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1 strates and their associated phosphorylation sites for 12 human kinases and kinase families, includin

2 ls of recently proposed 'off target' binding sites for [(18)F]AV-1451, such as neuronal monoamine oxi

3 olution (8 mg) or placebo into 2 intact skin sites for 2 days in 4 of 5 patients.

4 application 3 times daily at 2 open erosion sites for 2 weeks.

5 To date, a receptor/binding site for 20-HETE has been implicated based on the use of

6 n data through 2 years of follow-up at 55 US sites for 213 adults with PDR.

7 rly 2 kb upstream of the transcription start site for 68 alleles from 57 major lineages of classical

8 nce differed significantly between the study sites for 7/22 of the best-performing antigens.

9 e chlamydial inclusion serves as an enriched site for a deubiquitinating activity exerting a function

10 ers, rs11855145, directly alters the binding site for a nuclear factor.

11 cket in BGT1, which accommodates the binding site for a series of novel noncompetitive inhibitors.

12 mal treatment yields silica-supported M(III) sites for a broad range of metals.

13 ates competition between neighboring binding sites for a local pool of TF molecules explains this beh

14 is was used to determine genome-wide binding sites for a range of different TFs in multiple cell type

15 S) can be used to map small-molecule binding sites for a rapidly aggregating protein.

16 ods for specifically identifying which motif sites for a specific factor are bound has not been perfo

17 lity exists in footprint signal across motif sites for a transcription factor.

18 predicted to be two copies of each class of sites, for a total of four sites per receptor.

19 ts suggested that the colon is a significant site for absorption of bioactive components such as anth

20 to position a targeted lysine in the active site for acetylation.

21 Motor neuron innervation determined the sites for AChR clustering, a complete reversal of normal

22 RpL4 extension harbours overlapping binding sites for Acl4 and the nuclear transport factor Kap104,

23 was further demonstrated to serve as a major site for active TRIF signaling events, thus linking phag

24 solic region was found to have an allosteric site for acyl-CoA/CoA.

25 aceutical potential for targeting the APP673 site for AD drug development.

26 aceutical potential for targeting the APP673 site for AD drug development.SIGNIFICANCE STATEMENT beta

27 ts and finite number of receptor-methylation sites for adaptation go beyond perturbation theory.

28 ion in the moricin promoter contains binding sites for additional transcription factors.

29 Transiently reduced Pt atoms serve as active sites for Ag ions to grow, thereby playing a key role in

30 ing calculations around the observed binding site for all three states of the receptor, including a m

31 The Si site offers a novel target site for allosteric inhibitors and a molecular explanati

32 multi-segmented nexus with distinct binding sites for Ame1, Nkp1-Nkp2 and Ctf19-Mcm21.

33 ously unknown site adjacent to the canonical site for AMP.

34 RI) schedule in March 2015 and was the pilot site for an RI data module for the National Health Manag

35 surface of gold nanoarrays to produce active sites for anchoring the molecularly imprinted film.

36 s increasing interest in those ecosystems as sites for anthropogenic greenhouse gas emission offset p

37 d PB2, which could be important in targeting sites for anti-influenza intervention.

38 ing material, and a well-defined conjugation site for antibody modifications.

39 e the Nef dimerization interface as a target site for antiretroviral drug development.

40 One core element, containing binding sites for AP1 family and the macrophage-specific transcr

41 es at active enhancer regions and at binding sites for AP1-complex components, including c-Fos.

42 ns to the vlBNST, which is also the effector site for ATII-responsive SFO neurons.

43 A docking study revealed some critical sites for ATP binding and metal binding.

44 the engineered MBD1 function as a nucleation site for AuNP synthesis, allowing the construction of hy

45 It provides a site for authors to deposit experimental data as well as

46 prevents signaling by binding to a putative site for B7-H6 dimerization.

47 357, which forms a consensus phosphorylation site for basophilic kinases, markedly reduced the endocy

48 pid cardiolipin functions as a first contact site for Bax during its translocation to the MOM in the

49 The high RTDs on sun-exposed body sites for BCC and SCC are in keeping with sun exposure a

50 The Kindlin-2 binding sites for beta- and gamma-catenin reside within its F1 a

51 We found that the binding sites for betaEST and dFBr communicate with the Cys loop

52 urthermore, we identified that Ser255 is the site for Bmi-1 O-GlcNAcylation, and O-GlcNAcylation prom

53 nsensus sequence GGC(GC)|(CG) as the binding site for both TGF-beta and BMP-activated Smads and for S

54 es enriched toward the transcriptional start sites for both induced and repressed genes.

