ライフサイエンスコーパス: site of

1 bstituents in the BODIPY subunit defines the site of (1)O2 addition.

2 374W and R448C) or substrate-binding (W116C) site of 11beta-hydroxylase, or alterations in its stabil

3 ility regions with the transcriptional start sites of 304 target genes.

4 duplex is established between the 5' splice site of a pre-mRNA and the 5' end of the U1 snRNA.

5 and ICCV 96029, this gene was mapped to the site of a quantitative trait locus on Ca5 that explained

6 om AAV serotypes and homology of recognition sites of AAV Nab located on different capsid subunits fr

7 ents who harbor mutations in the ATP-binding sites of ABCB4.

8 At the molecular level, the sites of abnormal oral adhesions maintained periderm-lik

9 concentrations and targeted delivery to the site of action appear possible, and most importantly, re

10 c rescues, determining DAF-6/patched-related site of action during sensory-organ development.

11 n the rodent spinal dorsal horn, a principal site of action for opiate analgesia.

12 However, a peripheral site of action is indicated by the ability of intravenou

13 ify Adelta meningeal nociceptors as a likely site of action of fremanezumab in the prevention of head

14 ed antihyperalgesia indicating a supraspinal site of action.

15 ion of tissue distribution and access to the site of action; the second, engagement of the target; an

16 form interacting SNARE proteins reach their sites of action is virtually unknown.

17 We incorporated sites of action of four drugs (palbociclib, gemcitabine,

18 in pruritogen-induced scratching may involve sites of action other than the primary afferent terminal

19 d therefore offer both multiple and variable sites of action.

20 tility in transcriptional reporter analysis, site-of-action experiments and exogenous transgene expre

21 tion of mTORC1 to the lysosomal surface, its site of activation.

22 tion of mTORC1 to the lysosomal surface, its site of activation.

23 Microglia and macrophages accumulate at the sites of active demyelination and neurodegeneration in t

24 HMPV IBs were shown to be cytoplasmic sites of active transcription and replication, with the

25 eratinocyte-specific gene loci away from the sites of active transcription toward the heterochromatin

26 d plasmin inhibition system assembled at the site of acute pulmonary emboli in vivo.

27 cyclic trafficking of Ly6c(hi) monocytes to sites of acute inflammation.

28 s over acceptability of multiple injections, sites of administration, and safety.

29 ssibly other microorganisms and form EETs at sites of airway epithelial damage to protect the host fr

30 minus of chECL1, suggesting that the binding site of ALV-J gp85 on chNHE1 is probably located on the

31 information for patient care at the time and site of an encounter with the health care system.

32 It is also effective in locating the site of an unknown primary in NET patients who present w

33 ying functional genomics of important target sites of anthelmintics have been restricted to Caenorhab

34 we identified several P. gingivalis-binding sites of ArcA, which led to the discovery of an 11-mer p

35 cally interacts with the transcription start site of ARID5B, that alleles of rs7090445 have different

36 e as important as platelets to thrombosis at sites of arterial injury and that platelets contribute t

37 The mitochondrial network is a major site of ATP production through the coupled integration o

38 Papilla formation at the site of attack is essential for preinvasive immunity; in

39 ized with IgH-mu in the kidney, which is the site of B cell development.

40 tation of the electric field at the reactive site of [B12 Cl11 ](-) results in an energy barrier for

41 conformation of the inhibitor in the active site of BACE-1.

42 tion, shifted the preferential beta-cleavage site of BACE1 in APP from the Glu(11) site to the Asp(1)

43 he conservation of amino acids in the active site of BAM2, suggested that it might be catalytically a

44 studies have shed light on the question-the site of BDNF release at the synapse.

45 LS = 195 nm) and the mono- and trinuclear Cu sites of bilirubin oxidases.

46 es is highly efficient, identifying specific sites of biotinylation remains challenging.

47 th tranexamic acid, with no heterogeneity by site of bleeding (p=0.5956).

