ライフサイエンスコーパス: small animal

1 in 3D scaffolds subcutaneously implanted in small animals.

2 vers organelles, cells, tissues, organs, and small animals.

3 is widespread and is found in both large and small animals.

4 edictor for ejection fraction improvement in small animals.

5 ue types, which is not typically observed in small animals.

6 d function in complex and rapid movements of small animals.

7 r simultaneous cancer imaging and therapy in small animals.

8 e more significant in larger species than in small animals.

9 ars more drug from the tissue target than in small animals.

10 ke instrument for Raman molecular imaging in small animals.

11 a), with a highly diverse suite of large and small animals.

12 od for early detection of intimal changes in small animals.

13 ce vocalizations with lower frequencies than small animals.

14 nuously recording large amounts of data from small animals.

15 arge animals and as a constant frequency for small animals.

16 noninvasive study of biological processes in small animals.

17 Small animal (18)F-FDG PET/CT imaging on the same cohort

18 demonstrated the feasibility of quantitative small-animal (18)F-FDG PET in rats by performing it repe

19 A small-animal 4.7-T MR imager was used.

20 CLI) of in vivo radionuclide distribution in small animals, a method proven to be a high-throughput m

21 From 2009 to 2013, 60 small animals and 2250 mites were collected in the vicin

22 Such measurements are challenging in small animals because of their small blood volume.

23 thod enables insights into the physiology of small animals by tracking the 4D morphological dynamics

24 stingly, CSC therapy had a greater effect in small animals compared with large animals (P<0.001).

25 umin to the anatomic lung volume obtained by small-animal CT.

26 Recently, small animal (especially rodent) models have been an inv

27 rfusion decellularization can be achieved in small-animal experimental models (rat organs, 4-5 d) and

28 or dead time was found to be unnecessary for small-animal experiments, whereas propagation delay and

29 While Haller's rule states that small animals have relatively larger brains, minute Tric

30 in culturing HuNoVs in the laboratory and a small animal host, studies of human viruses have inheren

31 slice thickness in 1 h on a 4.7-T horizontal small animal imaging scanner equipped with an actively s

32 probes, such as GNPs, within the context of small animal imaging.

33 Noninvasive small-animal imaging has become an important research to

34 linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and Doppler

35 [(89)Zr]Zr-DFO-daratumumab PET/CT small-animal imaging was performed in severe combined im

36 expressing hTEM1 and by biodistribution and small-animal immuno-PET studies.

37 nal differences between and within large and small animals in the CSC therapy field.

38 fast micrometer scale internal movements of small animals is a key challenge for functional anatomy,

39 parabiosis, heterochronic blood exchange in small animals is less invasive and enables better-contro

40 enon show organ protective effects mostly in small animal ischemia reperfusion injury models.

41 hile it demonstrated a strong correlation in small animals, its translation to primates remains in qu

42 a protective passive vaccine antigen in this small animal model and merits further evaluation.

43 ototype arenavirus, can serve as a surrogate small animal model for arenavirus hemorrhagic fevers.

44 cture similar to that in humans, is the only small animal model for congenital CMV infection and reca

45 The guinea pig is the only small animal model for congenital CMV infection.

46 his study demonstrates the potential of this small animal model for studying BDBV and EBOV using wild

47 o demonstrate the usefulness of the rat as a small animal model for studying human VVRs.

48 The lack of a small animal model for this infection impedes the develo

49 ymphomas in chickens and serves as a natural small animal model for virus-induced tumor formation.

50 We developed a novel small animal model of co-infection in the humanized mous

51 A small animal model of coinfection would facilitate ident

52 tional profiling of LmnaH222P/H222P mouse, a small animal model of LMNA cardiomyopathy, suggested dec

53 gene targeting to develop a fully penetrant small animal model of this disease that recapitulates ma

54 A small animal model that develops progressive pulmonary m

55 The lack of a small animal model that mimics the symptoms of DENV infe

56 l, optimized NHP xenogeneic GVHD (xeno-GVHD) small animal model that recapitulates many aspects of NH

57 ease development; however, there is no valid small animal model that uses a human ehrlichial pathogen

58 tudied, likely due to the lack of a suitable small animal model.

59 tudies on this pathogen due to the lack of a small animal model.

60 ered in particular by the lack of a suitable small animal model.

61 articular importance, this is the only known small-animal model developed for Bundibugyo and the only

62 infection of susceptible mice is a tractable small-animal model for encephalitis, and the virus cause

63 to -4A chimera-infected marmosets provide a small-animal model for evaluating novel antiviral drugs

64 d have been shown to cure mouse norovirus, a small-animal model for HNoVs.