55 ffold protein TOPBP1(Dpb11) provides binding sites for both pro- and anti-resection factors at DSBs,

56 PKD prevalence in the sampled sites for both young-of-the-year (YOY) and adult brown t

57 Acetyl-lysine modifications create docking sites for bromodomains, which are structurally conserved

58 Instead, we identified a new site for c-Abl-mediated phosphorylation, Tyr-397.

59 Our results demonstrate that the binding site for C1 represents a new pharmacological vulnerabili

60 presence of high-nanomolar affinity binding sites for CaM at its universal gating brake and its uniq

61 Seagrass meadows are important sites for carbon storage.

62 s increasingly adopted as the primary access site for cardiac catheterization because of patient pref

63 we have identified the nucleolus as a novel site for caspase-2 activation and function.

64 teine ligand to create a vacant coordination site for catalysis and close by considering the implicat

65 Identification of active sites for catalytic processes has both fundamental and t

66 021 in PDGFRbeta was the primary interaction site for Cbl-b, with some contribution from Tyr-1009.

67 is on chromosome 8q24, adjacent to a binding site for CCAAT/enhancer-binding protein beta, a transcri

68 on powder diffraction studies on the binding sites for CD4 within MFM-132a and MFM-115a reveal that t

69 of NPC1, which contains the initial binding site for cholesterol.

70 exert force that exposes an otherwise buried site for cleavage.

71 allenge of identifying critical connectivity sites for conservation in the presence of global change.

72 n electropositive cavity and proposed "entry site" for copper ion delivery on immature Sod1.

73 tory tract represents an important induction site for cytotoxic T lymphocyte (CTL) immunity to airbor

74 Phytophthora infestans haustoria are thus sites for delivery of both apoplastic and cytoplasmic ef

75 ts monomers, exposing the PP2A/RACK1 binding site for dephosphorylation.

76 rted cycloalkynes, SNO-OCTs contain multiple sites for derivatization, display stability under a vari

77 The gut epithelium is a principal site for detecting such agents, but precisely how it com

78 rovides reproducible results across multiple sites for detection of carbapenemases.

79 he int-1-GATA site could serve as a valuable site for diagnosing XLSA in cases with unknown mutations

80 f the individual CN(-) ligands of the (2FeH) site for different redox states of the H-cluster.

81 Oylations of target proteins provide docking sites for distinct adapter and effector proteins importa

82 ealing that the ATPase domain is the primary site for DNA binding, and is required for nuclease activ

83 genome can be genetically encoded by binding sites for DNA-binding proteins and can also involve chan

84 re, PSI-photosystem II contact zones provide sites for docking phycobilisomes and the formation of me

85 The preferred sites for doped O atoms are the centers of Bi4 squares i

86 This finding raises questions about the sites for doped oxygen, the mechanism of superconductivi

87 hodology applicable to correlate gene damage sites for drug and pollutant metabolites with mutation s

88 e to acrylic acid) require specific reaction sites for each oxidation step and benefit from site isol

89 was collected from LAgP diseased and healthy sites for each participant.

90 ddition, the PGC-1alpha promoter has binding sites for early growth response 3 (Egr3), which plays a

91 oligomers with multiple independent binding sites for EGCG with a Kd approximately 10-fold lower tha

92 ystal termination planes are the most likely sites for electron trapping and thus nanometer-scale per

93 guinal white adipose tissue (iWAT), a common site for emergent active iBAT.

94 heteroatoms could provide additional defect sites for encapsulating iodine while the porous carbon s

95 These results show that HVC is a key site for encoding song syntax in the Bengalese finch.

96 ounds that directly acted on the orthosteric sites for endogenous ligands.

97 nances responded similarly to warming across sites for Engelmann spruce, but differently for limber p

98 flexible terminal and loop regions as major sites for enzyme diversification, and identify targets f

99 ting flow, either primarily through poration sites for fast ICWs or opening of mechanosensitive ion c

100 model therapeutic protein, were selected as sites for fatty acid-conjugation.

