ライフサイエンスコーパス: small T antigen

1 ive and transformation enhancing activity of small t antigen.

2 iscent of the role of simian virus 40 (SV40) small t antigen.

3 y a mechanism mediated, at least in part, by small t antigen.

4 d throughout the infection and unaffected by small t antigen.

5 quires both the SV40 large T-antigen and the small t-antigen.

6 and most tumors express the MCPyV large and small T antigens.

7 thin the common region shared by large T and small t antigens.

8 both the simian virus 40 (SV40) large-T and small-t antigens.

9 nd (iv) that this defines a new mechanism of small-t-antigen action to promote mitogenesis.

10 Sequences encoding large T antigen, small t antigen, agnoprotein, and the viral capsid prote

11 Small t antigen alters the activity of phosphatase pp2A

12 In contrast, small t antigen, an antagonist of PP2A-C, inhibited Dish

13 has a deletion that eliminates synthesis of small t antigen and a point mutation (E107K) that result

14 en coupled with expression of SV40 Large and Small T antigen and oncogenic ras.

15 n of 4E-BP1 is specifically mediated by SV40 small t antigen and requires the protein phosphatase 2A

16 cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen.

17 Small-t antigen and, to a lesser extent, large-T antigen

18 domain of human telomerase, large T antigen, small T antigen, and an oncogenic allele of H-ras to stu

19 ide some or all of the functions of the SV40 small T antigen, another well-characterized oncoprotein,

20 first 82 amino acids of large T antigen and small t antigen are identical, and genetic experiments s

21 transcriptase (hTERT) plus SV40 large T and small T antigens are transformed by either oncogenic Ras

22 somes to the TGN was established using SV-40 small t antigen as a diagnostic tool in vivo.

23 nhibited PP2A, and in HIRcB cells expressing small t antigen, beta-arrestin1 Ser-412 phosphorylation

24 Point mutations of small t antigen between residues 97-103 that reduced PP2

25 By binding YAP, small t antigen brings it together with protein phosphat

26 The two small T antigens can target different proteins for depho

27 )-terminal common domain of SV40 large T and small t antigens, can repress HER2/neu (also known as er

28 On its own, small t antigen controls cell survival and differentiati

29 ses of transgenic mice expressing T1-127 and small t antigen display acinar cell dysplasia at birth t

30 predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3

31 rkat T cells, inhibition of PP2A activity by small t antigen enhanced activation of CREB-mediated tra

32 Verhaegen et al. report MCPyV small T-antigen-expressing transgenic mice that now prov

33 association with Grb2 were also elevated in small-t-antigen-expressing cells.

34 at this dissociation was inhibited by 65% in small-t-antigen-expressing cells.

35 ase kinase (MEK) activities were elevated in small-t-antigen-expressing cells.

36 Small t antigen expression blocked both stimulus-induced

37 plasms were extremely rare in the absence of small t antigen expression.

38 in; (iii) that growth factor stimulation, or small-t-antigen expression, causes dissociation of the P

39 uppression of protein phosphatase 2A by SV40 small t-antigen has been reported to be critical for the

40 Comparisons of polyoma and SV40 small T antigens implicate Abeta in the control of diffe

41 henocopies an essential contribution of SV40 small T antigen in human cell transformation.

42 Small t antigen in trans supplied those activities.

43 ent of PP2A Abeta/Akt interaction by polyoma small T antigen increased turnover of Akt Ser-473 phosph

44 d indicate that the similar polyoma and SV40 small T-antigens influence PP2A to activate discrete cel

45 For small T antigens, interaction with PP2A is needed for ea

46 Polyomavirus small t antigen is a viral oncogene that cooperates with

47 Small t antigen is known to specifically inhibit PP2A by

48 In addition, we provide evidence that small t antigen is unlikely to be required.

49 nic mice that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A

50 In contrast, neither E1a, small t antigen, nor mutants of large T antigen defectiv

51 When melanophores express the small t antigen of SV-40 virus, a specific inhibitor of

52 The separate effects of large-T and small-t antigens on these two inhibitors may explain the

53 e 2A (PP2A) activity by either expression of small t antigen or depletion of PP2A/C by RNA interferen

54 The introduction of SV40 small t antigen or the suppression of PP2A B56gamma subu

55 hospholipase D survival signals, either SV40 small t-antigen or pharmacological suppression of protei