65 acle in ebolavirus research is the lack of a small-animal model for Sudan virus (SUDV), as well as ot

66 at humanized mice could be a highly relevant small-animal model for the study of dengue pathogenesis

67 and suggested that humice could be a useful small-animal model for the study of dengue pathogenesis

68 No small-animal model for this infection is currently avail

69 e: Evaluating viral protease inhibitors in a small-animal model is a critical step in the path toward

70 been lower in comparison, possibly because a small-animal model is not widely available.

71 A small-animal model of Ad14-induced lung infection was us

72 The lack of an appropriate small-animal model of dengue infection has greatly hinde

73 the disease, and the lack of an appropriate small-animal model of dengue infection has greatly incre

74 ggest that the marmoset offers an attractive small-animal model of human disease that recapitulates b

75 The development of a small-animal model of LASV infection that replicates hea

76 as recently proposed as the most appropriate small-animal model of listeriosis due to its susceptibil

77 entions for Marburg virus, in part because a small-animal model that is vulnerable to MARV/Ang infect

78 The lack of a small-animal model that mimics systemic DEN disease with

79 syndrome coronavirus (MERS-CoV) to provide a small-animal model to evaluate PLpro inhibitors of this

80 against SUDV is attributed to the lack of a small-animal model to screen promising compounds.

81 tributing to this situation is the lack of a small-animal model to screen promising drugs in an effic

82 nstrate that humanized mice can be used as a small-animal model to study the efficacy and mechanism o

83 Lack of an effective small-animal model to study the Kaposi's sarcoma-associa

84 he ferret model has emerged as the preferred small-animal model with which to study NiV disease, but

85 an efficient cell culture system and robust small-animal model, little is known about the innate hos

86 ossibility of studying HIV transmission in a small-animal model.

87 of lethal disease caused by SNV in an adult small-animal model.

88 uman NoV as it is not cultivable and lacks a small-animal model.

89 owever, in a smaller number of studies using small animal models (mice and rats), no abnormal behavio

90 ific function of BIN1 in vertebrates, robust small animal models are required.

91 Our work demonstrates that small animal models are valuable screening tools for the

92 cificities of HBV and HDV, and could lead to small animal models for studies of viral infection and r

93 Additionally, the lack of small animal models for these infections hinders the in

94 Experimental work in small animal models has revealed many details of the inf

95 Small animal models of chronic obstructive pulmonary dis

96 We propose that small animal models of genetic disorders combined with g

97 human livers offer a valuable alternative as small animal models of liver stage human malaria.

98 ptation has been used as a method to develop small animal models of pathogenesis, the molecular deter

99 The results in both large and small animal models of photoreceptor degeneration provid

100 benefit greatly from in vivo studies, using small animal models such as Caenorhabditis elegans for h

101 Although small animal models such as zebrafish are ideally suited

102 ach has been widely used in rodent and other small animal models to study neural circuitry [6-8], its

103 logical complexities in C. elegans and other small animal models used to investigate human disease an

104 man cells has facilitated the development of small animal models with inheritable HCV susceptibility.

105 Similar studies in small animal models, such as Caenorhabditis elegans (C.

106 lopment have been hampered by the absence of small animal models.

107 e magnitude of effect in large compared with small animal models.

108 flows at high spatial and time resolution in small animal models.

109 ysiology of AKI, mainly through the study of small animal models.

110 a biomarker of pancreatic beta-cell death in small animal models.

111 l molecule histone methylation modulators in small animal models.

112 peutics has been hampered by the scarcity of small animal models.

113 vo applications, e.g., for the bioimaging of small animal models.

114 has been hampered by the lack of appropriate small animal models; mice are naturally not susceptible

115 ly understood because of a lack of tractable small- animal models.

116 fficiently elicit neutralizing antibodies in small-animal models and primates.

117 oritize vaccine candidates more efficiently, small-animal models are needed.

118 The lack of small-animal models has impeded studies of antiviral imm

119 troduction of analogous Scn5a mutations into small-animal models has not recapitulated alterations in

120 Small-animal models have been developed for several Filo

121 em-cell-derived cardiomyocytes (hESC-CMs) in small-animal models have shown favourable effects of thi

122 Small-animal models of lentivirus transmission have repe

123 There is a need for small-animal models of MERS, but mice are not susceptibl

124 proved neutralizing responses induced in two small-animal models of MV immunogenicity.

125 Here we show, using established small-animal models of MV infection, that fusion-inhibit

126 have studied mice and hamsters as potential small-animal models of SFTSV infection following subcuta

127 Existing small-animal models of tuberculosis (TB) rarely develop

128 s herein the advantages and disadvantages of small-animal models that have been developed to replicat

129 ed mouse models have made them the preferred small-animal models to study HIV mucosal transmission.

