ライフサイエンスコーパス: skeletal muscle fiber

1 renal epithelial cells) and Cav-3 null mice (skeletal muscle fibers).

2 C on the myosin lever arm in a permeabilized skeletal muscle fiber.

3 ease properties of RYR in permeabilized frog skeletal muscle fibers.

4 t exerts both short and long term effects on skeletal muscle fibers.

5 pecifically inhibits the contraction of fast skeletal muscle fibers.

6 bone marrow can give rise to differentiated skeletal muscle fibers.

7 oponin C (TnC) was measured in permeabilized skeletal muscle fibers.

8 charge movement and intracellular Ca(2+) in skeletal muscle fibers.

9 tes, while E-Tmod is found in heart and slow skeletal muscle fibers.

10 similar to those reported in adult amphibian skeletal muscle fibers.

11 wo rhodamine probes bound to myosin heads in skeletal muscle fibers.

12 howed significant Evans blue accumulation in skeletal muscle fibers.

13 ths, and actomyosin crossbridge formation in skeletal muscle fibers.

14 echanisms that regulate energy metabolism in skeletal muscle fibers.

15 but not keratin, were all expressed in fish skeletal muscle fibers.

16 development after photorelease of Ca(2+) in skeletal muscle fibers.

17 suitability as rapid Ca2+ indicators in frog skeletal muscle fibers.

18 were examined in slow soleus and fast psoas skeletal muscle fibers.

19 tput from fully contracting segments of frog skeletal muscle fibers.

20 of influenza A viruses to replicate in avian skeletal muscle fibers.

21 probes on the myosin motor domain in relaxed skeletal muscle fibers.

22 compartment model of Ca(2+) dynamics in frog skeletal muscle fibers.

23 voltage dependent calcium signaling in frog skeletal muscle fibers.

24 rgo fusion events to share matrix content in skeletal muscle fibers.

25 of dysferlin during membrane repair in adult skeletal muscle fibers.

26 tudies of excitation contraction coupling in skeletal muscle fibers.

27 and accessory structures typical of striated skeletal muscle fibers.

28 enriched in the t-tubule membrane of mature skeletal muscle fibers.

29 rotein content across the continuum of human skeletal muscle fibers.

30 essential light chain (ELC) in permeabilized skeletal muscle fibers.

31 e nucleotide turnovers in relaxed, permeable skeletal muscle fibers.

32 aligned and highly differentiated cardiac or skeletal muscle fibers.

33 arms in the thick filaments of permeabilized skeletal muscle fibers.

34 androgen receptor (AR) exclusively in their skeletal muscle fibers.

35 we could achieve acute suppression of JPs in skeletal muscle fibers.

36 s region (R3614-3643) on Ca2+ sparks in frog skeletal muscle fibers.

37 e nucleus to the cytoplasm in cultured adult skeletal muscle fibers.

38 clear aggregates and TUNEL-stained nuclei in skeletal muscle fibers.

39 ng of tubular filaments within the nuclei of skeletal muscle fibers.

40 mitochondrial Ca2+ dynamics in permeabilized skeletal muscle fibers.

41 sses predominantly in cardiac cells and slow skeletal muscle fibers.

42 tiffness and aberrant mechanotransduction in skeletal muscle fibers.

43 tion in calsarcin-1 showed an excess of slow skeletal muscle fibers.

44 perimental and computational studies suggest skeletal muscle fiber activation is greatly augmented by

45 ereas beta 1A could not be detected in adult skeletal muscle fibers and cardiomyocytes by immunofluor

46 lt dissociated flexor digitorum brevis (FDB) skeletal muscle fibers and human embryonic kidney (HEK)

47 ite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as pre

48 apse type that forms between motoneurons and skeletal muscle fibers and that exhibits a high degree o

49 racellular [Ca(2+)] simultaneously in mature skeletal muscle fibers and that the voltage distribution

50 sion is up-regulated and observed throughout skeletal muscle fibers and within satellite cells.

51 t or greatly reduced in dystrophin-deficient skeletal muscle fibers, and are thought to undergo degra

52 endothelia, adipocytes, smooth muscle cells, skeletal muscle fibers, and cardiac myocytes.

