ライフサイエンスコーパス: small GTP-binding protein

1 GAP (RASA1), a negative regulator of the Ras small GTP-binding protein.

2 ting a specific role for a Rho family member small GTP-binding protein.

3 ation of ADP-ribosylation factor 6 (ARF6), a small GTP-binding protein.

4 that acts as a negative regulator of the Ras small GTP-binding protein.

5 n about which signaling events regulate this small GTP-binding protein.

6 nvolving the transcriptional activation of a small GTP-binding protein.

7 ignal transduction initiated through the Ras small GTP-binding protein.

8 ranyl and are likely members of the numerous small GTP binding proteins.

9 GTP exchange proteins for the Rab3 family of small GTP binding proteins.

10 y oncogenic member of the Ras superfamily of small GTP binding proteins.

11 cterial toxins that target the Rho family of small GTP-binding proteins.

12 the ADP ribosylation factor (ARF) family of small GTP-binding proteins.

13 kinase cascades partly regulated by upstream small GTP-binding proteins.

14 om mammals and yeast, which are activated by small GTP-binding proteins.

15 AK family, whose activities are regulated by small GTP-binding proteins.

16 which have been implicated as regulators of small GTP-binding proteins.

17 cytoskeletal locations to activate Rho-type small GTP-binding proteins.

18 R-Ras is a member of the RAS superfamily of small GTP-binding proteins.

19 the ARF (ADP-ribosylation factor) family of small GTP-binding proteins.

20 exchange of GDP for GTP on the Arf family of small GTP-binding proteins.

21 as-related RGK (Rad, Gem, and Kir) family of small GTP-binding proteins.

22 actor (GEF) for the Arf family of eukaryotic small GTP-binding proteins.

23 e exchange factors for the Rho/Rac family of small GTP-binding proteins.

24 or the proper function and activation of the small GTP-binding proteins.

25 king to the plasma membrane, in concert with small GTP-binding proteins.

26 ude a novel member of the Ras superfamily of small GTP-binding proteins, a novel Ser/Thr kinase, and

27 Rho small GTP-binding proteins activate mammalian diaphanous

28 GTPase that is a member of the Rho family of small GTP binding proteins, acts as a key molecular swit

29 peptide derived from the NH2 terminus of the small GTP-binding protein ADP ribosylation factor 1 (ARF

30 The small GTP-binding protein ADP-ribosylation factor (ARF)

31 The involvement of the small GTP-binding protein ADP-ribosylation factor (ARF)

32 This study shows that the small GTP-binding protein ADP-ribosylation factor 6 (ARF

33 lathrin-independent pathway regulated by the small GTP-binding protein ADP-ribosylation factor 6 (Arf

34 iched membranes requires the activation of a small GTP-binding protein, ADP ribosylation factor (ARF)

35 Here, we identify a small GTP-binding protein, ADP-ribosylation factor-like

36 and is activated by protein kinase C and the small GTP-binding proteins, ADP-ribosylation factor (ARF

37 acts specifically with myristoylated ARF1, a small GTP binding protein also located in the Golgi.

38 eukaryotic organisms is under the control of small GTP-binding proteins, although the underlying mole

39 Era is a small GTP-binding protein and essential for cell growth

40 EF, thereby regulating its activity toward a small GTP-binding protein and promoting the activation o

41 nalyzed the role of several Golgi-associated small GTP-binding proteins and found that Rab43 differen

42 Rap1 is a member of the Ras superfamily of small GTP-binding proteins and has 2 isoforms, Rap1a and

43 ate how GDIs serve as negative regulators of small GTP-binding proteins and how the isoprenoid moiety

44 not involved in the interaction of Dbl with small GTP-binding proteins and is incapable of transform

45 Rap1 is a member of the Ras superfamily of small GTP-binding proteins and is localized on pancreati

46 These findings indicate that small GTP-binding proteins and PKC alpha mediate PKD1-in

47 The Ras family of small GTP-binding proteins and their downstream effector

48 n cytoskeletal dynamics include the Rho-like small GTP-binding proteins and their exchange factors.