130 cancer-specific imaging agents and effective small-animal models to test them.

131 disease have been difficult to achieve, and small-animal models traditionally used to investigate vi

132 In contrast to small-animal models, non-fatal ventricular arrhythmias w

133 the effects of chemical compounds in living small-animal models.

134 ntrast, and specificity were achieved in the small-animal models.

135 both binding and neutralizing antibodies in small-animal models.

136 ple in the form of a multimodal CT scan of a small animal (mouse, ex vivo).

137 sed in the BioSpec 70/20 and 94/20 series of small-animal MRI systems, the insert can easily be insta

138 Furthermore, through small-animal MRI, we analyzed edema and vascular leakage

139 Finally, cell delivery into a small animal myocardial infarction model indicated that

140 perienced in marmoset care and handling, and small-animal neurosurgery; an assistant for monitoring t

141 Small-animal nuclear imaging modalities have become esse

142 The various bore sizes of small-animal nuclear imaging systems can potentially acc

143 r eukaryotes (protists, >0.8 micrometers) to small animals of a few millimeters.

144 Data acquired with our small-animal OT system were highly repeatable and reprod

145 We used a commercial small-animal OT system.

146 due to technological limitations of tracking small animals over large areas.

147 is was significantly higher in studies using small animals (p < 0.0001) and in peritonitis models (p

148 Small animal PET and biodistribution studies were perfor

149 cose ([F]FDG) and N-labeled ammonia ([N]NH3) small animal PET imaging in a well-established murine ca

150 The small animal PET scanner was fitted to a mechanical devi

151 Both organ distribution and small animal PET studies revealed limited brain uptake o

152 Small animal PET studies with [(76)Br]5 demonstrated goo

153 Dynamic (18)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulin

154 Biodistribution and small animal PET/CT studies in the mouse DBT model of gl

155 k, each rat underwent (18)F-FDG quantitative small-animal PET 6 times.

156 ted rat heart perfusion with high-resolution small-animal PET allows for the reliable quantification

157 ith those of (18)F-FDG and (18)F-FET through small-animal PET analyses.

158 red intravenously; <3 nmol/kg); and third, a small-animal PET and beta-microprobe cold blocking study

159 ropic glutamate 5 receptor, in rats by using small-animal PET and beta-microprobes after pharmacologi

160 o greatly improve the correspondence between small-animal PET and ex vivo quantification of tumor upt

161 kilogram (n = 5 each) and underwent dynamic small-animal PET beforehand and afterward to estimate le

162 Small-animal PET data were corroborated by ex vivo gamma

163 Small-animal PET data were obtained and quantitated with

164 oradiographic findings confirmed the in vivo small-animal PET data.

165 Noninvasive small-animal PET demonstrated that (18)F-DEG-VS-NT had a

166 ment (n = 3); second, a test-retest (n = 12) small-animal PET experiment (1 h scan; 27.75 MBq of (11)

167 The small-animal PET experiments did not show any significan

168 Small-animal PET experiments were performed in athymic n

169 In vivo small-animal PET experiments were performed on tumor-bea

170 In the small-animal PET experiments, LNCaP tumors were clearly

171 here was a high positive correlation between small-animal PET findings of microglial activation with

172 unohistochemical analyses confirmed the TSPO small-animal PET findings.

173 imaging: the liver uptake value derived from small-animal PET images correlated well with the transpl

174 Rat small-animal PET images showed (11)C-metformin uptake in

175 On small-animal PET images, the tumor was clearly delineate

176 murine xenograft tumor model condition using small-animal PET imaging and combined ex vivo autoradiog

177 utoradiography and in living rats by in vivo small-animal PET imaging and ex vivo autoradiography.

178 n = 4) underwent biodistribution and dynamic small-animal PET imaging for 60 min after intravenous in

179 Finally, small-animal PET imaging of an LNCaP tumor-bearing mouse

180 The in vivo biodistribution and dynamic small-animal PET imaging studies were investigated in BA

181 Small-animal PET imaging supported by biodistribution da

182 9)Zr-AMG 110 can be clearly visualized using small-animal PET imaging up to 72 h after injection.

183 In vivo biodistribution and small-animal PET imaging were performed in mice bearing

184 amyloid-beta pathology were obtained through small-animal PET imaging with (18)F-FDG, (18)F-periphera

185 Longitudinal quantitative small-animal PET imaging with an arterial input function

186 o-3-hydroxymethylbutyl) guanine ((18)F-FHBG) small-animal PET imaging.

