ライフサイエンスコーパス: skin disease

1 he future understanding of this debilitating skin disease.

2 iasis, a hyperproliferative and inflammatory skin disease.

3 dermatitis (AD) is the most common pediatric skin disease.

4 s underlying its pathogenic role in fibrotic skin disease.

5 or management strategies to control tropical skin disease.

6 ful application of non-viral gene therapy in skin disease.

7 and smartphone apps diagnosing and treating skin disease.

8 mple, scalable prodrug platform for treating skin disease.

9 a common inflammatory and hyperproliferative skin disease.

10 erlying phospholipase-dependent inflammatory skin disease.

11 , and about half of the patients have severe skin disease.

12 g candidates in the future treatment of this skin disease.

13 have a major impact on the overall burden of skin disease.

14 ants included 22 healthy individuals without skin disease.

15 atient visits associated with a diagnosis of skin disease.

16 (AD) is the most common chronic inflammatory skin disease.

17 are qualitatively defective in inflammatory skin disease.

18 nic urticaria is a frequent and debilitating skin disease.

19 mpact on skin homeostasis, and its effect of skin disease.

20 is issue), may be beneficial in inflammatory skin disease.

21 and the severity and natural history of this skin disease.

22 -mOVA mice resulted in strikingly attenuated skin disease.

23 itis (AD) is a chronic pruritic inflammatory skin disease.

24 sease resulted in long-term remission of the skin disease.

25 ouse model strongly reduced the inflammatory skin disease.

26 ity for S aureus-mediated exacerbation of AD skin disease.

27 orrelate negatively with the severity of SSc skin disease.

28 ay a critical role in the early stage of SSc skin disease.

29 logical process in this complex inflammatory skin disease.

30 s suppurativa (HS) is a chronic inflammatory skin disease.

31 mutations found in patients with phenotypic skin disease.

32 interest in the contribution of microbes to skin disease.

33 cal manifestations and pathology of allergic skin disease.

34 may change their occupation because of their skin disease.

35 o is of critical importance in understanding skin disease.

36 ecific gene expression and its disruption in skin disease.

37 is suppurativa (HS) is a common inflammatory skin disease.

38 judice in our society directed at those with skin disease.

39 ), with low cardiovascular risk and moderate skin disease.

40 apparently to repel ectoparasites and treat skin diseases.

41 contributes to the pathogenesis of fibrotic skin diseases.

42 can be targeted toward inflammation-related skin diseases.

43 shows therapeutic potential for inflammatory skin diseases.

44 ghlight an emerging role for Cx43 in genetic skin diseases.

45 phigoid are autoantibody-mediated blistering skin diseases.

46 atological services to patients with chronic skin diseases.

47 tes of global morbidity and mortality due to skin diseases.

48 JunB, in addition to molecular signatures of skin diseases.

49 stitute of Arthritis and Musculoskeletal and Skin Diseases.

50 n and/or activity is associated with chronic skin diseases.

51 a transformative impact on the treatment of skin diseases.

52 154 was suggested to exacerbate inflammatory skin diseases.

53 stitute of Arthritis and Musculoskeletal and Skin Diseases.

54 pecific next-generation treatments for human skin diseases.

55 target in the treatment of GVHD and related skin diseases.

56 considered for the treatment of inflammatory skin diseases.

57 llergic contact dermatitis (ACD), are common skin diseases.

58 actor in the pathophysiology of inflammatory skin diseases.

59 wo cytokines have been implicated in various skin diseases.

60 es show tantalizing promise for treatment of skin diseases.

61 ) is often associated with atopic airway and skin diseases.

62 bute to skin barrier defects in inflammatory skin diseases.

63 iferative keratinocytes, features of various skin diseases.

64 nnabinoids for the treatment of inflammatory skin diseases.

65 tissue, for example, in chronic inflammatory skin diseases.

66 en exploited therapeutically in inflammatory skin diseases.

67 mates of morbidity and mortality metrics for skin diseases.

68 utations in K1/K10 are associated with human skin diseases.

69 o a broad range of allergic and inflammatory skin diseases.

70 n mechanism by which S. aureus may influence skin diseases.

71 potential therapeutic target in inflammatory skin diseases.

72 pment of therapeutics to target inflammatory skin diseases.

73 either deafness or deafness associated with skin diseases.

