ライフサイエンスコーパス: small heat-shock protein

1 ontaining Arabidopsis (Arabidopsis thaliana) small heat shock protein.

2 ulin, and beta-catenin, were identified in a small heat shock protein.

3 nderlying the cytoprotective effects of this small heat shock protein.

4 with a regulatory role for O-GlcNAc on this small heat shock protein.

5 s an intracellular Golgi membrane-associated small heat shock protein.

6 promoter of ibpA, which encodes a universal small heat-shock protein.

7 ld-type levels of heat shock protein 101 and small heat shock proteins.

8 n genes, which encode proteins homologous to small heat shock proteins.

9 ppears to be a novel member of the family of small heat shock proteins.

10 5) encoding a cytoplasmic antigen related to small heat shock proteins.

11 amic interaction between the major mammalian small heat shock proteins.

12 tallin and HSP27 are mammalian intracellular small heat shock proteins.

13 smic protein inclusions containing GFAP, and small heat shock proteins.

14 r as cochaperones of Hsp90 or as independent small heat shock proteins.

15 controversial role of ATP in the function of small heat-shock proteins.

16 in the process of recognition and binding by small heat-shock proteins.

17 te filament protein GFAP in association with small heat-shock proteins.

18 inhibitor-1 of protein phosphatase 1 and the small heat shock protein 20, which affect the overall SE

19 nterior IX (posterior zone; PZ), whereas the small heat shock protein 25 (HSP25) is expressed in stri

20 Here we show that the small heat shock protein 27 (Hsp27) associates with casp

21 Activated PRAK in turn phosphorylated small heat shock protein 27 (HSP27) at the physiological

22 The small heat shock protein 27 (hsp27) increases in express

23 Here we describe how the expression of the small heat shock protein 27 (HSP27) is correlated with n

24 aling events revealed phosphorylation of the small heat shock protein 27 (HSP27) that was abolished b

25 The small heat shock protein 27, which interacts with Rpp20

26 erone function that proposes the coupling of small heat shock protein activation to the substrate fol

27 re we demonstrate that the expression of the small heat shock protein alpha B-crystallin is selective

28 An R120G missense mutation in the small heat shock protein alpha-B-crystallin (CryAB(R120G

29 An R120G missense mutation in the small heat shock protein alpha-B-crystallin (CryAB) caus

30 riptome revealed a striking induction of the small heat shock protein alpha-basic-crystallin (alphaB-

31 Here we report that the small heat shock protein alpha-basic-crystallin (alphaB-

32 abilized mutant of T4 lysozyme (T4L) and the small heat shock protein alpha-crystallin.

33 roach to characterize the interaction of the small heat-shock protein alpha-Crystallin with two subst

34 ause MKK6 increases levels of the protective small heat shock protein, alpha B-crystallin (alpha BC),

35 Molecular chaperones, including the small heat shock protein alphaA-crystallin, have recentl

36 Mice with deletion of genes for small heat shock proteins alphaA- and alphaB-crystallin

37 We have shown previously that the small heat shock protein alphaB-crystallin (alphaB) is e

38 The small heat shock protein alphaB-crystallin (CRYAB) has b

39 The small heat shock protein alphaB-crystallin (Cryab) regul

40 The therapeutic benefit of the small heat shock protein alphaB-crystallin (HspB5) in an

41 Genetic mutations in the human small heat shock protein alphaB-crystallin have been imp

42 We report here that the small heat shock protein alphaB-crystallin inhibits both

43 The small heat shock protein alphaB-crystallin interacts wit

44 The small heat shock protein alphaB-crystallin is an oligome

45 lococcus aureus-induced endophthalmitis, the small heat shock protein alphaB-crystallin is upregulate

46 The human small heat-shock protein alphaB-crystallin (alphaB) resc

47 e anti-stress properties established for the small heat-shock protein alphaB-crystallin, perhaps in r

48 The small heat shock protein, alphaB-crystallin, which accum

49 The small heat shock protein, alphaB-crystallin, which is ex

50 ins were identified as modified forms of the small heat shock protein, alphaB-crystallin.

