase required for the establishment of sister chromatid cohesion.

21 nsferase normally essential for establishing sister chromatid cohesion.

22 e cohesin, the protein complex that mediates sister chromatid cohesion.

23 spatially or temporally for establishment of sister chromatid cohesion.

24 ion of replication fork and establishment of sister chromatid cohesion.

25 anochemistry may occur before dissolution of sister chromatid cohesion.

26 is an essential protein complex required for sister chromatid cohesion.

27 in the homologs of yeast genes that regulate sister chromatid cohesion.

28 ation is a conserved mechanism in regulating sister chromatid cohesion.

29 ent manner during DNA replication to promote sister chromatid cohesion.

30 omes (sister chromatids) together to mediate sister chromatid cohesion.

31 the presence of a sister chromatid and hence sister chromatid cohesion.

32 function as antagonists to regulate meiotic sister chromatid cohesion.

33 ts of the cohesin complex and play a role in sister chromatid cohesion.

34 ltransferases that is involved in regulating sister chromatid cohesion.

35 nd suggest an essential role for CTCF during sister chromatid cohesion.

36 ith distinct sites on chromosomes to mediate sister chromatid cohesion.

37 III-associated proteins in establishment of sister chromatid cohesion.

38 ed for spindle pole body duplication and for sister chromatid cohesion.

39 onnection between replication initiation and sister chromatid cohesion.

40 omatin is important for normal regulation of sister chromatid cohesion.

41 s ChlR1, a DNA helicase that plays a role in sister chromatid cohesion.

42 cription) and Ctf4, which helps to establish sister chromatid cohesion.

43 auses mitotic arrest and complete failure of sister chromatid cohesion.

44 essential, cell cycle-dependent mediator of sister chromatid cohesion.

45 is required for chromosome condensation and sister chromatid cohesion.

46 ase activity, is required for Chl1's role in sister chromatid cohesion.

47 assembly, assembly, and the establishment of sister chromatid cohesion.

48 and helicase involved in DNA replication and sister chromatid cohesion.

49 ons in PDS5A or STAG2 resulted in inadequate sister chromatid cohesion.

50 acetylation of cohesin establishes enduring sister chromatid cohesion.

51 nucleosome positioning, gene expression and sister chromatid cohesion.

52 hought to form tripartite rings that mediate sister chromatid cohesion.

53 unction of cohesin distinct from its role in sister chromatid cohesion.

54 t of the cohesin ring, which ensures correct sister chromatid cohesion.

55 pl partakes in a cohesin function outside of sister chromatid cohesion.

56 eiotic cohesin to the chromosome to generate sister-chromatid cohesion.

57 by allowing separase, a protease, to disrupt sister-chromatid cohesion.

58 al silencing, heterochromatin formation, and sister-chromatid cohesion.

59 e cohesin, the protein complex that mediates sister-chromatid cohesion.

60 entromere-proximal CO promotes local loss of sister-chromatid cohesion.

61 -strand replication and the establishment of sister-chromatid cohesion.

62 ome structures to help establish or maintain sister-chromatid cohesion.

63 ndant and that both were required for proper sister-chromatid cohesion.

64 ed a conserved acetyltransferase involved in sister-chromatid cohesion.

65 on, and a stable complex may be required for sister-chromatid cohesion.

66 mosomes to promote chromosome compaction and sister-chromatid cohesion.

67 favoring homologous recombination linked to sister-chromatid cohesion.

68 cts lacking Tipin and And1 also show reduced sister chromatids cohesion.

69 3) heterodimeric ATPase, the kleisin subunit sister chromatid cohesion 1 (Scc1) that links the two AT

70 The sister chromatid cohesion 2 and 4 (Scc2-Scc4) complex lo

71 Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for corre

72 oss of proper mRNA production and defects in sister chromatid cohesion, a process important for both

73 It contributes to sister chromatid cohesion, a process mediated by the coh

74 e cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in

75 , encoding a replisome component involved in sister chromatid cohesion, also suppresses hst3 hst4 phe

76 hromosomes, or the Pds5 protein required for sister chromatid cohesion, alters gene expression and or

77 sed to encircle sister chromatids to mediate sister chromatid cohesion and also has key roles in gene

78 Mitotic abnormalities included loss of sister chromatid cohesion and chromosomal disruption.

79 DNA catenation has been implicated in both sister chromatid cohesion and chromosome condensation, b

80 thionine residue and is essential for proper sister chromatid cohesion and chromosome condensation.

