ライフサイエンスコーパス: skewing

1 -146a was required to prevent overt Th1/Th17 skewing.

2 educed T cell numbers/proliferation, and TH1 skewing.

3 T cell lymphopenia and unusual T helper cell skewing.

4 ourth: inappropriate T-helper 2 (Th2) immune skewing.

5 ation was sustained, leading to enhanced Th2 skewing.

6 s, can directly activate DCs to induce T(H)2 skewing.

7 ndicating the lack of requirement for clonal skewing.

8 ing CD8 T cells, and CXCL10 antagonizes this skewing.

9 ach positively regulate root waving and root skewing.

10 t the function of OX40 ligand (OX40L) in Th2 skewing.

11 characterized by lymphopenia and repertoire skewing.

12 ilure was associated with late memory T-cell skewing.

13 ated AD responses, with increased TH17/IL-23 skewing.

14 ed HSCs presenting with a pronounced lineage skewing, a hallmark of HSC ageing.

15 al appearance, transcriptional profiling, Ab skewing, Ab repertoire, and secretory response to stimul

16 ic cDCs from NP-exposed mice have potent Th2-skewing ability and secrete increased levels of IL-6 and

17 tor of transcription 3 (Stat3) in T cells in skewing adaptive immunity in visceral adipose tissue (VA

18 ral strategy for the rational design of Th17-skewing adjuvants by combining agonists of the CARD9 pat

19 In addition, Th-skewing after GP-based immunization was altered in C3(-/

20 role in Th1 development, the response to Th-skewing Ags was analyzed in Gadd45alpha(-/-) mice.

21 lopment in vivo, but this unexpected lineage skewing also highlights the importance of adequate spati

22 e results strongly suggest selection-induced skewing alters B-1a cell-derived natural Ab, which may i

23 atistically significant degree of positional skewing among epitopes; epitopes from both ends of antig

24 echanical development, including biased root skewing, an inability to penetrate hard agar layers, and

25 responses and protected against their T(H)1 skewing and apoptosis.

26 ence through the induction of laccase, a Th2-skewing and CNS tropic factor.

27 el finding on the direct association of Th17 skewing and disease severity illustrates the significanc

28 ding augmented specific IgG4 antibodies, Th1 skewing and enhanced IL-10.

29 New concepts on how T-cell skewing and epitope specificity are shaped by multiple e

30 r, concomitant with a peripheral Th2 profile skewing and ex vivo recipient hyporesponsiveness toward

31 t mice, we found that S6K2 loss reduces Th17 skewing and increases regulatory T cell differentiation

32 s prestimulation thresholds for inflammatory skewing and NF-kappaB amplification in macrophages and f

33 e has immunomodulatory effects including Th2 skewing and reduced IL-10-secreting T regulatory cells,

34 orted by frequent B cell receptor repertoire skewing and stereotypy.

35 to mimic the effects of IL-6 on both Th1/Th2 skewing and Tfh cell differentiation.

36 These studies revealed repertoire skewing and the presence of high-frequency clonotypes th

37 filtrating lymphocytes showed TCR repertoire skewing and upregulation of CD137.

38 ed increased T-cell activation, naive T-cell skewing, and elevated serum CXCL9 and CXCL10 levels.

39 em cell (HSC) self-renewal capacity, myeloid skewing, and immune cell depletion.

40 ficant chronic immune activation, phenotypic skewing, and inflammation driven by years of continuous

41 mportant pathway in T-cell proliferation, Th skewing, and inflammatory autoimmunity, and may be an at

42 plate, correcting for recombination, allelic skewing, and misincorporation/sequencing errors.

43 carriers, but the mechanisms underlying this skewing are unknown.