51 The small heat-shock proteins also delay the onset of polygl

52 an agonist-dependent relationship between a small heat shock protein and beta-arrestin to form a pre

53 alphaA-crystallin (Cryaa/HSPB4) is a small heat shock protein and molecular chaperone that pr

54 factor to activate transcription of both the small heat shock protein and the large heat shock protei

55 Because both the small heat shock proteins and LSP1 are F-actin binding p

56 heat shock proteins include ATP-independent small heat shock proteins and the larger ATP-dependent p

57 ation of many antiapoptotic genes, including small heat shock proteins and transcription factors.

58 tibility-1 on wheat chromosome 3AS encodes a small heat-shock protein and is a major susceptibility g

59 alphaB-crystallin, a ubiquitously expressed small heat shock protein (and a crystallin) in the ocula

60 Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined component

61 tain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins ar

62 of these mice are hypertrophic, up-regulate small heat-shock proteins, and contain inclusion bodies

63 se transcription-PCR analysis shows that the small heat shock proteins are also transcriptionally ind

64 sults show that the highly conserved E. coli small heat shock proteins are dispensable and that their

65 Small heat shock proteins are known to stabilize several

66 Small heat shock proteins are ubiquitous molecular chape

67 Small heat shock proteins are ubiquitous molecular chape

68 ast to the existing paradigm that classifies small heat-shock proteins as ATP-independent chaperones.

69 in the alpha-crystallin domain of mammalian small heat-shock proteins assemble a basic building bloc

70 rms heat shock granules containing canonical small heat shock proteins at high temperatures.

71 ons in neurofilament light (NFL) subunit and small heat-shock protein B1 (HSPB1) cause autosomal-domi

72 issense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) t

73 e therapeutic activity of alphaB crystallin, small heat shock protein B5 (HspB5), was shared with oth

74 mers are commonly observed in experiments on small heat-shock proteins, but their connection to the b

75 ion of metallothioneins and alpha-crystallin/small heat shock proteins by different metals indicates

76 TP hydrolysis and substrate binding, and the small heat shock protein can suppress protein aggregatio

77 ation, both at the RNA and protein level, of small heat shock proteins, chaperones, proteases, and pr

78 CryAB and HSPB2 are small heat shock proteins constitutively expressed in th

79 determine the roles of chloroplast-localized small heat shock proteins (CP-sHSPs) in heat tolerance.

80 The majority, all of which were small heat shock proteins, decreased in heat-shocked ale

81 Like other structurally related small heat shock proteins, each alpha-crystallin molecul

82 ring with the chaperone activity of a barley small heat shock protein essential for defense and stres

83 AlphaB-crystallin (alphaBC), a small heat shock protein expressed in high levels in the

84 Here we demonstrate that two small heat shock proteins expressed in embryonic zebrafi

85 alphaA-crystallin is a small heat-shock protein expressed preferentially in the

86 alphaB-crystallin is a member of the small heat shock protein family and can act as a molecul

87 AlphaB-crystallin is a member of the small heat shock protein family and is known to have cha

88 possibility that the S1R is a member of the small heat shock protein family is discussed.

89 In contrast, neither the closely related small heat shock protein family member Hsp27 nor Hsp70 i

90 nserved arginine in the ACD of several human small heat shock protein family members causes many comm

91 nd a protein with meaningful homology to the small heat shock protein family of chaperones.

92 As a member of the small heat shock protein family possessing chaperone-lik

93 ny proteins including Hsp27, a member of the small heat shock protein family that has cytoprotective

94 hat human alphaB-crystallin, a member of the small heat shock protein family, actively participates i

95 Mutations in HSPB1 and HSPB8, members of the small heat shock protein family, have recently been show

96 Two members of the small heat shock protein family, IbpA and IbpB, are pres

97 Hsp12 (heat shock protein 12) belongs to the small heat shock protein family, partially characterized

98 alphaB-crystallin, a member of the small heat shock protein family, possesses chaperone-lik

99 e homology with the alpha-crystallin-related small heat shock protein family.

