ライフサイエンスコーパス: skin thickening

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1 sional skin of patients with SSc with severe skin thickening.

2 t associated with a significant reduction in skin thickening.

3 most often within 3 years after the onset of skin thickening.

4 determine the significance of improvement in skin thickening.

5 TNFRII expression correlated with skin thickening.

6 m WT but not LTC(4)S-deficient mice restored skin thickening and collagen deposition in epicutaneous-

7 Skin thickening and collagen deposition were significant

8 as, which typically result in short stature, skin thickening and joint stiffness, have been linked to

9 ecreased the collagen content, and prevented skin thickening and tensile strength increase after bleo

10 Recurrent skin thickening and tethering again improved in the pati

11 h passive range-of-motion exercises once his skin thickening and tethering had begun to decrease.

12 Skin thickening and tethering were assessed using the mo

13 h patient displayed progressive reduction of skin thickening and tethering, with a steady decrease in

14 T3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier ab

15 Clinical trials are using changes in skin thickening as the primary outcome measure, and thus

16 the latter of which lack eosinophils, caused skin thickening, collagen deposition, and increased mRNA

17 that in patients entered into these 3 RCTs, skin thickening did not follow the same trend in natural

18 leroderma was associated with improvement in skin thickening, hand function, oral aperture, lung func

19 icrog/kg per day, is associated with reduced skin thickening, improved mobility, and improved functio

20 The natural history of changes in skin thickening in diffuse scleroderma is quite variable

21 Here we demonstrate that we can also prevent skin thickening in mice with Scl GVHD with a naturally o

22 This improvement in skin thickening is associated with improved survival.

23 HD) models human scleroderma, with prominent skin thickening, lung fibrosis, and up-regulation of cut

24 important features of scleroderma including skin thickening, lung fibrosis, and up-regulation of cut

25 Mice with Scl GVHD have skin thickening, lung fibrosis, cutaneous mononuclear ce

26 plantation showed significant improvement of skin thickening, lung function and quality of life, but

27 Improvement in skin thickening may be useful as a surrogate for improve

28 diffuse scleroderma, striking improvement in skin thickening may occur in up to two-thirds.

29 f diffuse scleroderma, including more severe skin thickening, more frequent heart and kidney involvem

30 Patients with an improvement in their skin thickening of >25% of their peak skin score and a r

31 Affected individuals had a linear pattern of skin thickening on the fingers and palms and circumscrib

32 fingers and palms and circumscribed areas of skin thickening on the soles.

33 no skin thickening (ssSSc) and those who had skin thickening only distal to elbows or knees and/or of

34 the improved group; patients with increased skin thickening or no improvement were termed the no imp

35 tudy was to determine whether improvement in skin thickening over time was associated with improved s

36 Patients were divided into those who had no skin thickening (ssSSc) and those who had skin thickenin

37 Other than the absence of skin thickening, the ssSSc group had no significant diff

38 These mice develop skin thickening, whereas control mice transplanted with

39 Several murine models demonstrate decreased skin thickening with tyrosine kinase inhibition.

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