49 TC21 is a member of the Ras superfamily of small GTP-binding proteins and, like Ras, has been impli

50 Small GTP-binding proteins are key regulators of these p

51 Several members of the rho/rac family of small GTP-binding proteins are known to regulate the dis

52 The Rho family small GTP-binding proteins are subjected to regulation b

53 The Rho small GTP-binding proteins are versatile, conserved mole

54 The small GTP binding protein ARF has been implicated in bud

55 AP-4 to the TGN in vivo is regulated by the small GTP-binding protein ARF1.

56 Several studies have implicated the small GTP-binding protein ARF6 in tumor cell invasion, a

57 The small GTP-binding protein Arf6 is known to be an importa

58 rane, we show that cellular depletion of the small GTP-binding protein ARF6 promotes the formation of

59 a guanine nucleotide exchange factor for the small GTP-binding protein Arf6 that localizes to the pos

60 ase-activating protein in hair cells for the small GTP-binding protein ARF6, known to participate in

61 The small GTP-binding proteins Arl2 and Arl3, which are clos

62 gs are consistent with the proposed roles of small GTP-binding proteins as molecular switches that re

63 Rab3A, a small GTP-binding protein attached to synaptic vesicles,

64 ication of cDNA clones which encode Ras-like small GTP-binding proteins by ligand blotting.

65 sm of activation for PI3K-C2alpha and that a small GTP-binding protein can activate a class II PI3K i

66 s indicate that members of the Rho family of small GTP-binding proteins can provoke the concomitant s

67 en demonstrated recently that binding of the small GTP binding protein Cdc42 is able to activate Ste2

68 The small GTP-binding protein Cdc42 is thought to induce fil

69 factor (EGF) promotes the activation of the small GTP-binding protein Cdc42, as well as its phosphor

70 vered proteins, SopE and SopB, stimulate the small GTP-binding proteins Cdc42 and Rac.

71 (GEFs) that facilitate the activation of the small GTP-binding proteins Cdc42, Rac, and Rho.

72 reases in Ca2+, receptor-coupled G proteins, small GTP binding proteins, ceramide metabolisms, and pr

73 Ras-related small GTP-binding proteins control a wide range of cellu

74 Certain small GTP-binding proteins control the enzymatic activit

75 ng microarray analysis reveals that RAB38, a small GTP binding protein, demonstrates a similar expres

76 s suggest that impairment of the function of small GTP-binding proteins, due to a lovastatin-induced

77 eins (alpha s, alpha q, alpha i2, alpha i3), small GTP-binding proteins, endothelial nitric oxide syn

78 Rab11a is a small GTP-binding protein enriched in the pericentriolar

79 The ras family of small GTP-binding proteins exerts powerful effects upon

80 ein named Rin, an incompletely characterized small GTP-binding protein expressed only in neurons.

81 idium botulinum C3 exoenzyme inactivates the small GTP-binding protein family Rho by ADP-ribosylating

82 forms of Rac and Cdc42Hs, members of the Rho small GTP-binding protein family.

83 tors (GEFs) that stimulate the activation of small GTP-binding proteins from the Rho family.

84 s (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases).

85 In all three steps, small GTP-binding proteins (G proteins) and their regula

86 The closely related small GTP-binding proteins H-Ras and R-Ras have opposing

87 rs of integrin activation, we identified the small GTP-binding protein, H-Ras, and its effector kinas

88 n as well as proliferation, the role of this small GTP-binding protein has not been addressed in the

89 The superfamily of small GTP-binding proteins has expanded dramatically in

90 The Rab family of small GTP-binding proteins has long been implicated in t

91 ed by cytosolic signaling pathways involving small GTP-binding proteins, heterotrimeric G proteins, i

92 idopsis genome contains 93 genes that encode small GTP-binding protein homologs.

