ライフサイエンスコーパス: skin

1 y limited in complexity (no parathyroids, no skin).

2 bio-inspired shapes (lotus flowers and shark skins).

3 re not active at the levels emitted by human skin.

4 ant adhesion strength ( 1.6Ncm(-2)) with rat skin.

5 ollagen autoantibodies in patients' blood or skin.

6 ture of the object and its motion across the skin.

7 DT response by AFXL pretreatment in diseased skin.

8 ns that delivers dry coated vaccine into the skin.

9 y can also occur in PIPs within normal human skin.

10 half-life of IgE in both the circulation and skin.

11 ugs or extracting diagnostic biomarkers from skin.

12 f systemically injected nanoparticles in the skin.

13 man DC subsets in blood, tonsil, spleen, and skin.

14 nt in the abdominal skin but not in the back skin.

15 snake models and scale patterns on the snake skin.

16 ory and an immunosuppressive response in the skin.

17 tooth-like "denticles" embedded within their skin.

18 s one form of neurogenic inflammation on the skin.

19 d extension and migration of melanoblasts in skin.

20 devices for drug delivery applications into skin.

21 o any spatiotemporal stimulus applied to the skin.

22 he functional and reparative capacity of the skin.

23 dissolution kinetics of the microneedles in skin.

24 onsible for DNA demethylation in UVB-exposed skin.

25 ed with iDCpp65 showed GVH-like signs on the skin.

26 Uncomplicated skin abscesses are common, yet the appropriate managemen

27 PAH concentrations in personal air and on skin accounted for 54% of the variation in fold changes

28 work has uncovered genetic contributions to skin aging and confirmed previous findings, showing that

29 air pollution is known to be associated with skin aging manifestations.

30 at pigmentation is a critical determinant of skin aging.

31 eding patterns for doctor's diagnosed eczema/skin allergy in the first 6 years of life, adjusting for

32 obes from the sand fly are egested into host skin alongside Leishmania parasites.

33 ed not only in lesional but also nonlesional skin and blood, more complex biomarker models of AD are

34 ypic differences between the mouse and human skin and broadly informs on the prevailing principles th

35 tablish a tumor-promoting role for TCF7L1 in skin and elucidate the mechanisms underlying its tumorig

36 analysis, utilizing RNA-seq data from human skin and found that LCE3B/C-del was associated with a ma

37 rse the dermis to reach the epidermis of the skin and hair follicles.

38 Treatment with crenolanib attenuated the skin and heart fibrosis.

39 e that commonly affects the apocrine-bearing skin and involves follicular occlusion and hyperkeratosi

40 ed to investigate alignment and migration of skin and lung fibroblasts from SSc patients and healthy

41 Rectal, mean skin and mean body temperature (Tb ), electromyographic

42 Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-induced oxidative stress,

43 Staphylococcus aureus is a major cause of skin and soft tissue infection.

44 SA CC398) is causing an increasing number of skin and soft tissue infections (SSTIs) in Denmark and o

45 Overall infection rates and rates of RTI, skin and soft-tissue infection, urinary tract infection,

46 en the keratin of the stratum corneum of the skin and the glass surface.

47 terol preferentially accumulated in diseased skin and these autoantigens directly activated CD1b-auto

48 ted reactions are mild, involving mainly the skin, and, rarely, anaphylaxis.

49 ssue and lateral diffusion and exchange with skin appendages is presented.

50 ctronics systems, and toward advanced bionic skin applications.

51 uch as reversibility and stability) of human skin are affected by the external stimuli, as well as th

52 icated that TRAF1 expression levels in mouse skin are induced by short-term solar UV irradiation, and

53 hanisms mediating Treg migration to neonatal skin are unknown.

54 ing at a specified site by the proportion of skin area of that site.

55 The role of the blood or skin as a source of infection to sand flies remains uncl

56 ssion in lesional macrophages implicates the skin as the source of circulating cytokines.

