ライフサイエンスコーパス: small ubiquitin-like modifier

1 g in aggregate clearance in the absence of a small ubiquitin-like modifier.

2 The novel targets were identified as the small ubiquitin-like modifier 1 (SUMO-1) activating enzy

3 The BRD, PHD, and ZZ domains interact with small ubiquitin-like modifier 1 (SUMO-1) and Ubc9, and f

4 HIV-1 p6 was found to interact with small ubiquitin-like modifier 1 (SUMO-1) as well as the

5 Small ubiquitin-like modifier 1 (SUMO-1) modification of

6 how that nonvisual arrestins are modified by small ubiquitin-like modifier 1 (SUMO-1) upon activation

7 quitin, it conjugates a ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), also known as

8 nal modification by the ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), has been estab

9 ed that Ubc9, an E2-like enzyme specific for small ubiquitin-like modifier 1 (Sumo-1), is required fo

10 We report small ubiquitin-like modifier 1 (SUMO1) as a major new p

11 -Maf can be modified at lysine 33 by SUMO-1 (small ubiquitin-like modifier 1).

12 ns are posttranslationally modified by SUMO (small ubiquitin-like modifier)-1 and SUMO-3.

13 Here we describe the involvement of the small ubiquitin-like modifier-1 (SUMO-1) conjugation pat

14 or attachment of the ubiquitin-like protein, small ubiquitin-like modifier-1 (SUMO-1), and the conser

15 we demonstrated that GATA4 is sumoylated by small ubiquitin-like modifier-1 (SUMO-1), which resulted

16 inadvertently found that SnoN is modified by small ubiquitin-like modifier-1 (SUMO-1).

17 Here we show that CDK6 is modified by small ubiquitin-like modifier-1 (SUMO1) in glioblastoma,

18 We demonstrate that CBS is modified by the small ubiquitin-like modifier-1 protein (SUMO-I) under b

19 ents with COS-7 cells using PIAS and SUMO-1 (small ubiquitin-like modifier-1) expression vectors.

20 t of the ability of Ubc9 to transfer SUMO-1 (small ubiquitin-like modifier-1) to proteins.

21 om RPA70, allowing RPA70 to be modified by a small ubiquitin-like modifier 2/3 (SUMO-2/3).

22 Here, we show that PIASy-mediated small ubiquitin-like modifier 2/3 (SUMO2/3) modification

23 dified in vivo on a single site (K53) by the small ubiquitin-like modifier-2 (SUMO-2).

24 s of full-length histone H2B modified by the small ubiquitin-like modifier-3 (SUMO-3) protein further

25 We cloned a new gene (SUMO4), encoding small ubiquitin-like modifier 4 protein, in the interval

26 Reversible modification of proteins by SUMO (small ubiquitin-like modifier) affects a large number of

27 fect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutating conserved lys

28 Proteins that regulate poly-SUMO (small ubiquitin-like modifier) chain conjugates play imp

29 In some cases, the transcription factor is a small ubiquitin-like modifier conjugated directly, thus

30 abrata We identified the enzymes involved in small ubiquitin-like modifier conjugation and show that

31 Small ubiquitin-like modifier conjugation represents a n

32 SUMO (Small Ubiquitin-like Modifier) conjugation onto target p

33 posttranslational modification by the SUMO (small ubiquitin-like modifier) conjugation pathway is es

34 SUMOylation (the process of SUMO [small ubiquitin-like modifier] conjugation to substrates

35 slation is accompanied by an increase in the small ubiquitin-like modifier-dependent nuclear localiza

36 nt in the cytoplasm and at S phase undergoes small ubiquitin-like modifier-dependent translocation to

37 In addition to small ubiquitin-like modifiers (e.g. Sumo and Nedd8), ub

38 e of Ubc8 among known ubiquitin E2s, nor the small ubiquitin-like modifier E2 Ubc9 supports protein I

