ライフサイエンスコーパス: skipping

1 e and function (e.g., intron retention, exon skipping).

2 n to matched HC (n = 13) amenable to exon 51 skipping.

3 toring functional dystrophin protein by exon skipping.

4 annot compensate for SMN1 loss due to exon 7 skipping.

5 und that the majority resulted in total exon skipping.

6 proteins are synthesized by way of ribosomal skipping.

7 g domain, with alternative splicing and exon skipping.

8 y mimic those that would be achieved by exon skipping.

9 nscription rate causes an increase of exon 5 skipping.

10 exons 6 and 9 closer, thereby promoting exon skipping.

11 the transcriptional elongation rate and exon skipping.

12 alysis of clinical trials for exon 44 and 45 skipping.

13 antisense oligonucleotide (AO)-mediated exon skipping.

14 ingle residue was sufficient to prevent exon skipping.

15 n, and Sudemycins more acute effects on exon skipping.

16 ce-shifting oligonucleotides that induce E29 skipping.

17 ggesting rs11573156 G allele-specific exon 2 skipping.

18 plicing, including intron retention and exon skipping.

19 on with these exonic sequences promotes exon skipping.

20 s to changes in stimulus duration) or period skipping.

21 current silent third base change, cause exon skipping.

22 lignancies to estimate the rate of said exon skipping.

23 ficient hDBR1 leads to a higher rate of exon skipping.

24 with different specificities to promote exon skipping.

25 sease course than those amenable to any exon skipping.

26 ic orientation that are favourable for water-skipping.

27 cally, encountering a high-cost choice after skipping a low-cost choice should induce regret.

28 gressed to the consecutive stage rather than skipping a stage.

29 No similar functional prion, skipping a stop codon, has been found in Escherichia col

30 dical problem (OR, 3.0; 95% CI, 1.6 to 5.9); skipping a test, treatment, or follow-up (OR, 2.1; 95% C

31 > C), previously described to cause exon 10 skipping (a truncating alteration), displays characteris

32 exons is widespread and correlates with exon skipping, a feature that adds considerably to the regula

33 , elastic spheres demonstrate superior water-skipping ability, but little is known about the effect o

34 istic explanation for the variations in exon-skipping activity and restoration of dystrophin protein

35 oligomers (PMOs) with glucose enhances exon-skipping activity in Duchenne muscular dystrophy (DMD) m

36 igher expression of hDBR1 only affected exon-skipping activity in malignant cells.

37 xpense of the inherent leading strand lesion skipping activity of the replisome, indicating that they

38 Exon skipping adds to the unexpected outcomes that must be ac

39 ted, c.[594-2A > C; 641A > G] caused exon 10 skipping, albeit not due to c.594-2A > C impairing the a

40 for two different Etaa1 mutations: an exon 2 skipping allele that deletes Gly78-Leu119, and a Cys166S

41 Antisense-oligonucleotide-induced exon skipping allows synthesis of partially functional dystro

42 ntly, a longer fasting period with breakfast skipping also increased the inflammatory potential of pe

43 ield lower levels of dystrophin than exon 51 skipping, although the resulting protein is functional e

44 Our data also indicate more skipping among smaller females and potential tradeoffs b

45 across years was extremely high, even after skipping an entire seasonal migration.

46 tion for running on computer clusters and by skipping an initial grid search by using parameters from

47 studies revealed that it leads to mRNA exon skipping and ABCA4 protein truncation.

48 pre-mRNA is differentially spliced, via exon skipping and alternate 5'-splice donor sites, to yield f

49 ing in minigene assays, and resulted in exon skipping and an in-frame deletion of 40 amino acids in p

50 recessive mutation in PIGQ that led to exon skipping and defective glycophosphatidyl inositol biosyn

51 The mutation leads to exon skipping and deletion of 52-amino acid residues of a PX

52 retroviral-derived exons and result in exon skipping and dysregulated alternative splicing of all MT

53 nd the ability of AVI-4658 to induce exon 51 skipping and dystrophin restoration by RT-PCR, immunohis

54 The ASOs promote aberrant exon skipping and generation of premature termination codon (

55 I editing demonstrate that both the Alu exon skipping and inclusion isoforms encode active enzymes.

56 ene knockdown, and change in two types, exon skipping and intron retention, was directly related to d

57 bstrate channeling and enzymatic multimodule skipping and iteration.