57 ative abundance and inhibitory properties of skin bacteria.

58 t that the dominant members of the amphibian skin bacterial community may be functionally important i

59 yte-bound lipid envelope leading to a severe skin barrier defect and premature death of newborn anima

60 Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensi

61 m, tumor progression, viral replication, and skin barrier formation.

62 eins, which may in turn alter the protective skin barrier function.

63 h significant expression of genes related to skin barrier repair.

64 We discovered that skin biopsies obtained during asymptomatic human HSV-2 r

65 wn-regulated in vitiligo cell line PIG3V and skin biopsy samples from vitiligo patients, whereas its

66 nsity in 1-mm basal layers was determined in skin biopsy specimens from all lesions stained with hema

67 A total of 15110 skin biopsy specimens were included.

68 s, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densit

69 Skin biopsy-derived RNAs from 14 early systemic sclerosi

70 nonmalignant respiratory disease, and lung, skin, bladder, and kidney cancers.

71 ased with gel water content in the abdominal skin but not in the back skin.

72 Colonization of the skin by Staphylococcus aureus (S. aureus) is increased i

73 Thus, small molecules applied locally to the skin can be used to modulate touch and may represent per

74 billing codes and categorized as nonmelanoma skin cancer (NMSC), viral-linked and "other" cancers.

75 ylated NFAT3-Ser259 were highly expressed in skin cancer compared with normal skin tissues.

76 vioral research addressing all points of the skin cancer control continuum, measuring interventions t

77 Calcipotriol suppressed skin cancer development in mice in a TSLP-dependent mann

78 ons: (1) How accurate is teledermatology for skin cancer diagnosis compared with usual care (face-to-

79 ess their budget effect and the influence on skin cancer epidemiological findings.

80 ed information on skin, hair, and eye color; skin cancer family history; and sun exposure history, su

81 n of positive section margins in nonmelanoma skin cancer from 8.4% to 12.8%.

82 s research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs),

83 he risk factors and trends in posttransplant skin cancer is fundamental to targeted screening and pre

84 ss all three trials, adjudicated nonmelanoma skin cancer occurred in five patients who received tofac

85 Sun-protective behavior affects skin cancer prevention.

86 is critical to emphasize sun protection and skin cancer screening in individuals who tan indoors.

87 the cost-effectiveness of 2 population-based skin cancer screening methods and to assess their budget

88 To describe a skin cancer screening quality initiative in a large heal

89 Incident skin cancer was determined through detailed medical reco

90 for age, sex, educational level, history of skin cancer, and history of AK.

91 Skin cancer, the most common human malignancy, is primar

92 imers (CPDs) are DNA photoproducts linked to skin cancer, whose mutagenicity depends in part on their

93 l proportion can progress into squamous cell skin cancer.

94 hnique for non-Hodgkin lymphoma and melanoma skin cancer.

95 biquitous carcinogen in sunlight that causes skin cancer.

96 melanoma (MM) is the most aggressive form of skin cancer.

97 (cSCC) is one of the most common metastatic skin cancers with increasing incidence.

98 bedrock and tool of choice for the study of skin cancers.

99 These results indicate that mutagenesis and skin carcinogenesis in IGF-1-deficient geriatric skin ma

100 t-term solar UV irradiation, and a long-term skin carcinogenesis study showed that deletion of TRAF1

101 keratinocyte stem cells in beta-HPV-induced skin carcinogenesis, we utilized a transgenic mouse mode

102 ays, 2 new employees presented with the same skin changes.

103 2 FLG LOF alleles were less likely to report skin clearance (odds ratio [OR], 0.20; 95% CI, 0.07-0.55

104 broad range of phenotypic values for eye and skin color due to the mix of West African and European a

105 Measurements with FONIRS enabled to estimate skin concentration of liposomes (percent of injected dos

106 s and 647 patients with primary inflammatory skin condition admission diagnosis were selected.

