ライフサイエンスコーパス: sleeping sickness

1 human African trypanosomiasis (HAT; African sleeping sickness).

2 and reduce the high mortality resulting from sleeping sickness.

3 thway as a drug target against African human sleeping sickness.

4 a brucei is the etiological agent of African sleeping sickness.

5 opment of novel therapeutics against African sleeping sickness.

6 osoma brucei, the causative agent of African sleeping sickness.

7 cei is an extracellular parasite that causes sleeping sickness.

8 ODC is a proven drug target to treat African sleeping sickness.

9 volved with restocking was a risk factor for sleeping sickness.

10 ven drug target for the treatment of African sleeping sickness.

11 m Trypanosoma brucei, the causative agent of sleeping sickness.

12 hould be considered to prevent the spread of sleeping sickness.

13 ally explain the weight loss associated with sleeping sickness.

14 m Trypanosoma brucei, the causative agent of sleeping sickness.

15 t for human African trypanosomiasis (HAT) or sleeping sickness.

16 n disease called African trypanosomiasis, or sleeping sickness.

17 asite that causes the deadly disease African sleeping sickness.

18 seases, including malaria, dengue fever, and sleeping sickness.

19 ucei rhodesiense, the cause of acute African sleeping sickness.

20 n trypanosomiasis (HAT), also called African sleeping sickness.

21 panosoma brucei, the causal agent of African sleeping sickness.

22 fforts to develop new treatments for African sleeping sickness.

23 ed by the tsetse fly and that causes African sleeping sickness.

24 the future therapeutic treatment of African sleeping sickness.

25 an African trypanosomiasis (HAT), or African sleeping sickness.

26 trypanosomiasis (HAT), also known as African sleeping sickness.

27 is a parasitic protozoan that causes African sleeping sickness.

28 osoma brucei, the causative agent of African sleeping sickness.

29 isease and human African trypanosomiasis, or sleeping sickness.

30 panosomal infection and protect from African sleeping sickness.

31 flagellum, is the causative agent of African sleeping sickness.

32 of such an approach for treatment of African sleeping sickness.

33 use the fatal human disease known as African sleeping sickness.

34 eneration of diamidines for the treatment of sleeping sickness.

35 lular protozoan parasite that causes African sleeping sickness.

36 ambiense Human African Trypanosomiasis (HAT, sleeping sickness), a disease that has often been consid

37 oma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-

38 Trypanosoma brucei causes African sleeping sickness, a disease for which existing chemothe

39 ing target to develop new treatments against sleeping sickness, a fatal disease caused by this protoz

40 t and Southern Africa are foci for Rhodesian sleeping sickness, a fatal zoonotic disease caused by tr

41 animal trypanosomiases, including Rhodesian sleeping sickness, a zoonosis associated with wilderness

42 e Trypanosoma brucei, the causative agent of sleeping sickness across sub-Saharan Africa, depends on

43 rucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and is a m

44 Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and

45 , leishmaniasis, Chagas disease, and African sleeping sickness affect hundreds of millions of people

46 Human African trypanosomiasis (sleeping sickness) affects up to half a million people e

47 Human African trypanosomiasis, also known as sleeping sickness, affects the CNS at the late stage of

48 here is little hope of a vaccine for African sleeping sickness and a desperate need for modern drug t

49 oma brucei is the causative agent of African sleeping sickness and is known for its unique RNA proces

50 African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-S

51 ors by parasitic protozoa that cause African sleeping sickness and malaria.

52 cei, the causative pathogen of human African sleeping sickness and nagana in domestic animals, myo-in

53 ia mexicana, the causative agents of African sleeping sickness and one form of leishmaniasis, respect

54 at includes the causative agents for African sleeping sickness and other devastating tropical and sub

55 osoma brucei, the causative agent of African sleeping sickness, and GlcNAc-PI de-N-acetylase has prev

56 ive, T. b. rhodesiense, which causes African sleeping sickness, and the non-human infective T. b. bru

57 osoma brucei, the causative agent of African sleeping sickness; and Plasmodium spp., the causative ag

58 trends in the development of diagnostics for sleeping sickness are considered and progress towards a

59 a brucei, causative agent of the fatal human sleeping sickness, are essential for the parasite.