100 B-crystallin is a chaperone belonging to the small heat shock protein family.

101 It is a member of the small heat-shock protein family and possesses chaperone-

102 ession of alphaB-crystallin, a member of the small heat-shock protein family, blocks activation of RA

103 ence that alphaB-crystallin, a member of the small heat-shock protein family, suppresses thermal unfo

104 Methanococcus jannaschii, is a member of the small heat-shock protein family.

105 ary structure between distant members of the small heat-shock protein family.

106 Small heat shock proteins form large cytosolic assemblie

107 , we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in

108 on conformation and dynamics of the 16.9 kDa small heat shock protein from wheat have been studied us

109 Here we report the crystal structure of a small heat-shock protein from Methanococcus jannaschii,

110 We have characterized a novel small heat shock protein gene, viscosity 1 (vis1) from t

111 n fluorescent protein (GFP)-tagged inducible small heat-shock protein gene (hsp-16-2).

112 ne world, but now the crystal structure of a small heat shock protein has been solved and mutation of

113 We investigated whether this archetypical small heat-shock protein has the ability to interact wit

114 Small heat shock proteins have been associated with cyto

115 Small heat shock proteins have been the Cinderellas of t

116 The small heat-shock protein, heat-shock protein 25 (Hsp25),

117 agues present data supporting a role for the small heat shock protein (HSP) 27 in keratinocyte termin

118 In this study, we demonstrate that the small heat shock protein (Hsp) 27 is a key regulator of

119 In vitro, small heat shock protein (Hsp) alphaB-crystallin suppres

120 phaB-crystallin (CryAB) is the most abundant small heat shock protein (HSP) constitutively expressed

121 titutive neuronal expression of HSP-16.48, a small heat shock protein (HSP) homolog of human alpha-cr

122 A maize (Zea mays L.) small heat shock protein (HSP), HSP22, was previously sh

123 orylate the PKC delta-preferential substrate small heat shock protein (HSP-27).

124 P70 family, three alpha B-crystallin-related small heat shock proteins (HSP-16s), and a putative orth

125 In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with inc

126 me (T4L) bound to engineered variants of the small heat shock protein Hsp16.5.

127 stingly, both CSEPs interact with the barley small heat shock proteins, Hsp16.9 and Hsp17.5, in a yea

128 The small heat shock protein Hsp20 protects cardiomyocytes a

129 the cofactors DnaJ1, DnaJ2, and GrpE and the small heat shock protein Hsp20.

130 The small heat shock proteins HSP20, HSP25, alphaB-crystalli

131 ransiently increased expression of a cardiac small heat-shock protein Hsp20.

132 Babesia bovis small heat shock protein (Hsp20) is recognized by CD4+ T

133 eron with two downstream genes that encode a small heat shock protein, Hsp20, and cdc48, an AAA+ ATPa

134 r, little is known about the role of another small heat-shock protein, Hsp20, which regulates activit

135 eases in expression and phosphorylation of a small heat-shock protein, Hsp20.

136 to resolve the structures of two forms of a small heat shock protein (Hsp26) that vary slightly in d

137 The small heat shock proteins, Hsp26 and Hsp42, also functio

138 The small heat shock protein HSP27 (or HSPB1) has multiple c

139 ation in all adult axotomized neurons of the small heat shock protein Hsp27 and the failure of such i

140 The small heat shock protein Hsp27 has been shown to confer

141 The small heat shock protein Hsp27 is expressed at high leve

142 iously identified high concentrations of the small heat shock protein hsp27 within podocytes as well

143 Mutations in the small heat shock protein Hsp27, encoded by the HSPB1 gen

144 ha B-crystallin, but not the closely related small heat shock protein Hsp27, renders C2C12 myoblasts

145 te the phosphorylation and expression of the small heat shock protein HSP27.

146 ones also showed increased expression of the small heat shock protein HSP27; and reporter assays reve

147 However, it is unclear whether the small heat shock proteins hsp27 and alphaB-crystallin pr

148 aternary structure and dynamics of the human small heat-shock protein Hsp27 are linked to its molecul

149 larly enhances chaperone function of another small heat shock protein, Hsp27.

150 TR), F508del, is initiated by binding of the small heat shock protein, Hsp27.

151 n the macromolecular associations of another small heat shock protein, HSP27.