107 of 413 patients with a primary inflammatory skin condition discharge diagnosis and 647 patients with

108 Additionally, skin conductance responses (SCRs) were weakly correlated

109 vary FGF2 exhibited significantly heightened skin conductance responses to the CS without shock durin

110 Skin conductance responses were used as an index of cond

111 re eye-blink reflexes and larger heart rate, skin conductance, and pupil area responses to loud sound

112 s in size, within normal chronically exposed skin contain mutations in multiple genes that are mutate

113 n an ex vivo human model of BP, normal human skin cryosections were incubated with purified human per

114 -catenin/E-cadherin in vitro and ameliorated skin damage in rodent models.

115 Skin sensitization did not require prior skin damage or enzymatic activity within HDM extract, ye

116 antibodies to deliver vaccine components to skin DC subsets.

117 lopment and in hair follicle polarity during skin development.

118 rogressive painful pruritic breast fullness, skin dimpling, and skin discoloration of the mastectomy

119 pruritic breast fullness, skin dimpling, and skin discoloration of the mastectomy scar and radiation

120 Psoriasis, a chronic inflammatory skin disease associated with increased susceptibility to

121 aneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transien

122 nding of this still underinvestigated severe skin disease in a European and largely white study popul

123 For the rare skin disease trichodysplasia spinulosa, we show that man

124 both AD and CD, and 10 HC with no history of skin disease was analysed using high-throughput proteomi

125 s (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte di

126 orrelate negatively with the severity of SSc skin disease.

127 involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is assoc

128 wing interest in the mechanical behaviour of skin due to the rapid development of microneedle devices

129 Tregs accumulate abruptly in the skin during a defined window of postnatal tissue develop

130 ltiple tissues during a high-fat diet and in skin during hair follicle growth.

131 and polymeric flavanols from withered grape skins during simulated maceration.

132 The skin epidermis and its appendages are subjected to daily

133 rminal domains of suprabasal keratins of the skin epithelium are very resistant to evidence-based str

134 e literature review who underwent total-body skin examinations (TBSE) were found to have MBAITs, sugg

135 Furthermore, in a skin excisional wound model, we found the effects of suc

136 que in vitro human graft-versus-host disease skin explant model.

137 treatment (P = 0.007) demonstrated increased skin expression of the anti-inflammatory mediator argina

138 s of volatiles and phenols that occur during skin fermentation in white winemaking.

139 Normal lung but not skin fibroblasts consistently elongated and aligned with

140 Using UV-exposed human skin fibroblasts, we found that, at the dose used, a sin

141 r its pharmacological inhibition, ameliorate skin fibrosis in experimental mouse models.

142 2) as a new profibrotic mediator in lung and skin fibrosis.

143 hylococcus epidermidis, a major component of skin flora, is an opportunist, often causing prosthetic

144 e, along with their potential application as skins for energy-saving buildings, is discussed.

145 syndrome, a genetic disease characterized by skin fragility, photosensitivity, and increased risk of

146 Shade works by physically shielding skin from direct harmful UV rays; however, skin may stil

147 of the nail unit followed by full-thickness skin graft reconstruction from January 1, 2000, to Augus

148 I on recipient DCs during the life span of a skin graft.

149 Here, we develop skin grafts from mouse and human epidermal progenitors t

150 tion and increased apoptosis in vitro and in skin grafts regenerated on mice, which was correlated wi

151 Actinic keratosis (AK), a skin growth induced by ultraviolet light exposure, requi

152 Actinic keratosis (AK) is a skin growth induced by UV light exposure that requires l

153 questionnaire that solicited information on skin, hair, and eye color; skin cancer family history; a

154 rown et al. (2017) shed new light on how the skin handles the activation of oncogenic pathways in the

155 technologies which utilise fermentation with skins have been developed for obtaining distinct white w

156 These microbial commensals are essential to skin health and can potentially lead to disease when the

157 RNA-seq analysis of whole skin identified a larger number of psoriasis-increased d

158 yielded a strong consensus on standards for skin imaging in dermatology practice.

