ライフサイエンスコーパス: skin disorder

1 isoform 1), causes Hailey-Hailey disease, a skin disorder.

2 s for this inherited, currently intractable, skin disorder.

3 a paradigm for treating a localized dominant skin disorder.

4 rstanding of the pathobiology of this common skin disorder.

5 Atopic dermatitis (AD) is a common skin disorder.

6 skin syndrome (PSS), an autosomal recessive skin disorder.

7 ncies and in psoriasis, a hyperproliferative skin disorder.

8 of a novel therapeutic approach for treating skin disorders.

9 icta, a close relative implicated in similar skin disorders.

10 sis and lamellar ichthyosis, two devastating skin disorders.

11 ectors, may be effective agents for treating skin disorders.

12 for wounds, hair loss and other degenerative skin disorders.

13 el targets for the treatment of inflammatory skin disorders.

14 n may positively affect the course of common skin disorders.

15 erapeutic benefit in some human inflammatory skin disorders.

16 ired for the development of Th1 inflammatory skin disorders.

17 novel therapy against constantly increasing skin disorders.

18 s to the pathogenesis of psoriasis and other skin disorders.

19 r a variety of cutaneous neoplasms and other skin disorders.

20 es various pathologies including cancers and skin disorders.

21 reatment of psoriasis and other inflammatory skin disorders.

22 regimens for the management of inflammatory skin disorders.

23 dermal gene expression in hyperproliferative skin disorders.

24 al approach to the treatment of inflammatory skin disorders.

25 treatment of skin cancer and possibly other skin disorders.

26 se compounds as pharmaceutics for cancer and skin disorders.

27 rovided valuable insights into human genetic skin disorders.

28 y activity in a number of chronic autoimmune skin disorders.

29 utic implications for the treatment of other skin disorders.

30 es for the topical treatment of inflammatory skin disorders.

31 is and other hyperproliferative inflammatory skin disorders.

32 , a validated quality of life instrument for skin disorders.

33 involvement of EMILINs in fibrillin-related skin disorders.

34 a role in inflammation, pain sensation, and skin disorders.

35 nsdermal drug carriers to treat a variety of skin disorders.

36 ytokine tightly associated with inflammatory skin disorders.

37 reating neutrophilia-associated inflammatory skin disorders.

38 f homeostasis, skin injury, and inflammatory skin disorders.

39 offer a potential tool for the treatment of skin disorders.

40 r loss, wound healing and other degenerative skin disorders.

41 eveloping treatments for hair loss and other skin disorders.

42 ial asthma, inflammatory bowel diseases, and skin disorders.

43 inflammation, and dominant negative genetic skin disorders.

44 sk of congenital malformations, alopecia, or skin disorders.

45 en exploring NRF2 as a therapeutic target in skin disorders.

46 egrity may underlie or contribute to various skin disorders.

47 ytokine that has pathogenic roles in various skin disorders.

48 s common to wound repair and many neoplastic skin disorders.

49 spiratory (15%), gastrointestinal (12%), and skin disorders (10%); polyneuropathy was infrequent (1%)

50 rash (88.6%), dry skin (34.3%), asthenia and skin disorders (31.4%), mucositis/stomatitis (25.7%), fe

51 The most frequent adverse events were skin disorders (35 patients [63%] in the lenalidomide gr

52 is is a highly pruritic chronic inflammatory skin disorder affecting 10-20% of children worldwide.

53 Acne vulgaris is the most common skin disorder affecting millions of people worldwide and

54 Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreate

55 Acne vulgaris is a common skin disorder among children and young adults that carri

56 c dermatitis is the most common inflammatory skin disorder and characterized by abnormalities in both

57 epidermis, results in a characteristic scaly skin disorder and excessive epidermal water loss.

58 , plakophilin 1 has been linked to a genetic skin disorder and shown to play important roles in desmo

59 member with a putative role in inflammatory skin disorders and a complex biology.

60 ly, retinoids are effective in treating many skin disorders and cancers.

61 idermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins

62 pproach to understanding the pathogenesis of skin disorders and for developing therapeutic strategies

63 oding connexin 26 (Cx26) have been linked to skin disorders and genetic deafness.

64 s the diagnosis and treatment of sun-related skin disorders and recommendations for reducing photodam

65 in the Cx26-encoding GJB2 gene lead to many skin disorders and sensorineural hearing loss.

66 We analyze genetic skin disorders and suggest a manually designed set of el

67 in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions.

