ライフサイエンスコーパス: six-membered ring

1 ved due to smaller hindrance for a five vs a six membered ring.

2 adjacent glycine residue to form an aromatic six-membered ring.

3 om to transform a former pyrrole ring into a six-membered ring.

4 planar hexagonal B36 cluster with a central six-membered ring.

5 mine nitrogen of doxorubicin into a five- or six-membered ring.

6 gs with heteroatoms in the 3-position of the six-membered ring.

7 p to Cgamma of the ligand giving a boat-like six-membered ring.

8 ene, thereby blocking cyclization to a third six-membered ring.

9 stituted in pairs on opposite sides of these six-membered rings.

10 nd length equalization in both the five- and six-membered rings.

11 es that the final structure consists of only six-membered rings.

12 ynthetic transformations for the assembly of six-membered rings.

13 itions within sofa-type conformation for the six-membered rings.

14 substitution on the strength of C-H bonds in six-membered rings.

15 These sites are the T5/T6 sites in the six-membered rings.

16 reochemistry: (1) conformational analysis of six-membered rings, (2) evaluation of stereoelectronic i

17 in (1)J(C-H) one-bond coupling constants in six-membered rings, (3) eclipsed conformation in cis-2-t

18 for the unusual thermal equilibration from a six-membered ring (3d) to a four-membered ring (4d) obse

19 ross Si:Al ratios, the volumetric density of six-membered-rings (6MR) containing two Al (2Al sites) i

20 xylic acid (APCH), which is constrained by a six-membered ring across its Calpha-Cbeta bond.

21 MPO spin trap, leading to the formation of a six-membered ring adduct, occurs through a very favorabl

22 nucleophilic displacement reaction forming a six-membered ring and releasing a stable cationic report

23 of two saturated carbon-carbon bonds of the six-membered ring and uses molecular oxygen as the hydro

24 With approximately 10 eq of these monomeric six-membered rings and with heating, cyclic esters (MeCH

25 the terminal alkene dipolarophile leads to a six-membered ring), and most efficient is the formation

26 elective cycloisomerization to construct the six-membered ring, and a diastereoselective hydroxylativ

27 l rate is similar for formation of five- and six-membered rings, and a substantial KIE (k(H)/k(D)) is

28 The results show that in the six-membered ring antiperiplanar lone pairs provide a we

29 Carbo- and heterocycles of five- and six-membered rings are obtained in good yields.

30 Cyclic imides within six-membered rings are shown to undergo efficient N-aryl

31 ch as the [4+2] Diels-Alder reaction to form six-membered rings, are among the most powerful and wide

32 ew reactions that yield benzo-fused five- or six-membered rings arising from conjugated ene-ene-yne p

33 s two alcohol molecules in a hydrogen bonded six-membered ring arrangement.

34 Introduction of nitrogen in the six-membered ring at the 2 position, to improve aqueous

35 lpha-bisallylaldehydes rearrange to generate six-membered rings by a mechanism triggered by aldehyde

36 ols with four- (C(4)-1), five- (C(5)-1), and six-membered rings (C(6)-1).

37 eveal that the conformational preferences of six-membered-ring cations depend significantly upon the

38 about the linking bond, stable nonracemizing six-membered ring chelates can be formed.

39 ly unreported autochelates contain two fused six-membered rings, cis-proline, chiral boron, and -NH(2

40 minal amino group of lysine 66 to form a new six-membered ring, cleaving the polypeptide backbone at

41 es are close to 0 degrees , but in five- and six-membered ring compounds and in open-chain compounds

42 d portion of the catalytic domain, such as a six-membered ring, confer selectivity for HKs.

43 The six-membered ring conferred increased RARbeta specificit

44 s only indole oxidation was observed for the six-membered ring congener.

45 ctions with the enzyme and a solvent exposed six-membered ring, consistent with its poor repair susce

46 The proteolipid subunits form a six-membered ring containing single copies of subunits c

47 ring, containing two double bonds, or into a six-membered ring, containing two double bonds and a six

48 t is the first time that RE-MOFs with double six-membered ring (d6R) secondary building units are iso

49 ansitive nets with a vertex figure as double six-membered-ring (d6R) building unit, namely the (4,12)

50 eogenic center, lying at the junction of two six-membered rings, defines the conformation of the subs

51 (m-aniline)s with 9 and 13 collinearly fused six-membered rings employed Pd-catalyzed aminations and

52 ich respectively possess two and three fused six-membered rings, exhibit a similar trend, with the fo

53 A key finding is that the five- to six-membered ring expansion process is not a viable reac

54 etals preferentially bind the substrate as a six-membered ring, exposing the exact same sites to the

55 have investigated the formation of five- and six-membered rings for the other two new ring sizes.

