ライフサイエンスコーパス: sleep disorder

1 related sleep disorder, and circadian rhythm sleep disorder.

2 : Narcolepsy is a chronic rapid eye movement sleep disorder.

3 ipants reported having been diagnosed with a sleep disorder.

4 psy, obstructive sleep apnea, and shift-work sleep disorder.

5 and without cognitive impairment or primary sleep disorder.

6 nxiety, learning disability, depression, and sleep disorder.

7 anxiety, depression and any other associated sleep disorder.

8 mpaired D3 activity could contribute to this sleep disorder.

9 this cohort had underlying mental health and sleep disorders.

10 al vulnerability to altered communication in sleep disorders.

11 s to identify genetic underpinnings of human sleep disorders.

12 lex relationship between epilepsy, sleep and sleep disorders.

13 onist under development for the treatment of sleep disorders.

14 nsure optimal treatment of both epilepsy and sleep disorders.

15 herapy for the treatment of circadian rhythm sleep disorders.

16 sfunction in these circuits can give rise to sleep disorders.

17 ers three areas: (a) Genetic determinants of sleep disorders.

18 l for transient insomnia in circadian rhythm sleep disorders.

19 toms include hyperexcitability, anxiety, and sleep disorders.

20 to exclude obstructive sleep apnea or other sleep disorders.

21 lar, pulmonary, and hematologic diseases and sleep disorders.

22 ment of rational treatments for a variety of sleep disorders.

23 tentially contribute to the genesis of these sleep disorders.

24 genes influencing risk for some neurological sleep disorders.

25 eep and wake signals, potentially preventing sleep disorders.

26 nificant differences in Parkinson disease or sleep disorders.

27 ight be effective in treating certain modern sleep disorders.

28 vents were primarily nausea and vomiting and sleep disorders.

29 ns in PD, the PPN could be involved in these sleep disorders.

30 ts and anxiety phenotype, without detectable sleeping disorders.

31 95% confidence interval [CI], 22.4 to 32.3), sleep disorders (11.6 excess cases per 1000; 95% CI, 8.3

32 (95% CI, 33.2 to 45.4), 23.5 excess cases of sleep disorders (95% CI, 19.4 to 27.6), 18.7 excess case

33 roactively identifying signs and symptoms of sleep disorders, a better understanding of their adverse

34 the high prevalence of gastrointestinal and sleep disorders among ASD children.

35 Untreated sleep disorders among police officers may adversely affe

36 Furthermore, QOL for many symptoms such as sleep disorder and malaise/feebleness was also significa

37 that we observed in patients with shift-work sleep disorder and resulted in a small but significant i

38 licated in an exceedingly common and complex sleep disorder and the development of an RLS animal mode

39 Lewy body dementia, rapid eye movement (REM) sleep disorder and/or multiple system atrophy, following

40 Hypersomnia, rapid eye movement sleep disorder and/or narcolepsy were identified in 11 s

41 e development of novel therapeutics to treat sleep disorders and anxiety.

42 erences in the progression of, for instance, sleep disorders and congestive heart failure in diabetic

43 overuse, stressful life events, depression, sleep disorders and cutaneous allodynia.

44 se (PD) is highly comorbid for a spectrum of sleep disorders and deep brain stimulation (DBS) of the

45 eurological comorbidities: motor impairment, sleep disorders and epilepsy.

46 ported in the setting of movement disorders, sleep disorders and even internal medicine disorders, su

47 ng as a new potential therapeutic target for sleep disorders and for neuropsychiatric diseases accomp

48 MOD) is used clinically for the treatment of sleep disorders and has been investigated as a potential

49 epresents a potential therapeutic target for sleep disorders and migraine-associated photophobia.

50 naptic GABA(A) receptors in the treatment of sleep disorders and other neurological conditions.

51 ntions to prevent and treat circadian rhythm-sleep disorders and social jet-lag.

52 Sleep disorders and substance abuse are highly comorbid

53 general medical condition, breathing-related sleep disorder, and circadian rhythm sleep disorder.