101 ng is successively changed by opening up new sites for finger placement.

102 By inserting binding sites for fluorescent proteins adjacent to the rRNA oper

103 a circumferential paraxial ring at putative sites for formation of the outer cortex/cuticle of the h

104 th more undercoordinated and enhanced active sites for fuel cell applications.

105 for RNaseH2 in protecting or marking nicked sites for further processing.

106 and located within their C-terminal binding sites for Gbetagamma proteins that mediate membrane-deli

107 omology domain harbored an exclusive binding site for GCAP1 with similar affinities as the full-lengt

108 catalytic selectivity of the nuclease active site for genome stability.

109 ch correlated with the two suggested binding sites for GMF.

110 33 IgV domain, which is the antibody-binding site for GO, as well as diagnostic immunophenotypic pane

111 Mac-1(-/-)) or mutation of the Mac-1-binding site for GPIbalpha have delayed thrombosis after carotid

112 m roots, where a physical separation between sites for gravity sensing and curvature response has fac

113 al groups in the pore as the primary binding sites for guest molecules.

114 surfaces represent the nature of the active site for H2O2 decomposition on the supported Pd catalyst

115 on of Lys9 of histone H3 (H3K9me), a binding site for heterochromatin protein 1 (HP1).

116 ficient real-time visualisation of available sites for HG crosslinking within cell wall microdomains.

117 s) within lymph nodes (LNs) serve as primary sites for HIV-1 replication.

118 t (FRT) is one of the major mucosal invasion sites for HIV-1.

119 The liver as transplantation site for human pancreatic islets is a harsh microenviron

120 is region of gD contains most of the binding site for HVEM, an HSV receptor important for virus infec

121 5' RACE indicates a transcription start site for HYDIN2 outside of the duplication and we observ

122 6 and cereblon away from the modeled binding site for Ikaros/Aiolos.

123 sistance, the intestine is emerging as a new site for immunologic changes that affect whole-body meta

124 potential were integrated into a single FRT site for inducible expression.

125 Skeletal muscle is the major site for insulin-stimulated glucose disposal, and muscle

126 es have implicated the spleen as an anatomic site for integration of inflammatory signals from the in

127 e concerns over the potential of the BM as a site for islet allotransplantation.

128 Subcutaneous tissue is a promising site for islet transplantation, due to its large area an

129 ly hydrophobic, but in complex I the binding site for its redox-active quinone headgroup is approxima

130 lial cells through lysine 183 as an acceptor site for K48 polyubiquitination.

131 onsistent with the brain forming a sanctuary site for latent virus and low-level viral replication in

132 The sigma-holes are binding sites for Lewis bases, and binding energies correlate wi

133 disciplinary scientists and accessible field sites for long-term monitoring of the Earth's subsurface

134 ains the following two high affinity binding sites for LRP1: one is located within domains 1 and 2, a

135 t the kinase C-lobe, adjacent to the binding site for Mam1.

136 The lymph node periphery is an important site for many immunological functions, from pathogen con

137 Moreover, the binding site for Mcm10 on MCM includes the Mcm2 and Mcm6 subunit

138 regulatory roles of the 3'UTRome as binding sites for microRNAs or RNA binding proteins, or during a

139 e 3'-UTR of CDKN1A, which contains a binding site for miR-95-3p.

140 repression of egl-1 is dependent on binding sites for miR-35 and miR-58 family miRNAs within the egl

141 KEY MESSAGE: The binding site for miR398 in an isoform of Cu/Zn superoxide dismut

142 show that HSPC uropods are the preferential site for MkMP binding, and that CD54 (ICAM-1), CD11b, CD

143 ference in the enzyme's second metal binding site for Mn(II) over Mg(II), suggesting that T7 DNA prim

144 horn (DH) of the spinal cord is an important site for modality-specific processing of sensory informa

145 kappaB-dependent kinase proviral integration site for Moloney murine leukemia virus-1 (PIM-1), which

146 all NMR parameters: Starting as a nucleation site for monomer-monomer contacts, this six-residue sequ

147 Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and t

148 procedure that creates additional recording sites for myoelectric prosthesis control.

149 s of the photoreceptor may serve as critical sites for myopia development.