93 odification of a variety of proteins such as small GTP binding proteins implicated in intracellular s

94 oratories has established a role for certain small GTP-binding proteins in controlling the enzymatic

95 ba myosin I, yeast myosin I, STE20, PAK, and small GTP-binding proteins in membrane- and cytoskeleton

96 1 activation, suggesting a critical role for small GTP-binding proteins in PKD1-mediated signaling.

97 ses as a subfamily of the Ras-superfamily of small GTP-binding proteins in the development of various

98 Rac, a small, GTP-binding protein in the Rho family, regulates

99 Several laboratories have demonstrated that small GTP-binding proteins including ADP-ribosylation fa

100 The levels of transcripts for two small GTP binding proteins involved in the secretory pat

101 This small GTP-binding protein is a member of the Ras superfa

102 Activation of the Ras small GTP-binding protein is necessary for normal T cell

103 The Rho family of small GTP-binding proteins is involved in the regulation

104 ft agar, indicating that activation of these small GTP-binding proteins is required for fibroblast tr

105 Prenylation of these small GTP-binding proteins is required for membrane atta

106 CDC42, a Ras-related small GTP binding protein, is involved in diverse cellul

107 ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesic

108 ings support the concept that dysfunction of small GTP-binding proteins lead to statin-induced muscle

109 The Rho subfamily of small GTP-binding proteins mediates many fundamental cel

110 RAS is a small GTP binding protein mutated in approximately 30% h

111 istics between heterotrimeric G proteins and small GTP binding proteins of the Ras superfamily is tha

112 These data demonstrate that one or more small GTP binding proteins of the Rho family has a centr

113 euronal development, is regulated in part by small GTP binding proteins of the Rho subfamily.

114 Ran is a small GTP-binding protein of the Ras superfamily regulat

115 vents guanine nucleotide exchange on RhoA, a small GTP-binding protein of the rho subfamily, which is

116 Membrane trafficking is regulated in part by small GTP-binding proteins of the ADP-ribosylation facto

117 We isolated the genes of two small GTP-binding proteins of the rab family from a huma

118 d in guanine nucleotide-exchange factors for small GTP-binding proteins of the Ras and Rho families,

119 The small GTP-binding proteins of the Rho family and its reg

120 ngers but that result from the activation of small GTP-binding proteins of the Rho family and their d

121 Small GTP-binding proteins of the Rho family are implica

122 Although small GTP-binding proteins of the Rho family have been i

123 Both phosphoinositides and small GTP-binding proteins of the Rho family have been p

124 Small GTP-binding proteins of the Rho family play a crit

125 tivation of a biochemical route dependent on small GTP-binding proteins of the Rho family.

126 ctin depolymerization, we considered whether small GTP-binding proteins of the rho subfamily might pa

127 Small GTP-binding proteins of the Rho-family, Rho, Rac,

128 These findings implicate small GTP-binding proteins of the Ypt/Rab family in a si

129 By expressing inhibitory mutant small GTP-binding proteins, p21-activated kinase (PAK) a

130 er of the GTPase-activating proteins for the small GTP-binding protein p21Rac, possesses a single cys

131 ARF6 (ADP-ribosylation factor 6) small GTP binding protein plays critical roles in actin

132 ADP-ribosylation factor (Arf) family of small GTP-binding proteins plays a central role in membr

133 The Rho family of small GTP-binding proteins plays important roles in the

134 Cdc42, a Rho-related small GTP binding protein, plays pivotal roles in actin

135 ce similarity to mammalian and plant Rab2, a small GTP-binding protein, possessing several conserved

136 Rem, Rem2, Rad, and Gem/Kir (RGK) family of small GTP-binding proteins potently inhibits high voltag

137 a calcium-dependent manner, and to Tem1p, a small GTP-binding protein previously found to be require

138 Small GTP-binding protein profiles were determined by [a

139 the Rad, Rem, Rem2, Gem/Kir (RGK) family of small GTP-binding proteins profoundly inhibit L-type Ca(