54 d phase, headache, pyrexia, nasopharyngitis, sleep disorder, and tremor were the most frequent advers

55 ing indications, such as insomnia, circadian sleep disorders, and depression, new potential therapeut

56 ass index, smoking, physical activity, other sleep disorders, and snoring status.

57 chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.

58 suggesting a role of vitamin A, adipokines, sleep disorders, and venous sinus stenosis in the pathog

59 investigated the associations of sleepiness, sleep disorders, and work environment (including truck c

60 fined by the International Classification of Sleep Disorders, and/or a large number of false-positive

61 are," "critical care," "earplugs," "sleep," "sleep disorders," and "delirium." STUDY SELECTION: Inter

62 estigate whether l-dopa treatment alleviates sleep disorders; and (3) to determine whether a choliner

63 Many genetic variants associated with sleep disorders are also implicated in neurological diso

64 Circadian rhythm sleep disorders are common causes of insomnia for millio

65 Sleep disorders are common in humans, and sleep loss inc

66 Evidence suggests that sleep disorders are common in individuals with CKD, but

67 Accurate identification and diagnosis of sleep disorders as well as epilepsy is clinically import

68 rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

69 rder presenting with pharyngitis followed by sleep disorder, basal ganglia signs (particularly parkin

70 tent hypoxia during sleep (IH), as occurs in sleep disordered breathing (SDB), induces spatial learni

71 implicated, including apnoea of prematurity, sleep disordered breathing and congestive heart failure.

72 Obstructive sleep disordered breathing can cause death and significa

73 have also highlighted the manifestations of sleep disordered breathing in children with sickle cell

74 In addition, sleep disordered breathing, inflammation, left ventricul

75 le lung disease, pulmonary hypertension, and sleep disordered breathing.

76 CIH-induced neuropathology in patients with sleep disordered breathing.

77 The prevalence of moderate-to-severe sleep-disordered breathing (>/=15 events per h) was 23.4

78 The prevalence of sleep-disordered breathing (apnea-hypopnea index of 15 o

79 isk factors for excessive sleepiness: severe sleep-disordered breathing (apnea-hypopnea index, >30 ep

80 t prevalence estimates of moderate to severe sleep-disordered breathing (apnea-hypopnea index, measur

81 Sleep-disordered breathing (characterized by recurrent a

82 sis was limited to those 27 patients who had sleep-disordered breathing (more than 5 apneas or hypopn

83 , and body mass index: (1) 228 subjects with sleep-disordered breathing (respiratory disturbance inde

84 ce index>or=30) and (2) 338 subjects without sleep-disordered breathing (respiratory disturbance inde

85 ing evidence suggests an association between sleep-disordered breathing (SDB) and cognitive decline i

86 of the insertion/deletion polymorphism with sleep-disordered breathing (SDB) and hypertension in 1,1

87 tional association has been reported between sleep-disordered breathing (SDB) and insulin resistance,

88 Sleep-disordered breathing (SDB) has been noted commonly

89 Sleep-disordered breathing (SDB) in children is associat

90 Sleep-disordered breathing (SDB) is a common disorder in

91 Whether sleep-disordered breathing (SDB) is a risk factor for le

92 There is increasing evidence that sleep-disordered breathing (SDB) is an independent risk

93 Sleep-disordered breathing (SDB) is associated with dayt

94 Clinic-based studies suggest that sleep-disordered breathing (SDB) is associated with gluc

95 Sleep-disordered breathing (SDB) is associated with hype

96 Sleep-disordered breathing (SDB) is associated with path

97 Sleep-disordered breathing (SDB) is both prevalent and a

98 Sleep-disordered breathing (SDB) is common in patients w

99 ng of intrinsic information in children with sleep-disordered breathing (SDB) is different from healt

100 Yet, sleep-disordered breathing (SDB) is highly prevalent in

101 We assessed the extent to which sleep-disordered breathing (SDB) may explain association

102 Genetic determinants of sleep-disordered breathing (SDB), a common set of disord

103 sibility (UAC) is increased in children with sleep-disordered breathing (SDB), but during wakefulness

104 Children with mild sleep-disordered breathing (SDB), who may not be recomme

105 en linked to disrupted sleep associated with sleep-disordered breathing (SDB).