150 r, the CeA has primarily been studied as the site for negative behaviors, and the causal role for CeA

151 The sternum is an uncommon site for neoplastic involvement and metastases are far c

152 Rosetta predicted receptor sites for nifedipine in the fenestration region and for

153 h contain phenylalanine-glycine (FG) binding sites for nuclear transport receptors.

154 rface area and an increased number of active sites for OER and ORR.

155 g and RNase H cleavage identified accessible sites for oligonucleotides in the revealed secondary str

156 ost Ribi gene promoters also contain binding sites for one or more General Regulatory Factors (GRFs),

157 ulatory region of the SbCAD2 can be a target site for optimizing lignin modification in sorghum and o

158 urrent rates of sea-level rise and, for most sites, for over a century with projected medium accelera

159 of the intermediate allylic free radical two sites for oxidative product formation are possible, and

160 M in MKK3 is distinct from the known binding sites for p38 or upstream kinases.

161 Transcription factor binding sites for p53, MEF2A and E2F1 were significantly (P < 0.

162 as expected to form a coating over favorable sites for PAA-nano-ZVI attachment and hence reduce the a

163 ACKGROUND DATA: The liver as transplantation site for pancreatic islets is associated with significan

164 477) of HIF-1alpha as a major ubiquitination site for Parkin.

165 This C-terminal tail displays the binding site for partner proteins and we report how it modulates

166 iscrete clusters coinciding with interaction sites for partner macromolecules: the methyl-CpG binding

167 to adopt radial access as the default access site for percutaneous coronary intervention wherever pos

168 erved domains and at the C terminus, contain sites for phosphorylation by multiple protein kinases.

169 in hSSCs was strikingly enriched in binding sites for pioneer factors (NFYA/B, DMRT1, and hormone re

170 n of ectopic neurites; the lack of potential sites for polyamination and polyglutamination on TBA-7 m

171 describe a newly identified, Sox4-regulated site for post-translational modification with small ubiq

172 orming key roles in catalysis and serving as sites for post-translational modification.

173 nal portions of the core histones constitute sites for posttranslational modifications of major epige

174 in allostery and design of unique allosteric sites for potential enzyme inhibitors with regulatory or

175 Previous studies have shown that the binding site for potentiating betaEST is in the C-terminal (post

176 electrophysiology, we identified the binding site for potentiating dFBr on the top half of a cavity b

177 aM signaling modules to specific subcellular sites for precise regulation of Ca(2+)-dependent process

178 other times, potentially liberating sorption sites for processing of subsequent incoming phosphorus.

179 er amino acid residues in the GERAMT-binding site for proper chaperone-dependent regulation of SOD2 a

180 the A-967079 cavity is a positive modulatory site for propofol.

181 nsight into the number of functional binding sites for propofol and the energetic contributions stemm

182 o additional functionally equivalent binding sites for propofol, other than those modified by substit

183 no acid sequence revealed potential cleavage sites for proteases of the proprotein convertase family

184 molecules present, provides many interaction sites for proteins, enabling high loading efficiency and

185 RT domain binds to the PH domain at the same site for PtdIns(4)P-binding, suggesting that the START d

186 We pinpoint macropinosomes as the sites for Rab8-mediated biasing of inflammatory signalin

187 entific sessions abstracts, and relevant Web sites for randomized trials with a follow-up of >/=2 yea

188 extension of MotifMap which predicts binding sites for RBP motifs across human and mouse genomes and

189 tions such as Na(+) and a spatially distinct site for reabsorption of divalent cations such as Ca(2+)

190 roughly half the mass of Env, the functional sites for recognition of receptor CD4 and co-receptor CX

191 septation and also acts to position the dif sites for recombination.

192 (PPT) nucleus has long been considered a key site for regulating wakefulness and REM sleep.

193 rtex gradually becomes critical as a storage site for remotely acquired memories.

194 ne receptors acting as scaffolds and docking sites for required downstream JAK/STAT proteins.