60 ere reported to have originated from endemic sleeping sickness areas.

61 soma brucei rhodesiense causes human African sleeping sickness because it has evolved an inhibitor of

62 ovide different levels of protection against sleeping sickness, but this comes with an increased risk

63 very that may undermine efforts to eliminate sleeping sickness by 2020.

64 en argued that the risk for trypanosomiasis (sleeping sickness), carried by tsetse flies in bushy env

65 We investigated the spatial clustering of sleeping sickness cases at the start of the outbreak.

66 The expansion of sleeping sickness caused by Trypanosoma brucei rhodesien

67 African sleeping sickness, caused by the protozoan parasite Tryp

68 s a drug target for the treatment of African sleeping sickness, caused by Trypanosoma brucei.

69 is a recognized drug target against African sleeping sickness, caused by Trypanosoma brucei.

70 Sleeping sickness, caused by two trypanosome subspecies,

71 evastating tropical diseases such as African sleeping sickness, Chagas' disease and leishmaniasis.

72 mania major, the causative agents of African sleeping sickness, Chagas' disease, and leishmaniasis.

73 rful approach to rational design of new anti-sleeping sickness chemotherapeutic drugs.

74 anosoma brucei, a causative agent of African Sleeping Sickness, constantly changes its dense variant

75 Sleeping sickness continues to be controlled by crisis m

76 osoma brucei, the etiologic agent of African Sleeping Sickness, deploys an RNA pol II that contains a

77 osoma brucei, the causative agent of African sleeping sickness, differs from its human host in severa

78 osoma brucei, the causative agent of African sleeping sickness, evades the host immune response by fr

79 ected from cattle in villages within the new sleeping sickness focus in Soroti District, Uganda.

80 ense imported to the market from the endemic sleeping sickness focus.

81 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and availa

82 anosoma brucei, the causative agent of human sleeping sickness, has an intrinsic circadian clock that

83 Human African sleeping sickness (HAT) is caused by the parasitic proto

84 century witnessed an alarming resurgence in sleeping sickness (human African trypanosomiasis).

85 Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT),

86 orcement of surveillance, for the control of sleeping sickness (human African trypanosomiasis, HAT).

87 Trypanosoma brucei, the causative agent of sleeping sickness in Africa, undergoes antigenic variati

88 , a protozoan parasite responsible for human sleeping sickness in Africa.

89 thereby reducing the public-health burden of sleeping sickness in east Africa.

90 e epidemic of Trypanosoma brucei rhodesiense sleeping sickness in eastern Uganda, which began in 1998

91 oma brucei is the causative agent of African sleeping sickness in humans and contributes to the debil

92 Trypanosoma brucei, the causative agent of sleeping sickness in humans and livestock, expresses at

93 , the protozoan parasite that causes African sleeping sickness in humans and nagana in cattle.

94 cei causes African trypanosomiasis, known as sleeping sickness in humans and nagana in domestic anima

95 the diseases caused by African trypanosomes: sleeping sickness in humans and Nagana in livestock.

96 oma brucei is the causative agent of African sleeping sickness in humans and one of the causes of nag

97 ican trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa.

98 panosomes are protozoan parasites that cause sleeping sickness in humans through a tsetse fly vector.

99 African trypanosomes cause sleeping sickness in humans, a disease that is typically

100 lated protozoan parasite that causes African sleeping sickness in humans.

101 When they infect mammals, they cause African sleeping sickness in humans.

102 atidae and a lethal parasite causing African Sleeping Sickness in humans.

103 te African trypanosomes, the agents of human sleeping sickness in sub-Saharan Africa.

104 present in all 29 samples from patients with sleeping sickness in Tororo District.