106 ial triggers for arrhythmia in patients with sleep-disordered breathing (SDB).

107 ronic sleepwalkers frequently presented with sleep-disordered breathing (SDB).

108 ongest in older participants in whom overall sleep-disordered breathing also increased atrial fibrill

109 Compared with those without sleep-disordered breathing and adjusting for age, sex, b

110 events, we aimed to assess the prevalence of sleep-disordered breathing and associated clinical featu

111 Although research supports a sleep-disordered breathing and atrial fibrillation assoc

112 ights the complex interrelationships between sleep-disordered breathing and cardiovascular disease, p

113 e directionality of the relationship between sleep-disordered breathing and heart failure is controve

114 born preterm exhibit increased incidence of sleep-disordered breathing and hypertension, suggesting

115 more in-depth discussion of indications for sleep-disordered breathing and recurrent throat infectio

116 gnificant relation was also observed between sleep-disordered breathing and ventricular ectopic beats

117 ent in HFpEF patients, but renal disease and sleep-disordered breathing burdens are similar.

118 Central sleep-disordered breathing can occur with associated car

119 Among older women, those with sleep-disordered breathing compared with those without s

120 drigeminy) were more common in subjects with sleep-disordered breathing compared with those without s

121 Sleep-disordered breathing contributes to cardiac chambe

122 articipants who had objective assessments of sleep-disordered breathing during pregnancy were asked t

123 Prospective data suggest that sleep-disordered breathing enhances risk for incident an

124 ds of complex arrhythmias than those without sleep-disordered breathing even after adjustment for pot

125 dered breathing, can itself trigger specific sleep-disordered breathing events including air leaks, p

126 airway resistance can increase the risk for sleep-disordered breathing events.

127 rdered breathing compared with those without sleep-disordered breathing had an increased risk of deve

128 ent coronary heart disease, individuals with sleep-disordered breathing had four times the odds of at

129 Sleep-disordered breathing has also been linked to these

130 thway whereby incident CVD causes or worsens sleep-disordered breathing has not been studied.

131 Common polysomnographic measures of sleep-disordered breathing have shown a disappointing ab

132 Individuals with severe sleep-disordered breathing have two- to fourfold higher

133 between the use of replacement hormones and sleep-disordered breathing in a sample of 2,852 noninsti

134 Sleep-disordered breathing in neuromuscular diseases is

135 e in addressing pitfalls in the diagnosis of sleep-disordered breathing in neuromuscular diseases, id

136 We estimated the prevalence of sleep-disordered breathing in the United States for the

137 m the brain, and hypoxemia characteristic of sleep-disordered breathing increases Abeta production.

138 Sleep-disordered breathing is a common disorder with a r

139 Sleep-disordered breathing is also more common in patien

140 Sleep-disordered breathing is associated with an increas

141 Sleep-disordered breathing is associated with major morb

142 Sleep-disordered breathing is highly prevalent in elderl

143 These results suggest that sleep-disordered breathing is highly prevalent, with imp

144 reathing, the current evidence suggests that sleep-disordered breathing may function as a risk factor

145 Sleep-disordered breathing occurs after surgery even in

146 lectively studied in populations at risk for sleep-disordered breathing or cardiovascular diseases.

147 ent studies show either absence of change in sleep-disordered breathing or improved sleep cardiovascu

148 , incident CVD was associated with worsening sleep-disordered breathing over 5 years.

149 gnition; however, it remains unclear whether sleep-disordered breathing precedes cognitive impairment

150 tion association, prospective data examining sleep-disordered breathing predicting incident atrial fi

151 oing obesity epidemic, previous estimates of sleep-disordered breathing prevalence require updating.