44 ed and is not due to underlying cytoskeletal skewing, as is the case in other known, phenotypically s

45 Ex vivo Th17 skewing assays demonstrate that genetic or pharmacologic

46 Skewing away from these conserved regions of the epitope

47 formation, Iglambda(+) and Igkappa(+) B cell skewing, B1/B2 development, and the initial extrafollicu

48 autologous lymphocytes, led to Th1 response skewing, based on significantly higher levels of IFN-gam

49 ts, the results indicated overlapping tissue skewings between the recipients, also between the tissue

50 of both genes correlated with X-inactivation skewing but no significant association with age-adjusted

51 supernatants were sufficient to promote Th17 skewing, but those from Treg-mast cell cultures were not

52 In vivo Treg skewing by adoptive transfer of H pylori-pulsed DCs redu

53 indings counter previous hypotheses that Th2 skewing by DCs is a passive response and support a model

54 We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibit

55 This skewing came at the expense of the number of lymphoid-pr

56 Since neonatal Th2 skewing can be modified by stimulation with Toll-like re

57 n rejection, establishing organ tolerance by skewing CD4 T helper polarization away from a proinflamm

58 udy highlights a role for these receptors in skewing CD8 T cell differentiation into effector and mem

59 In human TH1- or TH2-skewing cell culture systems, cotranscriptional R-loops

60 amma production by cells developed under Th1-skewing conditions and decreased interleukin (IL) -4, IL

61 ecomes activated in mouse T cells under Th17 skewing conditions and phosphorylates interferon regulat

62 m naive Ikaros(null) mice cultured under Th2-skewing conditions express the Th1 cytokine IFN-gamma an

63 potential to produce Th2 cytokines under Th1-skewing conditions in a signal transducer and activator

64 on of these effector-derived cells under Th1-skewing conditions leads to production of IFN-gamma alon

65 IL-13 production when cultured under type 1-skewing conditions, but maintained adequate levels of in

66 When placed under Th17-skewing conditions, CD4(+) T cells from fyn(-/-) mice ha

67 IL21, IL22, IL23R, RORC, and CSF2) under TH1-skewing conditions, suggesting a role for WASp in modula

68 In contrast, under Treg cell-skewing conditions, TEAD1 expression and sequestration o

69 After T cell activation under Tr1-skewing conditions, the AhR bound to c-Maf and promoted

70 In addition, under Th2 skewing conditions, which induce IL-10 production by wil

71 significantly inhibited even under specific skewing conditions.

72 L-10 production by cells developed under Th2-skewing conditions.

73 and TH2 cells under respective TH1- and TH2-skewing conditions.

74 Treg skewing confers activated Teff phenotypic and functional

75 aired efferocytosis in CGD due to macrophage skewing contributes to enhanced inflammation.

76 umbers, TH2 cytokines were detected, and TH2 skewing correlated with total IgE levels.

77 Centric-skewing correlates with a bias towards class I binding p

78 or CD4 IL-2 production and subsequent immune skewing could contribute to lupus susceptibility in huma

79 may respond negatively to the UAVs, thereby skewing counts.

80 hancer, alters how DCs metabolize glutamate, skewing cytokine secretion to bias T cell function.

81 ngevity, and augments their secretion of Th1-skewing cytokines and chemokines.

82 required to suppress expression of the Th17-skewing cytokines IL-6 and IL-23p19.

83 ducing T cells in the presence of additional skewing cytokines, IL-6 and TGF-beta.

84 with production of proinflammatory and TH17-skewing cytokines, resulting in a TH17 immune response w

85 during chorioamnionitis could be pivotal in skewing decidual monocyte differentiation to macrophages

86 optosis of CD8(+) T cells and are capable of skewing differentiation of macrophages into insulin-sens

87 tory response or increased T cell activation/skewing display a more impaired behavioral profile than

88 2B) and 5HT(7) receptors mediated the pro-M2 skewing effect of 5HT.

89 her these actions are related to its lineage skewing effects are poorly understood.

90 This did not reflect differential skewing efficiency in human versus mouse cultures, as th

91 her the cells are expanded under Th1- or Th2-skewing environment.

