ライフサイエンスコーパス: site of action

1 ec61alpha, thus revealing cotransin's likely site of action.

2 of the local exposure to unbound drug at the site of action.

3 fect by prolonging its residence time at the site of action.

4 y release drugs that may then diffuse to the site of action.

5 ontrol system and route to their physiologic site of action.

6 eously absorbed across the gut wall to their site of action.

7 particles can be targeted to their requisite site of action.

8 or 2 (BDM14471) revealed that it reaches its site of action.

9 g an effective release of doxorubicin at the site of action.

10 rticomuscular coherence partly via a central site of action.

11 h the cell envelope to reach their cytotoxic site of action.

12 abilized at 3'-DNA ends corresponding to its site of action.

13 plitude and kinetics indicates a presynaptic site of action.

14 ential for telomerase to be recruited to its site of action.

15 e of tetrodotoxin, suggesting a postsynaptic site of action.

16 ial translation as a previously unrecognized site of action.

17 th the carrier protein and duplex DNA at the site of action.

18 agonist binding domain, suggesting a unique site of action.

19 to target a dominant negative protein to its site of action.

20 ng therapeutics that target the specific CNS site of action.

21 indicates that norBNI did not persist at the site of action.

22 intravenously), which indicates a peripheral site of action.

23 d pulse ratio, consistent with a presynaptic site of action.

24 ntly established the Golgi as their probable site of action.

25 s enzymatic activity and guiding Dbp8 to its site of action.

26 other pains, and a predominantly peripheral site of action.

27 ting that motor activity brings Kip3p to its site of action.

28 nkage to the drug's clinical endpoint and/or site of action.

29 anslocates from its site of synthesis to its site of action.

30 ralgesia and antinociception at a peripheral site of action.

31 Together, these data suggest a postsynaptic site of action.

32 icient of variance, suggesting a presynaptic site of action.

33 itination state, suggesting a post-endocytic site of action.

34 ects on cell movement required a cytoplasmic site of action.

35 n and mechanical allodynia via only a spinal site of action.

36 ed antihyperalgesia indicating a supraspinal site of action.

37 ects on root meristem size, depending on its site of action.

38 aired-pulse stimuli indicated a postsynaptic site of action.

39 r RyR2 inhibition, both having a cytoplasmic site of action.

40 ith enhanced delivery of these agents to the site of action.

41 multiple copies of regulatory proteins to a site of action.

42 or concentrating toxic chemotherapies at the site of action.

43 ecruit proteins to or away from their normal sites of action.

44 tential to introduce mutations at off-target sites of action.

45 ther by allosteric effects or via additional sites of action.

46 eostasis involve both central and peripheral sites of action.

47 pathways recruit ESCRT-III proteins to their sites of action.

48 nti-dyspnea drug development with peripheral sites of action.

49 y target ER or AR; others have still unknown sites of action.

50 options to treat or modulate pain at various sites of action.

51 ies that neutrophils use to find their local sites of action.

52 us, vagus and brainstem regions as potential sites of action.

53 Antidepressants have multiple sites of action.

54 EC(50) of cyclothiazide, suggesting distinct sites of action.

55 f partner proteins, recruiting them to their sites of action.

56 eable molecules to reach their intracellular sites of action.

57 highly conserved catalytic subunits to their sites of action.

58 distinction required for excluding redundant sites of action.

59 d therefore offer both multiple and variable sites of action.

60 mensional chromosome contacts to move to its sites of action.

61 sary for the spreading of the complex to its sites of action along the X chromosome.

62 hosphate, at the putative vaginal and rectal site of action and its relationship to concentrations at

63 gnals during invasion, we have used genetic, site of action and live-cell imaging studies to examine

64 by inhalation are delivered directly to the site of action and may improve the therapeutic index req

65 he concentration of administered drug at the site of action and provides information concerning the e

66 In this study, we investigated the site of action and sleep-promoting mechanisms of glycine

67 However, the brain site of action and underlying cellular mechanisms remain

68 herbicides of different chemical groups and sites of action and can extend to new herbicide(s).

69 noparticles can preferentially accumulate at sites of action and hold great promise to improve the th

70 systems are discussed, along with analgesic sites of action and its effects at the cellular level.

71 l hypersensitivity via peripheral and spinal sites of action and mechanical allodynia via only a spin

72 However, their sites of action and their hierarchical relationships are

73 shield, target the F protein directly at its site of action, and expand the potential utility of inhi

74 n normal human male subjects the importance, site of action, and receptor-mediated processes involved

75 al to prevent the toxins from reaching their site of action, and thus avoid the ensuing diarrhoea.