152 The high prevalence of sleep-disordered breathing recorded in our population-ba

153 Although most children with sleep-disordered breathing respond to surgical treatment

154 We propose that sleep-disordered breathing results from loss of preBotC

155 Evaluation for sleep-disordered breathing should be a priority for meno

156 Cross-sectional studies have linked sleep-disordered breathing to poor cognition; however, i

157 thing in neuromuscular diseases, identifying sleep-disordered breathing triggered by noninvasive vent

158 Sleep-disordered breathing was ascertained by apnea-hypo

159 Sleep-disordered breathing was defined as an apnea-hypop

160 Sleep-disordered breathing was defined by an AHI of at l

161 inverse association between hormone use and sleep-disordered breathing was evident in various subgro

162 Sleep-disordered breathing was indicated by the frequenc

163 pause, perimenopause, and postmenopause with sleep-disordered breathing was investigated with a popul

164 The prevalence of sleep-disordered breathing was modeled as a function of

165 Sleep-disordered breathing was not associated with globa

166 rdered breathing, the 105 women (35.2%) with sleep-disordered breathing were more likely to develop m

167 ted with cardiorespiratory diseases, such as sleep-disordered breathing with apnoea, congestive heart

168 to determine the independent association of sleep-disordered breathing with risk of mild cognitive i

169 for sleep duration, sleep fragmentation, and sleep-disordered breathing) in the development of cognit

170 Obesity is a strong causal factor for sleep-disordered breathing, and because of the ongoing o

171 trategies for management of hypoventilation, sleep-disordered breathing, and cough insufficiency are

172 icity and alcohol's contribution to obesity, sleep-disordered breathing, and hypertension.

173 re, specific exercise, opioids, treatment of sleep-disordered breathing, and interventions to address

174 The primary outcome was prevalence of sleep-disordered breathing, assessed by the apnoea-hypop

175 opause is considered to be a risk factor for sleep-disordered breathing, but this hypothesis has not

176 on, a standard-of-care management option for sleep-disordered breathing, can itself trigger specific

177 s, dyslipidemia, obstructive sleep apnea and sleep-disordered breathing, certain cancers, and major c

178 ry artery disease, congestive heart failure, sleep-disordered breathing, gastro-oesophageal reflux di

179 iated with an increased likelihood of having sleep-disordered breathing, independent of known confoun

180 intermittent hypoxia (IH), such as occurs in sleep-disordered breathing, is associated with neurobeha

181 owever, its indication for all patients with sleep-disordered breathing, regardless of daytime sympto

182 Compared with the 193 women without sleep-disordered breathing, the 105 women (35.2%) with s

183 though stroke can lead to the development of sleep-disordered breathing, the current evidence suggest

184 entral apnea, Cheyne-Stokes respiration, and sleep-disordered breathing-age interaction terms were si

185 effects of oral antihistamines on asthma and sleep-disordered breathing.

186 omnography studies to assess the presence of sleep-disordered breathing.

187 malities in children with SCD are related to sleep-disordered breathing.

188 al importance to the patients suffering from sleep-disordered breathing.

189 sitive pressure ventilation in children with sleep-disordered breathing.

190 s is higher among subjects with than without sleep-disordered breathing.

191 eful second-line treatment for children with sleep-disordered breathing.

192 n the predominant abnormality leading to the sleep-disordered breathing.

193 lt patients evaluated by polysomnography for sleep-disordered breathing.

194 c respiratory cycles in adults evaluated for sleep-disordered breathing.

195 al impairments observed in a rodent model of sleep-disordered breathing.

196 uld have a role in preventing or alleviating sleep-disordered breathing.

197 me individuals may partially protect against sleep-disordered breathing.

198 When abnormal, these interactions lead to sleep-disordered breathing.

199 rdered breathing compared with those without sleep-disordered breathing: 4.8 versus 0.9% (p=0.003) fo

200 As epilepsy and sleep disorders can be treated and may contribute signif

201 a may worsen epilepsy and treatment of these sleep disorders can lead to improved seizure control.