92 to PI may include specific IgE, Th2 cytokine skewing, eosinophils, activation of the complement, and

93 al a role for NADPH oxidase and p40(phox) in skewing epitope selection and T cell recognition of self

94 In vitro Th1/Th17-skewing experiments excluded the intrinsic effect of gal

95 ore, showing that it can produce evaluations skewing far from intuitive expectations.

96 g-specific events while avoiding the extreme skewing frequently seen in purely monoclonal systems.

97 3, can induce maturation and T-helper type 1 skewing function in human Langerhans cell-like dendritic

98 , fueled by complement imbalance and therapy-skewing genetic variance, underscore the need for more c

99 Progressive X-chromosome skewing has recently been suggested by XCIP clonality st

100 ve TLI conditioning protects against GvHD by skewing host T-cell subsets to favor regulatory natural

101 e in animals models of autoimmunity and Th17-skewing human cell culture in vitro.

102 with the expression of CD56, indicative for skewing human pDCs toward an interferon-producing killer

103 nd TH22 (IL-22 and S100As) axes and some TH1 skewing (IFN-gamma and CXCL10) were present.

104 e data show an exosome-mediated mechanism of skewing IL-2 responsiveness in favor of regulatory T cel

105 Furthermore, the production of TH17-skewing IL-6, IL-23, and TNF-alpha by dendritic cells in

106 ell malignancy characterized by Th2 cytokine skewing, impaired T-cell responses, and overexpression o

107 There was skewing in favor of memory T cells and intense autoantib

108 om escape from XCI and from mosaicism or XCI skewing in females.

109 The 1,25D-triggered skewing in ILC3 function was not accompanied or caused b

110 beta-cell proliferation and islet yield with skewing in islet size distribution as well as higher pan

111 R1/2, reduced Treg function and induced Th17 skewing in MS patient samples more than in healthy contr

112 Blood phenotyping shows only TH2 skewing in patients with early-onset pediatric AD, but a

113 We connect this fate selection to skewing in production of hepatocyte growth factor (HGF)

114 Cytokine responses showed trends towards Th1 skewing in the GI-homing alpha4beta7+ cells of peanut-to

115 essing human MCL1 as a transgene exhibited a skewing in the proportion of CD8(+) T cells, away from S

116 ta7+ cells of peanut-tolerant groups and Th2 skewing in the skin-homing CLA+ cells of peanut allergic

117 ctions were proportional to the level of Th2 skewing in this model.

118 more suppressive, and were resistant to Th17 skewing in vitro.

119 r, for some mouse genes, there appears to be skewing, in some ways resembling skewed X-inactivation,

120 Th2 skewing is mediated by OX40L, and we speculate that this

121 This skewing is mediated by the recruitment by IL-4Ralpha(R57

122 Late memory T cell skewing is observed in the setting of immune recovery af

123 e underlying potential energy landscape, and skewing it in favor of the unloaded side, and in some si

124 aturation within the tumor microenvironment, skewing it toward a Th2 immune response and impairing CD

125 While HDM caused significant Th2 skewing, it also illustrated differences in Th2 inductio

126 Monocyte M2 skewing likely contributes to NO bioinsufficiency in fal

127 In addition, 4-fold expansion and skewing (lower T1/T2-ratio) of the immature B cell subse

128 LCN2 induced IL-10 formation by macrophages, skewing macrophage polarization in a STAT3-dependent man

129 This IRA B cell-dependent T helper-1 skewing manifests in an IgG1-to-IgG2c isotype switch in

130 (MPhi) antibacterial effector mechanisms by skewing MPhis toward an alternatively activated M2 pheno

131 esis, and the Foxn1 BM niche may function in skewing MPP development toward T lineage progenitors.