58 of novel transcriptomic events such as exon skipping and novel indels towards accurate downstream an

59 eotide conjugate designed to induce Dmd exon skipping and recover dystrophin protein expression cause

60 atment in cell culture increased SMN2 exon 7 skipping and reduced SMN protein levels.

61 from variable (V) Igkappa exons promote exon-skipping and synthesis of V domain-less kappa light chai

62 Regulation of exon skipping and tandem alternative 3' splice sites (NAGNAGs

63 FLT3 resulted from complete or partial exon skipping and utilization of cryptic splice sites.

64 f MICA intron 4 leading to exon 3 and exon 4 skipping and/or deletions.

65 correction of many genetic diseases via exon skipping, and the first AON-based drugs have entered cli

66 tation produce exon 33 skipping, exons 33-34 skipping, and WT VWF transcripts.

67 time the efficiency of the AAV-mediated exon skipping approach in the utrophin/dystrophin double-knoc

68 ryonic dystrophin in zebrafish using an exon-skipping approach severely impairs the mobility and musc

69 th other diseases that are eligible for exon-skipping approaches requiring whole-body treatment.

70 rol) than patients with BMD modeling exon 51 skipping (approximately 80% of control).

71 utations within the repeat that abolish exon skipping are corrected by compensatory mutations in the

72 The antisense oligonucleotides used for exon skipping are designed to bypass premature stop codons in

73 but alternative donor/acceptor site and exon skipping are mainly induced, indicating differential reg

74 ssing, alternative 5 and 3'ss usage and exon skipping are marked by distinct patterns of ordered intr

75 In addition to exon skipping, ASO treatment causes intron retention and redu

76 uction results from gradually increased exon skipping between exons 50 and 219 of titin mRNA.

77 ty, LaSSO identified both canonical and exon-skipping branch points.

78 iation, but not the causal relation, between skipping breakfast and obesity (final cumulative meta-an

79 d BRR in research about the proposition that skipping breakfast causes weight gain, which is called t

80 ut downstream eating behaviors subsequent to skipping breakfast in free-living individuals.

81 Skipping breakfast is associated with an increased odds

82 Skipping breakfast is considered a frequent and unhealth

83 ard may contribute to the negative impact of skipping breakfast on dietary habits and body weight and

84 ompared with high-energy breakfast, habitual skipping breakfast was associated with a higher prevalen

85 health effects of specific eating patterns: skipping breakfast, intermittent fasting, meal frequency

86 y energy intake (70% of the population); and skipping breakfast, when consuming <5% of total daily en

87 protein) breakfasts, or continued breakfast skipping (BS) for 6 d.

88 Exon skipping by ASOs is gaining traction as a therapeutic st

89 We demonstrate that Rbm20 mediates exon skipping by binding to titin pre-mRNA to repress the spl

90 alpha-chain mRNA splicing and favors exon 9 skipping by reducing the binding of the splicing enhance

91 We have now expanded the potential for exon skipping by testing whether an internal, in-frame trunca

92 These pathways include lesion skipping by the replisome, replication fork regression f

93 bear on the recent observation that exon 2B skipping can be found in metastatic melanoma.

94 expressed by cancer cells with MSI, via exon skipping caused by somatic deletions in the T(17) intron

95 found that rs10401969 regulates SUGP1 exon 8 skipping, causing non-sense-mediated mRNA decay.

96 prove and better predict the outcome of exon skipping clinical trials.

97 The extent of E29 skipping correlated with severity of weakness in tibiali

98 muscle disease and showed that multiple exon skipping could be induced in RNA that encodes a mutant h

99 ar trafficking correspond well with the exon-skipping data, with higher activity in myotubes than in

100 fat, and protein, respectively): a breakfast skipping day (BSD) and a dinner skipping day (DSD) separ

101 a breakfast skipping day (BSD) and a dinner skipping day (DSD) separated by a conventional 3-meal-st

102 , 24-h energy expenditure was higher on both skipping days (BSD: +41 kcal/d; DSD: +91 kcal/d; both P

103 s with deletions amenable to exons 44 and 46 skipping declined at a slower rate over 2 years (9 units

104 e muscular dystrophy, the rationale for exon skipping derived from observations in patients with natu

105 tely 80% cis), whereas species-specific exon skipping differences are driven by both cis- and trans-r

106 aucoma who reported taking smaller doses and skipping doses owing to cost dropped from 9.4% and 8.2%

107 on because gene splicing analysis shows exon skipping due to loss of the ESE.