53 (NMJ) is a synapse between motor neurons and skeletal muscle fibers, and is critical for control of m

54 ive capacity, including the heart and type I skeletal muscle fibers, and is regulated by the MyoD fam

55 Although extrafusal skeletal muscle fibers appeared normal, Egr3-deficient a

56 nd wild-type mtDNA molecules within the same skeletal muscle fiber are consistent with the "maintenan

57 Nuclei in multinucleated skeletal muscle fibers are capable of expressing differe

58 ese results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust

59 Our findings highlight that avian skeletal muscle fibers are capable of productive influen

60 Skeletal muscle fibers are defined by patterned covariat

61 These results show for the first time that skeletal muscle fibers are directly responsive to space

62 The thick filaments of mammalian and avian skeletal muscle fibers are disordered at low temperature

63 Due to their high energetic profile, skeletal muscle fibers are prone to damage by endogenous

64 etermine fast- and slow-twitch phenotypes of skeletal muscle fibers are thought to stem from depolari

65 of tension development in bundles of skinned skeletal muscle fibers as a function of the level of Ca(

66 ite cells (the myogenic stem cells of mature skeletal muscle fibers) as a model system, we elucidated

67 ectional signaling between motor neurons and skeletal muscle fibers at neuromuscular synapses.

68 activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-m

69 Skeletal muscle fiber atrophy develops in response to se

70 er atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy.

71 ssion, which is necessary and sufficient for skeletal muscle fiber atrophy.

72 eased levels of holo betaAPP751 and Abeta in skeletal muscle fibers became significantly weaker with

73 ng slow fiber type electrical stimulation of skeletal muscle fibers because of activation of the Ca(2

74 to act as a soluble relaxing factor in fast skeletal muscle fibers by acting as a delayed Ca(2+) sin

75 r system network (SSTN) has been detected in skeletal muscle fibers by confocal imaging after the rem

76 issue types and (ii) its localization within skeletal muscle fibers by immunofluorescence microscopy

77 yoplasmic proteins in frog (Rana temporaria) skeletal muscle fibers by using single Sephadex beads as

78 Adult skeletal muscle fibers can be categorized into fast and

79 ed by membrane depolarization in single frog skeletal muscle fibers can be terminated prematurely by

80 Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from

81 n (alpha-tropomyosin-slow) expressed in slow skeletal muscle fibers cause nemaline myopathy.

82 contribution of thick and thin filaments to skeletal muscle fiber compliance has been shown to be si

83 bryogenesis and early postnatal development, skeletal muscle fibers contain a previously unknown form

84 Vertebrate skeletal muscle fibers contain hundreds of nuclei, of wh

85 myloid-beta (Abeta) peptide within selective skeletal muscle fibers contributes to the degenerative p

86 active MMP-9 protein significantly increased skeletal muscle fiber cross-section area, levels of cont

87 Immunolocalization of caveolin-3 in skeletal muscle fibers demonstrates that caveolin-3 is l

88 es beta-fodrin (betaII) at the sarcolemma as skeletal muscle fibers develop.

89 down of Tid1 by short hairpin RNA (shRNA) in skeletal muscle fibers dispersed synaptic AChR clusters

90 The G93A skeletal muscle fibers display localized loss of mitocho

91 kd amyloid-beta and the carboxyl-terminus in skeletal muscle fibers during aging.

92 c enhancer in the somite myotomes and in all skeletal muscle fibers during embryogenesis and adulthoo

93 cium from the sarcoplasmic reticulum (SR) of skeletal muscle fibers during excitation-contraction (e-

94 ow angle x-ray diffraction pattern of rabbit skeletal muscle fibers during ramp stretch compared to t

95 At the plasma membrane of skeletal muscle fibers, dystrophin associates with a mul

96 potent activators of Ca2+ release via RyR in skeletal muscle fibers (e.g. Ca2+ sparks) and potent mod

97 Here, we find that unstimulated adult skeletal muscle fibers exhibit a previously unanticipate

98 Human skeletal muscle fibers express five highly conserved typ

99 Skeletal muscle fibers express members of the myosin hea

100 ocal expression of a growth factor in mature skeletal muscle fibers extends replicative life span of

101 e isoform that is normally expressed in fast skeletal muscle fibers (fast muscle-specific MLC2).

102 Multinucleated skeletal muscle fibers form through the fusion of myobla

103 confirmed by those obtained ex vivo on adult skeletal muscle fibers from a biopsy from a pseudomyoton

104 of ryanodine receptors uncoupled to DHPRs in skeletal muscle fibers from aging mammals.