68 ession of ErbB ligands in hyperproliferative skin disorders and wound healing.

69 seases, metabolic syndrome, renal disorders, skin disorders, and cancer.

70 aracterized as mild and included infections, skin disorders, and dizziness.

71 ople were for trauma, respiratory disorders, skin disorders, and infectious diseases (excluding the a

72 iated with barrier impairment and consequent skin disorders, and it is therefore important to monitor

73 Examples include hemophilia A, many skin disorders, and several cancers such as retinoblasto

74 Pustular skin disorders are a category of difficult-to-treat and

75 Many skin disorders are associated with increased numbers of

76 Skin disorders are common in the general population, and

77 que-type psoriasis is a chronic inflammatory skin disorder associated with chemoattractants driving n

78 s autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-ep

79 s commonly used to treat psoriasis, a common skin disorder associated with rapid proliferation of cel

80 nts could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or

81 However, the LTR/IFD can also be seen in skin disorders associated with systemic illnesses (lupus

82 onic spontaneous urticaria (CSU) is a common skin disorder, but its clinical course reported so far i

83 Psoriasis is a common chronic skin disorder, but the mechanisms involved in the resolu

84 common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are st

85 observed in patients with various inherited skin disorders, but not in connexin-related disease.

86 Despite clear exacerbation of several skin disorders by stress, the effect of psychologic or e

87 ly available microarray data from a range of skin disorders can elucidate disease pathways, generate

88 olysis bullosa (RDEB) is a complex inherited skin disorder caused by loss-of-function mutations in th

89 olysis bullosa simplex (EBS) is an inherited skin disorder caused by mutations in keratins K5 (kerati

90 is bullosa (RDEB) is an inherited blistering skin disorder caused by mutations in the COL7A1 gene-enc

91 However, the severity and type of the skin disorders caused by Cx26 mutations are heterogeneou

92 cause of ichthyosis vulgaris (IV), a common skin disorder characterised by dry skin, palmar hyperlin

93 -Hailey disease (HHD), an autosomal dominant skin disorder characterized by abnormal keratinocyte adh

94 underlie harlequin ichthyosis, a devastating skin disorder characterized by abnormal lamellar bodies

95 ARCI) is a heterogeneous group of hereditary skin disorder characterized by an aberrant cornification

96 ton syndrome is a severe autosomal recessive skin disorder characterized by congenital erythroderma,

97 amellar ichthyosis is a congenital recessive skin disorder characterized by generalized scaling and h

98 Psoriasis is a skin disorder characterized by hyperproliferation of epi

99 disease is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between

100 Darier disease (DD) is an autosomal-dominant skin disorder characterized by loss of adhesion between

101 se (DD) is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between

102 Vitiligo is a common chronic skin disorder characterized by loss of epidermal melanoc

103 erythema (KWE) is a rare autosomal-dominant skin disorder characterized by recurrent episodes of pal

104 iley-Hailey disease is an autosomal dominant skin disorder characterized by suprabasal cell separatio

105 Vitiligo, a skin disorder characterized by the spontaneous destructi

106 dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization wi

107 rier's disease (DD) is an autosomal dominant skin disorder characterized clinically by multiple kerat

108 ease (DD) is an inherited autosomal-dominant skin disorder characterized histologically by loss of ad

109 congenita (PC) is a rare autosomal dominant skin disorder characterized predominantly by nail dystro

110 ing could comprise a novel approach to treat skin disorders characterized by abnormalities in differe

111 ormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal pe

112 g was specific and was not observed in other skin disorders characterized by erythema and abnormal co

113 atin genes can cause a number of inheritable skin disorders characterized by intraepidermal blisterin

114 LIMK1 is lost in psoriatic lesions and other skin disorders characterized by lack of cell compaction

115 disease is an autosomal dominantly inherited skin disorder, characterized by loss of adhesion between

116 ies in adults and children, across different skin disorders, correlating blood and skin phenotypes an

117 ce offers therapeutic potential for treating skin disorders, delivery hurdles have hampered clinical

118 d that is associated with deafness but has a skin disorder distinct from the KID syndrome mutations.

119 The blistering skin disorder epidermolysis bullosa simplex (EBS) result

120 should be considered in the pathogenesis of skin disorders exacerbated by stress.

121 nockout mice harboring mutations relevant to skin disorders, few organotypic mouse skin models are av

122 Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility

123 r non-syndromic (W44S, R75W) or with various skin disorders (G59A, D66H, R75W).