140 This structure of a GAP-like domain for small GTP-binding proteins provides a framework for anal

141 ubcellular distribution and interaction with small GTP-binding proteins provides a mechanism to regul

142 In contrast, to H-Ras, a closely related small GTP-binding protein R-Ras has the opposite activit

143 Small GTP-binding proteins (rab proteins) have recently

144 We have previously shown that the small GTP-binding proteins, Rab11a and Rab25, are associ

145 The small GTP-binding protein Rab12 plays an important role

146 The four closely related small GTP-binding proteins Rab3A, Rab3B, Rab3C, and Rab3

147 synaptic vesicles involves the function of a small GTP-binding protein, Rab3A.

148 a was concomitant with the appearance of the small GTP-binding protein Rab7 on the vacuolar membrane.

149 A dominant-negative mutant of the small GTP-binding protein Rac (Rac N17, containing an as

150 ion of cells requires activation of both the small GTP-binding protein Rac and Jun N-terminal kinase;

151 We show here that the small GTP-binding protein Rac is activated by BCR/ABL in

152 a signal transduction pathway involving the small GTP-binding protein Rac that leads to JNK activati

153 omponent of the NADPH oxidase complex is the small GTP-binding protein Rac.

154 es are regulated in vitro and in vivo by the small GTP-binding proteins Rac and Cdc42 and lipids, suc

155 o undergo translocation after stimulation by small GTP-binding proteins Rac or Rho.

156 The small GTP-binding proteins Rac, Rho, and Cdc42 were show

157 trate here that members of the Rho family of small GTP binding proteins, Rac and CDC42, act downstrea

158 such as the early growth response 1 (Egr1), small GTP binding protein Rac1 (Rac1), neurogranin (Nrgn

159 lpha, anisomycin, UV irradiation, MEKK1, and small GTP binding proteins Rac1 and Cdc42Hs.

160 ion of a constitutively active mutant of the small GTP-binding protein rac1 (V12rac1) leads to a sign

161 Inhibition of the small GTP-binding protein Rac1 ameliorated post-SCI chan

162 P-1 production during ischemia, and that the small GTP-binding protein Rac1 and reactive oxygen speci

163 or loss of TRPC5 prevented activation of the small GTP-binding protein Rac1 and stabilized synaptopod

164 Translocation of the small GTP-binding protein Rac1 to the cell plasma membra

165 The small GTP-binding protein Rac1, a member of the Rho fami

166 expressing a dominant negative allele of the small GTP-binding protein Rac1, which is required for ox

167 s alphaVbeta5 integrin and activation of the small GTP-binding protein Rac1.

168 recently observed that in certain cells, the small GTP-binding proteins Rac1 and Cdc42 but not Rho re

169 nd to occur between the EGF receptor and the small GTP-binding proteins Rac1 and Cdc42Hs.

170 minal kinase domain, and is regulated by the small GTP-binding proteins Rac1 and Cdc42Hs.

171 The small GTP-binding proteins Rac1 and Rac2 are critically

172 to selected members of the Rho subfamily of small GTP binding proteins (Rac1, but not RhoA or Cdc42)

173 served that two members of the Rho family of small GTP-binding proteins, Rac1 and Cdc42, regulate the

174 signal transduction pathway mediated by the small GTP-binding proteins RalA and RhoA but independent

175 ress conditions requires the activity of the small GTP binding protein Ran-GSP1, but not the NLS-bind

176 a guanine nucleotide exchange factor for the small GTP-binding protein Ran, seven beta-repeat domains

177 a guanine nucleotide exchange factor for the small GTP binding protein, Ran.