132 Unlike a previously reported Th2-skewing murine iNKT cell agonist, the alphaGalCer C20:2

133 Skewing of allergen-specific effector T and effector B c

134 in HIV-infected individuals, focusing on the skewing of B-cell subsets that circulate in the peripher

135 mic autoimmune disease, displayed a profound skewing of blood CXCR5(+) Th cell subsets toward Th2 and

136 in EPC/CAC apoptosis, and by preventing the skewing of CACs toward nonangiogenic pathways.

137 Skewing of CD4(+) T cell differentiation toward Ag-speci

138 Le(X)-modification of OVA favored Th1 skewing of CD4(+) T cells and enhanced cross-priming of

139 atural hierarchies vary greatly in form, the skewing of contact patterns, introduced here through non

140 ion of normal T-cell proliferation and a Th2 skewing of cytokine production.

141 amma expression, poor help for CD8 CTLs, and skewing of DC subsets toward plasmacytoid DCs, coupled w

142 IFN-gamma expression, help for CD8 CTLs, and skewing of dendritic cell (DC) subsets toward CD8a DCs,

143 genome-wide survey of the degree of allelic skewing of DNA methylation with the aim of identifying p

144 terized by defective CD4 cell proliferation, skewing of effector CD4 T cells from a Th1 to a Th17 phe

145 PM3-myopathy, and is commonly accompanied by skewing of fibre-type ratios (either slow or fast fibre

146 Lastly, clonal skewing of hematopoiesis was detected in 67% of young, a

147 Moreover, pronounced skewing of Iglambda/Igkappa ratio was evident among TIL-

148 ed expression of activation markers, and the skewing of immune cells within the tumor toward an macro

149 patterns of response might contribute to the skewing of immune responses during mycotic infections an

150 showed that Ssa1 directly promotes early M2 skewing of lung mononuclear phagocytes during the innate

151 The preferential proinflammatory skewing of M16 relative to M14 was found to be mediated

152 cle promotes recruitment, proliferation, and skewing of macrophages toward a cyto-destructive phenoty

153 blems that would otherwise contribute to the skewing of mass assignments and reduction of S/N.

154 Indeed, a skewing of megakaryocyte commitment and differentiation

155 reatment, a dramatic reduction of TIMs and a skewing of MHCII(low) to MHCII(hi) macrophages were obse

156 Functional skewing of mononuclear phagocytes occurs in vivo under p

157 and reinfected animals, indicating that the skewing of mRNA gradient of viral gene expression, a mec

158 Immunoregulatory skewing of mucosal Th17 cell function, characterized by

159 oiesis, and granulomonocytic differentiation skewing of multipotent and common myeloid progenitors.

160 Chronic skewing of myeloid production occurred in parallel to a

161 ommitment, supported functionally by myeloid skewing of progenitors following treatment with a DNA me

162 Limitations included artifactual skewing of quantification by mass bias, a limited mass r

163 mice resulted in the aggravation of NTN and skewing of renal and systemic immune responses toward Th

164 Although skewing of responses toward primary infecting viruses wa

165 Importantly, the skewing of subsets correlated with disease activity and

166 demonstrate that PGE(2) was responsible for skewing of T cell responses, we infected macrophages fro

167 The skewing of T-cell differentiation is concomitant with ch

168 ially spares CD25+ natural Tregs which limit skewing of T-cell repertoire toward Tem phenotype among

169 ording to the original antigenic sin theory, skewing of T-cell responses induced by primary infection

170 that T reg (Foxp3(+)) cells showed a marked skewing of TCR usage by anatomical location in a manner

171 cognition it mediates cytokine responses and skewing of the adaptive immune system.

172 hanced allograft survival and protolerogenic skewing of the alloresponse is critically dependent on c

173 ences showed a secular trend toward positive skewing of the BMI distribution at younger ages.

174 FF is limited within GCs, perhaps to prevent skewing of the conventional B cell differentiation progr

175 at the Igkappa locus that showed a dramatic skewing of the expressed Igkappa repertoire.

