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1 ations of the EC barrier was confirmed using small interfering RNA.
2 onists and inhibitors and confirmed by using small interfering RNA.
3 by 1.6-fold, effects recapitulated by Card10 small interfering RNA.
4 mice and targeted MID1 in the esophagus with small interfering RNA.
5 ial cells in which ORMDL3 was inhibited with small interfering RNA.
6 he trans-acting function of phased secondary small interfering RNAs.
7 ated 3T3-L1 cells knocked down using Ppp2r2a small interfering RNAs.
8 -Pro mRNA and the appearance of 35S promoter small interfering RNAs.
9 transcriptional silencing, and targeting by small interfering RNAs.
10 Transcript levels were decreased by small interfering RNAs.
11 (IkBa) was knocked down in Caco-2 cells with small interfering RNAs.
13 ntegrin subunit using blocking antibodies or small interfering RNA abrogated the protection induced b
14 enhanced the expression of ARHGEF1, while a small interfering RNA against ARHGEF1 and a RhoGEF inhib
15 s vector carrying MMP2 sequence and specific small interfering RNA against calpain-1/2 were introduce
17 e incorporation to glycogen was unaltered by small interfering RNA against DAPK3, palmitate oxidation
20 forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young
21 ts and 5-HT release were inhibited by Piezo2 small interfering RNA and antagonists (Gd(3+) and D-GsMT
23 lastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover ep
24 s of transposable element accumulation, more small interfering RNAs and DNA methylation around genes,
25 perturbation approaches (kinase inhibitors, small interfering RNAs) and a novel system for rapalog-d
26 peat (CRISPR)-Cas9 technology, gene-specific small interfering RNAs, and a newly developed luciferase
27 ibited by transfection of primary ASMCs with small interfering RNAs, and the effect on ASMC phenotype
28 o3 activity inhibitor), Fbxl2 mRNA-targeting small-interfering RNA, and omega-conotoxin GVIA (a CaV2.
29 ogenous IKKepsilon was downregulated using a small interfering RNA approach, SPL's anti-influenza vir
34 nsequences of GNPAT deficiency, we performed small interfering RNA-based knockdown of GNPAT in the hu
35 by small-molecule inhibitors, antibodies, or small interfering RNA, blocked the GDF-15 effect on leuk
36 eived ZMapp monoclonal antibodies, TKM-Ebola small interfering RNA, brincidofovir, and/or convalescen
37 In this study, we developed allele-specific small interfering RNAs capable of selectively suppressin
38 PP1-alpha but not PP1-beta or PP1-gamma1 by small interfering RNA caused greater AS160 Ser(588) and
40 es through nanoparticle-mediated delivery of small interfering RNA caused severe liver damage and inh
41 in lungs by intratracheal administration of small interfering RNA could reduce lung ischemia-reperfu
42 ne, knockdown of the corresponding gene with small interfering RNA decreased cell viability when co-i
43 cell angiogenesis, and knockdown of VEGF by small-interfering RNA decreased endothelial cell prolife
46 tion of inclisiran, a chemically synthesized small interfering RNA designed to target PCSK9 messenger
48 mportantly, silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of
49 y gene deletion or downregulation of ODZ1 by small interfering RNAs drastically reduces the invasive
52 including microRNAs (miRNAs) and endogenous small-interfering RNAs (endo-siRNAs), are key gene regul
54 CLIP170 in C57BL/6 mice by CLIP170-specific small interfering RNA enhanced LPS-induced IL-6 and TNF-
55 ation of desmoglein-1 and filaggrin, whereas small interfering RNA for KLK6, KLK13, and KLK14 partial
57 (2) reduced accumulation of phased secondary small interfering RNAs from two genomic loci; (3) altere
58 C12 cells, the introduction of siRNA(GAPDH) [small interfering RNA(glyceraldehyde 3-phosphate dehydro
59 Levels of RNASET2 were knocked down with small interfering RNA in CD4(+) T cells and the effect o
60 PR2) is observed in PAH, we reduced BMPR2 by small interfering RNA in control PAECs and documented an
61 However, downregulation of MDM2 or MDM4 by small interfering RNA in either resistant cell line indu
62 , and SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells enhanced neut
64 knockout of PKC-delta or knockdown of p62 by small interfering RNA in MCF-7 cells abrogates Vps34-dep
72 ain 3 mimetic, A-1331852, or Bcl-xL-specific small interfering RNA induced apoptosis in PDGF-activate
73 ls and human bronchial epithelial cells with small interfering RNA-induced downregulation of MD2 were
74 ed in human pulmonary endothelial cells with small interfering RNA-induced knockdown of LXA4 formyl p
76 (dofetilide) in rats had similar effect, and small interfering RNA inhibition of hERG in beta and L c