74 on of which might promote the development of skin diseases.

75 6% for viral skin diseases, 0.15% for fungal skin diseases, 0.07% for scabies, 0.06% for malignant sk

76 riasis, 0.19% for urticaria, 0.16% for viral skin diseases, 0.15% for fungal skin diseases, 0.07% for

77 n: (1) oral mucosal disease and erythematous skin disease, (2) salivary gland dysfunction and lacrima

78 sis (5648), mild psoriasis (85 232), bullous skin diseases (4284), ulcerative colitis (12 203), Crohn

79 The growing diversity of heritable skin diseases, a practical challenge to clinicians and d

80 Integration may advance the control of skin disease across a range of domains, including mappin

81 VII collagen autoantibodies, which mirrored skin disease activity, support a potential role in their

82 l modeling can increase our understanding of skin disease, addressing both its benefits and challenge

83 Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the world population and

84 Psoriasis is a chronic inflammatory skin disease affecting 2.5-6 million patients in the Uni

85 Psoriasis is an inflammatory skin disease affecting approximately 2% of the world's p

86 pic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of a

87 ermal differentiation characterizes numerous skin diseases affecting >25% of the human population.

88 Loss of Nlrp3 also attenuated skin disease, albeit more variably.

89 The severity of the skin disease alters the strength of the association.

90 te analyses showed an association with lumpy skin disease and a protective effect for older animals (

91 n of IL-23 or IL-17A improves psoriasis-like skin disease and also improves cardiovascular disease in

92 se severe morbidities such as elephantiasis, skin disease and blindness, presenting a major public he

93 esults identify a major additional burden of skin disease and have important clinical implications.

94 els of skin inflammation, the psoriasis-like skin disease and inflammation were strongly attenuated,

95 ophan metabolism enzyme KYNU in inflammatory skin disease and its potential contribution to general h

96 f eczema herpeticum (ADEH+) have more severe skin disease and more highly T helper type 2 (Th2)-polar

97 This chytrid causes erosive skin disease and rapid mortality in experimentally infec

98 ovide a biological measure for the extent of skin disease and that could be combined into a longitudi

99 of epidermal barrier defects in both atopic skin disease and the development of broader allergic man

100 en who had used isotretinoin to treat severe skin disease and who were recruited from a single urban

101 l implications for skin repair, inflammatory skin diseases and cancer.

102 phocytic infiltrates in chronic inflammatory skin diseases and cutaneous malignancies including melan

103 ther connexins in keratinocytes will lead to skin diseases and hearing loss, whereas mutants having r

104 K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratifi

105 be targeted therapeutically in inflammatory skin diseases and lymphoma.

106 The high prevalence of skin diseases and their visible symptoms result in major

107 h2 cytokines to exacerbate S. aureus-induced skin disease, and provide a potential therapeutic target

108 these approaches have been extended towards skin disease, and their future directions.

109 is, melanoma, nonmelanoma skin cancer, viral skin diseases, and fungal skin diseases were well matche

110 empathetic about the emotional difficulty of skin disease; and cognizant of cost.

111 Impaired wound healing and inflammatory skin diseases are frequent DM-associated skin pathologie

112 medical sector and clinical trials to treat skin diseases are underway.

113 and a CCR2 inhibitor reduced the severity of skin disease as well as dermal cellularity.

114 Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response.

115 Psoriasis, a chronic inflammatory skin disease associated with increased susceptibility to

116 Allergic contact dermatitis is a common skin disease associated with inflammation and persistent

117 (AD), a T helper 2 (Th2) lymphocyte-mediated skin disease associated with loss-of-function mutations

118 ion of cis-UCA may be a potential target for skin diseases associated with IgE-mediated mast cell deg

119 lem in children with the common inflammatory skin disease atopic dermatitis (AD).

120 50 psoriasis patients and other inflammatory skin diseases (atopic dermatitis, lichen planus, contact

121 ith descriptions of obtaining photographs of skin disease, but universal imaging standards have not b

122 e potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampli

123 ns and induce a T cell-mediated inflammatory skin disease called contact hypersensitivity (CHS).

