ライフサイエンスコーパス: sloppy

1 us cortical activity also shows hallmarks of sloppy behavior and firing rate dependence.

2 models of increasing complexity that become sloppy in the limit of microscopic accuracy.

3 avior of multiparameter models is most often sloppy: insensitive to changes except along a few 'stiff

4 arameter estimation, and systematic error in sloppy models.

5 poses challenges for experimental design in sloppy models.

6 We developed a rapid, multiplexed sloppy molecular beacon (SMB) assay to identify these mu

7 This new sloppy molecular beacon assay should greatly simplify ri

8 symmetrical PCR followed by probing with two sloppy molecular beacons (SMBs) spanning the entire QRDR

9 Finally, newly designed sloppy molecular beacons identified many different mutat

10 Sloppy molecular beacons possess relatively long probe s

11 g this method, PCR assays with as few as six sloppy molecular beacons targeting bacterial 16S rRNA ge

12 The assay uses sloppy molecular beacons to probe an asymmetric PCR of t

13 Sloppy molecular beacons were exceptionally versatile, a

14 By using four sloppy molecular beacons, each possessing a different pr

15 We report here the use of novel "sloppy" molecular beacon probes in homogeneous PCR scree

16 developed a new class of mismatch-tolerant "sloppy" molecular beacons, modified them to provide an e

17 an clock in mammals consists of about 20000 'sloppy' neuronal oscillators within the hypothalamus tha

18 combinations of parameters, with an enormous sloppy neutral subspace.

19 or the forkhead domain transcription factor Sloppy Paired (Slp) has been shown to produce similar ef

20 stigate regulation and redundancy within the sloppy paired (slp) locus, we analyzed 30 kilobases of D

21 and appears to have no role in activation of sloppy paired (slp1).

22 These experiments identify sloppy paired 1 (slp1) as a gene that is activated and r

23 itial metameric expression of the Drosophila sloppy paired 1 (slp1) gene is controlled by two distinc

24 diate repressor activity as being encoded by sloppy paired 1 and 2 and showed that bona fide activati

25 In this paper, we show that sloppy paired 1 and sloppy paired 2 function as the down

26 ession of the forkhead transcription factors sloppy paired 1 and sloppy paired 2.

27 e enhancer region of an opa-responsive gene, sloppy paired 1.

28 this paper, we show that sloppy paired 1 and sloppy paired 2 function as the downstream targets of th

29 ad transcription factors sloppy paired 1 and sloppy paired 2.

30 ly with two different segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target g

31 he FoxG transcription factors encoded by the Sloppy paired genes (slp1 and slp2), which are direct ta

32 such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correc

33 Loss of Eyeless, Sloppy paired or Dichaete blocks further progression of

34 e transcription factors-Homothorax, Eyeless, Sloppy paired, Dichaete and Tailless-are sequentially ex

35 pped at different concentrations, paired and sloppy paired.

36 nes, while the functions of paired (prd) and sloppy-paired (slp) are secondary.

37 low Ubx levels in the P compartment, whereas sloppy-paired (slp) is required for high Ubx levels in t

38 The sloppy-paired (slp) locus contains two genes (slp1 and s

39 The sloppy-paired (slp) locus is a target of repression by b

40 Here we describe the ventral role of the Sloppy-paired (Slp) transcription factor, and its intera

41 or both of the secondary pair-rule genes, Tc-sloppy-paired (Tc-slp) and Tc-paired (Tc-prd), activated

42 Tribolium castaneum paired (Tc-prd) and sloppy-paired (Tc-slp) genes produced pair-rule phenotyp

43 This site is bound specifically by Sloppy-paired 1 (Slp1), which is expressed in a gap gene

44 We confirm that the relative expression of sloppy-paired and paired with respect to wingless and en

45 ontrolled by decapentaplegic, orthodenticle, sloppy-paired and tailless whose homologues control gsc

46 ify the forkhead domain transcription factor Sloppy-paired as the key intermediate in the initial act

47 le combinatorial rules for regulation of the sloppy-paired-1 (slp1) gene by the pair-rule transcripti

48 blishing the initial metameric expression of sloppy-paired-1 (slp1) in the Drosophila blastoderm embr

49 tributes to the Runt-dependent repression of sloppy-paired-1 (slp1), a role that is not shared with t

50 tion and repression of the segmentation gene sloppy-paired-1 (slp1).

51 The activity of neurons with sloppy parameters showed faster and larger fluctuations

52 enders it less predictive than it was in the sloppy regime where systematic error is small.

53 zing activators; (3) high-copy plasmids with sloppy replication control arise because intracellular s

54 nts did not think that serious misconduct or sloppy science occurred more often in AADR than in other

55 We introduce the concept of a sloppy system-a sequence of models of increasing complex

56 e limits of accurate parameter estimation in sloppy systems and argue that identifying underlying mec

57 ems can be usefully extended to characterize sloppy systems.

58 Dpo4 encounters the lesion, synthesis became sloppy, with bypass products containing a myriad of muta