108 ircuit of sense-antisense pairs and the exon skipping during alternative splicing, through interactin

109 We find that the skipping dynamics are governed by the wave propagation s

110 n normal adult tissues as a result of exon 6 skipping, enhanced exon 6 inclusion leads to expression

111 Particularly, exon-skipping event in Enhancer of Zeste Homologue 2 (EZH2) a

112 omplex PRC2, and the down-regulation of exon-skipping event may lead to the regain of functional EZH2

113 Both transcript isoforms from this skipping event site, i.e. in which the exon is either in

114 ing scanner (GESS), for de novo detection of skipping event sites from raw RNA-seq reads without prio

115 One particular mode of AS is the skipping event where an exon may be alternatively exclud

116 plice variants of KV10.1 resulting from exon-skipping events (E65 and E70) in human brain and cancer

117 ew target function for AS prediction in exon skipping events and show it significantly improves model

118 In addition, we observe exon-skipping events in c-MET, which are attributable to spli

119 identified by CoSREM may play a role in exon skipping events in several tumor samples.

120 Exon-skipping events increased in cells deficient for the nuc

121 Interestingly, 29 exon-skipping events induced by treatment were identified and

122 On the other hand, exon skipping events were rare in coding regions (1%) but enr

123 validation rate of 86% for differential exon skipping events with a MATS FDR of <10%.

124 ll annotated introns, hundreds of novel exon-skipping events, and thousands of novel introns.

125 s, but also pinpointed novel, but rare, exon-skipping events, which may reflect aberrantly spliced tr

126 force algorithms to detect all possible exon-skipping events, which were widespread but rare compared

127 xon-intron boundary establishment leading to skipping events.

128 in pre-mRNA splicing with prevalence of exon skipping events.

129 ars, with confirmed deletions correctable by skipping exon 51 and ability to walk 200 to 400 m on 6 M

130 phy (DMD) with genetic mutations amenable to skipping exon 51.

131 culated splice site strength around middle, 'skipping', exons compared to those in the inclusion-isof

132 for the c.5842+1G>C mutation produce exon 33 skipping, exons 33-34 skipping, and WT VWF transcripts.

133 ernally deleted dystrophins produced by exon skipping for different mutations; more insight would be

134 ver, antisense oligonucleotide-mediated exon skipping for DMD still faces major hurdles such as extre

135 rapid S phases that alternate with mitosis, skipping gap phases.

136 of CD46 cassette exon 13, whose inclusion or skipping generates different cytoplasmic tails with dist

137 its strategy of pruning the search space by skipping genetic markers whose upper bounds on test stat

138 ng snacking in overweight or obese breakfast-skipping girls.

139 s but for which no previous examples of exon-skipping had been demonstrated.

140 Meal skipping has become an increasing trend of the modern li

141 s.We investigated whether the timing of meal skipping impacts these risks by affecting circadian regu

142 ificity was observed, with differential exon skipping in 5% of genes otherwise coexpressed in both B

143 nscripts by both directly increasing exon 13 skipping in an allele-related manner and specifically st

144 were shown to cause intron retention or exon skipping in an allele-specific manner, with approximatel

145 Given the success of exon skipping in clinical trials to treat genetic diseases su

146 se that internal mechanisms underlying cycle skipping in head direction networks may be critical for

147 idespread intron retention and cassette exon skipping in leukemic cells regardless of Srsf2 genotype,

148 t these CD33 SNPs are associated with exon 2 skipping in leukocytes from AML patients and with a nove

149 n by antisense oligonucleotide-mediated exon-skipping in mdx mice and (2) stable restoration of alpha

150 ded RNA caused only a modest increase in E29 skipping in mice.

151 troduced c.205C>T base change induced exon 4 skipping in most mRNAs, leading to premature termination

152 equence and is tightly regulated in favor of skipping in neurons; however, its biological function is

153 ce site recognition and contributing to exon skipping in nonneural cells.

154 : the novel PSEN1 variant resulted in exon 9 skipping in patient's RNA, leading to a pathogenic misse

155 sgenes whose expression is activated by exon skipping in response to a specific protein inducer.