76 through the sharing of signalling pathways, sites of action, and evolutionary history.

77 concentrations and targeted delivery to the site of action appear possible, and most importantly, re

78 As the main CGRP-mAb site of action appears to be situated outside the brain,

79 the auditory and vestibular systems and its site of action are not well understood.

80 cytokines, or radiolabels to their intended site of action are required for these applications.

81 n channel, but the underlying mechanisms and site of action are unknown.

82 in colon cancer, but their relevant cellular sites of action are obscure.

83 that coordinate their expression at neuronal sites of action are poorly characterized.

84 They are transported to their site of action as blood-borne endocrine hormones but can

85 These results establish latonduines novel site of action as well as its proteostatic mechanism of

86 ear pore complex for recruitment to this new site of action at mitosis.

87 CXCL10 is unable to localize to its presumed site of action at the bacterial cell membrane, suggestin

88 degrade BST-2 and/or direct it away from its site of action at the cell surface.

89 iary space of the eye adjacent to the drug's site of action at the ciliary body.

90 ionships between their site-of-synthesis and site-of-action ("autonomy" versus "non-autonomy") remain

91 st of many ligand-gated ion channels, with a site of action believed to be within the ion-conducting

92 ble enzyme from its site of synthesis to its site of action, but the transport mechanism is unknown.

93 functions have been ascribed to postsynaptic sites of action, but there is now an appreciation that p

94 holerae genomes, identifying an antibiotic's site of action by identifying sequence differences betwe

95 e that these complexes are directed to their sites of action by long non-protein-coding RNAs (lncRNAs

96 Further, we propose these two sites of action comprise the likely mechanism underlying

97 nce for the cooperative contributions of two sites of action (decidua and ovary) toward preterm birth

98 /reoxygenation) demonstrated a mitochondrial site of action (decreased MitoSOX fluorescence), where t

99 channel opening, which is consistent with a site of action distal to the ATP-binding pocket.

100 t2 activity supports axon survival through a site of action distinct from Nmnat2 transport vesicles a

101 and the raphe nuclei, a postulated brainstem site of action during migraine, suggesting that dihydroe

102 c rescues, determining DAF-6/patched-related site of action during sensory-organ development.

103 sDNA and recruits multiple proteins to their sites of action during genomic maintenance.

104 ion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.

105 tility in transcriptional reporter analysis, site-of-action experiments and exogenous transgene expre

106 5-HT) signals in the nervous system and is a site of action for a variety of psychoactive drugs inclu

107 ling as a previously unrecognized pathogenic site of action for Abeta.

108 levels within the synaptic cleft and are the site of action for amphetamine (AMPH) and cocaine.

109 m of fast axonal transport of Nmnat2 and its site of action for axon maintenance.

110 Such a dual site of action for beta-arrestins helps explain the plei

111 he dopamine transporter (DAT) is the primary site of action for cocaine, and the dopamine system is k

112 nd bipolar disorders, and DAT is a prominent site of action for drugs such as amphetamines and cocain

113 al play, and identify the BLA as a prominent site of action for endocannabinoids to modulate the rewa

114 Escape mutations were used to map the site of action for FIP.

115 These new findings define the lysosome as a site of action for FLCN and indicate a critical role for

116 er, these data establish the lPBN as a novel site of action for GLP-1R-mediated control of food intak

117 suggest that the spinal cord is an important site of action for H(3) antagonism and the effect can be

118 in which the plasma membrane is an important site of action for Mats tumor suppressor to control tiss

119 Furthermore, this could be a site of action for mGlu2 PAMs to modulate cognitive proc

120 surface of the subunit interface at a likely site of action for modulatory proteins.

121 primary pathogenic mechanism and subcellular site of action for mutant Htt are still unclear.

122 n the rodent spinal dorsal horn, a principal site of action for opiate analgesia.

123 ons, indicating that the VTA is an important site of action for orexin's role in reward processing.

124 racellular cysteine-rich domain (CRD) as the site of action for oxysterols on Smo, involving residues

125 cholinergic interneurons (CINs) as a primary site of action for p11 in the NAC.

126 These results suggest a novel site of action for potentiation of NMDA receptors by sma

127 s efficacy in cancer therapy, mechanisms and site of action for progesterone remain unknown.