81 nd development independently of its roles in sister chromatid cohesion and chromosome segregation?

82 es, cohesin and condensin, are important for sister chromatid cohesion and condensation, respectively

83 alleles are inviable and defective for both sister chromatid cohesion and condensation.

84 aturation, mitotic entry, spindle formation, sister chromatid cohesion and cytokinesis.

85 Cohesins mediate sister chromatid cohesion and DNA repair and also functi

86 essential roles in chromosome condensation, sister chromatid cohesion and DNA repair.

87 interphase chromosomes and is essential for sister chromatid cohesion and DNA repair.

88 ns to the axis, plays an independent role in sister chromatid cohesion and double-strand break format

89 ing with DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis a

90 t this modification is required for accurate sister chromatid cohesion and for chromosome recruitment

91 icates that inactive units are necessary for sister chromatid cohesion and genetic stability of rDNA.

92 acetylatable form leads to increased loss of sister chromatid cohesion and genome instability in both

93 hroughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin str

94 yndrome characterized by cellular defects in sister chromatid cohesion and hypersensitivity to agents

95 somal domains nucleate kinetochores, mediate sister chromatid cohesion and inhibit recombination, yet

96 xit from mitosis indirectly leads to loss of sister chromatid cohesion and inviability in nocodazole.

97 on requires the proper spatial regulation of sister chromatid cohesion and its dissolution along chro

98 chromatin is separable from both its role in sister chromatid cohesion and its interaction with the c

99 EJ, in addition to its canonical function in sister chromatid cohesion and its recently suggested fun

100 se that spliceosome components contribute to sister chromatid cohesion and mitotic chromosome segrega

101 nd cyclin, which promotes the dissolution of sister chromatid cohesion and mitotic progression.

102 in and cyclin, leading to the dissolution of sister chromatid cohesion and mitotic progression.

103 rates long-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosom

104 to the initial steps of the establishment of sister chromatid cohesion and other chromosomal processe

105 The cohesin complex mediates sister chromatid cohesion and regulates gene transcripti

106 tein complex was discovered for its roles in sister chromatid cohesion and segregation, and the Polyc

107 g the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of pap

108 xhibited defects in chromosomal congression, sister chromatid cohesion and spindle positioning, there

109 ith a role of hChlR1 in the establishment of sister chromatid cohesion and suggest that its action ma

110 Smc1), which acts within chromatin to ensure sister chromatid cohesion and to effect several DNA dama

111 rt of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation

112 In contrast, sister-chromatid cohesion and chromosome segregation are

113 ires coordination between the dissolution of sister-chromatid cohesion and the establishment of prope

114 us work uncovered an unexpected link between sister-chromatid cohesion and the fidelity of achiasmate

115 mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA l

116 ing XPD (nucleotide excision repair), DDX11 (sister chromatid cohesion), and RTEL (telomere metabolis

117 Mitotic chromosome condensation, sister chromatid cohesion, and higher order folding of i

118 ng at the nuclear membrane, establishment of sister chromatid cohesion, and repair of certain types o

119 tein, a cohesin loading factor essential for sister chromatid cohesion, and with centromere-specific

120 a previously unsuspected role for Recql4 in sister-chromatid cohesion, and suggest that the chromoso

121 ng Smc3, but their relative contributions to sister chromatid cohesion are unknown.

122 These results suggest that defective sister chromatid cohesion as a result of somatic mutatio

123 is flexible enough to establish and maintain sister chromatid cohesion as well as ensure the fidelity

124 The abrupt loss of sister chromatid cohesion at anaphase creates a type of

125 vers and on selective release of a subset of sister chromatid cohesion at anaphase I.

126 dding yeast as a model, we show that loss of sister chromatid cohesion at anaphase onset would engage

127 ate early S phase DNA replication and robust sister chromatid cohesion at microtubule attachment site

128 ule attachment, but they also support robust sister chromatid cohesion at pericentromeres and facilit

129 ation and live-cell imaging, that persistent sister chromatid cohesion at telomeres triggers a prolon

130 During mitosis, sister-chromatid cohesion at centromeres enables the bio

131 on at the centromere region until release of sister-chromatid cohesion at the metaphase II/anaphase I

132 s described here is incompatible with stable sister chromatid cohesion because it permits chromatin f

133 the loss of normal spindle architecture and sister chromatid cohesion before anaphase onset.