156 r of the exons identified here as subject to skipping in S. pombe reveals high sequence conservation

157 to a silencer (ESS), causing frequent exon7 skipping in SMN2 pre-mRNA and yielding a truncated prote

158 n a reduction of dystrophin protein and exon skipping in the diaphragm.

159 binding site could efficiently induce exon 9 skipping in the presence of the G allele, and thereby re

160 hing and differential exon usage (i.e., exon-skipping), in addition to its effects on gene expression

161 involved in the regulation of HMGCR exon 13 skipping, in a founder population and in two distinct mi

162 ls after lunch.Compared with 3 meals/d, meal skipping increased energy expenditure.

163 e shown to be critical determinants for exon skipping, indicating that LINE1 acts as efficient modifi

164 herapeutic restoration of dystrophin by exon skipping induced widespread shifts in protein and mRNA e

165 can be placed into four major classes: exon skipping, intron retention, alternative 5' splice sites,

166 Breakfast skipping is a common dietary habit practiced among adole

167 Exon skipping is a promising therapeutic strategy for Duchenn

168 mprove this therapeutic approach to DMD.Exon skipping is a strategy for the treatment of Duchenne mus

169 Exon skipping is capable of correcting frameshift and nonsens

170 Exon skipping is considered a principal mechanism by which eu

171 Exon skipping is currently being tested in humans with dystro

172 under hypoxia revealed that hypoxia-induced skipping is dependent on poor exon definition due to the

173 Antisense-mediated exon skipping is one of the most promising approaches for the

174 Although SMN2 exon skipping is the principal contributor to SMA severity, m

175 er included (inclusion isoform) or excluded (skipping isoform), are typically present in one cell, an

176 analysis found that splice sites within the skipping-isoform-dominated group (SIDG) tended to exhibi

177 d that the c.893-1G>A mutation causes exon 7 skipping leading to deletion of 65bp, predicted to resul

178 ecific CPP-PMOs demonstrated comparable exon skipping levels for both pre-mRNA targets when compared

179 neutral polymorphisms, indicating that exon skipping may play a prominent role in aberrant gene regu

180 r meals are difficult to distinguish because skipping meals and snacking have become more prevalent.

181 Among adults, skipping meals is associated with excess body weight, hy

182 endogenous gene by exploiting the "ribosomal skipping" mechanism of the viral T2A peptide.

183 urrent in lung adenocarcinoma and cause exon skipping (METDelta14).

184 e stalling, that one replisome is capable of skipping multiple lesions, and that the rate-limiting st

185 To correct DMD by skipping mutant dystrophin exons in postnatal muscle tis

186 d family with a heterozygous in-frame exon 9 skipping mutation (c.835+2T>G) and in a CVID-affected fa

187 hogenic allele in exon 41, including an exon-skipping mutation that induced an in-frame deletion.

188 Patients with COL3A1 exon skipping mutations had higher plasma intercellular adhes

189 rticaria and immune dysregulation PLCG2 exon-skipping mutations resulting in protein products with co

190 Pairs of anti-synchronous theta cycle skipping neurons exhibited larger differences in head di

191 lear ribonucleoprotein H-dependent inclusion/skipping of a PRKCA alternative exon 3*.

192 kably, these dysregulations include complete skipping of agrin's Z exons, critical for NMJ maintenanc

193 ults in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (AL

194 e of PRRC2C, SRSF1 downregulation led to the skipping of an exon overexpressed in primary lung tumors

195 ly shown that these SNPs are associated with skipping of CD33 exon 2 in brain mRNA.

196 ice with morpholino oligomers to induce exon skipping of dystrophin exon 23 (that results in function

197 However, forced skipping of E29 in these mice, to levels approaching tho

198 45 (Delta45)-may theoretically be treated by skipping of either flanking exon (44 or 46).

199 that results in a splicing defect leading to skipping of exon 11 (p.Lys333Lysfs*3).

200 In the absence of ELAVL1, skipping of exon 11 of Eif4enif1 forms the stable, short

201 the frameshift p.Lys645AlafsTer12 and/or the skipping of exon 11 that results in deletion of 30 highl

202 erited a splice-site variant that results in skipping of exon 13, p.Ile459Profs( *)4 (not reported in

203 th endplate AChE deficiency causes exclusive skipping of exon 16.

