ライフサイエンスコーパス: skin pigmentation

1 oupled receptor involved in inflammation and skin pigmentation.

2 tor system participates in the regulation of skin pigmentation.

3 tor cells, and the treatment of disorders of skin pigmentation.

4 opulations to discover new genes influencing skin pigmentation.

5 tion of this analog still led to significant skin pigmentation.

6 HERC2 that are significantly associated with skin pigmentation.

7 n regenerate mature melanocytes for hair and skin pigmentation.

8 l processes including vision, olfaction, and skin pigmentation.

9 mbining different viable mutations affecting skin pigmentation.

10 p53-mediated upregulation of Kitl influences skin pigmentation.

11 attractive and distinct avenue of modulating skin pigmentation.

12 skin represents the key phenotypic event in skin pigmentation.

13 dvanced breast cancer among women with light skin pigmentation.

14 of exposure, latitude, season, and degree of skin pigmentation.

15 ammals to respond to UVR by increasing their skin pigmentation, a protective process driven by melani

16 Season, latitude, time of day, skin pigmentation, aging, sunscreen use, and glass all i

17 None had abnormalities of skin pigmentation, although other skin conditions were r

18 ta confirm the association of rs1426654 with skin pigmentation among South Asians, consistent with pr

19 the MC1R, a melanocyte receptor involved in skin pigmentation and animal coat coloration.

20 RMT1) and clinically characterized by patchy skin pigmentation and atrophy.

21 that MC1R350 acts as a negative regulator of skin pigmentation and demonstrate for the first time tha

22 xtracardiac myxomas in the setting of spotty skin pigmentation and endocrinopathy.

23 the effects of serine protease inhibitors on skin pigmentation and found that the protease-activated

24 ed transcription factor expression can alter skin pigmentation and further confirm the central role o

25 inherited syndrome associated with abnormal skin pigmentation and multiple neoplasias, including PPN

26 w failure disorder characterized by abnormal skin pigmentation and nail dystrophy.

27 ined in modern cohorts with detailed data on skin pigmentation and other covariates.

28 a crucial process underlying maintenance of skin pigmentation and photoprotection against UV damage.

29 This disparity contributes to differences in skin pigmentation and photoprotection, but the control o

30 rm-specific expression is closely related to skin pigmentation and photoprotection.

31 Skin pigmentation and receipt of vasopressors were not a

32 Resulting mice exhibit abnormalities in skin pigmentation and reproductive tissue architecture,

33 es reflecting cutaneous vitamin D synthesis (skin pigmentation and season) were also strongly associa

34 e determinants of vitamin D status including skin pigmentation and season.

35 The risk attributes of skin pigmentation and some dietary factors in cancer can

36 i et al. explore a direct connection between skin pigmentation and susceptibility to angiogenic disea

37 Skin pigmentation and the development of photoadaptation

38 n identified that are involved in regulating skin pigmentation and these act during development, surv

39 report that PDK1 contributes functionally to skin pigmentation and to the development of melanomas ha

40 intensity, (4) BCVA, (5) VEP asymmetry, (6) skin pigmentation, and (7) hair pigmentation (of head ha

41 SH), and beta-endorphin in the regulation of skin pigmentation, and a role has been put forward for a

42 such as vitamin D supplementation, degree of skin pigmentation, and amount and intensity of sun expos

43 d by the triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia; Hoyeraal-Hreida

44 e individual, growth abnormalities, abnormal skin pigmentation, and/or thumb/radius malformations.

45 Among the 24 patients, skin pigmentation appeared after a median HCQ treatment

46 al leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow

47 e (DDD) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5

48 ctivated receptor 2 (PAR-2) is important for skin pigmentation because activation of keratinocyte PAR

49 delineate a regulatory role of IFN-gamma in skin pigmentation biology.

50 confounders [baseline 25(OH)D concentration, skin pigmentation, body mass index, compliance, etc], sp

51 nship between self-reported hearing loss and skin pigmentation by using hair color, skin tanning abil

52 populations, we show how the architecture of skin pigmentation can vary across humans subject to diff

53 e neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine

54 tivation did not engage the key regulator of skin pigmentation, cyclic AMP, showing a major differenc

55 As safe and effective treatment options for skin pigmentation disorders are limited, these specific

56 w the potential for developing therapies for skin pigmentation disorders by manipulating McSCs.

57 and rs2470102) play an important role in the skin pigmentation diversity of South Asians.

58 Variation in human skin pigmentation evolved in response to the selective p

59 ated the association of two previously known skin pigmentation genes, SLC24A5 (minimum p = 2.62 x 10(

60 ividual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin

61 Our understanding of the genetics of skin pigmentation has been largely skewed towards popula

62 heir individual molecular relationships with skin pigmentation have not been clearly resolved.