105 In this work we tested the hypothesis that skeletal muscle fibers from aging mice exhibit a signifi

106 Interestingly, skeletal muscle fibers from Cav-3 (-/-) knock-out mice s

107 taining sarcolemmal integrity and protecting skeletal muscle fibers from damage.

108 rther protect laminin alpha2 chain-deficient skeletal muscle fibers from degeneration.

109 ->A)] were expressed in cultured adult mouse skeletal muscle fibers from flexor digitorum brevis (pre

110 Our results indicate that skeletal muscle fibers from male Cav-1(-/-) and Cav-2(-/

111 alpha-dystroglycan, and alpha-sarcoglycan in skeletal muscle fibers from mdx mice.

112 on patterns of single membrane-permeabilized skeletal muscle fibers from mice lacking Tmod1.

113 properties of the Ca(2+)-release process in skeletal muscle fibers from normal and mdx fibers were d

114 Skeletal muscle fibers from the flexor digitorum brevis

115 orce development was studied in skinned fast skeletal muscle fibers from wildtype (WT) and nebulin de

116 und that, by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a increases MEKK4 protein

117 t extracellular matrix remnants from injured skeletal muscle fibers, "ghost fibers," govern muscle st

118 Here, we show that segments of human skeletal muscle fibers harboring two pathogenic mtDNA mu

119 erologously expressed in HEK293 cells and in skeletal muscle fibers, hClC-4 localizes to the endoplas

120 ecular weight diazo dye, does not cross into skeletal muscle fibers in normal mice.

121 Permeabilized skeletal muscle fibers in rigor were labeled with a fluo

122 with Gadd45a as it induces atrophy in mouse skeletal muscle fibers in vivo We found that Gadd45a int

123 n internal vesicular membrane compartment in skeletal muscle fibers in vivo.

124 ned the kinetic properties of rabbit skinned skeletal muscle fibers in which the endogenous myosin re

125 Gadd45a interacts with multiple proteins in skeletal muscle fibers, including, most prominently, MEK

126 At birth, each mammalian skeletal muscle fiber is innervated by multiple motor ne

127 that nuclear factor-kappaB signaling within skeletal muscle fibers is a key pathway leading to diaph

128 stering of acetylcholine receptors (AChR) on skeletal muscle fibers is an early event in the formatio

129 The Golgi complex of skeletal muscle fibers is made of thousands of dispersed

130 nitric oxide synthase (nNOS) in fast-twitch skeletal muscle fibers is primarily particulate in contr

131 Gene expression in skeletal muscle fibers is regulated by innervation and i

132 at overexpression of wild-type caveolin-3 in skeletal muscle fibers is sufficient to induce a Duchenn

133 In summary, the restoration of dysferlin in skeletal muscle fibers is sufficient to rescue the MD in

134 rom multiple to single axonal innervation of skeletal muscle fibers is the most accessible example of

135 Skeletal muscle fibers isolated from TDP-43 transgenic m

136 xchange of signals between motor neurons and skeletal muscle fibers, leading to the accumulation of p

137 e distribution; Sk-Tmod predominates in fast skeletal muscle fibers, lens, and erythrocytes, while E-

138 In adult skeletal muscle fibers, levels of Syne-1 are highest in

139 to promote clearance of Abeta from affected skeletal muscle fibers mitigates the IBM-like myopatholo

140 n difference, hyperemic calf blood flow, and skeletal muscle fiber morphometry, oxidative enzyme acti

141 ge secrete exosomes, it is not known whether skeletal muscle fibers (myofibers) release exosomes.

142 nuclei isolated from flexor digitorum brevis skeletal muscle fibers of adult mice.