39 n experiments suggest that PIAS3 acts as the small ubiquitin-like modifier E3 ligase for FOXP2 sumoyl

40 s levels of the deSUMOylating (where SUMO is small ubiquitin-like modifier) enzyme SENP1, leading to

41 critical E2-binding surface on the E1 of the small ubiquitin-like modifier has unusually high populat

42 is associated with its conjugation by SUMOs (small ubiquitin-like modifiers) in response to the topo

43 SUMO (small ubiquitin-like modifier) is a member of the ubiqui

44 Protein modification by SUMO (small ubiquitin-like modifier) is an important regulator

45 nase C zeta and it's binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inh

46 bers are ubiquitin-protein isopeptide ligase-small ubiquitin-like modifier ligases for diverse transc

47 inhibitor of activated STAT) family of SUMO (small ubiquitin-like modifier) ligases has been implicat

48 tors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved

49 alate development is beginning to emerge for small ubiquitin-like modifier modification, a widely use

50 argest groups of proteins regulated by SUMO (small ubiquitin-like modifier) modification, and their s

51 We found that the SUMO (small ubiquitin-like modifier)-modification and ubiquiti

52 ugh post-translational modification with the small ubiquitin-like modifier nedd8.

53 riguingly, SUMOylation (where SUMO indicates small ubiquitin-like modifier) of AR inhibits its transc

54 plex, a newly identified player in the SUMO (small ubiquitin-like modifier) pathway, led to increased

55 Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but still

56 all of which are involved in conjugating the small ubiquitin-like modifier polypeptide, SUMO-1, to it

57 on that is balanced by the activity of ULP-4 small ubiquitin-like modifier protease.

58 c post-translational modification in which a small ubiquitin-like modifier protein (SUMO) is attached

59 ional modification of target proteins by the small ubiquitin-like modifier protein (SUMO) regulates m

60 The small ubiquitin-like modifier protein (SUMO) regulates t

61 ggesting that binding of Ubc9 and subsequent small ubiquitin-like modifier protein 1 (SUMO-1) modific

62 lating enzyme CgUlp2 leads to highly reduced small ubiquitin-like modifier protein levels, and impair

63 f the Snf1 catalytic subunt of SNF1 with the small ubiquitin-like modifier protein SUMO, catalyzed by

64 man histone H4 N-terminal tail region by the small ubiquitin-like modifier protein, SUMO-3, is associ

65 Conjugation of SUMO (Small Ubiquitin-like Modifier) protein to cellular targe

66 mediate both processing and deconjugation of small ubiquitin-like modifier proteins (SUMOs).

67 tly and reversibly on lysine residues by the small ubiquitin-like modifier proteins termed SUMOs.

68 slational modification of proteins by SUMOs (small ubiquitin-like modifier proteins; SUMOylation).

69 SUMO (small ubiquitin-like modifier)-specific proteases regula

70 ctive RNA polymerase I transcription and the small ubiquitin-like modifier-specific protease SENP3.

71 hird post-translational modification, by the small ubiquitin like modifier SUMO, is part of the same

72 udy, we have discovered a novel role for the small ubiquitin-like modifier SUMO in the regulation of

73 The small ubiquitin-like modifier SUMO regulates nuclear tra

74 We find that TBX22 is a target for the small ubiquitin-like modifier SUMO-1 and that this modif

75 isolated Ubc9, an enzyme that conjugates the small ubiquitin-like modifier SUMO-1.