195 on, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome cofactors Mt

196 ses the relative importance of mitochondrial sites for ROS production, ROS signaling-mediated regulat

197 ediated changes in the transcriptional start site for RTC4 and the production of a RTC4 transcript wi

198 P = .03) and KRAS (P = .02) by primary tumor site for SAR.

199 ylated CpG sites, which are also recognition sites for Sau96I and SacII, and is attached to a fluorop

200 e long-standing controversy about the active sites for SCR of NO with NH3 by supported V2O5-WO3/TiO2

201 RNAs, recoding oligo-U domains as potential sites for secondary structure or tertiary contact.

202 The basolateral amygdala is the main entry site for sensory information to the amygdala complex, an

203 ic inheritance of silencing requires binding sites for sequence-dependent activating transcription fa

204 d that the exon 11 sequences contain binding sites for serine/arginine-rich splicing factor 2 (SRSF2)

205 ivery of vaccines helps target the inductive sites for SIgA responses.

206 The coiled-coil is a docking site for sigma factors on RNA polymerase, and evidence i

207 nduced enhancers/SEs are enriched in binding sites for signal-dependent transcription factors and dep

208 nes are increasingly recognized as a primary site for silicic differentiation at a range of volcanic

209 KIgamma acts as the major ubiquitin acceptor site for Smurf1.

210 s not accessible to the corresponding active site for SOAT2 located on the luminal side.

211 Although binding sites for some activators have been identified, the loca

212 tibodies (bNAbs) but can also expose binding sites for some types of nonneutralizing antibodies (non-

213 (3) The binding sites for SOX2 and POU5F1 in mouse embryonic stem cells

214 Since nuclear speckles are storage sites for splicing factors, which leave these sites to s

215 istant mutants suggested a different binding site for SQAs on ATP synthase.

216 Noting that the two sites for ST8Sia-IV autopolysialylation flank the PBR, w

217 hiourea-based outer cleft, providing perfect sites for step-wise binding of two anions within a singl

218 on to the Orai C terminus, the main coupling site for STIM1, the Orai N terminus is indispensable for

219 large clusters in the bladder lumen that are sites for stone formation.

220 Antarctic ice-covered lakes are exceptional sites for studying the ecology of aquatic fungi under co

221 ity facilitate the exposure of the catalytic site for substrate cleavage.

222 ccinate and citrate, elucidating the binding sites for substrate and two Na(+) ions.

223 s identify K239 as the only high-probability site for SUMO modification.

224 tion of CO2 molecules, and offer rich active sites for surface redox reactions.

225 we inspected 293 significant archaeological sites for swine disturbance across a vast area.

226 Vinculin has binding sites for talin and F-actin, but effective binding requi

227 prefusion structures presents many potential sites for targeting in therapeutic interventions.

228 ning replication origins proximal to binding sites for Taz1, a component of the Shelterin telomere pr

229 conformational change that exposes a cryptic site for the actin-binding protein vinculin.

230 The conjunctiva is a common site for the allergic inflammatory response due to it be

231 2227473 is located within a putative binding site for the aryl hydrocarbon receptor, a master regulat

232 land and having a predicted promoter binding site for the As(III) oxidation regulator AioR.

233 phorylated LAT selectively on a single Y-171 site for the binding to adaptor complex GRB-2-SKAP1.

234 conserved MELT motifs to generate a binding site for the Bub3-Bub1 complex [4-7].

235 ore for the C4R1 dimer, but only one binding site for the C8R1 dimer.

236 The intestinal epithelium is a major site for the conversion of dietary beta-carotene to reti

237 nsensus sequence resembles the E-box binding site for the core circadian transcription factor CLOCK/C

238 l ankyrin repeat domain as the most critical site for the ERK-dependent modulation of TRPV3 channel a

239 hanging the affinity of a remote recognition site for the interlocked crown ether ring through electr

240 It affects a binding site for the miR-16 family and miR-103/miR-107 within th

241 dentification of the most relevant catalytic site for the oxygen reduction reaction (ORR) and (ii) de

242 ence of low levels of H3K9me3 at the binding site for the PF3D7_1466400 AP2 transcription factor.

243 bind to the sAC-specific, allosteric binding site for the physiological activator bicarbonate.

244 onformational shift that exposes the binding site for the PKR substrate eIF2alpha.