124 nvestigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis (GPP), pa

125 Transcriptomic changes in 3 pustular skin disorders, GPP, PPP, and AGEP, converged on neutrop

126 id, and parathyroid function; weight change; skin disorders; hair disorders; and teratogenicity.

127 ery of new genetic determinants of inherited skin disorders has been instrumental to the understandin

128 Genetic investigation of inherited skin disorders has informed the understanding of skin se

129 st, integrative biological analysis of human skin disorders has revealed unexpected functions for ele

130 Rosacea, a common facial skin disorder, has a poorly understood pathogenesis in w

131 dentified as the cause of the common genetic skin disorder ichthyosis vulgaris (IV), the most prevale

132 utations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant ri

133 cular basis of the filaggrin-deficient human skin disorder ichthyosis vulgaris.

134 nce their absence gives rise to a blistering skin disorder in neonatal epidermis, and hemorrhaging wi

135 Netherton disease is a rare recessive skin disorder in which atopy is a universal accompanimen

136 Hidradenitis suppurativa (HS) is a common skin disorder in which excessive inflammation is believe

137 hyosis vulgaris (IV) is an inherited scaling skin disorder in which expression of profilaggrin is red

138 of desmo-plakin and also the first inherited skin disorder in which haploinsufficiency of a structura

139 to epidermal barrier dysfunction in allergic skin disorders in mice and humans.

140 ) is a heterogeneous group of rare inherited skin disorders in which defects in cell adhesion compone

141 such events are particularly evident in some skin disorders in which normal clones develop on a backg

142 at may result in the development of fibrotic skin disorders in which reduced fibrinolysis is a featur

143 ing the molecular mechanisms of inflammatory skin disorders in which TGFbeta1 is overexpressed.

144 skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis.

145 involved in the pathogenesis of a number of skin disorders including photosensitivity diseases and s

146 nt of several ayurvedic preparations against skin disorders including psoriasis and herpes, though no

147 of LXR as a potential therapeutic target for skin disorders including skin aging, psoriasis, and atop

148 potential for the treatment of Th2-mediated skin disorders, including atopic dermatitis.

149 For some genetic skin disorders, including neurofibromatosis, tuberous sc

150 Although many skin disorders, including psoriasis and atopic dermatiti

151 isease Area Index (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), and Pemphigus Vul

152 ex (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48).

153 recently described ABSIS (autoimmune bullous skin disorder intensity score) instrument.

154 al, CTIP1-regulated avenues for treatment of skin disorders involving EBP defects.

155 sequences for the expression of inflammatory skin disorders involving Th17 cells.

156 Psoriasis, a common skin disorder, is widely regarded to be multifactorial i

157 group of autosomal dominant human blistering skin disorders it was discovered that defects in the ker

158 lantar keratoderma, a rare dominant-negative skin disorder, its functional significance is poorly und

159 neated in the autosomal recessive blistering skin disorder, junctional epidermolysis bullosa, particu

160 d individuals with a severe autoinflammatory skin disorder known as pustular psoriasis.

161 s produce syndromic deafness associated with skin disorders, like the Keratitis-Ichthyosis-Deafness s

162 s and is a potential target for treatment of skin disorders linked to abnormal sebaceous gland functi

163 In every pediatric practice, skin disorders make up a large percentage of outpatient

164 phenotype provides a model for inflammatory skin disorders, may have general relevance to polygenic

165 e most effective treatments for inflammatory skin disorders might concomitantly suppress the immune r

166 lammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carci

167 che (n = 87 [52.4%]), anemia (n = 83 [50%]), skin disorders (n = 81 [48.8%]), back pain (n = 54 [32.5

168 Allergic reactions and other skin disorders occurred significantly more after MM trea

169 nant condition characterized by the furrowed skin disorder of cutis gyrata, acanthosis nigricans, cra

170 Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that

171 asis (OMIM 177900) is a chronic inflammatory skin disorder of unknown pathogenesis affecting approxim

172 Single gene recessive genetic skin disorders offer attractive prototypes for the devel

173 c epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers.

174 ir loss, or alopecia, may occur as a primary skin disorder or because of an underlying health problem

175 f patients, most often because of cytopenia, skin disorders, or gastrointestinal reactions.

176 mutation responsible for the rare monogenic skin disorder pachyonychia congenita (PC), we demonstrat

177 ed in a phase 1b clinical trial for the rare skin disorder, pachyonychia congenita (PC).