159 rence tomography (OCT) has become a powerful skin imaging technique.

160 ommodate Li deposition/dissolution under the skin in a dendrite/moss-free manner.

161 S. aureus virulence was studied in a murine skin infection model.

162 Autoimmune manifestations, such as skin infiltration and autoantibodies, dramatically impro

163 TWEAK is therefore a critical contributor to skin inflammation and a possible therapeutic target in A

164 entiate cellular defense against UVB-induced skin inflammation and photocarcinogenesis through elevat

165 itochondrial respiratory chain complexes and skin inflammation and suggest that severe respiratory ch

166 bone marrow chimeric mice upon induction of skin inflammation by topical treatment with imiquimod cr

167 ylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis,

168 The associated skin inflammation was mediated by IL-5-expressing pathog

169 teolysis products from keratinocytes promote skin inflammation.

170 required for the development of spontaneous skin inflammation.

171 The major mechanism of skin injury common to these exposures is radiation-induc

172 This work suggests that sex-specific skin innate responsiveness to Hla and neutrophil bacteri

173 Trace minerals (TM) play a role in skin integrity and wound healing.

174 an, suggesting that WNV may migrate from the skin into the lymph node through another mechanism.

175 While causing little skin irritation, vaccination efficacy of BCG-MNAs was co

176 le transcript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding,

177 Skin is the largest human organ, and it provides a first

178 ifferent organic solutes within the membrane skin layer determined from attenuated total reflection F

179 er was more than 90% in the viable epidermis skin layer; whereas for BRAF inhibitors, discriminative

180 d biosynthesis in the epidermis of psoriatic skin leading to localized deficiency of cortisol.

181 Fibrosis in lung and skin leads to progressive bronchiolitis obliterans (BO)

182 current clinical setting, abrupt cutoff of a skin lesion determined by an examination of a dermatolog

183 sagA in MGAS315 synergistically reduced the skin lesion size and GAS burden in the liver and spleen.

184 rus to adjacent skin, thus leading to larger skin lesions and satellite lesions in IL-1R1(-/-) mice.

185 ontrol samples (n = 10), as well as fibrotic skin lesions from localized scleroderma and uninvolved s

186 r and lower limbs without pain, swelling, or skin lesions was noted at physical examination.

187 Skin lesions with pruritic vesicles on an erythematous b

188 ) is markedly upregulated in human psoriatic skin lesions.

189 essing potential overtreatment of suspicious skin lesions.

190 ouse model of imiquimod-induced psoriasiform skin lesions.

191 astatic tumours versus normal skin or benign skin lesions.

192 kin may change the molecular organization of skin lipids and proteins, which may in turn alter the pr

193 carcinogenesis in IGF-1-deficient geriatric skin may be caused by defects in multiple cellular respo

194 The uptake of solvent into the skin may change the molecular organization of skin lipid

195 ggests that transcriptomic profiling of bulk skin may inadequately capture the contribution of less a

196 g skin from direct harmful UV rays; however, skin may still remain exposed to reflected and indirect

197 remote target organ inflammation (eg, in the skin) may improve vascular diseases; however, randomized

198 e, we examine interindividual variability in skin MC responses to FcepsilonRI triggering vs those evo

199 Thus, the interplay between normal skin microbial interactions versus pathogenic microbial

200 ts an integral interaction between the human skin microbiome and ADSCs.

201 Because the skin microbiome is a rich source of LTA, a Toll-like rec

202 The skin microbiome was characterized in 30 patients with HS

203 contribution of the breast milk and areolar skin microbiomes to the infant gut microbiome.

204 We investigated the role of skin microbiota in cutaneous leishmaniasis and found tha

205 re is little information about resistance of skin microbiota in the biofilm form to antimicrobial dec

206 crobiota in Crohn's disease, but its role on skin microbiota is unknown.