245 n which the POTRA domains serve as a binding site for the preprotein as it emerges from the Toc75 cha

246 , both residues lie within the final docking site for the protease in the antithrombin-protease compl

247 Whereas NALTs served as the induction site for the recall expansion of memory CD8(+) T cells f

248 e ribosome biogenesis represents a potential site for the regulation of skeletal muscle protein synth

249 a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, thereby dir

250 I in two different CaV isoforms as a binding site for the SH3 domains and report a crystal structure

251 Some serve on-site for the synthesis of retinoic acid, a hormone-like

252 nformational switch that creates the docking site for the tail nozzle only after the assembly of adap

253 rnary complex reveals a noncanonical binding site for the toxin that adopts a novel conformation.

254 was predicted to disrupt a consensus binding site for the transcription factor ETS within an enhancer

255 uct, in which 2xCL denotes a tandem cleavage site for the viral protease.

256 se phosphorylations create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to

257 A Flower mutant lacking binding sites for the endocytic adaptor AP-2 proteins fails to r

258 rfaces provide more heterogeneous nucleation sites for the eta' precipitates in the MPZ.

259 ifs enriched in the PREs are cognate binding sites for the identified transcription factors and are n

260 xygen diffusion channels, but also preferred sites for the induced oxygen vacancies.

261 Apical dendrites of Betz cells are important sites for the integration of cortical input, however the

262 resent models for how MRX-Sae2 creates entry sites for the long-range resection machinery.

263 each isomer, clearly indicating the binding sites for the major conformers in the presence of multip

264 This CpG-island contains binding sites for the methylation-sensitive transcription factor

265 We reveal novel functional target sites for the microRNAs miR-181a, miR-30a, and miR-155 i

266 I155) in the syntaxin-1 linker region as key sites for the MUN domain interaction.

267 s to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion protein SlmA and genera

268 These colloids appear to provide nucleation sites for the perovskite crystallization, which critical

269 as a tethering complex with just two binding sites for the Rab7-like Ypt7 protein to determine their

270 In screening for collagen substrate sites for the remaining members of the vertebrate P3H fa

271 nhancers frequently contain multiple binding sites for the same transcription factor.

272 ent to the guide region, function as binding sites for the snoRNP proteins including the enzymatic su

273 s and support the use of tonsils as lymphoid sites for the study of germinal center reactions after v

274 They are of broad interest as a site for therapeutic intervention in serious mental illn

275 te PTEN and identify high-confidence binding sites for these miRNAs on the 3' UTR of protein coding g

276 ve identified pathways that link the binding sites for these modulators to the Cys loop, a region tha

277 Pathway analysis of binding sites for these three microRNAs revealed enrichment of t

278 cently identified as a mitochondrial binding site for thiazolidinediones, including MSDC-0602.

279 in clinical practice, the prototypic binding site for this class of drugs within pLGICs is yet to be

280 isparity discrimination, as yet the earliest site for this task.

281 thics committee approval was obtained at all sites for this prospective, multicenter study.

282 strate that the mucosae may be the preferred sites for this virus in mice.

283 have inserted two glycans into the dominant site for tier-1 NAbs, the gp120 V3 region, to block the

284 of human Timeless harbours a partial binding site for Tipin.

285 g a cavity suggestive of a potential binding site for transcription-promoting small molecules.

286 ecause of the presence in area IV of binding sites for transcription factors associated with pancreas

287 Among them there are multiple binding sites for transcription factors controlling the regulati

288 ver, about how DNA binding can affect distal sites for transcription factors.

289 ights the medial parietal cortex as a target site for transforming neural activity into control signa

290 mal and human studies reveal other potential sites for treatment in this complex host of disorders.

291 predominantly in liver and small intestine, sites for triglyceride-rich lipoprotein biogenesis and e

292 concertedly function as the primary docking site for twin-arginine signal peptides.

293 ur data indicate that the BNST is a critical site for U50,488-induced reinstatement of alcohol seekin

294 data suggest that there is only one binding site for ubiquinol in cyt bo3 and that site corresponds

295 ibutes to formation of a bowl-shaped binding site for ubiquitin.

296 in brown and beige adipocytes, the principal sites for uncoupled respiration.

297 detect arrhythmogenic substrate and critical sites for ventricular tachycardia.

298 metal/support interface provides the active site for WGS reaction, acting as a reservoir for oxygena

299 edominantly focuses on engineering the metal site, for which physical insights based on extensive the

300 We found moderate conservation of CpG sites for which methylation is altered with age, with bo