48 r modeling study demonstrated that A binding sites of BSA play the main role in the interaction with

49 urther indicate that Tyr-397 is the dominant site of c-Abl phosphorylation both in vitro and upon c-A

50 The inhibitor blocks the active sites of C1s and MASP-2, as well as the anion-binding ex

51 measure transfer frequency and identify the site of care completion for all patients seen in acute c

52 nal studies increasingly support iron as the site of catalytic activity but differ with respect to th

53 of the primary tumor (left vs right location site of CC) independent of other common clinicopathologi

54 viral proteins are actively recruited to the site of cell-cell contact where the viral material is ef

55 Using new reference models, we now identify sites of CENP-A and histone H3.1 binding within the mega

56 dicate that Hat1 is transiently recruited to sites of chromatin assembly, dissociating prior to the m

57 d recruitment of an XPA-ATR-pS435 complex to sites of cisplatin DNA damage.

58 lative T2 signal and anatomical adjacency to site of clinical onset.

59 atory glutamatergic synapse is the principal site of communication between cortical pyramidal neurons

60 ndent reduction of the dicarboxylate-binding site of complex II (site IIf); (b) pore opening in the i

61 series of homogeneous ADCs with a conserved site of conjugation, a monodisperse drug loading, a lyso

62 whole plant from their site of production to sites of consumption or storage.

63 t are far from the regulatory Ca(2+)-binding site of cTnC.

64 and attenuated global gene activation at the site of cutaneous VZV antigen challenge compared with yo

65 ucing-end mannoses into the domain A binding site of CV-N than with the nonreducing end unit.

66 These results indicate the first site of CWD prion entry is in the oropharynx, and the in

67 The relatively polar active site of CYP126A1 distinguishes it from its most closely

68 ves the mitotic spindle to the predetermined site of cytokinesis by pulling on astral microtubules.

69 recruit monocytes and dendritic cells to the site of damage through a breached blood-brain barrier or

70 By contrast, the site of delivery of the anti-IL-17A and anti-IL-13 Fab'

71 ly critical for cortical function and may be sites of deregulation in developmental brain disorders.

72 Furthermore, sites of differential methylation differed depending on

73 entially to DNA duplexes containing a single site of DNA damage (here a base mismatch) which inhibits

74 with deprotected telomeres and localized to sites of DNA damage in S phase.

75 D4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransfer

76 me-wide DNA damage, reduced end resection at sites of DNA damage, resulted in compromised HR and misr

77 ctivates ALC1 remodeling upon recruitment to sites of DNA damage.

78 nd is responsible for bringing the kinase to sites of DNA damage.

79 in the spatial exclusion of telomerase from sites of DNA repair.

80 sed to interact with the orthosteric binding site of dopamine receptors, was actually a negative allo

81 ents, which indicate two streams towards the sites of dorsal amniotic closure and ventral thoracic wa

82 and 2) its binding capability at interacting sites of Drp1 and Abeta complex.

83 The site of drug absorption was revealed by high spatial res

84 ly enriched for transcription factor binding sites of EBF1, EP300, and CEBPB (P < 5e-6).

85 The site of EHD affected survival, with portal, retroperiton

86 Around the transcription start sites of endo-MEGs, DNA methylation and H3K4me3 specific

87 Myo1p concentrates at the site of endocytosis and initiates a zone of actin filame

88 The liver is the primary site of endogenous glucose production, especially during

89 and functional studies and reveal additional sites of escape, such as positively charged mutations in

90 could improve delivery of antifungals to the sites of established infection and improve outcome in ex

91 The DNA-binding sites of estrogen receptor alpha (ERalpha) show great pl

92 MENT The accessory olfactory bulb (AOB) is a site of experience-dependent plasticity between excitato

93 usters surrounding the transcriptional start sites of expressed genes; its distribution was inversely

94 elial cells that houses the sperm and is the site of fertilization.

95 We therefore consider the likely site of first invasion and the probabilistic position of

96 uced microglial/macrophage activation at the site of focal inflammatory lesions, presumably by preven

97 minus were identified as the primary binding site of Gbetagamma.

98 We found FXR to bind to regulatory sites of genes encoding these proteins in control livers

99 (DSBs) can be directly generated by Top1 at sites of genomic ribonucleotides.