124 epidermolysis bullosa (RDEB), a rare genetic skin disease, carry mutations in the COL7A1 gene that co

125 Psoriasis is a chronic, inflammatory skin disease caused by a combination of environmental an

126 Psoriasis vulgaris is an inflammatory skin disease caused by hyperactivated T cells regulated

127 chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and envi

128 Buruli Ulcer is a devastating skin disease caused by the pathogen Mycobacterium ulcera

129 ases, impetigo, abscess, and other bacterial skin diseases, cellulitis, viral warts, molluscum contag

130 Tattoo skin disease (characterised by irregular, grey, black or

131 (AD) is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology

132 ic dermatitis (AD) is a chronic inflammatory skin disease characterized by a disturbed epidermal barr

133 Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte prol

134 ic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barr

135 Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neu

136 matitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening.

137 ommon immune-mediated, chronic, inflammatory skin disease characterized by hyperproliferation and abn

138 Atopic dermatitis (AD) is an inflammatory skin disease characterized by increased T-helper type 2

139 Atopic dermatitis is a chronic inflammatory skin disease characterized by infiltration of eosinophil

140 Atopic dermatitis (AD) is an inflammatory skin disease characterized by infiltration of skin homin

141 Atopic dermatitis (AD) is a common skin disease characterized by recurrent episodes of itch

142 Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pr

143 Bullous pemphigoid (BP) is an autoimmune skin disease characterized by the binding of autoantibod

144 aneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transien

145 opic dermatitis (AD) are common inflammatory skin diseases characterized by immune-mediated inflammat

146 erous diseases, including several ocular and skin diseases characterized by increased vascular growth

147 s is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and

148 Chronic urticaria (CU) is a widespread skin disease, characterized by the recurrence of transie

149 (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and s

150 n the phylum Chytridiomycota that causes the skin disease chytridiomycosis.

151 07 and April 2011 at a university autoimmune skin disease clinic.

152 Skin disease data were extracted from more than 4000 sou

153 ongitudinal pharmacodynamic biomarker of SSc skin disease decreased after fresolimumab treatment (P =

154 natures may distinguish between inflammatory skin diseases despite similar epidermal barrier disrupti

155 (12-LOX) because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis

156 however, raise concerns about the quality of skin disease diagnosis and treatment provided by many DT

157 Clinical skin disease dramatically and rapidly decreased (P < 0.0

158 Psoriasis is a chronic inflammatory skin disease driven by aberrant signals from the immune

159 igus vulgaris, a life-threatening autoimmune skin disease, epidermal blisters are caused by autoantib

160 Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases o

161 ted the GBD attributable to 15 categories of skin disease from 1990 to 2010 for 187 countries.

162 of psychological disorders to the burden of skin disease has been poorly explored, and this is a lar

163 allergic contact dermatitis are both common skin diseases having an immune pathogenesis.

164 es of eosinophilia including asthma, various skin diseases, helminths and reactions to medications.

165 tment of skin conditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer

166 More than 100 human genetic skin diseases, impacting over 20% of the population, are

167 decubitus ulcer, urticaria, scabies, fungal skin diseases, impetigo, abscess, and other bacterial sk

168 nding of this still underinvestigated severe skin disease in a European and largely white study popul

169 The severe, progressive skin disease in EKVP subjects with GJA1 mutations is dis

170 +) DCs was sufficient to induce psoriasiform skin disease in mice.

171 skin inflammation, we used imiquimod-induced skin disease in rodents and showed that rats with geneti

172 we have performed a detailed analysis of the skin disease in these mice.

173 Netherton syndrome (NS) is a severe genetic skin disease in which absence of a key protease inhibito

174 Psoriasis is an inflammatory skin disease in which activated immune cells and the pro

175 oriasis is a common and chronic inflammatory skin disease in which T cells play a key role.

176 sights into the immune mechanisms at play in skin diseases including acne continue to be made.

177 n normal epidermis and in hyperproliferative skin diseases including actinic keratosis, squamous and

178 involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is assoc

179 andscape of common recalcitrant human fungal skin diseases, including athlete's foot and toenail infe

180 rget for the treatment of CD8 T cell-related skin diseases, including CHS and GVHD.

181 on genes, many of which are mutated in human skin diseases, including FLG, LOR, ALOXE3, ALOX12B, ABCA

182 idermal development may lead to a variety of skin diseases, including melanoma.

183 identifying potential microbial triggers for skin diseases, including species- and strain-level resol

184 nd its role in development and treatments of skin diseases, including wound healing.

