ライフサイエンスコーパス: slightly deleterious mutation

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1 t about an increased rate of substitution of slightly deleterious mutations.

2 nymous mutations, suggesting the presence of slightly deleterious mutations.

3 ry mutations to Ohta's model of evolution by slightly deleterious mutations.

4 ersity is shaped by selection acting against slightly deleterious mutations.

5 e most easily explained by the occurrence of slightly deleterious mutations.

6 e appearance and subsequent fixation of both slightly deleterious mutations and advantageous mutation

7 This, in turn, suggests that slightly deleterious mutations are widespread in the hum

8 e for some time, and that it is accumulating slightly deleterious mutations as a result.

9 f mismatch repair increases the frequency of slightly deleterious mutations by approximately two orde

10 d that genetic drift and the accumulation of slightly deleterious mutations can explain this rate inc

11 ly occurred through the cumulative effect of slightly deleterious mutations causing a threshold-like

12 We estimate that these slightly deleterious mutations comprise at least 3% of a

13 n in the recent past or, alternatively, that slightly deleterious mutations constitute an important c

14 The accumulation of slightly deleterious mutations in populations leads to t

15 is little adaptive molecular evolution, then slightly deleterious mutations inflate estimates of the

16 A large number of slightly deleterious mutations may therefore have become

17 We find that in the presence of slightly deleterious mutations, MK estimates of alpha se

18 nd is reversed, with the majority of neutral/slightly deleterious mutations occurring in downstream e

19 les nor stronger purifying selection against slightly deleterious mutations on the X chromosome can a

20 erved RT residues and that selection against slightly deleterious mutations (purifying selection) in

21 ributed to generation-time, population size, slightly deleterious mutations, repair mechanisms, and t

22 mall populations, weakened selection against slightly-deleterious mutations results in an additional

23 theory of molecular evolution predicts that slightly deleterious mutations subject to purifying sele

24 neither the Muller's ratchet effect nor the slightly deleterious mutation theory sufficiently accoun

25 elected because they compensate for multiple slightly deleterious mutations throughout the mitochondr

26 iew was originally based on consideration of slightly deleterious mutations with a fixed distribution

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