152 ewly synthesized Btn2 can associate with the small heat shock protein Hsp42 to promote the sorting of

153 Here we show that the small heat shock protein HspB1 (hsp25/27) is phosphoryla

154 Our data suggest that down-regulation of small heat shock protein HSPB1 and disintegration of neu

155 In SCA17 transgenic mice, the small heat shock protein HSPB1, a potent neuroprotective

156 Mutations in the small heat-shock protein HSPB1 (HSP27) are responsible f

157 Small heat shock protein HSPB7 is highly expressed in th

158 Here, we investigated the small heat shock protein Hspb8, which, because of its pl

159 AG3(Ile81) displayed improved binding to the small heat shock protein (HspB8) in ischemic skeletal mu

160 erminal region with high similarity to plant small heat shock proteins (HSPs).

161 ucted an Escherichia coli strain lacking the small heat shock proteins IbpA and IbpB and compared its

162 f the stress-response regulon, including the small heat shock proteins IbpA and IbpB that protect E c

163 r genetics evidence for a critical role of a small heat shock protein in cell traction and motility.

164 unsuspected and critical role for a specific small heat shock protein in directly modulating actin th

165 phaB-crystallin (CryAB) is the most abundant small heat shock protein in the heart.

166 abundance of transcripts of a catalase and a small heat-shock protein in the silenced flowers.

167 binding capacity has been observed in other small heat shock proteins including lens alpha-crystalli

168 were identified: (i) fragmentation caused by small heat shock proteins, including alpha B-crystallin,

169 The specificity of the immunoreactivity to small heat shock proteins, including alpha-crystallins a

170 ular weight in patients with glaucoma was to small heat shock proteins, including alpha-crystallins a

171 Since homologs of the small heat shock protein inhibit F-actin polymerization

172 ith Hsp16.9 and Hsp17.5, confirming the CSEP-small heat shock protein interaction.

173 Crystallin-alphaB (CryAB) is a small heat shock protein involved in preventing protein

174 ased formation of aggregates associated with small heat-shock proteins is observed.

175 Upregulation of alphaB-crystallin (CryAB), a small heat shock protein, is associated with a variety o

176 c reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 nu

177 ported that alpha-crystallin, along with the small heat-shock proteins, is able to promote the functi

178 aB-crystallin is a developmentally regulated small heat shock protein known for its binding to a vari

179 tive substances, heat shock protein 101, and small heat shock protein levels were determined.

180 rs of circulating antibodies against retinal small heat shock proteins may have pathogenic significan

181 n chaperone activity and complex assembly of small heat shock proteins need to be characterized to un

182 The small heat shock protein of Neurospora crassa, Hsp30, wh

183 Owing to the dynamic nature of small heat shock protein oligomers, elucidating the stru

184 Here, we investigate the effect of small heat shock proteins on the keratin 8/18 intermedia

185 The small heat shock protein p27 has been shown to be a subs

186 hat Pax-6 can activate the alphaB-crystallin/small heat shock protein promoter via the lens-specific

187 One model for chaperone activity of small heat shock proteins proposes that ATP causes small

188 data are consistent with the hypothesis that small heat shock proteins recognize ENaC subunits at ER

189 a B or proteins closely associated with this small heat shock protein remain soluble.

190 Hsp27, a member of the family of the small heat-shock proteins, showed a similar interaction

191 The small heat shock protein (sHSP) alphaB-crystallin (alpha

192 How does the sequence of a single small heat shock protein (sHSP) assemble into oligomers

193 AlphaB-Crystallin is a small heat shock protein (sHsp) expressed at high levels

194 Eye lens alpha-crystallin is a member of the small heat shock protein (sHSP) family and forms large m

195 lphaA-Crystallin (alphaA) is a member of the small heat shock protein (sHSP) family and has the abili

196 HspB5 is a well-characterized member of the small heat shock protein (sHsp) family that reduces muta

197 alphaA-Crystallin, a member of the small heat shock protein (sHsp) family, is a large multi

198 The small heat shock protein (sHSP) from the hyperthermophil

199 To investigate the mechanism of small heat shock protein (sHsp) function, unbiased by cu

200 Two mutations (K141E, K141N) in the small heat shock protein (sHSP) HSP22 (HSPB8) are associ

201 ulus alba) through overexpression of a major small heat shock protein (sHSP) with convenient features

202 Expression of HSP42, the gene for a small heat shock protein (sHSP), from a high-copy-number

203 er was identified by peptide sequencing as a small heat shock protein (sHSP).