79 Intraluminal delivery of thrombospondin-2 small interfering RNA inhibits the vascular response to
80 uantitative real-time PCR, Western blotting, small interfering RNA interference, and kinase inhibitor
82 In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread
85 aired autophagy (pharmacological inhibition, small interfering RNA knockdown of autophagic proteins,
88 tion were decreased in both human TBCs after small interfering RNA knockdown of CALHM1 channel and in
91 oglial phagocytosis of PC12 was prevented by small interfering RNA knockdown of Gal-3 in microglia, l
93 ncer LNCaP, C4-2B and PC-3 cell lines, while small interfering RNA knockdown of MMP7 inhibited IL-17-
94 Inhibition of RIP1 with necrostatin-1 or small interfering RNA knockdown of RIP3 reduced palmitic
96 lation of SOCS-1 function, whereas selective small interfering RNA knockdown of Socs-1 resulted in in
97 ced expression of TGF-beta in splenocytes by small interfering RNA knockdown of STAT6 suggest that Na
98 clining cell numbers and cell cycles, and by small interfering RNA knockdown of the respective rate-l
100 subunit, MCU, in PASMCs was achieved through small interfering RNA knockdown or MCU plasmid-mediated
102 h diethyl maleate, with and without anti-xCT small interfering RNA knockdown, in vitro uptake studies
103 apitulated by statin-mediated inhibition, or small interfering RNA knockdown, of enzymes regulating c
105 Finally, inhibition of MMP10 expression by small interfering RNA led to a decrease in the gastric c
107 uptake, whereas gene knockdown with anti-xCT small interfering RNA led to decreased tracer uptake.
108 uptake, whereas gene knockdown with anti-xCT small interfering RNA led to decreased tracer uptake.
110 performed a genome-wide screen of E3 ligase small interfering RNA library based on western blot and
113 In addition, pharmacologic inhibition and small interfering RNA-mediated downregulation of Hsp70-1
114 sted by using chromatin immunoprecipitation, small interfering RNA-mediated downregulation, and pharm
124 nked kinase or protein kinase C mu either by small interfering RNA-mediated knockdown or pharmacologi
128 ZIP7 phosphorylation and were suppressed by small interfering RNA-mediated silencing of CK2alpha.
130 ling, whereas UnAG effects were prevented by small interfering RNA-mediated silencing of the autophag
131 ure genes, at mRNA and protein levels, after small interfering RNA-mediated silencing of YAP in Sk-He
134 c agents, antisense and oligonucleotides and small interfering RNAs, offer a promising platform for t
136 h were attenuated by administration of STAT1 small interfering RNA or fludarabine, a selective STAT1
137 ic phospholipase A2alpha by its inhibitor or small interfering RNA or inhibiting cyclooxygenase 2, re
139 that inhibition of Sirt1 deacetylase through small interfering RNA or selective inhibitor Ex527 great
142 ediated deletion or silencing of MANTIS with small interfering RNAs or GapmeRs inhibited angiogenic s
143 guanine nucleotide exchange factor, ARNO, by small, interfering RNA or pharmacological inhibitors led
144 cal inhibition, knockdown of expression with small interfering RNA, or expression of the dominant-neg
147 pon treatment with BRD4 inhibitors and c-MYC small interfering RNA (P < 0.01-0.001 for responding cel
150 ylene glycol that was formulated with Raptor-small interfering RNA plus spironolactone in vivo, which
152 EV71 release, whereas depletion of PinX1 by small interfering RNA promoted apoptosis induced by etop
153 tocyte-specific nanoparticle-delivered AEG-1 small interfering RNA provided marked protection from HF
158 ortantly, suppression of PP5 expression with small interfering RNA restored proper phosphorylation an
159 y, down-regulation of endogenous Rab43 using small interfering RNA resulted in an increase in the acc
160 lso, a knock down of Cdk5 in jck cells using small interfering RNA results in significant shortening
166 By combining mass spectrometry analysis with small interfering RNA screening, we identify the polarit
167 nterrogated by genetic manipulations through small interfering RNA/short hairpin RNA knockdown and ec
168 sphonates, squalene synthase inhibitors, and small interfering RNA showed that inhibition of farnesyl
170 s knockdown of endogenous GBP1 expression by small interfering RNAs significantly promoted CSFV growt
171 siRNA-1, a bacteria-induced plant endogenous small interfering RNA, silences the AtRAP gene, which en
172 for these KLKs in keratinocytes by targeted small interfering RNA silencing before S. aureus exposur
173 ficacy of noninvasive intranasal delivery of small interfering RNA (siRNA) against the Beclin1 gene u
175 silencing activity of Lipoplex, a complex of small interfering RNA (siRNA) and cationic liposomes.