63 lar mechanisms associated with alteration of skin pigmentation have remained elusive.

64 l role of the IFN-gamma signaling network in skin pigmentation homeostasis, which could have implicat

65 te the genetic factors influencing intrinsic skin pigmentation in a population of South Asian descent

66 a large fraction of the natural variation of skin pigmentation in a South Asian population.

67 heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a k

68 We also demonstrate that light skin pigmentation in Europeans was already present at hi

69 des the SLC24A5 allele associated with light skin pigmentation in Europeans, may represent gene flow

70 Skin pigmentation in humans and coat color in fleece-pro

71 Despite the wide range of skin pigmentation in humans, little is known about its g

72 Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both i

73 ly breastfed infants who have high levels of skin pigmentation, inadequate vitamin D supplementation,

74 rences in genetic factors, sun exposure, and skin pigmentation, iron deficiency may affect vitamin D

75 Skin pigmentation is a complex trait that varies largely

76 Rather, baseline skin pigmentation is a complex, polygenic trait in the K

77 To test whether clofazimine-induced skin pigmentation is due to CLDI formation, we synthesiz

78 We demonstrate that skin pigmentation is highly heritable, but known pigment

79 ese results suggest that clofazimine-induced skin pigmentation is not due to clofazimine precipitatio

80 Human skin pigmentation is the product of two clines produced

81 that clofazimine bioaccumulation results in skin pigmentation, its most common side effect.

82 e syndrome that is characterized by abnormal skin pigmentation, leukoplakia and nail dystrophy.

83 his, we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, S

84 Skin pigmentation measurements were taken on the upper u

85 keratinocytes and/or fibroblasts that affect skin pigmentation might be regulated differently by UV,

86 t neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and sc

87 bone marrow failure and a triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia.

88 from 21 to 58 years) with light-to-moderate skin pigmentation, none of whom had current or prior ski

89 t cancer among women with light constitutive skin pigmentation (odds ratio = 0.53, 95% confidence int

90 ng a reflectometer, we measured constitutive skin pigmentation on the upper underarm (a sun-protected

91 tamin D level appeared similar regardless of skin pigmentation or season.

92 and in adults of all ages who have increased skin pigmentation or who always wear sun protection or l

93 tem in India has a profound influence on the skin pigmentation patterns of the subcontinent.

94 y assembling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmen

95 nes (including OCA2 and BNC2) that influence skin pigmentation phenotypes.

96 toreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and

97 hromosomal breakage as well as pancytopenia, skin pigmentation, renal hypoplasia, cardiac defects, mi

98 dominant disorder characterized by abnormal skin pigmentation, retinal detachment, anodontia, alopec

99 Genes that encode functions related to skin pigmentation (SCL4A5) and cutaneous glands (EDAR) a

100 n in patients with Carney complex was spotty skin pigmentation, similar to that observed in Peutz-Jeg

101 susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface disease,

102 n, we examined polymorphisms associated with skin pigmentation (SLC24A5) and with the ability to tast

103 of several physiological functions including skin pigmentation, steroidogenesis, obesity, energy home

104 ortin pathway is an important participant in skin pigmentation, steroidogenesis, obesity, energy home

105 ene, a critical component of the facultative skin pigmentation system, has a highly complex and ineff

106 protease-activated receptor 2 is involved in skin pigmentation through increased phagocytosis of mela

107 put to the circuit controlling adaptation of skin pigmentation to background, changes the number of n

108 rtin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin cancer risk.

109 Here, we investigate skin pigmentation variation in a cohort of 1,167 individ

110 15 genes have been directly associated with skin pigmentation variation in humans, leading to its ch

111 associations because the trait under study (skin pigmentation) varies with admixture proportions.

112 ormone are well documented to regulate human skin pigmentation via action at the melanocortin-1 recep

113 ic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 recep

114 Skin pigmentation was measured by a color meter (chromom

115 , arthropathies, arrhythmias, impotence, and skin pigmentation were no more prevalent among the 152 i

116 In our cohort of white women, surrogates for skin pigmentation were not associated with risk of heari

117 haracteristics, receipt of vasopressors, and skin pigmentation were recorded at the time of a clinica

118 In study 1, 74 men and women with diverse skin pigmentation were recruited.

119 se to melanoma as a result of alterations in skin pigmentation (which affords less protection against

120 Skin pigmentation, which is regulated by the melanocorti

121 tic determinants of the natural variation of skin pigmentation within a human population.

122 anin-producing enzymes, resulting in delayed skin pigmentation within days [7].

123 mma-MSH-NH2 is ideal for inducing short-term skin pigmentation without sun for melanoma prevention.