100 glutamate receptors (AMPARs) to postsynaptic sites of glutamatergic synapses.

101 nhibitor that covalently binds in the active site of GSTO1-1 can be used to ameliorate the inflammato

102 a wide range of vascular plants and are the sites of guttation.

103 on 166 (H3 numbering) in the major antigenic site of HA was reported to be responsible for the antige

104 The major antigenic sites of HA are located in the globular head subdomain,

105 cells and their progenitors are an important site of HCMV latency, and one viral gene expressed by la

106 rombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which earl

107 It is found that nuclei develop at sites of high stored energy and they have crystallograph

108 mismatches (MMs) at the antigen recognition site of HLA molecules represent independent and incremen

109 other demographic groups and other anatomic sites of HNSCC is unclear.

110 c paths between catalytic and ligand binding sites of hPDI.

111 Histone marks around transcription start sites of HSV-1-induced and constitutively transcribed an

112 ort a dominant mutation in the ATPase active site of human CLPX, p.Gly298Asp, that results in patholo

113 emtosecond dynamic coupling at the catalytic site of human purine nucleoside phosphorylase (PNP).

114 highly vascular organ and also an important site of immune reactions with a high density of dendriti

115 nteracting elements overlap with the binding site of importins on TPX2.

116 Biofilm formation at the site of infection reduces antimicrobial susceptibility a

117 ith bias direction dependent on pathogen and site of infection.

118 e divergent roles for IL-10 depending on the site of infection.

119 Recruitment and activation of neutrophils at sites of infection are driven by cytokine and chemokine

120 eacon to target pathogens to their preferred sites of infection in vivo.

121 ground in many important tissues that may be sites of infection such as the lungs and soft tissues.

122 ucosal plasma cells to mediate protection at sites of infection with that of bone marrow plasmablasts

123 tween photoreceptors and RPE) is the primary site of inflammation in ARPE.

124 olonization of the lower airways, the actual site of inflammation in asthma, which is hardly accessib

125 was highly specific to pathogenic IgG at the site of inflammation, driven by local platelet release o

126 innate effector function of Th2 cells at the site of inflammation.

127 d the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge

128 nuclear phagocytes, poised to extravasate to sites of inflammation and differentiate into monocyte-de

129 at 1 year, suggesting that control of remote sites of inflammation may translate into reduced coronar

130 Similarly, these Mphi precursors also enter sites of inflammation, gaining CD115, F4/80, and CD16/32

131 ctive oxygen species that is also present at sites of inflammation, on the ligand recognition functio

132 bearing mice, as well as on controls bearing sites of inflammation; the results clearly identified th

133 The plant cell wall, often the site of initial encounters between plants and their micr

134 The axon initial segment (AIS) is the site of initiation of action potentials and influences a

135 y of obtaining information about the primary site of injury, namely the distal small intestine.

136 njuries, BSCs are activated and recruited to sites of injury.

137 tation enhances viral dissemination from the site of inoculation independently of interferon regulato

138 of T cell activation or T cell homing to the site of inoculation.

139 icities likely accommodate the more numerous sites of insertion versus deletion editing as editosomes

140 of EGP during a clamp, reaffirming that the site of insulin action to control EGP is extrahepatic.

141 t integration is a stochastic event and that site of integration may be largely a function of chance.

142 ructural integrity of the transgene, precise site of integration, or its impact on the host genome.

143 The intestinal tract is a site of intense immune cell activity that is poised to m

144 expression of alpha-synuclein mutated at the site of interaction with dopamine prevented dopamine-ind

145 nhancing or suppressing N-glycosylation at a site of interest and valuable data for a better understa

146 ChIP-seq is challenging because the binding sites of interest tend to be more common in high GC-cont

147 al DNMT3A concentration to methylate genomic sites of interest.

148 o function redundantly with the splice donor site of intron 36.

149 icoccum sorghinum The most common anatomical site of isolation was superficial tissue (66.5%), follow

150 dopamine receptor subtype nor identified the site of its action in mPFC.

151 ype responsible for the GABA release and the site of its modulation by dopamine.

