ライフサイエンスコーパス: skeletal muscle mass

1 lts in exencephaly and a marked reduction in skeletal muscle mass.

2 member that acts as a negative regulator of skeletal muscle mass.

3 rstanding the adaptive processes controlling skeletal muscle mass.

4 d body composition analysis revealed loss of skeletal muscle mass.

5 l inactivity, low energy intake, and loss of skeletal muscle mass.

6 8), that has an essential role in regulating skeletal muscle mass.

7 ary protein intake can attenuate the loss of skeletal muscle mass.

8 he age-related decline in total appendicular skeletal muscle mass.

9 and GDF11 are potent negative regulators of skeletal muscle mass.

10 and show a large and widespread increase in skeletal muscle mass.

11 uperfamily member, and negative regulator of skeletal muscle mass.

12 epatic encephalopathy through an increase in skeletal muscle mass.

13 nterleukin-6 and MCP-1 levels, and decreased skeletal muscle mass.

14 d nitrogen excretion, reflecting the loss of skeletal muscle mass.

15 ation and synthesis is essential to preserve skeletal muscle mass.

16 s) through which mechanical stimuli regulate skeletal muscle mass.

17 developed diaphragm and a reduction in total skeletal muscle mass.

18 ) and its splice variant PGC1alpha4 increase skeletal muscle mass.

19 t are involved in the negative regulation of skeletal muscle mass.

20 er-family, is a potent negative regulator of skeletal muscle mass.

21 mouse muscle leads to profound increases in skeletal muscle mass.

22 myostatin (MSTN) normally functions to limit skeletal muscle mass.

23 investigated the role of TWEAK in regulating skeletal muscle mass.

24 r beta superfamily that negatively regulates skeletal muscle mass (1).

25 iRNAs, die perinatally and display decreased skeletal muscle mass accompanied by abnormal myofiber mo

26 the fatigue resistance of muscle, increased skeletal muscle mass and ameliorated muscle injury in my

27 ressive body weight loss due to depletion of skeletal muscle mass and body fat.

28 an body mass, improved grip strength, higher skeletal muscle mass and diameter, and an increase in ty

29 energy expenditure and elevated appendicular skeletal muscle mass and energy intake in Alzheimer dise

30 ostatin inhibition would improve recovery of skeletal muscle mass and function after cerebral ischemi

31 RATIONALE: Loss of skeletal muscle mass and function is a common consequenc

32 Age-related loss of skeletal muscle mass and function is a key contributor t

33 Age-related loss of skeletal muscle mass and function is a major contributor

34 During aging, a significant loss of skeletal muscle mass and function occurs that can have a

35 Loss of skeletal muscle mass and function occurs with increasing

36 phenotype of accelerated age-related loss of skeletal muscle mass and function, although it is unclea

37 derlying sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear.

38 rized by progressive and generalized loss of skeletal muscle mass and function.

39 kine has now emerged as a major regulator of skeletal muscle mass and function.

40 h result in severe loss of motor ability and skeletal muscle mass and function.

41 ata show that targeting the ActRIIB improves skeletal muscle mass and functional strength in the mdx

42 Myostatin is a major negative regulator of skeletal muscle mass and initiates multiple metabolic ch

43 RP concentration and significantly increased skeletal muscle mass and lean body mass over time.

44 levels and no significant difference in both skeletal muscle mass and lean body mass.

45 on, 1 week of bed rest substantially reduces skeletal muscle mass and lowers whole-body insulin sensi

46 In contrast, reductions in both skeletal muscle mass and Mito(VD) have been reported fol

47 strophic mdx(5Cv) mice for 2 weeks increased skeletal muscle mass and normalized plasma creatine kina

48 current RDA or twice the RDA (2RDA) affects skeletal muscle mass and physical function in elderly me

49 we show that YAP positively regulates basal skeletal muscle mass and protein synthesis.

50 d UPR pathways are essential for maintaining skeletal muscle mass and strength and for protection aga

51 ective strategies for preventing declines in skeletal muscle mass and strength with age.

52 isk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as

53 Aging reduces skeletal muscle mass and strength, but the underlying mo

54 process, mammals lose up to a third of their skeletal muscle mass and strength.

55 ty is sarcopenia, the age-associated loss of skeletal muscle mass and strength.

56 sms underpinning this finding, such as a low skeletal muscle mass and/or fluid overload.

57 In 2-week-old mice, skeletal muscle masses and insulin responses were slight

58 insulin secretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation.

59 r LBM (beta = -0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did control

60 ssential for mechanically induced changes in skeletal muscle mass, and previous studies have suggeste

61 The ability to maintain skeletal muscle mass appears to be impaired in insulin-r

62 Bone and skeletal muscle mass are highly correlated in mammals, s

63 ment failed to prevent age-dependent loss of skeletal muscle mass associated with myofiber atrophy or

64 The adipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation

65 generate a mechanically induced increase in skeletal muscle mass, but the mechanism(s) through which

66 other catabolic conditions, induces loss of skeletal muscle mass by promoting fiber atrophy.

67 Skeletal muscle mass can be measured noninvasively with

68 mutants also exhibit a dramatic reduction in skeletal muscle mass, consistent with a defect in expans

69 During the later adult years, skeletal muscle mass decreases and body fat becomes cent

70 Skeletal muscle mass decreases in end-stage heart failur

71 a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber numbe

72 has been proposed to bind key regulators of skeletal muscle mass development, including the ligands

73 eding, total subcutaneous adipose tissue and skeletal muscle mass did not differ significantly betwee

74 Skeletal muscle mass, function, and repair capacity all

75 ABSTRACT: Significant skeletal muscle mass guarantees functional wellbeing and

76 ers of a genetic model that harbours reduced skeletal muscle mass have yet to be analysed.