204 have compared the tissue specificity of the small heat shock protein (shsp)/alphaB-crystallin promot

205 Mammalian small heat shock proteins (sHSP) are abundant in muscles

206 Mammalian small heat shock proteins (sHSP) form polydisperse and d

207 Small heat shock proteins (sHSP) make up a remarkably di

208 Small heat shock proteins (sHSP), HSP27 and alpha-B-crys

209 to the core "alpha-crystallin" domain of the small heat-shock protein (sHsp) and molecular chaperone,

210 her develop the mechanistic understanding of small heat-shock protein (sHSP) chaperone activity, we i

211 Clustered class-I small heat-shock protein (sHSP) chaperone genes, SlHSP17

212 alpha-Crystallin is a member of the small heat-shock protein (sHSP) family and consists of t

213 The small heat-shock protein (sHSP) from Methanococcus janna

214 sage corresponding to HSP26, which encodes a small heat-shock protein (sHsp) in yeast was up-regulate

215 AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chapero

216 We report that two members of the family of small heat-shock proteins (sHsp) (alpha-crystallin and S

217 lpha-crystallin is a member of the family of small heat-shock proteins (sHSP) and is composed of two

218 cing as the alpha-crystallin-related, 16-kDa small heat shock protein, sHsp16.

219 uppressors restored solubility of aggregated small heat shock proteins (sHsps) after heat stress, rev

220 The small heat shock proteins (sHSPs) and alpha-crystallins

221 e chaperone activity and subunit dynamics of small heat shock proteins (sHSPs) and establishes a work

222 Small heat shock proteins (sHSPs) and the related alpha-

223 Small heat shock proteins (sHsps) are a diverse group of

224 Small heat shock proteins (sHsps) are a family of ATP-in

225 Small heat shock proteins (sHsps) are a family of large

226 Small heat shock proteins (sHSPs) are a ubiquitous class

227 The small heat shock proteins (sHSPs) are a ubiquitous class

228 Small heat shock proteins (sHsps) are a ubiquitous famil

229 Small heat shock proteins (sHSPs) are chaperones that ar

230 Small heat shock proteins (sHSPs) are dynamic oligomeric

231 Small heat shock proteins (sHSPs) are essential 'holdase

232 Small heat shock proteins (sHsps) are molecular chaperon

233 Small heat shock proteins (sHsps) are molecular chaperon

234 Small heat shock proteins (sHsps) are oligomers that per

235 In myocytes, small heat shock proteins (sHSPs) are preferentially tra

236 Small heat shock proteins (sHSPs) are ubiquitous chapero

237 Small heat shock proteins (sHsps) are ubiquitous low-mol

238 Small heat shock proteins (sHsps) are virtually ubiquito

239 Small heat shock proteins (sHSPs) are virtually ubiquito

240 The ubiquitous small heat shock proteins (sHSPs) are well documented to

241 Small heat shock proteins (sHSPs) belong to a family of

242 Small heat shock proteins (sHsps) bind destabilized prot

243 rn more about the function and regulation of small heat shock proteins (sHSPs) during seed developmen

244 Small heat shock proteins (sHSPs) exist as large polydis

245 Small Heat Shock Proteins (sHSPs) have important roles i

246 tailed understanding of the evolution of the small heat shock proteins (sHSPs) in plants, we have exa

247 How small heat shock proteins (sHsps) might empower proteost

248 Small heat shock proteins (sHSPs) play a central role in

249 nder conditions promoting protein unfolding, small heat shock proteins (sHsps) prevent the irreversib

250 The small heat shock proteins (sHSPs) recently have been rep

251 Small heat shock proteins (sHsps) regulate cellular func

252 Small heat shock proteins (sHSPs) serve as a first line

253 Oligomerization is an essential property of small heat shock proteins (sHSPs) that appears to regula

254 The ability of small heat shock proteins (sHSPs) to prevent thermal agg

255 nant protein in the lens, is a member of the small heat shock proteins (sHSPs) which are a ubiquitous

256 Small heat shock proteins (sHSPs), as ubiquitous molecul

257 Molecular chaperones, such as the small heat shock proteins (sHsps), maintain normal cellu

258 /Zn-superoxide dismutase), and mitochondrial small heat shock proteins (sHsps).