76 TDP1 is a substrate for modification by the small ubiquitin-like modifier SUMO.

77 zed by immunofluorescence with antibodies to small ubiquitin-like modifier (SUMO) 1 localized to nucl

78 A small ubiquitin-like modifier (SUMO) acceptor site was r

79 Mms21 promotes cohesin-dependent small ubiquitin-like modifier (SUMO) accumulation at las

80 tification by mass spectrometry of a site of small ubiquitin-like modifier (SUMO) adduction, Lys-679

81 Dynamic modification of proteins with the small ubiquitin-like modifier (SUMO) affects the stabili

82 4 ICD is posttranslationally modified by the small ubiquitin-like modifier (SUMO) and functionally in

83 .7 was enhanced by conjugation of CRMP2 with small ubiquitin-like modifier (SUMO) and further control

84 neering studies on the interplay between the small ubiquitin-like modifier (SUMO) and influenza A vir

85 Remarkably, small ubiquitin-like modifier (SUMO) attenuates AR aggre

86 of TDG mutants defective for sumoylation and Small Ubiquitin-like Modifier (SUMO) binding and by alte

87 the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif.

88 The small ubiquitin-like modifier (SUMO) can form polymeric

89 ss the accumulation of high molecular weight small ubiquitin-like modifier (SUMO) conjugates.

90 Small ubiquitin-like modifier (SUMO) conjugation also oc

91 Small ubiquitin-like modifier (SUMO) conjugation is a re

92 Posttranslational modification by small ubiquitin-like modifier (SUMO) conjugation regulat

93 The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation.

94 post-translational modifications, including small ubiquitin-like modifier (SUMO) conjugation.

95 Small ubiquitin-like modifier (SUMO) conjugation/deconju

96 We show here that Cav-3 has a small ubiquitin-like modifier (SUMO) consensus motif (Ps

97 we report that SHMT1 is ubiquitinated at the small ubiquitin-like modifier (SUMO) consensus motif and

98 e show that lysine residues within conserved small ubiquitin-like modifier (SUMO) consensus sites in

99 sin response mediator protein 2 (CRMP2) by a small ubiquitin-like modifier (SUMO) could affect NaV tr

100 Small ubiquitin-like modifier (SUMO) covalently attaches

101 study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylate

102 Hsp27 interacted physically with Ubc9, the small ubiquitin-like modifier (SUMO) E2 conjugating enzy

103 tin proteasome system, and expression of the small ubiquitin-like modifier (SUMO) E2 enzyme UBC9 impr

104 evidence establishes that AtSIZ1 is a plant small ubiquitin-like modifier (SUMO) E3 ligase and is a

105 In keeping with the small ubiquitin-like modifier (SUMO) E3 ligase function

106 tion factor IIIA (TFIIIA) interacts with the small ubiquitin-like modifier (SUMO) E3 ligase PIAS2b an

107 ligase, we find that TIF1gamma operates as a small ubiquitin-like modifier (SUMO) E3 ligase that prom

108 re, we show that PIAS1, which functions as a small ubiquitin-like modifier (SUMO) E3 ligase, associat

109 vitro, demonstrating that E4-ORF3 acts as a small ubiquitin-like modifier (SUMO) E3 ligase.

110 Small ubiquitin-like modifier (SUMO) E3 ligases are know

111 The small ubiquitin-like modifier (SUMO) E3, RanBP2, confers

112 , but not C/EBP beta-2, is conjugated to the small ubiquitin-like modifier (SUMO) family members, SUM

113 tional modification in which a member of the small ubiquitin-like modifier (SUMO) family of proteins

114 l to the recognition site for members of the small ubiquitin-like modifier (SUMO) family of ubiquitin

115 oylation involves activation and transfer of small ubiquitin-like modifier (SUMO) from the thioester

116 st-translational modification of proteins by Small Ubiquitin-like Modifier (SUMO) has been reported t

117 Dynamic modification involving small ubiquitin-like modifier (SUMO) has emerged as a ne

118 osttranslational modification of proteins by small ubiquitin-like modifier (SUMO) has received much a

119 s for the post-translational modification of small ubiquitin-like modifier (SUMO) in regulating the r

120 Here we report that BRCA1 is modified by small ubiquitin-like modifier (SUMO) in response to geno

121 Posttranslational modification by small ubiquitin-like modifier (SUMO) is a major regulato

122 Small ubiquitin-like modifier (SUMO) is a member of the

123 ere we demonstrate that conjugation with the small ubiquitin-like modifier (SUMO) is a novel PTM requ