202 stipation, pain, genitourinary problems, and sleep disorders, can be improved with available treatmen

203 arm); physical disorders (cancers, diabetes, sleep disorder, cardiovascular diseases, chronic lower r

204 rcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic

205 y-two of 538 subjects (5.9%) examined in our sleep disorders center received diagnoses of restless le

206 Obstructive sleep apnea (OSA) is a sleep disorder characterized by disruptions of normal sl

207 Patients with shift-work sleep disorder chronically have excessive sleepiness dur

208 Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and

209 e, idiopathic insomnia, and circadian rhythm sleep disorder-delayed sleep phase type.

210 resence of psychiatric complications such as sleep disorder, depression, anxiety and somatoform disor

211 xt revision; International Classification of Sleep Disorders: Diagnostic and Coding Manual II, Intern

212 rcadian disorders, or specific physiological sleep disorders--eg, sleep apnoea and periodic limb move

213 Sleep disorders, especially insomnia, occur in up to 83%

214 positive for obstructive sleep apnea or any sleep disorder had an increased prevalence of reported p

215 erse health consequences of sleep habits and sleep disorders has flourished in recent years.

216 Sleep duration, mostly short sleep, and sleep disorders have emerged as being related to adverse

217 Inadequate sleep and sleep disorders have important adverse consequences on m

218 pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer.

219 disturbance, cognitive decline and dementia, sleep disorders, hyposmia and autonomic failure.

220 The striking sleep disorder in these kindreds implicates TFAP2B-depen

221 nd video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep U

222 s study were as follows: (1) to characterize sleep disorders in a monkey model of PD; (2) to investig

223 we explored the mechanistic basis for these sleep disorders in a mouse model of Angelman syndrome (U

224 Sleep disorders in adolescents are both very common and

225 ese findings reveal potential treatments for sleep disorders in AS patients.

226 e sleep apnea(OSA) is one of the most common sleep disorders in kidney transplant recipients, however

227 ing, and the presence of physician-diagnosed sleep disorders in metropolitan, urban, and rural US Geo

228 of 2911 men in the observational Outcomes of Sleep Disorders in Older Men (MrOS) Sleep Study cohort u

229 llow-up (2009-2012) waves of the Outcomes of Sleep Disorders in Older Men Study (an ancillary study t

230 he efficacy of l-dopa treatment in improving sleep disorders in parkinsonian monkeys, and that adding

231 ve illnesses, but this is the first study of sleep disorders in PPND.

232 n promise for the treatment of insomnias and sleep disorders in several recent clinical trials in vol

233 an deficits that we report may contribute to sleep disorders in severe myoclonic epilepsy of infancy

234 s with some of the more commonly encountered sleep disorders in this age group, and to review their d

235 ort the use of melatonin in the treatment of sleep disorders in which the circadian melatonin rhythm

236 ut the prevalence of insomnia, a distressing sleep disorder, in these populations has yet to be deter

237 knowledge on the role of genetic factors in sleep disorders, in particular circadian disorders, narc

238 that occur in PD such as depression, apathy, sleep disorders (including rapid-eye movement sleep beha

239 The management of pediatric and adolescent sleep disorders is in the forefront of the pediatric lit

240 The development of new therapeutics for sleep disorders is increasingly dependent upon understan

241 At the same time, research guided by human sleep disorders is leading to important basic sleep conc

242 iency epidemic, as is the high prevalence of sleep disorders like insomnia.

243 Narcolepsy is a chronic sleep disorder, likely with an autoimmune component.

244 patients undergoing sleep evaluation for any sleep disorders (low pretest probability for narcolepsy)

245 avior with implications for the treatment of sleep disorders, metabolic disease, and cancer.

246 ants, 40.4% screened positive for at least 1 sleep disorder, most of whom had not been diagnosed prev

247 d with comorbid medical conditions including sleep disorders, motor hyperactivity, and seizures.