176 Skewing of the human oral microbiome causes dysbiosis an

177 ophage invasion into biofilms in vivo, and a skewing of the immune response away from a microbicidal

178 infiltration of immune cells as well as the skewing of the immune response toward a Th2 cytokine pro

179 Skewing of the immunoglobulin heavy variable (IGHV) gene

180 iatic skin and that risk carriers manifest a skewing of the inflammatory network toward stronger IFN-

181 ed two hallmarks of MHC-dependent education: skewing of the Ly49 receptor repertoire and differential

182 These changes indicate a skewing of the memory population toward the central memo

183 te per se creates pro-oncogenic, genome-wide skewing of the molecular landscape, with translational a

184 n BM and spleen were increased, suggesting a skewing of the OC precursors toward DC differentiation.

185 as accelerated concomitantly with a dramatic skewing of the proportion of pStat5-expressing cells rel

186 hromosome inactivation may contribute to the skewing of the sex prevalence of parkinsonism toward wom

187 of T2 B cells, suggesting a link between the skewing of the T1/T2 ratio and the formation of immune c

188 These results depict a skewing of the TIGIT/CD226 axis from CD226 co-stimulatio

189 However, CD4(+) T cells exhibited unique skewing of the Vbeta2 and 11 families in only BALB.B rec

190 lar artery geometry strongly influenced both skewing of the velocity profiles and the wall shear stre

191 tivation and excessive T-helper type 1 (Th1) skewing of Treg cells into Th1-like Treg cells.

192 majority of MLS-affected females have severe skewing of X chromosome inactivation, suggesting that mu

193 s musculus x Mus spretus cells with complete skewing of X inactivation, relying on expression of sing

194 Skewing of X-chromosome allelic usage, based on preferen

195 Extreme skewing of X-chromosome inactivation (XCI) is rare in th

196 Females manifest phenotypes despite 100% skewing of X-inactivation and normal MECP2 RNA levels in

197 does promote augmentation, and Th1-mediated skewing, of anti-DNA autoantibodies.

198 We investigated the effect of Treg skewing on the phenotypic and functional properties of C

199 gamma production by CD4 T cells and not to a skewing or expansion of Th2 or regulatory T cells.

200 covering from past disturbances, potentially skewing our interpretations of forest dynamics and our u

201 ene, GPA1, exhibit wild-type root waving and skewing, our results may indicate that the AGB1 subunit

202 ipulations, Dnmt3a+/- mice developed myeloid skewing over time, and their hematopoietic stem/progenit

203 tribution of X chromosome inactivation (XCI) skewing percentages (range: 50%-100%) among women with s

204 establishment of the aged-associated myeloid skewing phenotype, which may contribute to age-associate

205 evealed that Zbtb16(lu/lu)HSCs had a lineage-skewing potential from lymphopoiesis toward myelopoiesis

206 em cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoieti

207 Our findings implicate public TCR in skewing repertoire response during autoimmunity and sugg

208 against graft-versus-host disease (GVHD) by skewing residual host T-cell subsets to favor regulatory

209 ormonal determinants of root-waving and root-skewing responses in plants and possibly interact in a t

210 nd that PCR stochasticity is the major force skewing sequence representation after amplification of a

211 vated levels of c-di-GMP inhibit swarming by skewing stator selection in favor of the nonfunctional,

212 as specifically induced by T(H)2- and T(H)17-skewing stimuli, as the T(H)1-inducing adjuvant, CpG oli

213 colipids are a major determinant of cytokine skewing, suggesting a pathway for designing therapeutic

214 regulatory T cells showed marked oligoclonal skewing, suggesting that their peripheral expansion was

215 Skewing T cell differentiation toward a Th2-dominated ph

216 It is reported that Opn exacerbates EAE by skewing T cell differentiation toward IFN-gamma-producin

217 between inflammation and immune tolerance by skewing T-cell fate decisions toward either the T-helper

218 nction, apoptosis, T helper (Th)1 versus Th2 skewing, T cell receptor signaling, and MHC class II ant

219 iratory epithelial function, and immune cell skewing that are hallmarks of asthma.