56 aldol and Michael cycloreductions, five- and six-membered ring formation occurs in good yield with hi

57 Where six-membered ring formation operates, cyclization can be

58 inones were synthesized intramolecularly via six-membered ring formation with high regio- and diaster

59 er hand the systems with fused benzene and a six-membered ring formed atropisomers separated by a bar

60 Two of the six-membered rings formed by the diphosphine ligands and

61 For 6b, all four six-membered rings formed upon coordination of the dipho

62 In contrast, if the six-membered ring-fusion is across the C(2)-C(3) cyclope

63 tivity is strongly ring size dependent, with six-membered rings giving exclusively alpha-benzyl pente

64 e isomer of 1H-benz[f]indene, with separated six-membered rings, has an electron affinity of -0.07 eV

65 nsecutive aza-Michael additions assemble the six-membered ring heterocycle, while in the second domin

66 d borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.

67 ns undergo ring contraction, giving five- or six-membered ring heterocycles.

68 etries revealed that the syn isomer favors a six-membered ring hydrogen bond to nitrogen and the anti

69 bonds of the five-membered ring in 15 or the six-membered ring in 12b are discussed, and the conseque

70 A heptaene that contains a six-membered ring in the central unit also was prepared

71 trong intramolecular hydrogen bonds within a six-membered ring in the enones and the enols.

72 five-membered ring is more aromatic than the six-membered rings in 3a and 3b.

73 own to be quite general for the formation of six-membered rings in good yields and was tolerant of a

74 y planar with a central B atom and an AlB(5) six membered ring, in contrast to that of B(7)(-), which

75 The reactions of three-, four-, five-, and six-membered rings incorporating the S-Se bond with HS-

76 binding affinities of those having three- to six-membered rings increase incrementally with ring size

77 single or multiple hydrophilic moieties on a six-membered ring inhibited the Hh pathway in both Hh-de

78 plexes of neuraminidase with known five- and six-membered ring inhibitors revealed that potent inhibi

79 t as effectively as those of the established six-membered ring inhibitors such as DANA (2), zanamivir

80 By low-temperature NMR spectroscopy the six-membered-ring interconversion could be frozen at 103

81 iimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile pre

82 A union of five- and six-membered ring intermediates by an efficient pi-allyl

83 veral syn-pentane interactions which force a six-membered ring into a twist-boat conformation.

84 In the bicyclic six-five series, the six-membered ring is accommodated in the cation, but it

85 les with a high level of substitution on the six-membered ring is described.

86 ure for one of the complexes showed that the six-membered ring is very distorted and the thiophene ri

87 ketopiperazine at both the five-membered and six-membered rings is described.

88 The formation of five- and six-membered rings is possible using this methodology.

89 controlled while an "expected" product with six-membered rings is thermodynamically more favored.

90 zation through the N- and B-termini, forming six-membered rings, is a common occurrence at neutral pH

91 lative to the previously published five- and six-membered ring ketone-based inhibitor series.

92 le N-methylamide function into a more stable six-membered ring lactam 4, resulting in increased stabi

93 Five- and six-membered ring lactams bearing aromatic, heteroaromat

94 be a hydrogen-bonded OH-HONO(2) complex in a six-membered ring-like configuration.

95 henomenon in the conformational chemistry of six-membered ring molecules.

96 pX subunits (Mr 46, 000) associate to form a six-membered ring (Mr approximately 280, 000) that is st

97 ally dealing with the synthesis of five- and six-membered ring nitrogen containing heterocycles, then

98 ere found to cyclize to give either five- or six-membered ring nitrogen heterocycles.

99 Both the six-membered ring nitroxides and substituted five-member

100 For six-membered ring nitroxides, the compounds exhibiting t

101 cyclization to a phenyl-substituted five- or six-membered-ring occurs.

102 hosphate and through pi-pi stacking with the six-membered ring of adenine.

103 le saturation of adjacent C=C bonds within a six-membered ring of C60.