56 ition of PP2A with okadaic acid, fostriecin, small T antigen, or PP2A knockdown abrogated rapamycin-i

57 or differences between SVST and polyomavirus small T antigen (POLST) in their effects on differentiat

58 This inhibition requires the small T-antigen PP2A-interacting domain.

59 Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell surviv

60 Polyoma small T antigen (PyST), an early gene product of the pol

61 We show that Py small T-antigen (PyST) blocks ARF-mediated activation of

62 -antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cel

63 Interestingly, the polyoma small T-antigen (PyST), which shares with MTA both parti

64 e p53 and Rb-family of tumor suppressors and small T antigen's action on the pp2A phosphatase, are im

65 The simian virus 40 small t antigen (small-t) is required for optimal viral

66 t least three regions of the simian virus 40 small-t antigen (small-t) contribute to the protein's ab

67 Small t antigen specifically inhibited PP2A, and in HIRc

68 The tumor antigens simian virus 40 small t antigen (ST) and polyomavirus small and medium T

69 Simian virus 40 (SV40) small t antigen (ST) binding to N-terminal HEAT repeats

70 The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A)

71 We recently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hipp

72 We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin

73 ary was carried out with a bait of wild-type small T antigen (sT) fused N terminally to the DNA-bindi

74 SV40 small t antigen (ST) has been reported to be necessary a

75 Polyomavirus small t antigen (ST) impedes late features of retinoic a

76 can also be complemented for p53 override by small t antigen (st) in a manner independent of its J do

77 Simian virus 40 small t antigen (st) is required for optimal transformat

78 Coexpression of SV40 small t antigen (st), but not other tested oncogenes, ef

79 f the SV40 large T antigen (LT) and the SV40 small t antigen (ST).

80 the major transforming protein, to that from small T antigen (ST).

81 er some of the functions of the polyomavirus small T antigens (ST) are shared by the E6 and E7 oncopr

82 SV40 small t-antigen (ST) collaborates with SV40 large T-anti

83 ual SV40 oncogenes (large T antigen [LT] and small t antigen [st]) and human papillomavirus oncogenes

84 ls express putative polyomavirus oncoprotein small T antigen (sTAg) and truncated large T antigen.

85 In these studies, small t antigen stimulated cyclin D1 promoter activity 7

86 full-length T antigen, as well as wild-type small t antigen, stimulated the ATPase activity of hsc70

87 SV40 small T antigen (SVST) has received considerable attenti

88 ge T antigen (T antigen), and 174 amino acid small T antigen (t antigen), in transformation have been

89 pends on the region of T antigen shared with small-t antigen (T/t common region).

90 lpha (TGFalpha) or simian virus 40 large and small T antigen (TAg), each under the control of the pho

91 We also determined that the SV40 small t-antigen (tag) plays an important role in inducin

92 0) encodes two proteins, large T antigen and small t antigen that contribute to virus-induced tumorig

93 an inhibitor of PP2A, and is blocked by SV40 small T antigen that is known to disrupt B subunit bindi

94 s 2 transforming proteins, large T (Tag) and small t antigen, that produce neuroendocrine tumors in t

95 cooperated strongly with the simian virus 40 small t antigen to elicit aggressive anchorage-independe

96 gment (T1-127) expressed in conjunction with small t antigen under control of the rat elastase-1 (E1)

97 ormation induced by Merkel cell polyomavirus small T antigen viral oncoprotein.

98 the Ras/MAP kinase pathway, simian virus 40 small t antigen was expressed in Rat-1 fibroblasts which

99 ced levels of p21(WAF1), while expression of small-t antigen was required to decrease p27(KIP1).

100 a deletion that eliminated expression of the small t antigen were expressed in transgenic mice under

101 Rb tumor suppressors, respectively, and SV40 small t antigen were required to allow mutant K-Ras(12D)

102 CRE sites were sufficient for activation by small t antigen when linked to an heterologous promoter.

103 talized by it in the presence and absence of small t antigen, which can provide the T-common-region t

104 he transforming proteins large T-antigen and small t-antigen, which are involved in viral replication

105 The SV40 small T-antigen, which is similar to PyST in containing

106 This work shows how this association of small t antigen with YAP is important for its effects on

107 oncoproteins, by replacing SV40 large T and small T antigens with sh-p53, mutant CDK4 (CDK4(R24C)),

108 y cyclin A, cyclin E, or the simian virus 40 small-t antigen with no decrease in the levels of WAF1 p