207 th Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abund

208 ophobicity of the peptide and the species of skin model used in laboratory studies.

209 er and deeper perforations were found in the skin models with increasing water content.

210 dividual cell populations distinct from bulk skin, most strikingly in the least abundant CD8+ T effec

211 amic XB behavior were measured in chemically skinned myocardial preparations isolated from human dono

212 ns from localized scleroderma and uninvolved skin (n = 6).

213 te an existing data set on eye (n = 625) and skin (n = 684) color from Cape Verde, an island nation o

214 mplex microbial communities (such as patient skin, nasopharynx, and stool) as well as environmental b

215 n infected haematoma and an area of proximal skin necrosis were surgically treated.

216 Here, we report that the human skin odour profile is affected by malaria infection.

217 molecular mechanisms of suspected RM in the skin of a patient with keratitis-ichthyosis-deafness (KI

218 biome's effect on MCs by applying LTA to the skin of GF mice.

219 e quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose.

220 all tactile fibers innervating the glabrous skin of the hand to any spatiotemporal stimulus applied

221 melanomas arising in chronically sun-damaged skin on the head and neck has favorable recurrence rates

222 clic main chain, serves as a grafted polymer skin on the Li metal anode not only to incorporate ether

223 ting inflammation in a target organ (eg, the skin) on vascular diseases.

224 detected in metastatic tumours versus normal skin or benign skin lesions.

225 employing a Li metal anode with the grafted skin paired with LiNi0.5Co0.2Mn0.3O2 cathode has a 90.0%

226 mutations result in hearing loss alone or in skin pathologies with comorbid hearing loss.

227 Ex vivo intradermal neonatal porcine skin penetration of VD3 NMP from bilayer MN was quantita

228 inate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invas

229 hat particle size and formulation influences skin permeability and that lipophilic particles smaller

230 = 1.01, 95% CI: 0.93, 1.08), or Fitzpatrick skin phototype (for type IV vs. type I, multivariable-ad

231 Skin pigmentation and receipt of vasopressors were not a

232 We demonstrate that skin pigmentation is highly heritable, but known pigment

233 his, we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, S

234 Here, we investigate skin pigmentation variation in a cohort of 1,167 individ

235 Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), wh

236 ercise, were all negative.The results of the skin prick test (SPT) for Citrus unshiu and specific IgE

237 Infants with a skin prick test (SPT) response to egg white (EW) of less

238 nical-demographic questionnaire, spirometry, skin prick test and specific IgE were evaluated yearly.

239 ng hay fever, eczema, food allergy, positive skin prick testing (SPT), or elevated allergen-specific

240 s defined as one or more positive results on skin prick testing and clinically relevant symptoms of r

241 promote the growth of cancers of the brain, skin, prostate, pancreas, and stomach.

242 high-dose group; only one (an acute allergic skin reaction in the low-dose group) was assessed to be

243 ble-adjusted RR = 0.98, 95% CI: 0.92, 1.05), skin reaction to prolonged sun exposure (for painful bur

244 ls (RS = 0.53, P = .03) and allergen-induced skin reactions (RS = 0.63, P = .008).

245 The most common adverse events were skin reactions occurring in 49 (48%) of 103 CGM particip

246 of the melanoma cells in a three-dimensional skin reconstruct model and was associated with a decreas

247 -1 (P = 0.005), and a sustained reduction in skin redness (P = 0.02), correlating with significant ex

248 ing in 49% of patients) were most frequently skin related, GI, endocrine, and hepatic; grade 3 to 4 s

249 strated similar trends that roasted hazelnut skin rendered the highest activity.

250 pressure variability however the sympathetic skin response of the foot was impaired and sweat gland i

251 WBP2 deletion in mouse skin results in reduced proliferation in neonatal and wo

252 cted by the external stimuli, as well as the skin's structure and mechanical properties.