176 essential for HIV replication in genome-wide small interfering RNA (siRNA) and clustered regularly in
179 e F1 hybrids showed that the majority of the small interfering RNA (siRNA) clusters had a higher expr
180 or metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progest
183 uman SLX4 (huSLX4) and could be abolished by small interfering RNA (siRNA) depletion of any member of
184 r challenges for the clinical translation of small interfering RNA (siRNA) include overcoming the poo
185 Clinical translation of therapies based on small interfering RNA (siRNA) is hampered by siRNA's com
187 3 (GSK3) performed using a Wnt inhibitor and small interfering RNA (siRNA) knockdown of critical comp
188 logically relevant for VLP budding since (i) small interfering RNA (siRNA) knockdown of endogenous WW
189 tivation properties was further indicated by small interfering RNA (siRNA) knockdown of SHP-1 in syng
190 ls depleted of these autophagic effectors by small interfering RNA (siRNA) knockdown or clustered reg
193 Accordingly, PI4KB or ACBD3 depletion by small interfering RNA (siRNA) leads to a reduction in PI
194 ropism in human cancer cells, we performed a small interfering RNA (siRNA) library screen targeting t
196 y pathway in HL-1 cardiomyocytes with either small interfering RNA (siRNA) or Mdivi-1 caused marked r
202 formed a series of parallel, high-throughput small interfering RNA (siRNA) screens and compared genet
206 which herpes simplex virus (HSV) carrying a small interfering RNA (siRNA) targeting platelet-derived
207 Inhibiting anticoagulation in mice by using small interfering RNA (siRNA) targeting Serpinc1 and Pro
211 ooth muscle cells using inhibitor screening, small interfering RNA (siRNA), immunoprecipitation (IP),
212 WNV-infected mosquitoes indicated an active small interfering RNA (siRNA)-based antiviral response f
216 n between fission yeast PAF1 repressing AGO1/small interfering RNA (siRNA)-directed silencing [13, 14
217 at HDAC5 decreased LSD1 protein acetylation, small interfering RNA (siRNA)-mediated HDAC5 knockdown d
218 through an antibody-neutralizing approach or small interfering RNA (siRNA)-mediated inhibition prolon
221 ed Rab14 or dominant negative Rab14, or with small interfering RNA (siRNA)-mediated knockdown of Rab1
222 junction with pharmacologic PLK1 inhibitors, small interfering RNA (siRNA)-mediated knockdown, and ov
224 en ER-mitochondria contacts impairs, whereas small interfering RNA (siRNA)-mediated loss of VAPB or P