178 It has been widely reported that the small GTP-binding protein Rap1 has an anti-Ras and anti-

179 scribes the effect of high glucose (HG) on a small GTP-binding protein, Rap1b, expression and activat

180 In this study, we identified the small GTP-binding protein Rap2a as a common target of bo

181 We now show that the small GTP-binding protein Rap2A is the obligate effector

182 of NF-kappaB by osteopontin depended on the small GTP-binding protein Ras and the tyrosine kinase Sr

183 of Erk2 is preceded by the activation of the small GTP-binding protein Ras in fibronectin-adherent ce

184 The small GTP-binding protein Ras is pivotal in transmitting

185 l growth factor (EGF) receptor activates the small GTP-binding protein Ras, which in turn, mediates E

186 The small GTP-binding proteins Ras, Rac, and Cdc42 link prot

187 Small GTP binding proteins regulate diverse biological p

188 Small GTP-binding proteins regulate diverse processes in

189 Moreover, the Ser(863) mutant prevented small GTP-binding protein Rheb from enhancing the phosph

190 ation by insulin or by overexpression of the small GTP-binding protein RheB under nutrient starvation

191 Blockage of the small GTP binding protein Rho or actin-myosin interactio

192 Changes in the activated state of the small GTP-binding protein Rho A and its associated prote

193 eceptors activate TRPC3 channels through the small GTP-binding protein Rho and subsequent phospholipa

194 anisms that require the participation of the small GTP-binding protein Rho and the integrity of the a

195 tidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to

196 al inactivation by C. botulinum toxin of the small GTP-binding protein Rho caused a 41 +/- 12% decrea

197 We have investigated the role of the small GTP-binding protein Rho in cytokinesis by microinj

198 ) Lbc oncoprotein specifically activates the small GTP-binding protein Rho in mammalian fibroblasts t

199 t evidence that altering the activity of the small GTP-binding protein Rho induces cadherin-mediated

200 The ras-related small GTP-binding protein rho p21 is at least partially

201 botulinum C3 exoenzyme which inactivates the small GTP-binding protein rho p21, also inhibited tyrosi

202 protein target for the activated form of the small GTP-binding protein Rho, preferentially binds the

203 with C3 exotransferase, an inhibitor of the small GTP-binding protein Rho.

204 nce factor, glucosylates and inactivates the small GTP-binding proteins Rho, Rac, and Cdc42.

205 s a GTPase-activating protein domain for the small GTP-binding protein, Rho.

206 In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose pro

207 The small GTP-binding protein, Rho1/RhoA plays a central rol

208 es strong evidence that m1, Galpha12 and the small GTP-binding protein RhoA are components of a novel

209 a yeast two-hybrid screen, we identified the small GTP-binding protein RhoA as a necessary component

210 The small GTP-binding protein RhoA becomes inactivated by hy

211 tional study revealed the involvement of the small GTP-binding protein RhoA.

212 rtex, directly induces the expression of the small GTP-binding protein Rnd2 in newly generated mouse

213 plasmic reticulum and the Golgi requires the small GTP-binding proteins Sar1 and Arf1 and that its gl

214 f the related Rab proteins, but not on other small GTP binding proteins such as Ran or R-Ras2/TC21.

215 Small GTP-binding proteins such as ADP- ribosylation fac

216 ap-1A without affecting the farnesylation of small GTP-binding proteins such as Ras.

217 thway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and thei

218 iated by inhibition of isoprenylation of the small GTP-binding proteins such as Rho GTPase.

219 al neurons by inducing the expression of the small GTP-binding proteins such as Rnd2 and Rnd3.

220 nd muscle cell surface is thought to involve small GTP-binding proteins such as the Rab4 protein.

221 plexes that form in response to signals from small GTP-binding proteins, such as Cdc42, Rho, and Ras.

222 TP exchange protein for ral p24, a member of small GTP-binding protein superfamily.

223 inase and the other to the activation of the small GTP binding protein TC10.

224 osphatidylinositol 3-kinase (PI 3-K) and the small GTP-binding protein TC10, respectively.

225 rafts, where C3G specifically activates the small GTP-binding protein TC10.