259 HSP 16.3 displays several characteristics of small heat shock proteins (sHsps): its expression is inc

260 ne families Hsp70, Hsp104, Hsp90, Hsp60, and small heat-shock proteins (sHsps) apparently act as unfo

261 Small heat-shock proteins (sHSPs) are a conserved group

262 Small heat-shock proteins (sHSPs) are a ubiquitous famil

263 Small heat-shock proteins (sHSPs) are a widely conserved

264 Mammalian small heat-shock proteins (sHSPs) are molecular chaperon

265 The small heat-shock proteins (sHSPs) form a diverse family

266 Small heat-shock proteins (sHsps) prevent aggregation of

267 In vivo, molecular chaperones, such as the small heat-shock proteins (sHsps), normally act to preve

268 classes: HSP100, HSP90, HSP70, HSP60 and the small heat-shock proteins (sHSPs).

269 s conserved among lens alpha-crystallins and small heat-shock proteins (sHSPs).

270 ing rat lens alphaA is a membrane-associated small heat shock protein similar to alphaB but with rema

271 Higher plants synthesize small heat-shock proteins (smHSPs) from five related gen

272 ress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role fo

273 er size, symmetry, and polydispersity in the small heat shock protein super family.

274 As a member of the small heat shock protein superfamily, alpha-crystallin h

275 hsp20 appears to encode a new member of the small heat shock protein superfamily, DR1314 is predicte

276 on substrate recognition and binding by the small heat shock protein superfamily.

277 eterminants of structure and function in the small heat-shock protein superfamily, was determined in

278 ndicated that HSP22 is a member of the plant small heat-shock protein superfamily.

279 Small heat shock proteins, superoxide dismutase, quinone

280 ons of passive molecular chaperones, such as small heat-shock proteins, suppress thermodynamic instab

281 e to the study of the 200-kDa complex of the small heat shock protein TaHSP16.9, revealing both its d

282 coma had a higher titer of autoantibodies to small heat shock proteins than did age-matched patients

283 AlphaA-crystallin is a small heat shock protein that functions as a molecular c

284 our knowledge, the first evidence of a plant small heat shock protein that has both developmental and

285 AlphaB-crystallin (alphaBC) is a small heat shock protein that is constitutively expresse

286 eased the expression of alphaB-crystallin, a small heat shock protein that is enriched in astrocytes

287 alpha-Crystallins are small heat shock proteins that regulate cellular damage

288 Human alphaB-crystallin is a small heat-shock protein that functions as a molecular c

289 e molecular chaperone alphaB-crystallin is a small heat-shock protein that is upregulated in response

290 in domain conserved in nearly all identified small heat-shock proteins that act as molecular chaperon

291 heat shock proteins proposes that ATP causes small heat shock proteins to release substrates, which a

292 d these as the monomer and dimer of hsp27, a small heat shock protein up-regulated by stress and cell

293 ha-crystallin domain, typically conserved in small heat shock proteins, was found in Mx Hsp16.6.

294 in human alphaB crystallin, the archetype of small heat-shock proteins, was identified and characteri

295 It was observed that when antibodies against small heat shock proteins were applied directly to retin

296 The direct effects of antibodies specific to small heat shock proteins were then studied in isolated

297 of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevi

298 Crystallins are small heat shock proteins with chaperone function that p

299 tigate if TM expresses alpha B-crystallin, a small heat-shock protein with chaperone activity, and wh

300 pletion of cytokinesis, suggesting that this small heat shock protein, with its chaperone-like activi