185 vity (CHS), are T cell-mediated inflammatory skin diseases induced by contact allergens.

186 These mice displayed slower onset skin disease initially, but then worsened over time, sug

187 signaling changes may underlie or exacerbate skin disease is limited.

188 Currently, diagnosis of skin diseases is based primarily on the visual pattern r

189 Topical delivery of NAs for the treatment of skin diseases is especially advantageous since it bypass

190 s (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte di

191 mmatory responses, dietary manipulation, and skin diseases lacking biomarkers and therapeutic targets

192 wn to cause Buruli ulcer (BU), a necrotizing skin disease leading to extensive cutaneous and subcutan

193 stone deacetylase (HDAC) inhibitors to treat skin diseases led us to investigate HDAC's role in the r

194 ibroblasts, we demonstrate that in the human skin disease lichen simplex chronicus, WNT5a and KRT9 ar

195 rrier are important features of inflammatory skin diseases like atopic dermatitis.

196 VB irradiation (290-320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and

197 t could potentially be used as a therapy for skin diseases like psoriasis, where AQP3 is abnormally e

198 to increase their benefits for patients with skin disease; low awareness and patient referrals among

199 trophic epidermolysis bullosa is a heritable skin disease manifesting with sub-lamina densa blisterin

200 Final validation into a skin disease model showed that impaired autophagy contri

201 nhibitor, by using murine CD8 T cell-related skin disease models, including contact hypersensitivity

202 Buruli ulcer (BU) is a necrotizing skin disease most prevalent among West African children.

203 nd excretions and progressively cause severe skin disease (myiasis).

204 stitute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, Damon Runyon C

205 dvances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper

206 Psoriasis is a chronic inflammatory skin disease of unknown etiology.

207 Rosacea is a common chronic inflammatory skin disease of unknown etiology.

208 Psoriasis is an autoinflammatory skin disease of unknown etiology.

209 nhibitory ligands as an approach to treating skin diseases of inflammatory etiology.

210 cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrit

211 Tissue samples of patients with eosinophilic skin diseases or eosinophilic esophagitis were used for

212 has not been explored in patients with these skin diseases or in general human immunology.

213 lated to the acquisition or use of images of skin disease (or related conditions).

214 Three skin conditions, fungal skin diseases, other skin and subcutaneous diseases, and

215 nges in diffuse cutaneous systemic sclerosis skin disease over time.

216 mmasome as an important initiating signal in skin disease pathogenesis and provide novel insights abo

217 The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies a

218 antibodies from patients with the blistering skin disease pemphigus vulgaris (PV) IgG is reduced in m

219 rved in the autoantibody-mediated blistering skin disease pemphigus vulgaris (PV), we applied antibod

220 al differentiation is a main feature of many skin diseases, pharmacological agents targeting AHR sign

221 topic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western

222 These results argue strongly to include skin disease prevention and treatment in future global h

223 ealthy individuals and from the inflammatory skin disease psoriasis.

224 t risk for the development of the autoimmune skin disease psoriasis.

225 is strongly associated with the inflammatory skin disease psoriasis.

226 identified in patients with the inflammatory skin diseases psoriasis and pityriasis rubra pilaris.

227 hould balance consideration of the extent of skin disease, psoriatic arthritis, and severity of nail

228 ify new therapeutic targets for inflammatory skin diseases related to epidermal barrier defects.

229 on resident skin cells, the role of TLR4 in skin diseases remains poorly understood.

230 scovery of pathogenic mutations in inherited skin diseases represents one of the major landmarks of l

231 anced MRI in pregnancy, connective tissue or skin disease resembling nephrogenic systemic fibrosis (N

232 me (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mutations in FERM

233 onths post-ECP were compared with changes in skin disease scores or global organ involvement, or the

234 nvestigate the association between change in skin disease severity and change in vascular inflammatio

235 Improvement in psoriasis skin disease severity was associated with improvement in

236 n those who had higher than 75% reduction in skin disease severity.

237 In psoriasis, an IL-17-mediated inflammatory skin disease, skin lesions resolve with therapy, but oft

238 r (BDNF) play a role in chronic inflammatory skin diseases such as atopic dermatitis (AD).

239 nd to be upregulated in chronic inflammatory skin diseases such as atopic dermatitis and psoriasis.