187 g and enhanced accumulation of (18)F-FHBG by small-animal PET imaging.

188 In this first triple-tracer small-animal PET in a well-established AD mouse model, w

189 Tumor xenografts were clearly detectable by small-animal PET in all cases.

190 Amyloid imaging by small-animal PET in models of Alzheimer disease (AD) off

191 nces in BPND measurements were observed with small-animal PET in the test and retest conditions on th

192 The small-animal PET measurements showed high tumor-to-backg

193 A small-animal PET scan of a rhesus monkey revealed modera

194 for a human brain scanner and adapted for a small-animal PET scanner in this work, eliminates intraf

195 oenvironment and to integrate the TBR with a small-animal PET scanner to facilitate imaging biomarker

196 Two small-animal PET scanners, 1 with electronic collimation

197 Small-animal PET scans of the brain region of male Wista

198 Small-animal PET scans of Wistar rats revealed moderate

199 Three small-animal PET scans with (18)F-FDG were obtained: on

200 Small-animal PET scans with arterial blood sampling were

201 Dynamic small-animal PET showed binding of (11)C-JNJ-54173717 in

202 Small-animal PET studies confirmed the intracellular loc

203 was subjected to receptor-binding assay and small-animal PET studies in a murine xenograft model.

204 The purified (18)F-FLT was suitable for small-animal PET studies in multiple nude mice xenograft

205 In vivo small-animal PET studies in Sprague-Dawley rats were per

206 ings, we completed 12 (18)F-FDG quantitative small-animal PET studies on 2 rats.

207 ings, we completed 12 (18)F-FDG quantitative small-animal PET studies on 2 rats.

208 Dynamic small-animal PET studies were performed in rats and a rh

209 Dynamic small-animal PET studies were performed in vector-inject

210 vitro binding, in vivo biodistribution, and small-animal PET studies were performed on GPC3-expressi

211 steadily before and after the 6 quantitative small-animal PET studies.

212 sively imaging the PD-L1 status of tumors by small-animal PET studies.

213 prostate cancer imaging was demonstrated by small-animal PET studies.

214 prostate cancer imaging was demonstrated by small-animal PET studies.

215 8)Ga]6 and [(68)Ga]8 and specific binding in small-animal PET studies.

216 o AD pathology, we undertook a triple-tracer small-animal PET study to assess microglial activation a

217 In vivo small-animal PET successfully confirmed specific uptake

218 s x 30 s, 20 frames x 60 s) with a dedicated small-animal PET system and postmortem tissue counting i

219 mages obtained with the SiPM-based MiniPET-3 small-animal PET system are similar in quality to those

220 ated perfused rat heart by a high-resolution small-animal PET system may offer both reliable evaluati

221 We recently completed construction of a small-animal PET system-the MiniPET-3-that uses state-of

222 bits were studied with (18)F-LMI1195 using a small-animal PET system.

223 field of view of the commercially available small-animal PET system.

224 novel assay is readily adapted to available small-animal PET systems and may be useful for understan

225 In the present study, we used small-animal PET to characterize the expression of molec

226 Therefore, we used dual-tracer small-animal PET to examine directly the link between ne

227 Small-animal PET was used to determine (18)F-FES uptake

228 Small-animal PET with (11)C-MPDX can be used to assess a

229 Performing quantitative small-animal PET with an arterial input function has bee

230 locator protein (TSPO) ((18)F-GE180; n = 58) small-animal PET, with volume-of-interest and voxelwise

231 d-type mice of various ages were examined by small-animal PET.

232 ')2 for intrahepatic tumor localization with small-animal PET.

233 itative determination of GPC3 expression via small-animal PET.

234 cell biodistribution was investigated using small-animal PET.

235 ography contrast agent, then scanned using a small-animal PET/computed tomography scanner.

236 mine for (89)Zr radiolabeling and subsequent small-animal PET/CT acquisition and ex vivo biodistribut

237 vein and noninvasively imaged by optical and small-animal PET/CT at different time points.

238 Small-animal PET/CT clearly visualized PC-3 tumors, with

239 Small-animal PET/CT images were acquired, and tracer bio

240 culated according to the MIRD formalism from small-animal PET/CT images.

241 graft tumors (BxPC-3) and investigated using small-animal PET/CT imaging 1, 2, and 4 h after injectio

242 f tumors, we performed in vitro and in vivo (small-animal PET/CT imaging and autoradiography) experim

243 cantly increased (18)F-FDG uptake at 24 h on small-animal PET/CT imaging and autoradiography.