204 ive exonic splicing enhancer that allows for skipping of exon 2, while retaining the functional RPGR-

205 KBKAP gene that results in a tissue-specific skipping of exon 20 and a corresponding reduction of the

206 o additional novel transcripts involving the skipping of exon 3 or exons 3, 4, and 5 and are referred

207 Patient-derived PPCs showed skipping of exon 39 or exons 39 and 40 in the mRNA.

208 s splice site mutation (c.555G>A) leading to skipping of exon 4, and a homozygous 4 kb deletion of ex

209 conclude that in DMD patients with Delta45, skipping of exon 44 and multiexon skipping of exons 46 a

210 s 46-48) are better potential therapies than skipping of exon 46 alone.

211 to those of full-length channels (Cav1.4FL), skipping of exon 47 dramatically alters Cav1.4 function.

212 ense oligonucleotide-mediated (ASO-mediated) skipping of exon 6 decreased MDM4 abundance, inhibited m

213 This mutation resulted in skipping of exon 6 of SLC41A1, resulting in an in-frame

214 n the C57BL/6J strain and is associated with skipping of exon 6 or a combination of the exons 5 and 6

215 e f35-42 deletion could be the result of the skipping of exon 6, generating an exon 6-deleted variant

216 enhancer (ESE) within exon 6 is required for skipping of exon 6.

217 a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of an unstable protein

218 ompensate for this deficiency because of the skipping of exon 7 during pre-messenger RNA (mRNA) proce

219 h causes premature protein truncation due to skipping of exon 7.

220 ls to compensate for the loss of SMN1 due to skipping of exon 7.

221 site mutation (c.730+4A>G), causing in-frame skipping of exon 8.

222 Diverse CUL3 mutations all result in skipping of exon 9, producing an in-frame deletion.

223 h Delta45, skipping of exon 44 and multiexon skipping of exons 46 and 47 (or exons 46-48) are better

224 g cDNA showed the splice site variant led to skipping of exons 6 of the FHL1A isoform, equivalent to

225 these SR proteins promote both inclusion and skipping of exons in vivo, but their binding patterns do

226 nne muscular dystrophy, we propose that exon skipping of FcepsilonRIbeta is a potential approach for

227 direction signal, but eliminated theta cycle skipping of head direction cells and grid cell spatial p

228 Consistently, we show that skipping of MKK7 exon 2 enhances JNK pathway activity, a

229 induced by dexamethasone, which leads to the skipping of mutations upstream of nucleotide residue 845

230 disrupted the developmentally regulated exon skipping of Ndel1 mRNA, which is bound by MBNL1 and crit

231 scination and engineering application, water-skipping of rigid stones and spheres has received consid

232 calcium levels induce robust and reversible skipping of several alternative exons from endogenously

233 P A1-binding sites prevented hypoxia-induced skipping of SMN exon 7 and was found to bind both hnRNP

234 A1 and Sam68 as modifiers of hypoxia-induced skipping of SMN exon 7.

235 euron 1 (SMN1) gene coupled with predominant skipping of SMN2 exon 7.

236 The skipping of some exons may be more efficacious than othe

237 s antisense oligonucleotides, to induce exon skipping of specific mutations or drugs developed to all

238 s significantly on those genes, resulting in skipping of the alternative exons.

239 sing antisense oligonucleotide-mediated exon skipping of the beta-subunit of the high-affinity IgE re

240 in a PTBP1-binding site that disrupts normal skipping of the FLNA poison exon in NPCs and causes a br

241 es an autoinhibitory domain, induces partial skipping of the in-frame exon and nuclear accumulation o

242 on induced by histone depletion promotes the skipping of variable exons in the CD44 gene.

243 deletions with an end-point of exon 51 (the skipping of which could rescue the largest group of Duch

244 ng of Survival Motor Neuron 2 (SMN2) exon 7, skipping of which is linked to spinal muscular atrophy (

245 Here using exon skipping oligonucleotides we predominantly restored dyst

246 near the 3' splice site promoted either exon skipping or inclusion.

247 ross species that are generated through exon skipping or insertion that encodes proteins containing o

248 e single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exons.

249 in nocardicin A biosynthesis, unless module skipping or other nonlinear reactions are occurring.