226 ane dissociation rate of GFP-tagged K-ras, a small GTP binding protein that localizes to plasma membr

227 Ras is a small GTP binding protein that operates as a molecular s

228 Ran is a small GTP binding protein that was originally identified

229 factors (ARFs), members of the RAS family of small GTP binding proteins that regulate various cellula

230 Gem is a small GTP-binding protein that has a ras-like core and e

231 ADP-ribosylation factor (ARF) is a small GTP-binding protein that has been implicated in in

232 Rab11 is a small GTP-binding protein that in cultured mammalian cel

233 The synaptic vesicle protein Rab3A is a small GTP-binding protein that interacts with rabphilin

234 alian ADP-ribosylation factor 1 (mARF1) is a small GTP-binding protein that is activated by a Golgi g

235 Rac1, a small GTP-binding protein that is activated upon LPS sti

236 d with the transferrin receptor and Rab11, a small GTP-binding protein that is concentrated in the pe

237 RhoB is a small GTP-binding protein that is involved in apoptotic

238 ADP-ribosylation factor (ARF) is a small GTP-binding protein that is thought to regulate th

239 FoxO1 increased expression of Rab7, a small GTP-binding protein that mediates late autophagoso

240 Rab8 is a small GTP-binding protein that plays a role in vesicular

241 dies have shown that YPT1, which encodes the small GTP-binding protein that regulates membrane traffi

242 ADP-ribosylation factor 6 (ARF6) is a small GTP-binding protein that regulates peripheral vesi

243 Rho, a small GTP-binding protein that regulates the actin cytos

244 c42 (cell division cycle 42) is a Rho family small GTP-binding protein that works as a molecular swit

245 Rop belongs to the RHO family of Ras-related small GTP-binding proteins that are key molecular switch

246 ADP-ribosylation factors (ARFs) are small GTP-binding proteins that are regulators of vesicl

247 example of a regulator of the Rho family of small GTP-binding proteins that exhibits binding to a pr

248 Rab proteins are small GTP-binding proteins that form the largest family

249 TC10 is a member of the Rho family of small GTP-binding proteins that has previously been impl

250 Ras proteins are small GTP-binding proteins that play an essential role i

251 Rac1 is a member of the Rho family of small GTP-binding proteins that regulate reorganization

252 in for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1.

253 Gem and Rad are members of another family of small GTP binding proteins (the Rad, Gem, and Kir family

254 ering this diversity of target molecules for small GTP-binding proteins, their likely tissue specific

255 e factor that specifically activates the Rho small GTP binding protein, thus resulting in biologicall

256 nucleus makes it only the second of over 100 small GTP-binding proteins to be identified in the nucle

257 naling route communicating the Rho family of small GTP-binding proteins to the JNK pathway.

258 el MLK family of highly related kinases link small GTP-binding proteins to the JNK signaling pathway.

259 ther guanine nucleotide exchange factors for small GTP-binding proteins, together with the recent ide

260 Clostridium difficile toxin B (a Rho family small GTP-binding protein toxin) directly correlated wit

261 ross-talk between two distinct regulators of small GTP-binding proteins using structural and biochemi

262 NK), downstream effectors of Ras or Ras-like small GTP-binding proteins, we evaluated the role of the

263 features of cell shape rearrangement involve small GTP-binding proteins, we examined the contribution

264 Cdc42 is a small GTP-binding protein which has been implicated in a

265 Ras proteins are small GTP-binding proteins which are critical for cell s

266 The rho family of small GTP-binding proteins, which include rho, rac, and

267 The ARL15 gene encodes a small GTP-binding protein whose function is currently un

268 Xanthine nucleotide-selective small GTP-binding proteins with an Asp/Asn mutation are

269 Gem is a small GTP-binding protein within the Ras superfamily who

270 Once the vesicle binds to TRAPP I, the small GTP binding protein Ypt1p is activated and other t

271 In addition, overexpression of the small GTP-binding protein Ypt1p, or of a gain if functio

272 ons of Bet1p with Bos1p are regulated by the small GTP-binding protein Ypt1p.