134 ions in the cohesin complex disrupt not only sister chromatid cohesion but also homologue pairing and

135 topology is used not only for the purpose of sister chromatid cohesion, but also to dynamically defin

136 nd to chromosomes with only minor defects in sister chromatid cohesion, but sister chromatids synapse

137 e to alterations in microtubule dynamics and sister-chromatid cohesion, but robust against alteration

138 opo II-driven decatenation, cohesin mediates sister chromatid cohesion by an indirect mechanism as we

139 t role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic

140 LAB-1 preserves meiotic sister chromatid cohesion by restricting the localizatio

141 Since the dissolution of sister chromatid cohesion by separase and cyclin B destr

142 P1) has been proposed to protect centromeric sister-chromatid cohesion by directly targeting Sgo1 to

143 along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle ch

144 Both kinetochore function and sister chromatid cohesion can depend upon pericentromere

145 chromosomes necessitates the coordination of sister chromatid cohesion, chromosome condensation, and

146 n chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA

147 rder chromosome structure, thereby promoting sister chromatid cohesion, chromosome condensation, DNA

148 is a conserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA

149 mosome during the late G1 phase, establishes sister chromatid cohesion concomitant with DNA replicati

150 Sister chromatid cohesion conferred by entrapment of sis

151 Sister chromatid cohesion, conferred by the evolutionari

152 The cohesin complex that mediates sister chromatid cohesion contains three core subunits:

153 essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregatio

154 ngly, deficiency of SFPQ alone also leads to sister chromatid cohesion defects and chromosome instabi

155 physically interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mito

156 Initiation of sister chromatid cohesion depends on a separate complex,

157 Sister chromatid cohesion depends on Sororin, a protein

158 chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptiona

159 cohesin, a complex previously implicated in sister chromatid cohesion, DNA repair, and the formation

160 Cohesin plays a critical role in sister chromatid cohesion, double-stranded DNA break rep

161 The establishment of stable sister chromatid cohesion during DNA replication require

162 Our work identifies residual sister chromatid cohesion during early anaphase and reve

163 x on chromatin following DNA replication and sister chromatid cohesion during G(2).

164 associates with chromosomes and establishes sister chromatid cohesion during interphase.

165 protease that is required for the release of sister chromatid cohesion during meiosis and mitosis.

166 hat function to prevent premature release of sister chromatid cohesion during meiosis I in C. elegans

167 n during prophase I of meiosis and deficient sister chromatid cohesion during metaphase II predispose

168 indle checkpoint activity and maintenance of sister chromatid cohesion during metaphase.

169 nonsumoylatable Scc1 mutant (15KR) maintain sister chromatid cohesion during mitosis but are defecti

170 Sgo1 plays a key role in protecting sister chromatid cohesion during mitosis.

171 Cohesins establish sister chromatid cohesion during S phase and are removed

172 h modify cohesin's Smc3 subunit to establish sister chromatid cohesion during S phase, but differ in

173 In addition to mediating sister chromatid cohesion during the cell cycle, the coh

174 usly that HTP-1/2 prevents premature loss of sister chromatid cohesion during the meiotic divisions b

175 The cohesin complex maintains sister-chromatid cohesion during cell division in eukary

176 t that in budding yeast Scc2 is required for sister-chromatid cohesion during meiosis for two reasons

177 lex plays a dual role in gene regulation and sister-chromatid cohesion during meiotic differentiation

178 ginally described for its role in regulating sister-chromatid cohesion during mitosis and meiosis.

179 uman Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion during prophase and prevents p

180 ere we show that three proteins required for sister chromatid cohesion, Eco1, Ctf4, and Ctf18, are fo

181 latory mechanism helps optimize the level of sister chromatid cohesion, ensuring a robust and efficie

182 ally, meiotic crossovers in conjunction with sister-chromatid cohesion establish a physical connectio

183 coordinates replication fork progression and sister chromatid cohesion establishment.

184 is thought to be coupled to establishment of sister chromatid cohesion, facilitating identification o

185 Mutations in the sister chromatid cohesion factor genes NIPBL, SMC1A and

186 e, a phenotype that is caused by the loss of sister chromatid cohesion following a prolonged metaphas

187 for proper cell division, because it secures sister-chromatid cohesion following DNA replication unti

188 ound that GA leads to a more general loss of sister chromatid cohesion for cellular chromosomes.