250 uencing regulatory elements, leading to exon skipping, or by creating a new cryptic splice site.

251 At low temperatures, we observed caustics of skipping orbits extending over hundreds of superlattice

252 ation dynamics, we further observed both the skipping orbits of excited atoms traveling down the syst

253 ers a lesion in the leading-strand template, skipping over the damage by reinitiating replication at

254 nuniform sampling (NUS) obtained by randomly skipping points in the first dimension corresponding to

255 Drug-induced exon skipping preferentially affects shorter alternatively sp

256 cing modulator-induced intron-retention/exon-skipping profile, which correlates with the differential

257 sion synthesis came at the expense of lesion-skipping replication restart.

258 AON-induced exon skipping resulted in specific Alk4 down-regulation, inhi

259 .345C>T (p.S115S), markedly increased exon 4 skipping, resulting in the overexpression of a minor spl

260 novel computational method, graph-based exon-skipping scanner (GESS), for de novo detection of skippi

261 The proximate cause of skipping seems to be insufficient energy to initiate ooc

262 l not capture the fitness benefits gained by skipping sexual reproduction.

263 tations at splice junctions often cause exon skipping, short deletions, or insertions in the mature m

264 The subset of patients amenable to exon 51 skipping showed a more severe disease course than those

265 sortium and experimentally validated several skipping site predictions by RT-PCR.

266 Skipping (snapping) elbow syndrome is an uncommon cause

267 s and increased fat oxidation with breakfast skipping suggest the development of metabolic inflexibil

268 in patients with mutations amenable to exon skipping than in those not amenable.

269 role is to funnel a rough folding landscape, skipping the accumulation of kinetic traps, providing a

270 three families and was shown to induce exon skipping; the other mutations were frameshift mutations

271 Exon-skipping therapies aim to convert Duchenne muscular dyst

272 eletions and insertions are targeted by exon-skipping therapies.

273 mers (PMOs) has shown great promise for exon-skipping therapy of Duchenne Muscular Dystrophy (DMD).

274 deno-associated virus (AAV)-U7-mediated exon-skipping therapy was shown to decrease drastically after

275 implications for the development of DMD exon-skipping therapy.

276 Although very effective in correcting exon skipping, they also induced retention of the short downs

277 also affects splicing by facilitating exon 2 skipping, thus also being in effect a loss-of-function a

278 plasmid DNA with the bioreducible polymers, skipping time-consuming steps such as generation and cha

279 ead-through of translation stop codons, exon skipping to restore the reading frame and increased expr

280 lement, the subjects completed 6 min of rope-skipping to stimulate collagen synthesis.

281 These exon-skipping transcripts are therefore unlikely to be functi

282 The pervasive exon-skipping transcripts were stochastic, did not increase i

283 pe 1 VWD through mRNA degradation of exon 38 skipping transcripts.

284 hy with deletions relevant for on-going exon skipping trials in Duchenne muscular dystrophy.

285 Exon skipping uses antisense oligonucleotides (ASOs) to alter

286 Exon skipping uses antisense oligonucleotides as a treatment

287 ystrophin production can be achieved by exon skipping using antisense oligonucleotides targeted to sp

288 corresponding to LBD to produce namely exon-skipping variants.

289 The average splicing rate by exon skipping was approximately 0.24% in wild type and approx

290 ly from on-target integration, and ribosomal skipping was highly efficient.

291 3846662, an HMGCR SNP that regulates exon 13 skipping, was predicted to alter an HNRNPA1 binding moti

292 To prevent exon-skipping, we have targeted an intronic repressor, Elemen

293 mitant with T cell activation-induced exon 5 skipping, we observed a downregulation of SRSF1.

294 polymerase chain reaction to detect exon 14 skipping were performed where sufficient tissue was avai

295 were >/=7 years old and amenable to exon 51 skipping were randomized to eteplirsen (30/50mg/kg) or p

296 Inaccuracies in splicing (exon 2 skipping) were found to increase during the first 5 days

297 regulated exons PTBP1 tends to promote their skipping, whereas binding to downstream sites often stim

298 d reading frame upstream of the IRES by exon skipping, which led to synthesis of a functional N-trunc

299 Exon 44 or 45 skipping will likely yield lower levels of dystrophin th

300 iring on alternate theta cycles (theta cycle skipping) with fixed synchronous or anti-synchronous rel