178 ong chain fatty acid uptake may underlie the skin disorder phenotype of null mice.

179 The chronic and highly prevalent skin disorder psoriasis vulgaris is characterized by a h

180 e responses, as observed in the common human skin disorders psoriasis and atopic dermatitis.

181 atin genes as the cause of several inherited skin disorders raised the possibility that molecular-bas

182 rited human diseases, such as the blistering skin disorder recessive dystrophic epidermolysis bullosa

183 Current therapeutic strategies for genetic skin disorders rely on the complex process of grafting g

184 of stem cells in the pathogenesis of mosaic skin disorders remains unclear.

185 Inflammatory skin disorders result in significant epidermal changes,

186 suggested that a number of different LTR/IFD skin disorders share a common inflammatory signaling pat

187 from a kindred with the dominantly inherited skin disorder, striate palmoplantar keratoderma.

188 ance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or androgenetic

189 Common inflammatory skin disorders such as atopic dermatitis and psoriasis e

190 n of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis.

191 ay be therapeutic in a range of inflammatory skin disorders such as psoriasis and AD.

192 In humans, inflammatory skin disorders such as psoriasis are associated with acc

193 can be highly beneficial in the treatment of skin disorders such as psoriasis.

194 may be a mechanism for hyperproliferation in skin disorders such as psoriasis.

195 Certain skin disorders, such as contact dermatitis and chronic u

196 and cause syndromic deafness associated with skin disorders, such as keratitis-ichthyosis-deafness sy

197 at typically occur in human Th1 inflammatory skin disorders, such as psoriasis.

198 tis (AD) is a chronic relapsing inflammatory skin disorder that affects approximately 15% of children

199 Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the pop

200 s in mice and to Darier disease in humans, a skin disorder that also involves keratinocytes.

201 sive macular hypomelanosis (PMH) is a common skin disorder that causes hypopigmentation in a variety

202 genic systemic fibrosis (NSF) is a fibrosing skin disorder that develops in patients with kidney fail

203 e affected transgenic mice manifested with a skin disorder that fulfilled the clinical diagnostic cri

204 rpetiformis (DH) is an autoimmune blistering skin disorder that is associated with gluten sensitivity

205 rpetiformis (DH) is an autoimmune blistering skin disorder that is associated with intestinal gluten

206 lantar keratoderma) is an autosomal dominant skin disorder that is associated with the early onset of

207 Psoriasis is an inflammatory skin disorder that is inherited as a complex trait.

208 Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trai

209 Vitiligo is an autoimmune skin disorder that reacts against melanocytes.

210 s in several different benign and neoplastic skin disorders that are characterized by a prominent ang

211 ine model of hyperproliferative inflammatory skin disorders that is induced by transfer of minor hist

212 orm the clinical management and treatment of skin disorders through diagnostic tests to stratify pati

213 Association of congenital skin disorders to mutations in different connexins has u

214 d genes and increase the categories of human skin disorders to which parallels could be drawn.

215 Mg(2+) deficiency causes skin disorders under certain pathological conditions suc

216 CD1d in normal skin, psoriasis, and related skin disorders, using a panel of CD1d-specific mAbs.

217 e pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression.

218 This skin disorder was diminished when memory T cells were co

219 analysis of normal skin as well as specific skin disorders was carried out.

220 al pain, Crohn's disease-related anemia, and skin disorders was similar in both groups.

221 Vitiligo, an autoimmune skin disorder, was evaluated in 49 metastatic melanoma p

222 rom normal human skin and hyperproliferative skin disorders were examined by immunohistochemistry and

223 Rosacea is a common chronic inflammatory skin disorder where upregulation of matrix metalloprotei

224 Atopic dermatitis (AD) is a common chronic skin disorder, which may persist into adulthood; however

225 gs in normal human skin and in parakeratotic skin disorders, which exhibit nuclear staining of granul

226 r keratosis (NPPK) is an autosomal recessive skin disorder with a high, unmet medical need that is ca

227 Psoriasis is an inflammatory skin disorder with aberrant regulation of keratinocytes

228 r type 6 (PTPN6) in a mouse that developed a skin disorder with clinical and histopathological featur

229 f Siemens (IBS) is a rare autosomal dominant skin disorder with clinical features similar to epidermo

230 Bullous pemphigoid is a blistering skin disorder with increased mortality.

231 Psoriasis is a chronic skin disorder with multifactorial aetiology.

232 Two common inflammatory skin disorders with impaired barrier, atopic dermatitis