152 fected with John Cunningham virus (JCV), the sites of JCV persistence remain incompletely characteriz

153 The north African site of Jebel Irhoud contains one of the earliest direct

154 tal samples obtained from the Greater Nicoya sites of Jicaro and La Cascabel in northwest Costa Rica

155 e, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-ba

156 nsuberized endodermal cells, rather than the sites of lateral root emergence, mediates the transport

157 The structure of the effector site of LmFBPase shows different structural features com

158 ry T-cell proliferation in tissues distal to site of lymphatic injury contributes to impaired innate

159 IV-1 as a model system strongly suggest that sites of m(6)A addition not only are evolutionarily cons

160 Contrary to the sites of Mcm2-7 recruitment being precisely defined, onl

161 Age at diagnosis and body site of melanoma.

162 isease, with the liver being the most common site of metastatic disease.

163 se findings support the role of EVs as early sites of mineral nucleation and demonstrate their value

164 cans situated at variable distances from the site of misfold.

165 17b, which bind within the substrate-binding site of MMP-13 and surround the catalytically active Zn(

166 ows structural similarity to the GTP-binding site of MoaA, suggesting that the viperin substrate may

167 ity of the protein targets of CRMs and their sites of modification.

168 Mapping all detected and validated sites of modifications on a structural model of C9, as p

169 ical ubiquitination reactions identified two sites of mono-ubiquitination on the 40S protein eS10 as

170 (HER) activities at the edge and basal-plane sites of monolayer molybdenum disulfide (MoS2 ) synthesi

171 uantitative proteomics, we identify multiple sites of Mps1-regulated phosphorylation at the outer kin

172 f mutagenesis in the target protein-encoding sites of MSTN.

173 two CpG islands near the transcription start site of MYBL1 were identified, and O-GlcNAc levels regul

174 MYC ESE looping to the transcriptional stat site of MYC was dependent on EBNAs.

175 rden and less infiltration of macrophages to sites of mycobacterial infection, thus impairing granulo

176 marked by impeded blood conductance through sites of narrowed vessels.

177 NR4A3 expression is also increased at sites of neutrophilic inflammation in a human model of i

178 es , an intermediate form of the Cu4S active site of nitrous oxide reductase (N2OR) that is observed

179 GFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but

180 ses key amyloidogenic regions as a potential site of nucleation enabling dimerisation and subsequent

181 ns its known interaction with the intronic 3 site of NUMB exon 9 contributing to regulation of the No

182 e plant biotrophs that establish a sustained site of nutrient acquisition induce localized host endor

183 ) hydroperoxides docked well into the active site of Ohr from Xylella fastidiosa and were efficiently

184 effects of C9orf72 on survival by gender and site of onset.

185 immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regula

186 ription factor signatures of their embryonic site of origin, the pallium and subpallium.

187 associated with climate factors at accession sites of origin, indicating its potential involvement in

188 2(1H)-one does not bind to the kinase active site of over 380 human kinases including Akt.

189 The site of overt attention (fixation point) defines a spati

190 small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes with ac

191 In lipin 1, the PBD is the site of PA binding and sensing of the PA electrostatic c

192 The site of pain depends on the pain type or underlying mech

193 (n = 9; A.D. 800-1250) and the Casas Grandes sites of Paquime and Convento in northwest Mexico (n = 5

194 The evidence for a second functional site of PARTICLE triplex formation at WWOX suggests that

195 ainst numerous pathogens and is recruited to sites of pathogen detection where it accumulates within

196 uence (I56-K68) overlapping with the binding sites of patients' serum IgEs.

197 y conserved -GH- residues in the CGHC active site of PDI, we created PDI variants with a slowed react

198 (Glu-31 and Glu-61) in these domains may be sites of pH-sensitive interactions, and variants E31A an

199 bation with RBCs EhRab35 is recruited to the site of phagocytic cups as well as to the nascent phagos

200 vated genes requires the conserved predicted sites of phosphorylation in BT0366.

201 alf the identified proteins possess multiple sites of phosphorylation that are often clustered, where

202 a FRET-biosensor comprising the cGMP-binding sites of PKGIalpha.

203 endence of "hydrogen" adsorption in the step sites of platinum electrodes.

