ライフサイエンスコーパス: skeletal myoblast

1 trisphosphate (IP3) response to BK in L8 rat skeletal myoblasts.

2 ed for leucine-induced activation of S6K1 in skeletal myoblasts.

3 d PDGF-BB, induces a fate switch in adjacent skeletal myoblasts.

4 in that promotes myogenic gene expression in skeletal myoblasts.

5 that EGLN3 promotes differentiation of C2C12 skeletal myoblasts.

6 ucose uptake by L6 myotubes and neonatal rat skeletal myoblasts.

7 in insulin receptor knock-out mouse-derived skeletal myoblasts.

8 lso repressed the myogenic capacity of human skeletal myoblasts.

9 elded multipotent mesenchymal precursors and skeletal myoblasts.

10 ncluding 3T3E1 osteoblasts and human primary skeletal myoblasts.

11 ival functions in terminally differentiating skeletal myoblasts.

12 re it proved to be more active than in C2C12 skeletal myoblasts.

13 imary cell line derived from mammalian (rat) skeletal myoblasts.

14 y derive from direct conversion of committed skeletal myoblasts.

15 ter myocardial injury to a similar degree as skeletal myoblasts.

16 , and many aspects of the differentiation of skeletal myoblasts.

17 myoblasts, whereas hTra2beta increases it in skeletal myoblasts.

18 ferentiation and the coincident apoptosis of skeletal myoblasts.

19 icted genes, and cellular differentiation of skeletal myoblasts.

20 licated previously in the differentiation of skeletal myoblasts.

21 ssues made from genetically modified primary skeletal myoblasts.

22 apidly, and clinical trials using autologous skeletal myoblasts and bone marrow cells are under way.

23 l of several cell types, and both autologous skeletal myoblasts and bone marrow progenitor cells have

24 ols a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.

25 miR-1, miR-206 and miR-133 is restricted to skeletal myoblasts and cardiac tissue during embryo deve

26 be an in vitro model of hypertrophy in C2C12 skeletal myoblasts and demonstrate that induction of hyp

27 nking region was an active promoter in C2C12 skeletal myoblasts and exhibited increased expression up

28 so shown to be necessary for the survival of skeletal myoblasts and for the efficient formation of in

29 we used two differentiated cell types, C2C12 skeletal myoblasts and LLC-PK1 kidney epithelial cells,

30 Cocultures of human skeletal myoblasts and rat cardiomyocytes resulted in re

31 In animals, both skeletal myoblasts and stem cells partially restore myoc

32 restriction (GR) impaired differentiation of skeletal myoblasts and was associated with activation of

33 Rem is expressed in primary skeletal myoblasts and, when overexpressed in C2C12 myob

34 stics of endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells.

35 entiates BK-induced IP3 production in L8 rat skeletal myoblasts, and this action of insulin involves

36 Skeletal myoblasts are an attractive cell type for trans

37 Using differentiated C2C12 skeletal myoblasts as a model system, we observe that ca

38 chondrocytes, adipocytes, stroma cells, and skeletal myoblasts) as well as visceral mesoderm (endoth

39 on of the dominant negative protein in C2C12 skeletal myoblasts blocked the differentiation-induced e

40 These cell types include skeletal myoblasts, bone-marrow derived cells, endotheli

41 ) pathway is required for differentiation of skeletal myoblasts, but how the pathway is activated dur

42 Work began with committed cells such as skeletal myoblasts, but recently the field has expanded

43 es nuclear entry of NFAT in undifferentiated skeletal myoblasts, but the IP3R Ca(+2) pool in differen

44 osarcoma SVR cells) and control cells (mouse skeletal myoblast C2C12 cells).

45 To accomplish this goal, we determined if skeletal myoblasts can distinguish among differences in

46 Thus, skeletal myoblasts can establish new muscle tissue when

47 he Raf kinase signal transduction pathway in skeletal myoblasts causes a complete cessation of myofib

48 Skeletal myoblast cell proliferation and subsequent diff

49 During terminal differentiation of skeletal myoblasts, cells fuse to form postmitotic multi

50 induced during the differentiation of C2C12 skeletal myoblasts, coincident with myoblast fusion.

51 isease who were transplanted with autologous skeletal myoblasts concurrent with left ventricular assi

52 Based on these results, we propose that skeletal myoblasts contain multiple mechanosensory eleme

53 To determine if skeletal myoblasts could establish new contractile tissu

54 In this study, neonatal rat skeletal myoblasts cultured within 3-dimensional enginee

55 volved in it, a parallel study on normal rat skeletal myoblast cultures was conducted.

56 Heat-shocked skeletal myoblasts demonstrated improved tolerance to hy

57 Skeletal myoblasts derived from SIRT1+/- heterozygous mi

58 ith the functional benefits of newly formed, skeletal myoblast-derived muscle in the later phase.

59 Expression of MURF is required for skeletal myoblast differentiation and myotube fusion.

60 nduces the secretion of a novel inhibitor of skeletal myoblast differentiation.

61 port that EGLN3 levels increase during C2C12 skeletal myoblast differentiation.

62 rom a genome-wide transcriptional dataset of skeletal myoblast differentiation.

63 tion of the i-proteasome also impaired human skeletal myoblast differentiation.

64 sin heavy chain and myogenin, two markers of skeletal myoblast differentiation.

65 Bone marrow and skeletal myoblasts do not promote true tissue regenerati

66 n exposed to Dll4 and PDGF-BB, but not Dll1, skeletal myoblasts downregulate myogenic genes, except M

67 and specifically expressed in proliferating skeletal myoblasts during myogenesis was identified.