104 ropenyl-like electronic structure within the six-membered ring of the 1,3,5-benzene triradical.

105 dless of whether the site is on the five- or six-membered ring of the purine.

106 tion of the alcohol at the 3 position of the six-membered ring of the spiroketal subunit, the configu

107 een the seven-membered rings of ClpP and the six-membered rings of ClpX.

108 wo adjacent carbon atoms located between two six-membered rings of the C60 cage affects the orientati

109 ridge and the centroids of three of the four six-membered rings of the pyrene system of a neighboring

110 reaction is effective for forming five- and six-membered rings of widely divergent structure.

111 cal modeling suggest that 7 was formed via a six-membered ring oxathiaphosphenine intermediate rather

112 ons of trimethylsilyl cyanide with five- and six-membered ring oxocarbenium ions are attributed to th

113 y as compared to that of reactions involving six-membered-ring oxocarbenium ions.

114 amine sugar, one compound with a nonaromatic six-membered ring (pirarubicin) in place of the 4'-OH, a

115 tive reaction to form unprecedented five- or six-membered rings possessing a geometrically defined en

116 o give a pair of diastereomeric heterocyclic six-membered ring products due to the newly formed sulfu

117 s, a ruthenium-based system that affords the six-membered ring products was also developed.

118 Five- and six-membered ring products were obtained in good to exce

119 bis(enone) substrates afford both five- and six-membered ring products.

120 to a methyl-aryl or isopropyl carbon to form six-membered ring products.

121 lectron-deficient alkenes and imines to form six-membered-ring products diastereoselectively.

122 s undergo SN2 reactions, while the five- and six-membered rings react via the addition-elimination pa

123 tion/combination with cyclopropane to form a six-membered ring reference compound.

124 ioxirane (DO) has been estimated relative to six-membered ring reference compounds by dimerization of

125 i(2+): forming a five-membered ring versus a six-membered ring, respectively, thus exposing different

126 proton acceptor is located in the five- and six-membered rings, respectively.

127 e displays a boat conformation for its Ge-Se six-membered ring ("six-ring"), while the previously kno

128 ields primarily high-energy dications with a six-membered-ring structure.

129 unique ring expansion reaction to provide a six-membered ring suitably functionalized for introducti

130 Formation of a six-membered ring supports the hypothesis that epoxy est

131 group abilities already established for the six-membered ring system (NHBn >> OH > NBn2), an N,N-dib

132 ere found to be consistently higher with the six-membered ring system than its cycloheptane counterpa

133 ntramolecular alkene hydroaminations forming six-membered ring systems are rare, especially for syste

134 The functionalized five- and six-membered ring systems obtained by these novel cycliz

135 h 1,3,5-triazinanes, leading to the five- or six-membered ring systems under mild conditions in yield

136 The method employs a six-membered ring template to control the relative stere

137 le access to biaryl sultams annulated into a six-membered ring that are otherwise difficult to obtain

138 in the enamine-iminium complex by forming a six-membered ring that favors one helicity of the electr

139 are found with many of the oxygen-containing six-membered rings that were investigated.

140 For the five- and six-membered rings, the reaction proceeds via the additi

141 was easily achieved, ultimate closure of the six-membered ring to form ring D remains an unsolved pro

142 ivity, suggesting a strict requirement for a six-membered ring to maintain potency.

143 However, annelation of a six-membered ring to the conformationally mobile D'-pipe

144 y, electron density suggestive of a puckered six-membered ring was discovered at a site structurally

145 ontal lineNH and cis-1,3-butadiene to form a six-membered ring was examined by quantum calculations.

146 synthesis of N-arylated cyclic imides having six-membered rings was restricted largely to strongly he

147 '-(3''-piperidone-1''-yl)doxorubicin (with a six-membered ring) were tested in vitro, the former bein

148 ues 21, 22, 46, and 54, comprising four- and six-membered rings, were synthesized using two different

149 of the methyl groups, to close a [LiOCCZnC] six-membered ring; whereas 8 displays an open structure

150 nd "closed." The gp61 structure is clearly a six-membered ring, which may be a trimer of dimers or a

151 The complex forms a distorted, six-membered ring with the water unit acting as both a h

152 of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded

153 clidine derivative salts with fused five and six-membered rings (X-ray) were obtained via modificatio