105 itted trypanosomes (Trypanosoma spp.) cause "sleeping sickness' in man and have a serious impact on l

106 ma brucei rhodesiense (agent of east African sleeping sickness), including a multidrug resistant clon

107 Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Sah

108 African sleeping sickness is a disease caused by Trypanosoma bru

109 African sleeping sickness is a fatal disease that is caused by t

110 e disease away from the market suggests that sleeping sickness is becoming established in this new fo

111 Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of Trypano

112 African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and mor

113 Human African trypanosomiasis (HAT), or sleeping sickness, is a major threat to human health thr

114 Human African trypanosomiasis, also known as sleeping sickness, is a neglected disease, and it contin

115 Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites

116 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites

117 osoma brucei, the protozoan parasite causing sleeping sickness, is transmitted by a tsetse fly vector

118 osoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host

119 , which cause such human diseases as African sleeping sickness, leishmaniasis and Chagas disease.

120 Trypanosomatids, the etiologic agents of sleeping sickness, leishmaniasis, and Chagas' disease, c

121 Trypanosoma brucei, the etiological agent of sleeping sickness, localized its replication origins to

122 he parasitic trypanosomes that cause African sleeping sickness, mating occurs during transmission by

123 African trypanosomes, the cause of sleeping sickness, need massive amounts of myristate to

124 orm Trypanosoma brucei, the agent of African sleeping sickness, normally requires mitochondrial gene

125 African sleeping sickness or human African trypanosomiasis, caus

126 copeia for human African trypanosomiasis (or sleeping sickness), orally dosed fexinidazole stands poi

127 port on a recent outbreak of T b rhodesiense sleeping sickness outside the established south-east Uga

128 ket was a highly significant risk factor for sleeping sickness (p<0.001) and that there was a signifi

129 evelopmental events in the life-cycle of the sleeping sickness parasite comprise integrated changes i

130 e-3-phosphate dehydrogenase (GAPDH) from the sleeping sickness parasite Trypanosoma brucei is a ratio

131 In the mammalian bloodstream, the sleeping sickness parasite Trypanosoma brucei is held po

132 Trypanosomatids, such as the sleeping sickness parasite Trypanosoma brucei, contain a

133 Motility of the sleeping sickness parasite, Trypanosoma brucei, impacts

134 Although similar to T. brucei, the sleeping-sickness parasite, these trypanosomes do not cy

135 The strategy that sleeping sickness parasites use to evade the mammalian i

136 ction of rare cell types in blood (including sleeping sickness parasites), and has the potential to e

137 Protozoan parasites such as the sleeping sickness pathogen Trypanosoma brucei adapt to d

138 Sleeping sickness presents clinically as two distinct di

139 oma brucei is the causative agent of African sleeping sickness, putting at risk up to 50 million peop

140 osoma brucei, the causative agent of African sleeping sickness, relies on glycolysis as its sole ener

141 , such as anaplasmosis, relapsing fever, and sleeping sickness, remains untested.

142 sites that cause Chagas' disease and African sleeping sickness, respectively.

143 The parasites causing African sleeping sickness respond to citrate or cis-aconitate (C

144 tance against Trypanosoma that cause African sleeping sickness, resulting in positive selection of th

145 ite Trypanosoma brucei, which causes African sleeping sickness, TbISWI down-regulates RNA polymerase

146 osoma brucei (the causative agent of African sleeping sickness) the glycosylphosphatidylinositol (GPI

147 osomes, protozoan parasites that cause human sleeping sickness, the increased levels of IFN-gamma do

148 s the only example of cross-resistance among sleeping sickness therapies.

149 occurs in the protozoan that causes African sleeping sickness (Trypanosoma brucei), and the protein

150 agas disease (Trypanosoma cruzi) and African sleeping sickness (Trypanosoma brucei).

151 s typified by the causative agent of African sleeping sickness, Trypanosoma brucei In mitochondria of

152 energy metabolism in the causative agent of sleeping sickness, Trypanosoma brucei, with that of huma

153 The human sleeping-sickness trypanosome, Trypanosoma brucei rhodes

154 The sleeping sickness trypanosomes Trypanosoma brucei rhodes

155 de that one mechanism of resistance of human sleeping-sickness trypanosomes to human serum is decreas

156 can trypanosomes, parasites that cause human sleeping sickness, undergo a density-dependent different

157 cei, a eukaryotic human parasite that causes sleeping sickness, uses three elongases instead of type

158 f Trypanosoma brucei rhodesiense (Rhodesian) sleeping sickness, which is a fatal zoonotic disease tha

159 tive agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs