ライフサイエンスコーパス: slow

1 hyperparameters, which can be cumbersome and slow.

2 al regulators and their promoters may be too slow.

3 g their underlying brain mechanisms has been slow.

4 stillbirth and neonatal mortality have been slow.

5 or later in life when cell proliferation has slowed.

6 ctroencephalography showed generalized theta slowing.

7 on toward higher upper thermal tolerance was slow (0.04 +/- 0.008 degrees C per generation).

8 chit-GO showed average pore size of 1mumwith slow (2 h) curing process.

9 l amplitude of low-frequency fluctuations in slow-4 band (fALFF4).

10 on, we show that a major contributor to this slow accumulation is reduced NTL8 dilution due to slow g

11 -11)), and SLC6A1 with "EEG with generalized slow activity" (HP: 0010845; p = 0.018).

12 Structural results suggest that the slow acylation by the K234R enzyme is due to a conformat

13 cell proliferation is an effective means of slowing ADPKD progression caused by inactivation of Pkd1

14 red both increased localized recruitment and slowed advancement of the raid as they targeted the odou

15 examine the most promising interventions to slow ageing and group them into two tiers based on the r

16 ctions with BrM represents a new strategy to slow AMD progression in humans.

17 adult mutants displayed a typical pattern of slow and fast muscle fiber distribution, and regained no

18 BDNF rescues select molecular mechanisms in slow and fast muscle that may underlie the improved cell

19 rom observational studies suggests that both slow and fast rates of net fluid removal (that is, net u

20 Because forest growth is slow and incremental, changes in the carbon density in f

21 tion, soil-sediment-water treatments) showed slow and inefficient performance when it came to unconve

22 directional, and encamped movements that are slow and meandering.

23 rted into double-stranded DNA, is that it is slow and non-processive.

24 s when AMP synthesis and bacterial growth is slow and pathogen pressure from this cool-adapted fungus

25 thods used to determine these quantities are slow and require additional sensitivity.

26 In nonpolar solvents, slow and reversible isomerization corresponding to chemi

27 s with diabetes mellitus and hypertension to slow and stabilize coronary artery disease progression a

28 This reaction is generally slow and takes place over 6 to 14 days.

29 Doses of 40 and 55 Gy caused slowing and interruption of cardiac impulse propagation

30 GluA3 slows and attenuates synaptic depression, and makes it l

31 Caseins and whey proteins are known as 'slow' and 'fast' proteins, respectively, based on their

32 AFDs; 21 AF termination and 33 cycle length slowing) and occurred in all 27 patients.

33 st rate makes an intermediate test rate feel slow, and adapting to a slow rate makes the same moderat

34 eployment of RT-PCR tests has been extremely slow, and key reagents such as PCR primers and RNA extra

35 stics are highly sensitive and specific, but slow, and require expensive equipment.

36 on an efficient control of Na(+) -permeable slow- and fast-vacuolar channels that mediate the back-l

37 bination of long-range exciton transport and slow annihilation highlights the unique attributes of tw

38 over the past 10 years, though the rate was slow at some sites.

39 Brown carbon formation slows at 50-60% RH and when the aerosol particles are ac

40 of lever arm priming (recovery stroke) while slowing ATP hydrolysis, demonstrating that it uncouples

41 or domains in the microtubule-bound state by slowing ATP-binding, resulting in high-force production

42 sociation with increased P-wave duration and slowed atrial conduction velocity.

43 lations that predicted and defined fast- and slow-attaching subpopulations, as well as nonattaching s

44 eatment with lysozyme-functionalized origami slows bacterial growth more effectively than treatment w

45 in (EC) and epigallocatechin (EGC) exhibited slow binding kinetics (in the order of minutes), epicate

46 Some compounds followed slow-binding and reversible kinetics, e.g., methyl beta-

47 pensity to approach the experimenter after a slow blink interaction than when they had adopted a neut

48 Collectively, our results suggest that slow blink sequences may function as a form of positive

49 this time where an experimenter provided the slow blink stimulus, cats had a higher propensity to app

50 peared to originate from areas of relatively slow blood flow speeds.

51 adjacent to dural venous sinuses: regions of slow blood flow with fenestrations that can potentially

52 st by spectral-domain OCT were classified as slow by SAP and vice versa.

53 hat disease progression could potentially be slowed by disrupting the machinery of cell migration.

54 in (CREB) transcription factor significantly slows Caenorhabditis elegans' reproductive decline, an e

55 This is reminiscent of the slow, cAMP-induced activation reported for the hyperpola

56 enting excessive cellular enlargement during slowed cell cycles by down-regulating translation capaci

57 e recent history of postsynaptic spiking and slow changes in postsynaptic excitability.

58 ment learning, rodent evidence suggests that slow changes in tonic VTA activity and associated accumb

59 curring, ocular position exhibits continuous slow changes, often referred to as drifts.

60 dditional therapies to reduce CKD incidence, slow CKD progression, and lower hospitalization risk are

61 erated in rats and monkeys and exhibited the slow clearance from circulation and tissue biodistributi

62 lubility, aggregation, photodegradation, and slow clearance from the body.

63 for personalized therapeutic approaches for slowing clinical progression of AD.

64 eatable, and therapeutic strategies aimed to slow cognitive decline have not yet been successful.

65 ed functionally in delayed gastric emptying, slowed colonic motility, and prolonged total gastrointes

66 e apparent velocity of the body was reduced (SLOW condition), the pull-force required to induce a ste

67 further in the direction of the pull in the SLOW condition.

68 ed that shortened action potential duration, slow conduction and triggered activity occur due to elec

69 ce of expression of genes required for nodal slow conduction physiology.

70 rom Pyrococcus horikoshii suggested that the slow conformational transition from the outward- to the

71 ue-specific gene expression, concurrent with slowed cycling behaviour.

72 half-life of p53 and uses p53 to initiate a slow-cycling state following stress (DNA damage, targete

73 ecause a subset of cells can transition to a slow-cycling state, rendering them resistant to most tar

74 Upon removal of 5-Fu, slow-cycling stem cells regenerated both the structure a

75 Transmitter diffusion, rebinding, or slow deactivation kinetics of channels are candidates.

76 revealed a transition from deterministic and slow decision-making to a fuzzy and rapid regime dominat

77 lity and cardiovascular hospitalizations and slows decline in quality of life compared with placebo.

78 ation rates), the GMRF-based model detects a slow decrease whereas the HSMRF-based model detects a ra

79 KCNE1 subunits together mediates the cardiac slow delayed rectifier current (I (Ks) ), which is partl

80 y of KCNQ1, which can function either as the slow delayed rectifier current (I(Ks)) of the cardiac ac

81 The channels which generate the cardiac slow delayed rectifier K(+) current (I (Ks) ) are compos

82 th an estimated EC(50)-value of pH 6.7 and a slow-developing, non-desensitizing current that required

83 ly, targeted immunotherapy could potentially slow disease progression.

84 tive alternative drugs are clearly needed to slow disease progression.

85 2 increased cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony

86 c AST for Ng is challenged by the pathogen's slow doubling time and the lack of methods to quickly qu

87 Today, no therapy is available to block or slow down AD progression, and the mechanisms of the dise

88 tina from oxidative damage and to prevent or slow down diabetic retinopathy.

89 matic species in the cages may substantially slow down or facilitate the diffusion process.

90 ent codons in the P and A site that markedly slow down or speed up elongation.

91 ) that act on the translational machinery to slow down protein synthesis via phosphorylation of the e

92 let; calculations confirm that this does not slow down the droplet.

93 nd women beyond childbearing age, would only slow down the increase in levels of NNRTI PDR.

94 binds to actin filaments and is required to slow down the turnover of apical actin.

95 y of these ageing-associated diseases can be slowed down and even reversed by restoring NAD(+) levels

96 Both wild salmon groups slowed down in response to predator cues, whereas hatche

97 and secondary lipid oxidation products, and slowed down the degradation of the furan fatty acids and

98 n the case of the hairpin ribozyme, pressure slowed down the self-cleavage reaction on the basis that

99 Enhanced immune response slowed down tumor progression in a prophylaxis model.

100 By slowing down microtubule dynamics, we reveal such a mech

101 incidence might not exhibit typical critical slowing down properties before a critical transition, th

102 Specificity may be increased by slowing down the kinetics of regulation: by increasing t

103 a relatively large number of photons, hence slowing down total acquisition times.

104 es in entering and leaving such pores, which slows down charging and discharging processes.

105 the interaction with the channel wall, which slows down the permeation by several orders of magnitude

106 This slows down the RNA production until it is bound by the e

107 ce of proline in the ribosome's P- or A-site slows down translation, but the effect of other pairs of

108 The effect of climate change on the slowing-down of SCA at MLO is mainly exerted by intensif

109 nalyzed the potential driving factors of SCA slowing-down, with an ensemble of dynamic global vegetat

110 by spin diffusion when molecular tumbling is slow due to solvent viscosity, thus strongly favoring ma

111 -cell coupling due to structural remodelling slow electrical propagation and provide obstacles to att

112 When exposed to a slow electron beam, the NPs exhibit a charge/discharge b

113 m to demonstrate that inhibitory codon pairs slow elongation rates which are partially rescued by inc

114 rect measure of neuronal firing and reflects slow-evolving hemodynamic activity that fails to capture

115 It relies on the slow exchange between the invisible antigen-mAb complex

116 t building blocks and/or under conditions of slow exchange, as kinetic traps and nonequilibrium produ

117 that interspecific competition dramatically slows expansion across a landscape over multiple generat

118 ic inhibition of DA neurons in either region slowed fear extinction, with the relevant time period fo

119 The slow fibers, which express a slow fiber-specific myosin heavy chain 1 (Smyhc1), are t

120 The slow fibers, which express a slow fiber-specific myosin

121 lerating actin filament assembly locally and slowing filament capping.

122 followed by a brief fast decline and then a slow final decline.

123 distance to goal, and licking) in sustained slow firing modulation.

124 f geochemically reducing, highly saline, and slow-flowing fluids around the waste emplacement zone, a

125 ce of the fork remodeler HLTF, forks fail to slow following replication stress, but underlying mechan

126 ods are often sampling based and can be very slow for large data.

127 ion or cleanup prior to analysis and are too slow for large-scale screening campaigns.

128 e rate constant for pyrophosphate release is slowed for certain misincorporation events.

129 One additional freezing-thawing cycle at slow freezing rate caused appearance of a 160 kDa myosin

130 n medial temporal lobe phase lock to ongoing slow-frequency (1-7 Hz) oscillations during WM maintenan

131 Thus, these results elucidates a novel slow gain-control mechanism able to support linear trans

132 val [CI], 5.2-23.9), 2.6 times the odds of a slow gait speed (95% CI, 1.4-4.8), and 3.2 times the odd

133 of O-glycan-deficient cargos is due to their slow Golgi export.

134 se and decay phases, newborn neurons display slow GPSCs with characteristics of spillover signaling.

135 egulated gene integrity (RGI) cases has been slow-growing because IGEs have been challenging to preci

136 rich nutrients are substantially larger than slow-growing cells.

137 nes that contribute to biofilm production in slow-growing mycobacteria.

138 Bacteria invest in a slow-growing subpopulation, called persisters, to ensure

139 However, it is clear that slow-growing subsets of bacteria emerge during infection

140 ent with a life history-physiology axis from slow-growing winter annuals to fast-growing spring/summe

141 n leatherwood (Dirca palustris) because this slow-growing woody shrub is known for its flexible stems

142 rive at the thermodynamic limit of life, are slow-growing, and in most cases form syntrophic consorti

143 rucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might be harm

144 accumulation is reduced NTL8 dilution due to slow growth at low temperatures.

145 f large crystals of challacolloite indicates slow growth from solution.

146 aT, although a second gene, dat, can support slow growth of an L-alanine auxotroph.

147 sotopically labelled in situ, indicate their slow growth.

148 degraded RNF128 Iso1 protein in BE cells and slowed growth of EAC xenograft tumors in mice.

149 below 1 h, extension of these dogmas to the slow-growth regime has not been consistently achieved.

150 fected WT and CSE(-/-) macrophages using the slow H(2)S releaser GYY3147 and the CSE inhibitor DL-pro

151 including secondary structures in template, slowed helicase, or uncoupled helicase-polymerase, incre

152 The slow heteroepitaxial crystal growth enlarged the perovsk

153 the laboratory to the field is likely to be slowed, however, by the lack of constructive dialogue be

154 using linear mixed models and classified as slow if change was slower than -1.0 mum/year; moderate i

155 use its cofactors, MAP7-family proteins, are slow in populating these ends.

156 Contractile kinetics were slowed in HF, with dramatically slowed relaxation in car

157 effects, including accelerating the onset of slow inactivation and impairing recovery from inactivati

158 d use (buffer areas) from 1995-2009 (stable, slow increase, fast increase) using remote sensing data

159 association of the fluorophores, followed by slow insertion of hydrophobic moieties into the lipid bi

160 However, its slow intramolecular electron transfer (IET) rate from th

161 Here, we aim at testing whether this EEG slowing is linked to the pathological intrusion of sleep

162 segregation of occupations continues but has slowed its pace.

163 show that genetic ablation of IFT20 in vitro slows keratinocyte migration during wound healing.

164 charging rates are typically limited by the slow kinetics of Faradaic reactions and sluggish ion dif

165 ssive permeability for small molecules and a slow lateral diffusion of proteins.

166 hemical vapor deposition (CVD) is limited by slow lateral growth rates, which result in a tendency fo

167 e role of distinct interneuronal subtypes in slow (<60 Hz) and fast gamma states remains unclear.

168 icient way to bypass the problems related to slow mass transfer and inaccessibility of internal space

169 ratory strategies in long-lived animals with slow maturation remain enigmatic.

170 Woody species are inherently slow maturing, meaning that seeders are confined to infr

171 factors contributing to timing variability: slow memory fluctuation that degrades performance and re

172 We assessed whether oral insulin slowed metabolic decline after 1 year of treatment in in

173 t that 1 year of treatment with oral insulin slows metabolic deterioration in individuals at high ris

174 ic uptake consistent with TSPO expression, a slow metabolism in blood (69% of parent at 120 min), a h

175 er neurotransmitters, exhibits both fast and slow modes that are strongly determined by the anatomy o

176 fast motions but minimal resistance against slow motions, allowing for the integration of diverse mo

177 he sensorimotor cortex before the go-cue and slowed movement initiation in healthy motor control.

178 ts show a 10-percentage-point shift from the slow-moving to the fast-moving end of the translation-sp

179 scle fiber distribution, and regained normal slow muscle formation.

180 hc1 is essential for myogenesis in embryonic slow muscles, and loss of Smyhc1 results in defective sa

181 We have measured slow net flow and high net oxygenation in the placenta i

182 aled that increasing age was associated with slowing of action selection performance.

183 ing the percentage of DMPC leads to a marked slowing of CNTP diffusion.

184 round state cooling of mechanical motion and slowing of light.

185 ent in ATM or NBN did not show a significant slowing of mitotic progression.

186 n the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the

187 ecological systems can be described as fast, slow or abrupt.

188 entification of genes and interventions that slow or reverse aging is hampered by the lack of non-inv

189 ery of modulators of FGF signalling that can slow or stop the progression of osteoarthritis.

190 water depth, stabilizing grounding lines and slowing or reversing glacial retreat.

191 ificant decrease (p < 0.001) in the power of slow oscillations and increase (p < 0.001) in cortical c

192 ucleus reuniens at the UP state onset during slow oscillations.

193 oise and other sounds to elicit delta power, slow oscillatory power, and N3 sleep.

194 N variant, the current block showed fast and slow phases, in contrast to the single phase found for a

195 system properties (e.g., rapid hydrolysis or slow photolysis).

196 erization that would weaken the affinity and slow polymerization.

197 Fourteen day administration of a slow-pressor dose of AngII in male mice was associated w

198 We discovered that fold-switching is a slow process, on the order of seconds, whereas domain mo

199 for estimating the rate coefficients of very slow processes of pharmacological interest.

200 in older adults that is often accompanied by slowed processing and gait speed.