248 determine whether patients with a non-apnea sleep disorder (NA-SD) and comorbidity have an increased

249 tin/orexin (Hcrt), whose loss results in the sleep disorder narcolepsy and that has also been implica

250 The sleep disorder narcolepsy has been linked to loss of hyp

251 The sleep disorder narcolepsy is characterized by excessive

252 he discovery of a single gene underlying the sleep disorder narcolepsy, and identification of loci th

253 neuropeptides that are dysfunctional in the sleep disorder narcolepsy, may be involved in the expres

254 xin neurons in humans is associated with the sleep disorder narcolepsy, which is characterized by exc

255 In humans, loss of these cells causes the sleep disorder narcolepsy.

256 markedly decreased in most patients with the sleep disorder narcolepsy.

257 An increased incidence in the sleep-disorder narcolepsy has been associated with the 2

258 ebilitating symptom of the neurodegenerative sleep disorder, narcolepsy.

259 portant areas for pediatric office practice: sleep disorders, new immunizations, sports injuries, and

260 our important office-based pediatric topics: sleep disorders, new immunizations, sports injuries, and

261 t guidelines pertaining to the management of sleep disorders of children on the autism spectrum.

262 plications of drowsy driving, and the common sleep disorders of obstructive sleep apnea and insomnia.

263 Sleep disorders often remain undiagnosed.

264 (c) The impact of sleep disorders on obesity and diabetes.

265 erent samples: controls, patients with other sleep disorders, patients with other hypersomnias, and p

266 toms including anxiety, cognitive defect and sleep disorder precede the onset of motor impairment, an

267 colepsy type 1 is a devastating neurological sleep disorder resulting from the destruction of orexin-

268 Narcolepsy is a human sleep disorder resulting from the loss of neurons contai

269 International Classification of Sleep Disorders, second edition (ICSD2) derived insomnia

270 orders, or in the context of another primary sleep disorder such as restless legs syndrome, or second

271 n rhythm period and phase, which can lead to sleep disorders such as Familial Advanced Sleep Phase Sy

272 The understanding of the neurophysiology of sleep disorders such as insomnia, parasomnias, and narco

273 of the switching mechanism may contribute to sleep disorders such as narcolepsy.

274 especially with respect to the treatment of sleep disorders such as narcolepsy.

275 More recent studies have shown that primary sleep disorders such as obstructive sleep apnoea may wor

276 Additionally, symptoms of some sleep disorders such as parasomnias and narcolepsy can b

277 f REM sleep mechanisms underlie debilitating sleep disorders such as REM sleep behaviour disorder and

278 iated with space flight and circadian rhythm sleep disorders such as shift-work disorder.

279 Sleep disorders such as short sleep duration and increas

280 wever, a positive MSLT may be found in other sleep disorders, such as behaviourally induced inadequat

281 imately 14 loci increasing susceptibility to sleep disorders, such as narcolepsy and restless leg syn

282 Given that insomnia is a common sleep disorder that disrupts the ability to initiate and

283 1,2,3,6-tetrahydropyridine treatment induced sleep disorders that comprised sleep episodes during day

284 nsider the pathophysiological basis of major sleep disorders that often are seen by neurologists, inc

285 ature's solutions to heart, lung, blood, and sleep disorders through future research in this area.

286 ndomly assigned 209 patients with shift-work sleep disorder to receive either 200 mg of modafinil or

287 iew the evidence relating sleep duration and sleep disorders to cardiometabolic risk and call for hea

288 ehavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian

289 pulation-based controls or all patients with sleep disorders undergoing a nocturnal sleep study (area

290 een healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, follo

291 hose respondents who screened positive for a sleep disorder vs those who did not had a higher rate of

292 t visit of 5 years (range 2-12); in four the sleep disorder was the initial and most prominent featur

293 g a group of North American police officers, sleep disorders were common and were significantly assoc

294 ent with NA-SD, two matched controls without sleep disorders were randomly selected for comparison.

295 All other patients with other sleep disorders were treated only for their associated p

296 ng physical disorders, such as cirrhosis and sleep disorders, were also noted as well as the use of m

297 on with broad medical implications including sleep disorders, which can exacerbate metabolic disturba

298 t of circuit-selective drugs might alleviate sleep disorders with fewer side effects.

299 Combinations of other sleep disorders with RLS further increased the risk of E

300 Insomnia is a common sleep disorder, yet its pathophysiological basis remains