ライフサイエンスコーパス: skin aging

1 at pigmentation is a critical determinant of skin aging.

2 rinkling is one of the most notable signs of skin aging.

3 nt studies expand our understanding of human skin aging.

4 enes to study the molecular basis of healthy skin aging.

5 beta), which is a known gene associated with skin aging.

6 n performed in women with varying degrees of skin aging.

7 gen production stimulators, were examined in skin aging.

8 this self perpetuating cycle promotes human skin aging.

9 ar target for antioxidant protection against skin aging.

10 attenuate solar UVB light-induced premature skin aging.

11 s such as dermal elastin and collagen during skin aging.

12 ous effects and may thereby retard premature skin aging.

13 y a key role in the pathophysiology of human skin aging.

14 creen group showed no detectable increase in skin aging after 4.5 years.

15 ene supplementation had no overall effect on skin aging, although contrasting associations were seen

16 ajor external insults to cells and can cause skin aging and cancer.

17 UVR) from sunlight is the major effector for skin aging and carcinogenesis.

18 Chronic exposure to sunlight plays a role in skin aging and carcinogenesis.

19 work has uncovered genetic contributions to skin aging and confirmed previous findings, showing that

20 We also show that skin aging and reported experience of sunburns was propo

21 characterized by skin blistering, premature skin aging and skin cancer of unknown etiology.

22 tion damages human skin and causes premature skin aging and skin cancer.

23 nctions of senescent cells in the context of skin aging and wound healing.

24 whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans.

25 d intrinsic skin aging (collectively termed "skin aging"), and the impact of broadband light (BBL) tr

26 y SCINEXA (SCore for INtrinsic and EXtrinsic skin Aging) and airflow obstruction by spirometry, using

27 olet light can cause inflammation, premature skin aging, and cancer.

28 between 25-hydroxyvitamin D and features of skin aging are causal.

29 on numbers of nevi and atypical nevi, and on skin aging as measured by microtopography.

30 the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollut

31 It is considered a feature of skin aging, but risk factors other than aging are largel

32 antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking.

33 ith alphaVbeta3 integrin contribute to human skin aging by stimulating MMP-1-mediated collagen fibril

34 Photoaging, which is premature skin aging caused by long-term UV exposure, is of aesthe

35 sociated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and the i

36 D concentration was not associated with any skin aging feature (P-values > 0.05).

37 Facial pigmented spots are a common skin aging feature, but genetic predisposition has yet t

38 50.5% women, median age 63.1 years), facial skin aging features (perceived age, wrinkling, pigmented

39 Associations between 25-hydroxyvitamin D and skin aging features were tested by multivariable linear

40 n the dermal matrix may serve as markers for skin aging, for photoaging, and for immediate assessment

41 Skin aging from baseline to the end of the trial was 24%

42 roxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian randomization st

43 Regular sunscreen use retards skin aging in healthy, middle-aged men and women.

44 echanisms underlying intrinsic and extrinsic skin aging, including reactive oxygen species formation,

45 The hallmark of skin aging is fragmentation of collagen fibrils.

46 Skin aging is linked to reduced epidermal proliferation

47 Skin aging is not associated with systematic changes in

48 In the skin, aging is associated with overall epidermal thinnin

49 natural aging, we determined whether natural skin aging, like photoaging, gives rise to increased mat

50 the indoor PM2.5 exposure is associated with skin aging manifestation in a Chinese population.

51 osure levels were positively associated with skin aging manifestation, including score of pigment spo

52 e association between the PM2.5 exposure and skin aging manifestations by linear regression.

53 irect link between indoor air pollutants and skin aging manifestations has ever been shown.

54 air pollution is known to be associated with skin aging manifestations.

55 ents, there is neither increased photodamage/skin aging nor a higher incidence for sun-induced nonmel

56 O(2)-induced oxidative stresses that lead to skin aging or skin cancer has not been fully studied.

57 t irradiation from sunlight causes premature skin aging (photoaging), characterized in part by wrinkl

58 ar matrix (ECM), thereby promoting premature skin aging (photoaging).

59 diation, is a major determinant of premature skin aging (photoaging).

60 feature of the pathophysiology of premature skin aging (photoaging).

61 ctive tissue and may contribute to premature skin aging (photoaging).

62 cepted as an effective approach to delay the skin aging process.

63 that may lead to new insights into the human skin aging process.

64 Skin aging processes are modeled by treating keratinocyt

65 In conclusion, skin aging processes may involve ROS-induced protein dys

66 rapeutic target for skin disorders including skin aging, psoriasis, and atopic dermatitis.

67 Skin aging-reducing strategies should incorporate the se

68 ulates rather than enhance the expression of skin aging-related biomarkers ex vivo.

69 nd controls were identified by global facial skin aging severity including intrinsic and extrinsic pa

70 Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and wea

71 dermal pathology in radiation dermatitis and skin aging through IKK modulation and motivate the explo

72 gen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulf

73 clinical inflammation are concomitant during skin aging, thus raising the question of a causal link.

74 t rs185146 near SLC45A2 is associated with a skin aging trait at genome-wide significance (P = 4.1 x

75 We find that skin aging was associated with a significantly altered e

76 No overall effect of beta-carotene on skin aging was identified, and further study is required

77 Skin aging was not associated with residence or holidays

78 s suggest that vitamin D reduces the rate of skin aging, whereas population studies suggest the oppos