226 RNaseIII enzyme resembling the budding yeast small interfering RNA (siRNA)-producing Dcr1 enzyme.
232 2B knockdown with RNA interference for MUC4 (small interfering RNA [siRNA]-MUC4) was used to analyze
233 lexes in the nucleus, and using inhibitor or small interfering RNAs (siRNAs) against caveolin-1 or Ti
234 h as nonsteroidal anti-inflammatory drugs or small interfering RNAs (siRNAs) against COX-1 and COX-2,
236 ifferentially methylated loci and some 21-22 small interfering RNAs (siRNAs) and long noncoding RNAs
237 f transgenes involves abundant 21-nucleotide small interfering RNAs (siRNAs) and low-abundance 22-nuc
238 suppressors of the cer7 mutant revealed that small interfering RNAs (siRNAs) are direct effectors of
241 r by transfection of HEK-EqCXCL16 cells with small interfering RNAs (siRNAs) directed against EqCXCL1
243 ted by 21- to 22-nucleotide or 24-nucleotide small interfering RNAs (siRNAs) generated from previousl
244 terials for cellular transfection of DNA and small interfering RNAs (siRNAs) has recently been report
248 d interplay between Global Genome Repair and small interfering RNAs (siRNAs) in the recognition of DN
249 Incorporation of chemical modifications into small interfering RNAs (siRNAs) increases their metaboli
251 A methylation directed by 24-nucleotide (nt) small interfering RNAs (siRNAs) plays critical roles in
252 leles, which inhibit seed color by producing small interfering RNAs (siRNAs) targeting chalcone synth
253 of total coding space can precisely generate small interfering RNAs (siRNAs) that are active in the R
254 ss RNAi as their hosts produce virus-derived small interfering RNAs (siRNAs) that direct specific ant
256 Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), play a variety of impor
258 iochemical analysis, and the use of specific small interfering RNAs (siRNAs), we demonstrated (i) tha
263 cyclosporine A or knockdown of NFATc4 using small interfering RNA suppressed ET-1-induced TRPC6 up-r
265 miRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs) for efficient and
266 the biogenesis of TAS3-derived trans-acting small interfering RNA (ta-siRNA), which represses ARF3 e
267 ng them, microRNAs (miRNAs) and trans-acting small interfering RNAs (ta-siRNAs) mainly inhibit gene e
269 articles (LNP) loaded with a Dicer substrate small interfering RNA targeting catenin beta 1 (CTNNB1;
272 r ischemia-reperfusion in lungs treated with small interfering RNA targeting Fas compared with lungs
273 48 hours after treatment with intratracheal small interfering RNA targeting Fas, control small inter
274 lmonary cell apoptosis of lungs treated with small interfering RNA targeting Fas, which did not affec
275 ajor histocompatibility complex molecules by small interfering RNA targeting of class II transactivat
277 hanced pLTF via intrathecal (C4) delivery of small interfering RNAs targeting BDNF or TrkB mRNA, and
278 on of HCV, were transfected these cells with small interfering RNAs targeting inhibitory SMADs to ana
280 blotting, receptor binding, gene expression, small interfering RNA technology, reporter activity, and
281 ent because reduction of GPR32 expression by small interfering RNA, TGF-beta, and IL-6 treatment abla
282 t are used by the S-PTGS pathway to build up small interfering RNAs that guide transgene RNA cleavage
283 which RHBDL2 cleaves CLEC14A, and targeted, small interfering RNAs that knockdown endogenous CLEC14A
284 sts and/or transfected with short hairpin or small interfering RNAs that reduced expression of TRESK.
285 l of murine neutrophil progenitor cells, and small interfering RNA to NR4A2 decreases neutrophil prod
286 s targeting tissue factor pathway inhibitor, small interfering RNA to reduce antithrombin expression
287 up to 90% of lipid nanoparticles loaded with small interfering RNA to the procollagen alpha1(I) gene
289 als testing messenger RNAs to combat cancer, small interfering RNAs to treat renal and hepatic disord
291 erative modification of endothelial cells by small interfering RNA transfection could shape the natur
292 egeneration, whereas ES treatment after FIG4-small interfering RNA transfection enhanced neural diffe
293 Moreover, inhibition of Wnt5a signaling by small interfering RNA transfection in vitro or by use of
294 more susceptible to bacterial infection, and small interfering RNA treated-macrophages showed reducti
295 sms and recombination, and the virus-derived small interfering RNA (vsiRNA) sequences indicate distin
296 R-LIKE 4 (DCL4)-mediated biogenesis of viral small interfering RNAs (vsiRNAs) of 21 nucleotides (nt)
297 can trigger the biogenesis of virus-derived small interfering RNAs (vsiRNAs), we show that features
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