77 eriod has been associated with reduced adult skeletal muscle mass; however, the mechanisms responsibl

78 trauterine growth restriction (IUGR) reduces skeletal muscle mass in fetuses and offspring.

79 aneous AT, visceral AT (VAT), and total-body skeletal muscle mass in healthy sedentary African Americ

80 al-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients.

81 (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals.

82 ction has been shown to underlie the loss of skeletal muscle mass in many acquired and genetic muscle

83 s that is essential for proper regulation of skeletal muscle mass in mice.

84 e role of ER stress and UPR in regulation of skeletal muscle mass in naive conditions and during canc

85 inversely associated with total appendicular skeletal muscle mass in older men (r = -0.43; slope: -0.

86 offset the age-related loss of appendicular skeletal muscle mass in older men.

87 ture research directives designed to protect skeletal muscle mass in physically active, normal-weight

88 Mechanistically, the better recovery of skeletal muscle mass in PINTA745-MCAO mice involved an i

89 the complex molecular mechanisms controlling skeletal muscle mass in response to increased physical a

90 ABSTRACT: Reduced skeletal muscle mass in the fetus with intrauterine grow

91 s reported here, we investigated the role of skeletal muscle mass in the regulation of liver:body mas

92 is (TWEAK)-Fn14 system are key regulators of skeletal muscle mass in various catabolic states.

93 y in cellular models, has a direct impact on skeletal muscle mass in vivo.

94 tion mutations are associated with increased skeletal-muscle mass in mice, cattle, and humans.

95 Stair climbing correlates included skeletal muscle mass (in kilograms) and its change, pain

96 ne inactivation prevented the severe loss of skeletal muscle mass induced in mice engrafted with Lewi

97 Maintenance of skeletal muscle mass is contingent upon the dynamic equi

98 The maintenance of skeletal muscle mass is critical for sustaining health;

99 ABSTRACT: The maintenance of skeletal muscle mass is essential for health and quality

100 uals because attenuating the extent to which skeletal muscle mass is lost during energy deficit could

101 Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height2 (m2) being less than t

102 In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and les

103 Ten percent of women had skeletal muscle mass levels less than a proposed cutpoin

104 Skeletal muscle mass loss and dysfunction have been link

105 ammation is associated with cachexia-induced skeletal muscle mass loss in cancer.

106 Skeletal muscle-mass loss with age has severe health con

107 The relationship between bone and skeletal muscle mass may be affected by physical trainin

108 rmation even though the largest increases in skeletal muscle mass occur after birth.

109 Loss of skeletal muscle mass occurs during aging (sarcopenia), d

110 free mass (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution o

111 urthermore, an effect of age on appendicular skeletal muscle mass persisted after standing height and

112 An effect of age on appendicular skeletal muscle mass persisted after standing height and

113 found that PGC1beta progressively decreases skeletal muscle mass predominantly associated with loss

114 in gene (Mstn) have a widespread increase in skeletal muscle mass resulting from a combination of mus

115 eight (body-mass index [BMI] <20 kg/m(2)) or skeletal muscle mass (sarcopenia).

116 perative discrimination of patients with low skeletal muscle mass (sarcopenic patients) using compute

117 intake, restore energy balance, and maintain skeletal muscle mass should be a future area of investig

118 n of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mo

119 al muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regen

120 prediction equations to quantify whole-body skeletal muscle mass (SM) in adults.

121 mposition method is estimation of total-body skeletal muscle mass (SM, in kg) from 24-h urinary creat

122 study aims were to characterize deficits in skeletal muscle mass, strength and physical performance,

123 ned as a progressive and generalized loss of skeletal muscle mass, strength, and function.

124 s in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally

125 tracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mas

126 indicate that TP53INP2 negatively regulates skeletal muscle mass through activation of autophagy.

127 A rapid and early loss of skeletal muscle mass underlies the physical disability c

128 We measured body fat and skeletal muscle mass using whole-body dual X-ray absorpt

129 e decile values of fat mass and appendicular skeletal muscle mass utilizing the LMS statistical proce

130 At all ages examined the loss of skeletal muscle mass was accompanied by a loss of myobla

131 sition was determined anthropometrically and skeletal muscle mass was determined as the creatinine-he

132 Total appendicular skeletal muscle mass was determined by dual-energy X-ray

133 ometric equation for predicting appendicular skeletal muscle mass was developed from a random subsamp

134 s, liver weights were preserved and instead, skeletal muscle mass was reduced in GCN2(-/-) mice fed a

135 of myostatin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal

136 d body composition (lean mass and total body skeletal muscle mass), weight, and walking capacity.

137 Participants' LBM and appendicular skeletal muscle mass were measured using dual energy x-r

138 racterized by a continuous loss of locomotor skeletal muscle mass, which causes profound muscle weakn

139 F11, and activins are negative regulators of skeletal muscle mass, which have been reported to primar

140 that predominantly results from the loss of skeletal muscle mass, which is in part associated with a

141 ed muscle contraction secondary to a reduced skeletal muscle mass, which may be related to pulmonary

142 ibuted to greater gains in fat-free mass and skeletal muscle mass with RT in older men than did an LO

143 We investigated the relationship between skeletal muscle mass (with dual-energy x-ray absorptiome

144 orial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass)

145 We hypothesized that loss of skeletal muscle mass would include inspiratory muscles a