220 state of activation results in B cell subset skewing that is likely the result of alterations in home

221 od of melanoma patients showed strong type 2 skewing that was dramatically reversed by IL-12p70 trans

222 a marked basophilia, a constitutive Th2 cell skewing that was exacerbated upon in vivo challenge of b

223 t lymphoma B cells play an important role in skewing the balance between T(reg) and T(H)17 cells resu

224 ivity (maximal velocity, Vmax), particularly skewing the balanced hydrolysis of isomers to favor the

225 iferating T cells, diminishing the yield and skewing the CD4/CD8 ratio in the T-cell population, jeop

226 ns such as ARVs can induce metabolic stress, skewing the cell's immune response and restricting (cell

227 that the current AVA vaccine is effective in skewing the development of PA CD4(+) T cells to the Th2

228 frequencies of CD127(+) NK cells in CR mice, skewing the function of the total NK cell pool.

229 Thymic stromal lymphopoietin, a cytokine skewing the immune response toward a Th2 direction, was

230 sion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype

231 (Mfge8), in directing cardiac remodeling by skewing the inflammatory response after myocardial infar

232 The total effect of OPN on skewing the leukocyte population balance was observed as

233 lection contributes to effective immunity by skewing the mature TCR repertoire toward highly effectiv

234 CD56(dim)CD57(+)NKG2C(+) NK cell population, skewing the NK cell repertoire in favor of cytotoxic res

235 tates of high free energy for too long, thus skewing the obtained population frequencies.

236 ived growth factor receptor (PDGFR), thereby skewing the PI3K axis toward tumor cell proliferation.

237 The iTreg migrated into the CNS in quantity, skewing the ratio of regulatory to effector T lymphocyte

238 (Tregs) and decreased numbers of Th17 cells skewing the ratio of Tregs to autoreactive effector T ce

239 by reducing species number (richness) and by skewing the relative abundance of species (evenness).

240 perienced the greatest DNA damage responses, skewing the response toward lower-affinity responders wi

241 Finally, skewing the response toward neutrophil-inducing lymphocy

242 elied on double-knockout models, potentially skewing the role of Bcl-2, and the use of Bcl-2 as a mar

243 cerbate the effects of viral reactivation on skewing the T cell repertoire in CMV-infected individual

244 hese results demonstrate a role for Notch in skewing the T cell response from a T helper (Th)2 to a T

245 cial effect during pulmonary inflammation by skewing the Th2 response toward that of a Th1 type, sugg

246 nputs from both the Imd and Toll pathways by skewing the transcriptional output of the NF-kappaB dime

247 ll or DC lineages protected mice from AAI by skewing the typical TH2 immune response toward a TH1 res

248 TCR-mediated proliferation and Th1 and Th17 skewing, the former corresponding with an inability to s

249 milies that exhibited alloreactive CDR3-size skewing, there was a robust overlap between the in vitro

250 enhancing the overall magnitude but also by skewing this response to one that is dominated by IgG is

251 hat factors in the RCC microenvironment were skewing TIL phenotype toward EM.

252 Despite a 100-fold increase in IL-12 and Th1 skewing to a foreign Ag, OVA, synergistic TLR activation

253 MM cells also cause Th17 skewing to foreign Ag in normal mice without Th17-polari

254 changes in function and structure, including skewing to myeloid lineages, lower reconstitution potent

255 LOS biosynthetic genes indicated significant skewing to specific alleles, dependent on the disease ou

256 roid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relatio

257 p1-deficient CD4(+) T cells also resulted in skewing to the Th2 lineage and increased IL-4 production

258 ated CD8(+) T cells inhibit Ab production by skewing toward a proinflammatory cytokine profile, where

259 mmatory transcriptional programming, and (3) skewing toward a T helper (Th)/T cytotoxic (Tc)17 transc

260 ly naive T cells acquire a memory phenotype, skewing toward a T(EM) phenotype was prominent in the ab

261 CD4(+) T cells also demonstrate significant skewing toward a TH17 phenotype that is implicated in au

262 associated with increased CD4+ T cells, with skewing toward a Treg- and Th2-dominated phenotype, sugg

263 d by enhanced clearance by macrophages and a skewing toward an M2 phenotype.