68 Here, we report that undifferentiated rat skeletal myoblasts expressed N-cadherin and connexin43,

69 and host myocytes following transplantation, skeletal myoblasts expressing an enhanced green fluoresc

70 L6 rat skeletal myoblasts expressing ss-galactosidase (ss-gal)

71 tal myotubes differentiated from C2C12 mouse skeletal myoblasts for three weeks by utilizing micromol

72 Skeletal myoblasts form grafts of mature muscle in injur

73 Implanted skeletal myoblasts form viable grafts in infarcted myoca

74 The implanted skeletal myoblasts formed viable grafts in heavily scarr

75 alyzed GRalpha and 11beta-HSD1 expression in skeletal myoblasts from men (n = 14) with contrasting le

76 Skeletal myoblast fusion in vitro requires the expressio

77 Thus engraftment of skeletal myoblasts generated spatial heterogeneity of [C

78 Skeletal myoblast grafts can form contractile tissue to

79 Skeletal myoblasts grown in vitro and induced to differe

80 infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy m

81 types, including myogenic cell lines, adult skeletal myoblasts, immoratalized atrial cells, embryoni

82 er, bovine serum albumin (BSA), fibrin glue, skeletal myoblasts in BSA, or skeletal myoblasts in fibr

83 s as an autocrine differentiation factor for skeletal myoblasts in culture.

84 induced during the differentiation of C2C12 skeletal myoblasts in culture.

85 After five weeks, the mean area covered by skeletal myoblasts in fibrin glue was significantly grea

86 , fibrin glue, skeletal myoblasts in BSA, or skeletal myoblasts in fibrin glue were injected into the

87 Since the initial report of cell therapy (skeletal myoblasts) in HF in 1998, research has proceede

88 to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the

89 lcium levels inhibits the differentiation of skeletal myoblasts into mature myotubes.

90 Differentiation of skeletal myoblasts into multinucleated myotubes is a mul

91 Direct injection of autologous skeletal myoblasts into the peri-infarct area has been p

92 Raf on the differentiation and apoptosis of skeletal myoblasts is dictated by the level of Raf signa

93 Expression of oncogenic Ras in 23A2 skeletal myoblasts is sufficient to induce both a transf

94 lar, we find that the predominant isoform in skeletal myoblasts is Tbx5c, and we show that it is dram

95 initiation of differentiation of C2C12 mouse skeletal myoblasts, knockdown of USP9X increases mTORC2

96 d in endothelial cells, smooth muscle cells, skeletal myoblasts (L6, BC3H1, C2C12), fibroblasts, and

97 Cardiomyoplasty with skeletal myoblasts may benefit cardiac function after in

98 In primary skeletal myoblasts pioglitazone also up-regulates PGC-1a

99 ver, when cocultured with endothelial cells, skeletal myoblasts, previously treated with Dll4 and PDG

100 ions of endogenous erythropoietin to promote skeletal myoblast proliferation and survival and wound h

101 cleus and thus control the fate of committed skeletal myoblasts remains poorly understood.

102 Skeletal myoblast (SkM) implantation improves cardiac fu

103 Strategies to enhance skeletal myoblast (SkM) survival after transplantation i

104 tion of AdVEGF-165 to the transplantation of skeletal myoblasts (SKMB) transfected with AdVEGF-165 in

105 ar cells (MN), mesenchymal stem cells (MSC), skeletal myoblasts (SkMb), and fibroblasts (Fibro) expre

106 ion chronic heart failure model, we compared skeletal myoblast (SMB) with bone marrow cell (BMC) inje

107 Cell transplantation of skeletal myoblasts (SMs) is one possible treatment for r

108 restricted, being 80-fold greater in primary skeletal myoblasts than in liver-derived HepG2 cells.

109 for SHP-2 as a nutrient-sensing regulator in skeletal myoblasts that is required for the activation o

110 aling system via a tyrosine kinase in L8 rat skeletal myoblasts that results in increased IP3 formati

111 Exposure of undifferentiated skeletal myoblasts to DIs, followed by incubation in dif

112 mized, multicenter pilot study of autologous skeletal myoblast transplantation concurrent with CABG o

113 Skeletal myoblast transplantation has been shown to impr

114 Successful autologous skeletal myoblast transplantation into infarcted myocard

115 Skeletal myoblast transplantation is a potential treatme

116 Graft survival after skeletal myoblast transplantation is affected by various

117 Skeletal myoblast transplantation is promising for the t

118 Autologous skeletal myoblast transplantation is under investigation

119 monstrated the feasibility and efficiency of skeletal myoblast transplantation via the intracoronary

120 Primary skeletal myoblasts were stably transfected with a hFIX e

121 One million primary skeletal myoblasts were then infused via the coronary ar

122 Primary rat skeletal myoblasts were transfected with the human VEGF(

123 ologous, unfractionated bone marrow cells or skeletal myoblasts were used in early clinical trails to

124 We found that hESC-derived skeletal myoblasts were viable after transplantation int

125 losely resemble quiescent, stably programmed skeletal myoblasts with the capacity to differentiate wh

126 Survival and proliferation of skeletal myoblasts within the cardiac environment are cr

127 n documented survival and engraftment of the skeletal myoblasts within the infarcted myocardium.

128 ther supplementing infarcted myocardium with skeletal myoblasts would (1) result in viable myoblast i