128 he dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such as cocaine

129 e expression of diffuse anxiety and is a key site of action for the anxiogenic neuromodulator, cortic

130 has previously been found to be an important site of action for the dysphoric effects of dynorphin-ka

131 Studies seeking a dominant site of action for the hormone leptin have focused on le

132 sulin resistance, pointing to a hypothalamic site of action for the metabolic dysregulation of atypic

133 within the RVM offer an additional potential site of action for the modulation of visceral pain by tr

134 y reveals that inhibition of PHOX is a novel site of action for the mu-opioid receptor-independent ef

135 that the bacterial membrane was the primary site of action for these agents.

136 en C9orf72 and SMCR8 and support a lysosomal site of action for this protein complex.

137 ransferase (CT) domain of this enzyme is the site of action for three different classes of herbicides

138 thermore, these studies demonstrate that the site of action for TRPV1 blockade elicited hyperthermia

139 targeted the mesolimbic dopamine system, the site of action for virtually all abused substances.

140 se models, we identify mitochondria as a key site of action for Wld(S) neuroprotective function.

141 These results suggest possible sites of action for CRF-induced facilitation of pair bon

142 action on muscle promotes atrophy, nonmuscle sites of action for inflammatory mediators are less well

143 nicotinic acetylcholine receptors as common sites of action for nicotine and alcohol.

144 inted interactions with multiple established sites of action for other known drugs of abuse including

145 These findings disclose new sites of action for statins against Abeta-induced neuron

146 s in NAD synthesis and suggest that critical sites of action for supplemental NAD precursors reside o

147 tion and identify these domains as potential sites of action for the targeted development of KAR-spec

148 he RPCs, it appears that these cells are the sites of action for this entire enzymatic pathway in Dro

149 one secretagogue receptors (GHS-R), the only sites of action for this gastric hormone identified to d

150 Major groups of genes were classified as to site of action, functional pathway, and possible regulat

151 food intake and body weight, but few central sites of action have been identified for its effect on e

152 erapies, as delivering siRNA directly to its site of action helps to ensure that a sufficient dose re

153 acilitate access of alphaTAT1 to its luminal site of action if microtubules undergo lateral opening b

154 nervous system, in part attributable to its site of action in blocking the function of monoamine reu

155 ovides for high concentrations at the target site of action in patients with pulmonary infections.

156 ansport short interfering RNA (siRNA) to the site of action in the cells of target tissues.

157 first definitive evidence that the PFC is a site of action in the cognition-enhancing and presumably

158 e therapeutic concentration of a drug at the site of action in the eye.

159 , and our genetic analyses indicate that its site of action in the formation of birefringent material

160 nic acid (AA) was conducted to determine the site of action in the PGD2 synthetic pathway.

161 in-containing histone demethylases and their sites of action in budding yeast S. cerevisiae.

162 n channels/pumps/transporters to physiologic sites of action in cardiomyocytes.

163 However, their roles and sites of action in each pathway remain to be determined.

164 l nucleus of the amygdala (CeA) as potential sites of action in mediating the side effects of cisplat

165 efficient access of these molecules to their sites of action in the cytosol or nucleus.

166 tions with plant cells, to accumulate at its sites of action in the host nucleus.

167 of data regarding its temporal dynamics and sites of action in the living human brain.

168 Cannabinoids are known to have multiple sites of action in the nociceptive system, leading to re

169 m from the photoreceptor, but their relative sites of action in the transduction pathway are unknown.

170 lerance, but their functional mechanisms and sites of action in vivo are poorly defined.

171 d replication forks, representing the likely sites of action in vivo.

172 articles that can be translocated to desired sites of action (including cytosolic positions), protein

173 spite the widespread use of these drugs, the sites of action involved in their cognition-enhancing an

174 ric oxide (NO) dependent, although the exact site of action is controversial.

175 One potential site of action is in lipid raft membrane microdomains.

176 However, a peripheral site of action is indicated by the ability of intravenou

177 The site of action is located at the extracellular vestibule

178 eliminate hyperthermia, suggesting that the site of action is predominantly outside of the blood-bra

179 e receptor (RyR2); however, an extracellular site of action is suggested because of the hydrophilic n

180 migraine prophylaxis, but their mechanism or site of action is uncertain.

181 form interacting SNARE proteins reach their sites of action is virtually unknown.

182 hetic input to the heart, suggesting a novel site of action leading to Kv1.1-associated cardiac brady

183 food intake and reward, was identified as a site-of-action mediating the anorectic effects of amylin

184 To elucidate the sites of action mediating this effect, we initially foun

185 tes synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs.