264 by inhibiting proinflammatory cytokines and skewing toward anti-inflammatory response presumably by

265 In these animals, a preferential skewing toward CD4 repopulation and proliferation was ob

266 ) and CD8(+) cellular immune responses, with skewing toward CD4(+) T-cell activity against MARV GP.

267 Interestingly, gp140 boost induced a skewing toward CXCR3 expression on germinal center TFH c

268 of the ALAS2 mutation, there was a complete skewing toward expression of the WT allele in mRNA from

269 s is required for myeloid progenitor lineage skewing toward granulocyte-macrophage progenitors, incre

270 ve transfer into NOD.Rag recipients due to a skewing toward impaired Treg suppression.

271 issue (AT) MPhi abundance was increased with skewing toward M1 polarization.

272 fivefold in Runx1 KO mice, with a prominent skewing toward megakaryocyte (Meg) progenitors.

273 , there was a weaker effector response and a skewing toward memory precursor cells.

274 apacity with an altered cell differentiation skewing toward monocytic/granulocytic lineages.

275 Skewing toward myeloid cell production is often observed

276 ch as the increase in number of HSCs and the skewing toward myeloid-biased HSCs during aging.

277 Our findings provide evidence that T-cell skewing toward TEM may be associated with antigraft reac

278 ice, lacking Treg1 cells, showed spontaneous skewing toward Th1 immunity.

279 Instead, they show skewing toward TH2 responses, which, together with immun

280 ors have been shown to reprogram the marrow, skewing toward the expansion of myelopoiesis.

281 ive VDJ rearrangement, there was significant skewing toward the incorporation of proximal VH gene seg

282 ockout (DKO) iNKT cells displayed pronounced skewing toward the NKT17 lineage, with increased DNA met

283 e while maintaining higher IP-10 production, skewing toward the type I interferon pathway.

284 he T cell-to-MDSC balance, associated with a skewing toward type 2 immunity, may predict bladder tumo

285 Skewing toward Vkappa4 genes was observed in the pancrea

286 that Act-A-iTreg cells dampened crucial TH2-skewing transcriptional networks in DCs.

287 tion at these upstream sites, differentially skewing translation and protein expression.

288 SCLC may evade tumor immune surveillance by skewing tumor antigen-specific T cells to this unusual n

289 atures suppress endogenous immune responses, skewing tumor growth data and the severity of graft vers

290 Interestingly, this Treg skewing was a property of even early-stage tumors, sugge

291 This myeloid skewing was cell intrinsic, as arthritic HSPPCs up-regul

292 The Th2 cell skewing was dependent on basophils, immunoglobulin E, an

293 The Treg skewing was independent of H pylori VacA and CagA and de

294 Most important, Th17 skewing was prominent in advanced PBC patients with inte

295 This skewing was reflected in increases in average oligomer s

296 Th2 skewing was seen in both ADFM and ADWT, with no differen

297 susceptibility to PD as well as Th1/Th2 cell skewing, we crossed the IL-17RA gene knockout onto the B

298 mics as a key mediator of CTRA transcriptome skewing, which may both propagate perceived social isola

299 kdown of Lin28A led to hematopoietic lineage-skewing, with increased myeloid and decreased B-cell num

300 the hematopoietic compartment shows lineage-skewing, with myeloid cell numbers dramatically increase