240 lts suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a d

241 an important role in the pathophysiology of skin diseases such as eczema.

242 constitutes an innovative way to treat some skin diseases such as Netherton syndrome.

243 or suppression of IL-33-induced inflammation skin diseases such as psoriasis.

244 the onset and progression of immune-mediated skin diseases such as psoriasis; however, it is not know

245 wever, in patients with chronic inflammatory skin disease, such as psoriasis and atopic dermatitis (A

246 Chronic inflammatory skin diseases, such as atopic dermatitis, affect a large

247 ion and skin damage as well as aging-related skin diseases, such as epidermal thinning (atrophy), per

248 to the pathogenesis of chronic inflammatory skin diseases, such as psoriasis.

249 Atopic dermatitis is a chronic inflammatory skin disease that affects 15-30% of children and approxi

250 Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population,

251 is (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in ch

252 Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular

253 itis is a chronic T cell-driven inflammatory skin disease that is caused by repeated exposure to cont

254 s et progressiva (EKVP) is a rare, inherited skin disease that is characterized by transient figurate

255 Rosacea is a common, chronic skin disease that is currently incurable.

256 enhanced xanthomatosis in apoe(-/-) mice, a skin disease that is not associated with diet-induced at

257 opic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a c

258 e (Ptpn6(spin) mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in h

259 atitis (AD) is a common chronic inflammatory skin disease that results in significant morbidity.

260 to the development of a chronic inflammatory skin disease that shares many features with human atopic

261 s to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012.

262 s to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2013.

263 s to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2014.

264 the C-82-treated skin of biomarkers of local skin disease, THBS1 and COMP.

265 t cells play a critical role in inflammatory skin diseases through releasing proinflammatory mediator

266 G mutations also influence pregnancy-related skin disease; thus, women with FLG mutations had an incr

267 For the rare skin disease trichodysplasia spinulosa, we show that man

268 c dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving I

269 In comparison, acne vulgaris, bacterial skin diseases, urticaria, pruritus, scabies, cellulitis,

270 Individual skin diseases varied in size from 0.38% of total burden

271 both AD and CD, and 10 HC with no history of skin disease was analysed using high-throughput proteomi

272 Clinical skin disease was assessed using the modified Rodnan skin

273 icacy and safety of robed-siRNA for treating skin disease was confirmed by its ability to limit break

274 susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 millio

275 The 15 skin diseases were matched to their respective DALYs fro

276 r 5 of the 15 studied skin diseases, while 3 skin diseases were overrepresented, and 7 were underrepr

277 Excluding mortality, skin diseases were the fourth leading cause of disabilit

278 skin cancer, viral skin diseases, and fungal skin diseases were well matched.

279 rent respiratory tract infections and severe skin disease, whereas the brother was fairly asymptomati

280 Chytridiomycosis is a skin disease which disrupts transport of essential ions

281 Atopic eczema (AE) is a chronic inflammatory skin disease, which has increased in prevalence.

282 h disability metrics for 5 of the 15 studied skin diseases, while 3 skin diseases were overrepresente

283 Rosacea is a chronic inflammatory skin disease whose pathophysiological mechanism is still

284 dverse effects, and its role in inflammatory skin diseases will have the potential to open up new ave

285 Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide.

286 Psoriasis is a chronic inflammatory skin disease with a clear genetic contribution, characte

287 tis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation.

288 pic dermatitis (AD) is a common inflammatory skin disease with a global prevalence ranging from 3% to

289 Psoriasis is an immune-mediated inflammatory skin disease with a strong genetic background in which a

290 ris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis.

291 Psoriasis is a common inflammatory skin disease with complex genetics and different degrees

292 Atopic dermatitis is an inflammatory skin disease with early onset and with a lifetime preval

293 ppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment.

294 Acne is a multifactorial inflammatory skin disease with high prevalence.

295 Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalence, is closely asso

296 Skin diseases with an allergic background such as atopic

297 titis (AD) is a T cell-mediated inflammatory skin disease, with TH2 cells initiating acute flares.

298 oriasis, one of the most common inflammatory skin diseases worldwide.

299 To measure the burden of skin diseases worldwide.

300 to the upper dermis in several inflammatory skin diseases, yet in systemic sclerosis, it can occur i