201 These results demonstrate a slow progression from elevated GH release to the formati

202 ation, characterized by the combination of a slow-progressive feedforward process and a fast-reactive

203 tumors, cells transition reversibly between slow-proliferating tumor-initiating cells (TIC) and thei

204 seemingly detrimental effect of aneuploidy, slowed proliferation, provides a selective benefit to ca

205 cy, lowered pollen germination frequency and slowed PT elongation.

206 rapid adoption of LEPA technologies did not slow pumping, but it reduced energy use by 19.2% and GHG

207 These lipids slow Ras' translational and orientational diffusion and

208 diate test rate feel slow, and adapting to a slow rate makes the same moderate test rate feel fast.

209 quired immune deficiency syndrome, given its slow rate of CD4 decline, low to undetectable viremia, a

210 n the peripheral nervous system (PNS) is the slow rate of regrowth.

211 1-2 years), then continued to decrease in a slowing rate.

212 inetics were slowed in HF, with dramatically slowed relaxation in cardiomyocytes from patients with H

213 choroidal MC stimulation and activation in a slow release fashion in the rat.

214 the food industry, enabling a controlled and slow release of active antimicrobial agents, such as ess

215 mmonium supply, equivalent to application of slow-release fertilizer, or high rates of supply, equiva

216 d to investigate the effect of intra-uterine slow-release insemination (SRI) on pregnancy rates in wo

217 ed temperature subphenotypes: "hyperthermic, slow resolvers" (n = 19 cohort 1; n = 13 cohort 2), "hyp

218 er responders, 17% early responders, and 25% slow responders.

219 and arousal by asymmetrically modulating the slow response fluctuations of local excitatory and inhib

220 tein vaccines restored immune responses, and slowed response decay compared to the 6-month vaccinatio

221 ical responses closely track climate change, slow responses substantively lag climate forcing, causin

222 redominantly on mitochondria, because of its slow retrotranslocation and mediated apoptosis as effici

223 igh responsivities with additional gain, but slow rise and recovery times.

224 Slowed RTs on correct proactive trials reflected startin

225 Surprisingly, rotated circular coins slowed search for elliptical targets, even when subjects

226 lipid bilayers proceeds in two steps, with a slow second step occurring over many days where native l

227 ne secretion has evolved to support fast and slow signaling modes, with fast release requiring the Ca

228 Our results suggest that PVs mediate slow spillover signaling in addition to conventional fas

229 complex binding within the channel, and the slow step in the current block is the formation of a Cu-

230 Furthermore, we develop a slow sustained-release strategy to overcome the limited

231 The presence of GluA3 reduces and slows synaptic depression, which is achieved by lowering

232 exhibit high sensitivity to fast but not to slow temporal variations, whereas cone-driven responses

233 lement the loss in rod-driven sensitivity to slow temporal variations.

234 rily on photosynthesis; while if turnover is slow the accumulation of respiring biomass is high and r

235 diagnostic and treatment strategies that may slow the aging process based on the unique biochemistry

236 ift the voltage dependence of activation and slow the deactivation of I(Ks).

237 ased filter aerosol mass loading is shown to slow the evaporation rates of deposited compounds.

238 cticing retrieval shortly after learning can slow the forgetting process.

239 ssible removes competitive barriers that may slow the growth of resistant cells.

240 -2), with unprecedented policies designed to slow the growth rate of infections.

241 hways whose therapeutic modulation will help slow the progression of motor neuron disease, offering a

242 including one proposed to disrupt the dimer, slow the rate of substrate processing by ~35 %.

243 Policy measures adopted to slow the transmission of disease are decreasing the dema

244 ntation of NAD(+) with nicotinamide riboside slowed the axon degeneration and demyelination, although

245 ctions of 1 of these compounds, penfluridol, slowed the growth of xenograft tumors in the different m

246 cial effect on the key efficacy outcomes and slowed the rate of kidney function decline in patients w

247 cing and mask-wearing, although effective in slowing the epidemic and in reducing mortality, would al

248 s evidence suggesting a protective effect in slowing the progression of GA.

249 [K(+) ](c) , which speeds the activation and slows the inactivation and deactivation of a second pota

250 ile protection of bound TFs from degradation slows the time-scale of fluctuations in the unbound TF l

251 onsidered the possibility that the drug is a slow, tight-binding inhibitor.

252 ppler ensemble was motion corrected prior to slow-time power Doppler integration.