143 Our results indicate that avian skeletal muscle fibers of chicken and duck could be sign

144 muscle fiber size and increased fibrosis in skeletal muscle fibers of D2-mdx mice compared with B10-

145 UDP-glucose (UDP-Glc) and glycogen levels in skeletal muscle fibers of defined fiber type were measur

146 ally, mRNA for both clc and clf was found in skeletal muscle fibers of embryonic mice during the moto

147 the organization of the membrane skeleton of skeletal muscle fibers of mdx mice, which lack dystrophi

148 In single isolated skeletal muscle fibers of the frog, we studied (i) the r

149 SERCA1 isoform, which is essential for fast skeletal muscle fiber phenotype.

150 c oxide modulate the contractile function of skeletal muscle fibers, possibly via direct interaction

151 ight chain phosphorylation in skinned rabbit skeletal muscle fibers (potentiation of force developmen

152 cellularly applied tubular system markers in skeletal muscle fiber preparations with a combination of

153 infection rescues macrophage homeostasis and skeletal muscle fiber regeneration, showing that Tregs c

154 These findings demonstrate that skeletal muscle fibers release exosomes which can exert

155 It was shown previously that skeletal muscle fibers require merosin for survival and

156 repolarizing pre-pulse to a depolarized frog skeletal muscle fiber restores a small fraction of the t

157 hannels causes a prolonged depolarization of skeletal muscle fibers, resulting in membrane inexcitabi

158 Skeletal muscle fibers show a high level of constitutive

159 anges, as well as increases in the number of skeletal muscle fibers showing mitochondrial enzyme abno

160 In Nedd4 mutant embryos, skeletal muscle fiber sizes and motoneuron numbers are s

161 In voltage-clamp studies of single frog skeletal muscle fibers stained with the potentiometric i

162 insulin receptor substrate (IRS)-1 in human skeletal muscle fiber strips in vitro.

163 Ca(2+) release and Ca(2+) currents in adult skeletal muscle fibers subjected to voltage-clamp and on

164 scribe a method to isolate nuclei from adult skeletal muscle fibers that are suitable for electrophys

165 Finally, in skeletal muscle fibers that coexpress both Sk- and E-Tmo

166 is a synapse formed between motoneurons and skeletal muscle fibers that is covered by Schwann cells

167 hanism underlying the diversity of mammalian skeletal muscle fibers, the elementary steps of the cros

168 The first skeletal muscle fibers to form in vertebrate embryos app

169 and population differences in the ability of skeletal muscle fibers to function in the presence of TT

170 atrix LDH is strategically positioned within skeletal muscle fibers to functionally interact with mit

171 mote inflammation and muscle necrosis and in skeletal muscle fibers to limit regeneration through the

172 While alpha-MNs innervate extrafusal skeletal muscle fibers to mediate muscle contraction, ga

173 w in exercising muscle by diffusing from the skeletal muscle fibers to the nearby microvessels where

174 iously appreciated that the determination of skeletal muscle fiber type (fast or slow) could be regul

175 ion, these mice provide unique insights into skeletal muscle fiber type composition.

176 hat the influence of motor nerve activity on skeletal muscle fiber type is transduced to the relevant

177 proach establish a reliable method for human skeletal muscle fiber type specific protein analysis.

178 These results indicate that Fnip1 controls skeletal muscle fiber type specification and warrant fur

179 ignaling plays a critical role in regulating skeletal muscle fiber type switching but not hypertrophy

180 NFATc1, NFAT2) may contribute to slow-twitch skeletal muscle fiber type-specific gene expression.

181 owth, bone development, and specification of skeletal muscle fiber type.

182 C1alpha) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-t

183 We compared the percent distribution of skeletal muscle fiber types, cross-sectional areas, and

184 al fashion throughout the continuum of human skeletal muscle fiber types, further highlighting the ne

185 g the voltage sensor-is demonstrated in frog skeletal muscle fibers under voltage clamp.

186 Labeled RLC was reconstituted into skeletal muscle fibers using a modified method that resu

187 calcium release events in permeabilized frog skeletal muscle fibers, using laser scanning confocal mi

188 Up-regulation of class I MHC in skeletal muscle fibers was an early and consistent featu

189 Activation in skinned skeletal muscle fibers was enhanced with all TnI mutants

190 ese mutated proteins to TnC-depleted skinned skeletal muscle fibers was investigated as well as the r

191 ases 1 and 2 (ERK1/2) in slow-twitch, type 1 skeletal muscle fibers, we studied the soleus muscle in

192 re highly expressed in innervated regions of skeletal muscle fibers, where it is externalized and att

193 rce and relaxation were performed in skinned skeletal muscle fibers whose endogenous TnI (along with

194 trophic, necrotic, and immature/regenerating skeletal muscle fibers with characteristic central nucle

195 CK is expressed predominantly in fast-twitch skeletal muscle fibers with insignificant amounts in hea