186 and suggest the vasculature as the potential site of action of Adamts16 to lower BP.

187 lation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represent

188 imple protocol is described for locating the site of action of an antioxidant (AO) in a micro-heterog

189 In addition, it is the site of action of antidepressants (which block the trans

190 ologic features of anxiety disorders and the site of action of anxiolytic drugs.

191 A major site of action of apolipoprotein mimetic peptides was fo

192 hromatin immunoprecipitation to identify the site of action of CPIC.

193 is particularly useful in discriminating the site of action of delta receptor-mediated hypothermia.

194 The critical site of action of DRs is completely dependent on the nat

195 ify Adelta meningeal nociceptors as a likely site of action of fremanezumab in the prevention of head

196 To elucidate the site of action of GSK3beta in regulating DA- or lithium-

197 The site of action of JA in the context of reproductive deve

198 e glycine site or which occurs distal to the site of action of kynurenic acid.

199 action with the 5-HT(2A) receptor, a primary site of action of lysergic acid diethylamine (LSD), appe

200 e to multiple receptor subtypes that are the site of action of many clinically important drugs.

201 and has been used extensively to examine the site of action of many gastrointestinal (GI) neuropeptid

202 Voltage-gated potassium channels are the site of action of many therapeutic drugs.

203 s are known to modulate nociception, but the site of action of MC4R signaling on nociception remains

204 nt, identify a step involving TFIIB as a key site of action of Mediator.

205 -dependent manner, indicating that GC is the site of action of Mn2+.

206 ough the activation of opioid receptors, the site of action of morphine and related analogues, there

207 iation in the dopamine transporter (DAT1), a site of action of MPH, could influence the effects of MP

208 effects of NO on M-channels and identified a site of action of NO to be the redox modulatory site at

209 an distal convoluted tubule (DCT) and is the site of action of one of the most effective classes of a

210 of photoreactive derivatives to identify the site of action of oxazolidinones in the ribosomes of bac

211 y intracellular GTP have been invoked as the site of action of peripheral inflammatory mediators that

212 of latrunculin B, suggesting that a critical site of action of Pet PLC1 is in regulating actin struct

213 after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and o

214 onin 2A (5-HT2A) receptor densities (the key site of action of psychedelic drugs [4]).

215 results unveil what we believe to be a novel site of action of resistin on GP and inflammation and su

216 m for the gating of the Kv7.3 PM and for the site of action of RTG as a Kv7.2/Kv7.3 K(+) current acti

217 ium channel in the distal collecting duct, a site of action of SPIRO and a potential target for thiaz

218 lity of expanding plant tissue, which is the site of action of thaxtomin.

219 Sensitisation is independent of the site of action of the agonist, because covalent and non-

220 , hypothalamic LepRb(NOS1) neurons are a key site of action of the leptin-mediated control of systemi

221 he high-affinity, slow washout, and external site of action of the MalH-lectin conjugates support the

222 RMG is the central site of action of the neuropeptide receptor gene npr-1,

223 on loss when deficient, the precise cellular site of action of the SMN protein in SMA remains unclear

224 Therefore, to functionally identify the site of action of the vesicle-associated membrane protei

225 metabolism and repress growth; however, the site of action of these diverse effects remains unclear.

226 In an attempt to map the site of action of these inhibitors, we generated mutant

227 Our work suggests that the principal site of action of TNF to cause this change in gastric fu

228 The N-heptad repeat (N-HR) of gp41 is the site of action of two classes of inhibitors.

229 Here we present findings on the site of action of YbcL and demonstrate a novel mode of s

230 meric approach, we were able to localize the site-of-action of NS8593 to the K(Ca)2 pore.

231 dopamine receptor subtype (D2) are important sites of action of antipsychotic drugs.

232 Advances in our understanding of the novel sites of action of EPO in the vasculature, brain, heart

233 We incorporated sites of action of four drugs (palbociclib, gemcitabine,

234 The sites of action of known drugs are limited in number, ar

235 dium and potassium, the known mechanisms and sites of action of loop and thiazide diuretics and the s

236 ne domains, which are a recent focus for the sites of action of many allosteric modulators.