253 rate constant of only 4.1 x 10(4) s(-1), too slow to compete with other processes such as radical cat

254 Unfortunately, symptoms of the disease are slow to develop and indistinct from symptoms of other bi

255 , and interruption of transmission have been slow to emerge.

256 2) used for cell-specific activation are too slow to follow the high rates required for effective DBS

257 nds support substantial biodiversity and are slow to recover if destroyed by human land uses (e.g., t

258 t a relatively early age and most (67%) have slow-to-moderate progression of their visual field defec

259 throughout follow-up, while 8 eyes (67%) had slow-to-moderate progression.

260 atients with brain pathologies revealed that slow tracer accumulation characterizes areas surrounding

261 ver, cells with constitutive PTEN expression slow transcription, an evolutionary mechanism that may s

262 ntify are enriched four-fold relative to the slow-translating pairs across Saccharomyces cerevisiae's

263 ccharomyces cerevisiae's proteome, while the slow-translating pairs are enriched downstream of domain

264 enriched on diverse sequence motifs known to slow translation.

265 g, Gln4p depletion was simulated, confirming slowed translation.

266 ive motions of the vertebrae and ribs during slow treadmill locomotion in three savannah monitor liza

267 in 3-5 weeks; injections of anti-PD1 did not slow tumor development.

268 iltrating CD8(+) T and natural killer cells, slowed tumor growth, and improved mouse survival.

269 r extent as a combination with anti-PD1, SG7 slows tumor growth in multiple syngeneic mouse models.

270 of the ovary to those of the mantle muscle (slow turnover rate tissue, representing an energy reserv

271 types: synaptic strength was rescued only in slow-twitch muscle, while contractile strength was impro

272 rations of bioavailable dissolved U species, slow U uptake rates from food, and fast U elimination.

273 hemical reaction that would be otherwise too slow under diluted conditions.

274 to the 40S ribosomal subunit, followed by a slow unimolecular reaction consistent with a conformatio

275 ow x arterial [O(2) ], QO2 ) dependency that slows VO2 kinetics, decreasing CP and VO2max , increasin

276 rlap of bursts between the two STN was high, slowing was more pronounced.

277 annels, and was strongly correlated with the slow wave component of NR arousals (r = 0.99, p < 0.0001

278 s share specialized forms of sleep including slow wave sleep (SWS) and rapid eye movement sleep (REM)

279 depression, revealing not only a decrease in Slow Wave Sleep, but also a disinhibition of REM (rapid

280 e is the P3b event-related potential, a late slow wave that appears when observers are aware of a sti

281 n if auditory stimulation is used to enhance slow-wave activity.

282 o significant effects on the distribution of slow-wave origin probability across hemispheres.

283 t the main responsible for cross-hemispheric slow-wave propagation.

284 traces are spontaneously reactivated during slow-wave sleep (SWS), leading to the consolidation of r

285 the unmarked reward zone to patterns during slow-wave sleep (SWS).

286 egative affect stage, there is a decrease in slow-wave sleep and some limited recovery in REM sleep w

287 the production of sharp-wave ripples during slow-wave sleep in a unilateral or bilateral manner, res

288 e postreserpine days, sleep was dominated by slow-wave sleep with fast intrusions and reduced hierarc

289 f stimulation in memory consolidation during slow-wave sleep.

290 techniques, including automated detection of slow waves and eye movements.

291 ccurrence of prominent sleep-like TMS-evoked slow waves and off-periods-reflecting transient suppress

292 Importantly, slow waves behave as traveling waves, and their propagat

293 te the role of optogenetically induced sleep slow waves in an animal model of ischemic stroke and ide

294 it did not have a significant impact on the slow waves or memory performance after sleep.

295 ding period-amplitude analysis of individual slow waves.

296 ve tendency of each hemisphere at generating slow waves.

297 The slow, winter-long upregulation of VERNALIZATION INSENSIT

298 life-critical reactions would be infeasibly slow without metal cofactors, a detailed understanding o

299 the discovery of the Wallerian degeneration slow (Wld(S)) mouse, research has generated extensive kn

300 bution of movements in the environment (the "slow world" prior) as premised by Bayesian accounts.