189 ae complex required for the establishment of sister chromatid cohesion functions as an efficient unlo

190 In the absence of Wapl, sister chromatid cohesion functions well, suggesting tha

191 multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damag

192 In addition to its role in sister chromatid cohesion, genome stability and integrit

193 n to centromeres, which disrupts centromeric sister chromatid cohesion, had no effect on this spindle

194 iotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and

195 nt with its predicted role in the release of sister chromatid cohesion, immunolocalization studies sh

196 We have identified a regulator of sister chromatid cohesion in a screen for cell cycle-con

197 cate that they function together to maintain sister chromatid cohesion in Drosophila meiosis.

198 tive acetyltransferase that is important for sister chromatid cohesion in Drosophila melanogaster, bu

199 Timely resolution of sister chromatid cohesion in G2/M is essential for genom

200 We showed that San is critical for sister chromatid cohesion in HeLa cells, suggesting that

201 (MRE11A and CDC4) also resulted in abnormal sister chromatid cohesion in human cells.

202 -mRNA splicing factors that are required for sister chromatid cohesion in human cells.

203 localization and, therefore, the control of sister chromatid cohesion in meiosis.

204 cate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion es

205 These data suggest that PP2A regulates sister chromatid cohesion in Pds1-dependent and -indepen

206 C) subunit Mnd2 is necessary for maintaining sister chromatid cohesion in prophase I of meiosis by in

207 for LAB-1 in promoting the establishment of sister chromatid cohesion in prophase I.

208 epletion of lab-1 results in partial loss of sister chromatid cohesion in rec-8 and coh-4 coh-3 mutan

209 1121A) cells are viable but fail to maintain sister chromatid cohesion in response to the disruption

210 has been implicated in the establishment of sister chromatid cohesion in S phase, yet its function o

211 Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wi

212 nt mechanisms controlling the dissolution of sister chromatid cohesion in the absence of securin.

213 Unlike in budding yeast, sister chromatid cohesion in vertebrate cells is resolve

214 f Ctf18-RFC, while required for establishing sister chromatid cohesion in vivo, did not function spec

215 y in vitro, and its activity is required for sister chromatid cohesion in vivo.

216 depletion of H2A.Z causes precocious loss of sister chromatid cohesion in yeast without loss of Mcd1

217 Shugoshin 1 (Sgo1) protects centromeric sister-chromatid cohesion in early mitosis and, thus, pr

218 has previously been shown to play a role in sister-chromatid cohesion in metazoans.

219 they modify different effectors and regulate sister-chromatid cohesion in opposing ways.

220 Proper sister chromatid cohesion is critical for maintaining ge

221 Timely release of sister chromatid cohesion is essential for accurate chro

222 Cohesin-mediated sister chromatid cohesion is essential for chromosome se

223 Sister chromatid cohesion is essential for tension-sensi

224 Sister chromatid cohesion is essential to maintain stabl

225 The mechanistic details by which sister chromatid cohesion is established and maintained

226 Sister chromatid cohesion is established during replicat

227 , and essentially nothing is known about how sister chromatid cohesion is established in plants.

228 cent studies have provided insights into how sister chromatid cohesion is established, less is known

229 Sister chromatid cohesion is generated during DNA replic

230 Sister chromatid cohesion is mediated by entrapment of s

231 Sister chromatid cohesion is normally established in S p

232 lents lack normal asymmetrical features, and sister chromatid cohesion is prematurely lost during the

233 To investigate how and when sister chromatid cohesion is released from chromosomes i

234 Sister chromatid cohesion is thought to involve entrapme

235 The contribution of DNA catenation to sister chromatid cohesion is unclear partly because it h

236 At the onset of anaphase, sister-chromatid cohesion is dissolved abruptly and irre

237 binational exchange of chromosome arms after sister-chromatid cohesion is established but before chro

238 Sister-chromatid cohesion is established by Eco1-mediate

239 We provide genetic evidence to show that sister-chromatid cohesion is not necessary for activatio

240 Cohesin, the protein complex that mediates sister chromatid cohesion, is required for faithful chro

241 cohesin-associated protein known to regulate sister chromatid cohesion, is required for homologue pai

242 Apart from its role in mediating sister chromatid cohesion, it is also important for DNA

243 ophase chromosome morphology and for meiotic sister-chromatid cohesion leading to a reductive chromos

244 proteins SOLO, SUNN, and ORD is required for sister-chromatid cohesion, localizes to the centromeres

245 a decrease in securin that ultimately causes sister chromatid cohesion loss.