244 Small-animal PET/CT imaging of 5F7 Nanobody labeled usin

245 and hyperpolarized (13)C-DHA MR imaging on a small-animal PET/CT scanner and a (1)H/(3)C 3-T MR scann

246 he performance of a novel mobile human brain/small-animal PET/CT system.

247 fter inoculation, all mice were scanned with small-animal PET/CT using two new uPAR PET ligands ((64)

248 The nanoScan integrated small-animal PET/MR imaging system has excellent spatial

249 uman brain imaging: a systematic study using small animal positron emission tomography (PET), autorad

250 le for molecular imaging was confirmed using small animal positron emission tomography (PET).

251 ke was measured in tumor xenografts by using small-animal positron emission tomographic/computed tomo

252 PR biodistribution and imaging in mice using small-animal positron emission tomography (PET).

253 Small animals possess intriguing morphological and behav

254 irradiated (IR) to the marked area using the Small Animal Radiation Research Platform (SARRP).

255 Here, we present a unique and dedicated small-animal Raman imaging instrument that enables rapid

256 cine MRI sequence was implemented on a 9.4T small animal scanner.

257 T scans in rhesus monkeys were obtained on a small-animal scanner to assess the pharmacokinetic and i

258 igh spatial resolution of a recent dedicated small-animal scanner to extract the input function from

259 stom firmware to enable measurements next to small-animal scanners.

260 Recent observations of feeding dynamics in small animals showed feeding patterns of bursts and paus

261 In rodents and other small animals, slow oscillations of local field potentia

262 that consisted of diverse wild ungulate and small animal species.

263 barrier to infection for other nonpermissive small-animal species, namely, ferret, guinea pig, and ha

264 tumor colonies could be visualized with both small-animal SPECT and fluorescence imaging from the fir

265 After dynamic small-animal SPECT and short CT acquisitions, time-activ

266 ith (99m)Tc-TCP-1 or control peptide using a small-animal SPECT imager: Group I (n=5) received no blo

267 Small-animal SPECT images and optical images were acquir

268 cked with CT, echocardiography, MMP-targeted small-animal SPECT imaging using (99m)Tc-RP805, and hist

269 nsplantation in a rat model with a dedicated small-animal SPECT scanner by targeting the glucagonlike

270 was manufactured and mounted in a stationary small-animal SPECT system.

271 istance protein 2 (Mrp2) was investigated by small-animal SPECT.

272 ginase was performed in C57BL/6 mice by both small-animal SPECT/CT and ex vivo biodistribution studie

273 On in vivo small-animal SPECT/CT and ex vivo planar images, the MMP

274 MG xenografts were clearly visualized using small-animal SPECT/CT at 3 h after injection.

275 MMP activation was imaged by in vivo small-animal SPECT/CT followed by ex vivo planar imaging

276 In vivo (99m)Tc-RYM1 small-animal SPECT/CT images showed higher uptake of the

277 Biodistribution and small-animal SPECT/CT imaging (18.5 +/- 2.6 MBq) with 25

278 Biodistribution and small-animal SPECT/CT imaging studies were performed to

279 uno-PET imaging with (64)Cu-cetuximab and of small-animal SPECT/CT imaging with (177)Lu-cetuximab, in

280 nfused apoE(-/-) (n = 16) mice were used for small-animal SPECT/CT imaging.

281 Small-animal SPECT/CT-based MMP-targeted imaging of the

282 There was a significant correlation between small-animal SPECT/CT-derived MMP signal and CD68 expres

283 B-DAR4-MMAE could clearly be visualized with small-animal SPECT/CT.

284 However, our recent small animal studies found large numbers of recipient st

285 Minor publication bias was observed in small animal studies.

286 rug response studies or pricks of blood from small animal studies.

287 Small-animal studies suggest that miRs might offer novel

288 ing and analyzing the locomotion behavior of small animals such as Drosophila larvae or C. elegans wo

289 Small animals such as the roundworm C. elegans are excel

290 Small-animal surgery experience is required to successfu

291 ulate guilds help to suppress populations of small animals that act as agricultural pests and disease

292 The small animal tumor model is the most versatile and effec

293 Most of these strategies were from small animal tumor models which are our primary tool for

294 Small animals typically localize sound sources by means

295 We used small-animal ultrasound imaging to monitor autochthonous

296 eeks of age were imaged by using a dedicated small-animal US system after intravenous injection of 5

297 Drugs can be released remotely inside the small animals using pre-implanted, novel vertically alig

298 assessed by premortem lung physiology with a small animal ventilator and by postmortem histologic mor

299 tment, using a nebuliser integrated within a small-animal ventilator circuit.

300 suited for cardiac imaging, particularly in small animals with rapid heart rates.