253 ribed longitudinal change in modified Rodnan skin score, using linear mixed models.

254 llicles (HFs), which house a major subset of skin SCs (HFSCs).

255 was quantitatively analysed after cryostatic skin sectioning, with 74.2+/-9.18% of VD3 loading delive

256 Skin sensitization did not require prior skin damage or

257 C or greater between affected and unaffected skin showed an 87.5% accuracy in cellulitis diagnosis.

258 violet B light or Benzo(a)pyrene exposure of skin shows that SNP309G allele actually protects against

259 cin solution (8 mg) or placebo into 2 intact skin sites for 2 days in 4 of 5 patients.

260 ssue sodium content in humans, we determined skin sodium content at the level of the calf in 99 patie

261 ons in the molecular composition of residual skin surface components (RSSC).

262 We assessed the diagnostic utility of skin surface temperature in differentiating cellulitis f

263 When Foxc1 was specifically ablated in skin, sweat glands appeared mature, but the mice were se

264 , 95% confidence interval (CI): 0.90, 1.09), skin tanning ability (for dark tan vs. no tan, multivari

265 ed in decreasing order by quebracho tannins, skin tannins, seed tannins and finally gallotannins.

266 Of 278 ST patients, 179 (64%) were skin test eligible; 43 (24%) received testing and none w

267 (phenotype 1); ii) positive reactors to the skin test regardless of post-mortem examination results

268 ndicator traits: i) positive reactors to the skin test with positive post-mortem examination results

269 on-reactors and inconclusive reactors to the skin tests with positive post-mortem examination results

270 e patient developed spots of healthy-looking skin that grew in size and number within widespread eryt

271 characterized by T-cell infiltration in the skin that leads to fibrosis, which can be life-limiting.

272 Vitiligo is an autoimmune disease of the skin that results in the destruction of melanocytes and

273 ugment the transmission of virus to adjacent skin, thus leading to larger skin lesions and satellite

274 w that all resulting growths that deform the skin tissue architecture regress, irrespective of their

275 retion of inflammatory cytokines in affected skin tissue from NC/Nga mice.

276 nse) long non-coding RNAs are deregulated in skin tissue of systemic sclerosis patients suggesting a

277 xpressed in skin cancer compared with normal skin tissues.

278 onset of select AEs ranged from 5 weeks for skin to 15 weeks for renal AEs.

279 We show that the response of the skin to hypoxia feeds back on a wide range of cardiovasc

280 6(th) or 7(th) rib with adjacent muscle and skin to restore bone defects, internal lining, and exter

281 f Raman spectroscopy to detect apparition of skin toxicity in patients treated with tyrosine kinase i

282 These T cells proliferated modestly after skin transplantation and underwent relatively weak funct

283 mice results in a significant inhibition of skin tumor formation.

284 Ge et al. now show that skin tumors exhibit merged chromatin profiles from disti

285 ures between persons with darker and lighter skin types who have CAD.

286 ognizant of CAD in younger women with darker skin types.

287 t; colitis in two patients, and neuritis and skin ulcer in one patient.

288 ls of terminal mTEC development with that of skin, undergoing an alternative route of cell death, nam

289 nza vaccine, we demonstrate the advantage of skin vaccination over intramuscular delivery of a two-fo

290 nspired by this unique feature of cuttlefish skins, we present a general approach to remote-controlle

291 Thermal images of affected and unaffected skin were obtained for each patient.

292 Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in ski

293 view focuses on the epithelial stem cells of skin, where they come from, where they reside, and how t

294 Psoriasis is a complex disease of skin with a prevalence of about 2%.

295 nalysis that P450 27C1 is localized to human skin, with two proteins of different sizes present, one

296 patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate b

297 During skin wound healing, CD26-positive cells accumulated over

298 which to track ASCs after transplantation to skin wounds.

299 anistic triggers of pathological scarring in skin wounds.

300 d to assess the effects of 0.5% PVI on acute skin wounds.