246 Sister chromatid cohesion mediated by the cohesin comple

247 Sister chromatid cohesion mediated by the cohesin comple

248 Sister-chromatid cohesion mediated by cohesin ensures pr

249 Sister chromatid cohesion, mediated by cohesin complexes

250 ition to its canonical function of mediating sister chromatid cohesion, might also be involved in reg

251 CR) recruits protein complexes that regulate sister chromatid cohesion, monitor tension, and modulate

252 either sever a univalent along the plane of sister chromatid cohesion or knock out one of a univalen

253 ility by impairing homologous recombination, sister chromatid cohesion, or mitotic spindle function.

254 in genes implicated in kinetochore function, sister chromatid cohesion, or relatively late steps of D

255 usly envisioned and suggest that CDK acts in sister chromatid cohesion parallel to Ctf7p reactions.

256 he ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the natur

257 a cohesin-interacting protein essential for sister chromatid cohesion, plays a novel role in the res

258 The prevailing embrace model for sister chromatid cohesion posits that a single cohesin c

259 xibility, enhancing our understanding of the sister chromatid cohesion process.

260 pl-Pds5 binding to the cohesin subcomplex of sister chromatid cohesion protein 1 (Scc1) and stromal a

261 PDS5B is a sister chromatid cohesion protein that is crucial for fa

262 Our data suggest that sister-chromatid cohesion proteins not only maintain the

263 ilitating the recruitment of kinetochore and sister-chromatid cohesion proteins, both required for co

264 Sister chromatid cohesion provides the mechanistic basis

265 rization (Kinesin-8, Kinesin-13), or mediate sister-chromatid cohesion (Rad21) in order to explore ho

266 r results indicate that Aust is required for sister chromatid cohesion, recruitment of the CPC to kin

267 Sister chromatid cohesion refers to the process by which

268 In MAD2/mad2Delta cells with normal sister chromatid cohesion, removing one copy of MAD1 res

269 The process, termed sister chromatid cohesion, requires the multisubunit coh

270 During mitosis and meiosis, sister chromatid cohesion resists the pulling forces of

271 We suggest that, in the absence of SeqA, the sister-chromatid cohesion 'safety spacer' is destabilize

272 sure correct meiotic chromosome segregation, sister chromatid cohesion (SCC) needs to be maintained f

273 Sister chromatid cohesion (SCC), efficient DNA repair, a

274 meiosis begins, sisters are held together by sister chromatid cohesion (SCC), mediated by the cohesin

275 e cohesin, the protein complex that mediates sister chromatid cohesion (SCC).

276 o observe that loss of Hst3 function impairs sister chromatid cohesion (SCC).

277 chromatin requires the heterodimeric complex sister chromatid cohesion (Scc)2 and Scc4 (Scc2/4), whic

278 Other conditions, like sister-chromatid cohesion (SCC), may span several chromo

279 During meiosis, sequential release of sister chromatid cohesion (SSC) during two successive nu

280 lls depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role

281 without premeiotic chromosomal replication, sister chromatid cohesion, synapsis or recombination.

282 cellular functions including gene silencing, sister chromatid cohesion, telomere biology, heterochrom

283 During the cell cycle, sister-chromatid cohesion tethers sister chromatids toge

284 Sororin is a positive regulator of sister chromatid cohesion that interacts with the cohesi

285 te the establishment and two-step release of sister chromatid cohesion that underlies the production

286 ability, including homologous recombination, sister chromatid cohesion, the spindle checkpoint, postr

287 lso provide evidence that implicates SepB in sister-chromatid cohesion, thereby suggesting that cohes

288 g S phase is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome

289 Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell sur

290 hanistic) importance in linking the sites of sister chromatid cohesion to the chromosomal regions tha

291 Loss of sister-chromatid cohesion triggers chromosome segregatio

292 A role of ChlR1 helicase in sister chromatid cohesion was first evidenced by studies

293 In addition, defective sister chromatid cohesion was observed in five HNSCC cel

294 Kleisin-like protein and ORD is required for sister-chromatid cohesion, we tested the hypothesis that

295 ubunits of the cohesin complex that controls sister chromatid cohesion, whereas NIPBL facilitates coh

296 rotein complex is best known for its role in sister chromatid cohesion, which is crucial for accurate

297 Cohesins mediate sister chromatid cohesion, which is essential for chromo

298 Sister chromatid cohesion, which is essential for mitosi

299 Sister chromatid cohesion, which is mediated by the cohe

300 The ring model predicts that sister chromatid cohesion would be lost by transient hin