237 e transporters also constitute the principal sites of action of many psychoactive drugs, including am

238 ic sensory neurons that are also the primary sites of action of nerve growth factor, a powerful modul

239 The specific functions and sites of action of p24 proteins are still unknown.

240 al-specific manner and investigate the major sites of action of phytochromes during seedling developm

241 Binding studies further supported distinct sites of action of small molecules relative to that of c

242 These findings reveal the respective sites of action of systemically administered MJN110 and

243 being able to order, for the first time, the sites of action of the various reaction components: GR <

244 into host plant cells, yet the functions and sites of action of these effectors in promoting pathogen

245 to reverse this effect, suggesting that the sites of action of these pesticides are COX enzymes.

246 that has been made in defining new cellular sites of action of this receptor, the mechanisms through

247 m different chemical families to share their site of action on a channel accessory subunit.

248 alization of the vitamin D receptor (VDR) at sites of action on a genome-scale using ChIP sequence an

249 of additional proteins and enzymes to their sites of action on DNA.

250 ipid precursors and is believed to reach its sites of action on the CB1 and CB2 receptors through fas

251 itation (ChIP) as a way of determining their sites of action on the encoded mRNA.

252 Depending upon their nervous system site of action, opioid receptor agonists alter food cons

253 TDF protein has no identified site of action or receptor, and its mechanism of action

254 Mash1, and Hes5 either by controlling their site of action or their activity.

255 in pruritogen-induced scratching may involve sites of action other than the primary afferent terminal

256 protection against natural antibiotics whose site of action overlaps that of linezolid.

257 Although the NEG site of action overlaps with that of tetracycline (TET),

258 of this characteristic region and thus, the site of action potential generation are of particular im

259 dium and potassium channels that defines the site of action potential generation.

260 s, in conjunction with a distal shift in the site of action potential initiation and increased preval

261 y specialized neuronal subregion that is the site of action potential initiation and the boundary bet

262 The axon initial segment (AIS) serves as the site of action potential initiation in most neurons, but

263 The axon initial segment (AIS) is the site of action potential initiation in neurons.

264 that T-type Ca(2+) channels localized to the site of action potential initiation in the axon initial

265 re highly excitable and are likely to be the site of action potential initiation in these neurons.

266 xcitability is likely to be regulated by the site of action potential initiation, the location on a n

267 egion near the start of the axon that is the site of action potential initiation.

268 ial segments (AISs) and nodes of Ranvier are sites of action potential generation and propagation, re

269 l segment (AIS) and nodes of Ranvier are the sites of action potential initiation and regeneration in

270 se between the transductive membrane and the site of action-potential generation.

271 be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.

272 NMD, but for which the precise function and site of action remain unclear.

273 se anorexigenic effects, their mechanism and sites of action remain poorly understood.

274 although the precise cellular and metabolic sites of action remain undefined.

275 y of oligonucleotides to their intracellular sites of action remains a major issue.

276 eled Lipoplex and the amount of siRNA at its site of action RISC (RNA-induced silencing complex) were

277 one (GnRH) neurons, suggesting an additional site of action that has not been studied at the cellular

278 dle proteins may be useful models of in vivo sites of action that allow the use of a wide range of te

279 These concentrations, evaluated at the site of action, the brain, have been correlated with ora

280 with reduced effects of cocaine at its main site of action, the dopamine transporter (DAT).

281 cient to deliver neuroactive levels to their site of action: the bee brain.

282 Pemetrexed has more than one site of action; the primary site is thymidylate synthase

283 ion of tissue distribution and access to the site of action; the second, engagement of the target; an

284 array of genome maintenance enzymes to their sites of action through direct protein interactions.

285 We address the neural sites of action through which ghrelin regulates the hypo

286 tor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subeso

287 partner proteins and recruits them to their sites of action using its four intrinsically disordered

288 d T cell function, as well as the anatomical site of action, varies extensively with the pathogen.

289 we considered that choosing a physiological site of action was a priority and focused on the locus c

290 A peripheral site of action was also suggested by studies on the extr

291 vo electrophysiology, evidence for a central site of action was provided by dose-dependent reductions

292 Consistent with that site of action, we detect FBF and FOG-1 in the germ line

293 Thus, rather than being recruited to its sites of action when replication forks stall at these si

294 ponents to achieve a desired response at the site of action, which imparts nanogels the ability to pa

295 atural product demonstrated an extracellular site of action, which requires the extracellular domain

296 crobial agents, having only a single mode or site of action, will not alleviate the situation because

297 eral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathw

298 in the tumor and delivering the drug to its site of action within the tumor tissue.

299 e, GNA is also capable of delivering Hv1a to sites of action within the insect central nervous system

300 holipids--are proposed to have intracellular sites of action, yet a conduit for these choline phospho