204 ydroxylation activity which occurs in active sites of polysaccharide deacetylases (PDAs) from bacteri

205 onto the anterior wall of the uterus at the site of previous LSCS scar in a multipara female.

206 of 15 cases and may represent the preferred site of primary attack through cob(I)alamin.

207 ement of 20%, minimisation by hospital site, site of primary tumour, WHO performance status, 16-week

208 hus suggest that LFS transiently acts at the site of primordia initiation, where it provides a specif

209 Although TRM are often concentrated at sites of prior infection, it has been shown that TRM can

210 ported throughout the whole plant from their site of production to sites of consumption or storage.

211 The adrenals are a major endocrine site of production/secretion of constitutive pepcan-12,

212 and specificity, and detects extramedullary sites of proliferating clonal plasma cells while providi

213 omposition alone can be used to modulate the site of protein induction in vivo, highlighting the crit

214 -mediated endonucleolytic cleavage of DNA at sites of protein adducts requires ATP hydrolysis at both

215 dence of genes to the disparate, cytoplasmic sites of protein synthesis.

216 Identifying sites of protein-ligand interaction is important for str

217 Coastal wetlands are sites of rapid carbon (C) sequestration and contain larg

218 - depending on the host's immune status and site of reactivation - encephalitis or myositis can deve

219 Virus-specific CD8 T cells home to the site of recurrent infection and participate in viral cle

220 , despite substantial change in the specific sites of regulation.

221 Furthermore, fitness of S. aureus in these sites of replication is not compromised by the absence o

222 to transport to and from their intracellular sites of replication.

223 around branches, appear to be the preferred sites of resealing.

224 uring nodule formation in tissues underlying sites of rhizobial infection.

225 E, are used together to pinpoint the binding sites of rifamycin SV, doxycycline, and another molecule

226 at SA acts at or near the ubiquinone binding site of SDH to stimulate activity and contributes to pla

227 incrementally increasing copy number, may be sites of secondary selective pressure.

228 These hotspots may be sites of selective susceptibility to double-strand-break

229 ing SGS1 accumulate R-loops and gamma-H2A at sites of Sgs1 binding, replication pausing regions, and

230 d the lipoprotein signal peptide recognition site of signal peptidase II (SpII).

231 omethylated regions are enriched for binding sites of similar transcription factors, suggesting that

232 in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammator

233 The Cu(2+) complex binds to the active sites of SlyD, which suppresses its PPIase and chaperone

234 h infection in the seminiferous tubules, the site of spermatozoon development.

235 mboid enhancers mediating expression at each site of Spitz processing.

236 that NET2A-PRK interactions mediate discreet sites of stable interactions between the cortical longit

237 nmental stresses, where the signals from the site of stimulus perception are transmitted to distal or

238 ocalizes to the cell wall and is enriched at sites of stomatal pore initiation in cotyledons.

239 of an NSAID allosteric site-the MEF-binding site of SULT1A1-is determined using spin-label triangula

240 ng SUMO-remnant diglycyl-lysine (KGG) at the site of SUMO modification.

241 ns in the rostral raphe pallidus (rRPa), the site of sympathetic premotor neurons controlling thermog

242 n the cortex specific to dendrites, the main site of synaptic plasticity.Different stages of sleep, m

243 ays remained unchanged, suggesting divergent sites of synthesis for dominating and long-chain Dols.

244 The glycan-binding site of T1 sigma1 is located in the head domain and is p

245 8_Met2309dup), all falling in the nucleation site of the alpha/beta spectrin heterodimer region.

246 stigated the nature of the molybdenum active site of the arsenite oxidase from the Alphaproteobacteri

247 assume that the position of each connection site of the AZM macromolecules on their SV, directly lin

248 ted amino acid substitution in the catalytic site of the C-terminal nucleotide binding domain restore

249 zing the upper airways, at the human mucosal site of the disease.

250 ccur, they must first be bound in the active site of the enzyme in their phenolate anion form.

251 subplate cells in the lateral pallium at the site of the future insular cortex.

252 Here, we identify a new methylation site of the HIF1alpha protein antagonized by LSD1 and th

253 y of the 3' end to the ribosomal recruitment site of the mRNA could induce a feedback in the translat

254 ed a weak-binding ligand covering the active site of the protease without addressing the S1' pocket,

255 rporated into the nascent polypeptide at the site of the PTC.

256 indication of acetaminophen, and the precise site of the relevant CB1 receptors have remained elusive

257 We also noticed that the site of the RET gene mutation slightly influenced the ge

258 nd its bacterial ortholog EF-P bind in the E site of the ribosome where they contact the peptidyl-tRN

259 rmediates wherein peptidyl-tRNA enters the P site of the small ribosomal subunit via reversible, swiv

260 1A (eEF1A) delivers aminoacyl tRNAs to the A-site of the translating 80S ribosome.

261 activity excludes action through the genomic site of the VDR.

262 e two true local recurrences occurred at the site of the vessel.

263 face morphology, phase purity and the defect sites of the Al-TiO2 nanoparticles.

264 Multiple hospital sites of the Aravind Eye Care System, India.

265 d -poor functionality displayed at different sites of the arene.

266 ell as be a reservoir for infection at other sites of the body.

267 ed by coupling the dye molecules to specific sites of the DNA particle-linker strands, thereby modula

268 e aminocatalysis and anion-binding catalysis sites of the dual-function rotaxane catalyst can be sequ

269 ive in liver cells, enriched for the binding sites of the FOXA1, FOXA2 and HNF4A transcription factor

270 12 clinical research sites of the HIV Prevention Trials Network and AIDS Clin

271 urvival, estimated AA MMs at peptide-binding sites of the HLA-DRB1 molecule account for an important

272 Protonation of all basic sites of the hybrid material nearly doubles its conforma

273 Here we identify several acetylation sites of the influenza A virus nucleoprotein (NP), inclu

274 protein highly expressed at pressure-bearing sites of the mammalian footpad.

275 Large calderas, or supervolcanoes, are sites of the most catastrophic and hazardous events on E

276 ore particle, which contains the proteolytic sites of the proteasome.

277 leotides to the canonical nucleotide binding sites of the regulatory Bateman domain induces different

278 anglion cell and inner plexiform layers, the sites of the retinal ganglion cell bodies and dendrites,

279 two enzymes when they methylate two distinct sites of the same substrate may aid in developing therap

280 hese molecules directly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet un

281 active promoters, CpG island shores, binding sites of the transcription factor CTCF and brain eQTLs.

282 re we recorded from neurons within different sites of the vestibulo-spinal circuitry of behaving maca

283 reas, such as the hypothalamus, which is the site of thermoregulatory neurons, is critical for the fe

284 cs simulation studies elucidated the binding site of these aniline-based influenza fusion inhibitors,

285 comprehensively map the identity and binding sites of these RNAs are lacking.

286 f GSH and a base-off cobalamin in the active site of this enzyme.

287 f blood leukocytes across the endothelium to sites of tissue infection is central to inflammation, bu

288 is relatively restricted in distribution to sites of tissue injury.

289 gulatory lncRNAs that are targeted, at their site of transcription, by the YTH domain of the RNA-bind

290 hese interactions for recruitment of Spt6 to sites of transcription and for the maintenance of repres

291 ents were stratified by chemotherapy centre, site of tumour, and tumour stage.

292 papers; specificity, 82%); identification of site of unknown primary in patients with metastatic NET

293 Platelet aggregation at the site of vascular injury is essential in clotting.

294 is by enhancing platelet accumulation at the site of vessel injury.

295 cellular repair factors, such as Pol eta, to sites of viral DNA damage via BPLF1, thereby allowing fo

296 rall, T cell differentiation was enhanced in sites of viral persistence with age.

297 ally identifying the ampullae as the primary sites of viral persistence, combined with the fact that

298 (MRV) forms viral factories (VFs), which are sites of viral transcription, translation, assembly, and

299 e high-risk lesions for tumour flare (eg, >5 sites of visceral disease or bone lesions with impending

300 13-4 to WPBs and a clustering of Munc13-4 at sites of WPB-plasma membrane contact.