124 Small ubiquitin-like modifier (SUMO) is a small protein

125 The small ubiquitin-like modifier (SUMO) is a ubiquitin-like

126 Here we report that the small ubiquitin-like modifier (SUMO) is conjugated (SUMO

127 The small ubiquitin-like modifier (SUMO) is covalently linke

128 The small ubiquitin-like modifier (SUMO) is implicated in va

129 Small ubiquitin-like modifier (SUMO) is involved in vari

130 Post-translational modification by small ubiquitin-like modifier (SUMO) is one such possibl

131 osttranslational modification of proteins by small ubiquitin-like modifier (SUMO) is required for sur

132 Small ubiquitin-like modifier (SUMO) is used by the intr

133 slational modification of ZBP-89 by multiple small ubiquitin-like modifier (SUMO) isoforms occurs at

134 single-strand binding protein POT-1, and the small ubiquitin-like modifier (SUMO) ligase GEI-17.

135 nction except for Nse2/Mms21, which is an E3 small ubiquitin-like modifier (SUMO) ligase important fo

136 This process is carried out by the E3-small ubiquitin-like modifier (SUMO) ligase protein inhi

137 ultiple subunits and identify SIZ1 as the E3 Small Ubiquitin-like Modifier (SUMO) ligase responsible

138 tein inhibitor of activated STAT1 (PIAS1), a small ubiquitin-like modifier (SUMO) ligase that regulat

139 hat the yeast proline isomerase Fpr3 and the small ubiquitin-like modifier (SUMO) ligase Zip3 ensure

140 transcription) RING domain characteristic of small ubiquitin-like modifier (SUMO) ligases, two struct

141 The small ubiquitin-like modifier (SUMO) modification alters

142 Small ubiquitin-like modifier (SUMO) modification has em

143 UBC9 and was a substrate for UBC9-catalyzed small ubiquitin-like modifier (SUMO) modification in vit

144 ey mechanism by which this occurs is through small ubiquitin-like modifier (SUMO) modification of Maf

145 We recently described a critical role for a small ubiquitin-like modifier (SUMO) modification of NF-

146 Small ubiquitin-like modifier (SUMO) modification of pro

147 Small ubiquitin-like modifier (SUMO) modification of seq

148 Small ubiquitin-like modifier (SUMO) modification of tra

149 p14 Arf promotes small ubiquitin-like modifier (SUMO) modification of WRN

150 Small ubiquitin-like modifier (SUMO) modification regula

151 We show here that BLM is a substrate for small ubiquitin-like modifier (SUMO) modification, with

152 lation of NRL in vivo and in vitro, with two small ubiquitin-like modifier (SUMO) molecules attached

153 In this context, small ubiquitin-like modifier (SUMO) often provides a bi

154 dified in vitro and in cultured cells by the Small ubiquitin-like modifier (SUMO) on two independent

155 Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cere

156 Here, we show that the small ubiquitin-like modifier (SUMO) pathway is required

157 mber of the E3 ligase family involved in the small ubiquitin-like modifier (SUMO) pathway, we show fu

158 ue to a defect in a gene encoding a putative small ubiquitin-like modifier (SUMO) peptidase.

159 Protein modifications by ubiquitin and small ubiquitin-like modifier (SUMO) play key roles in c

160 Modification of proteins by small ubiquitin-like modifier (SUMO) plays an important

161 osttranslational modification of proteins by small ubiquitin-like modifier (SUMO) plays essential rol

162 In this study we show that the small ubiquitin-like modifier (SUMO) plays multiple role

163 The covalent attachment of small ubiquitin-like modifier (SUMO) polypeptides regula

164 ing evolution, the enzyme Ubc9 activates the small ubiquitin-like modifier (SUMO) prior to its covale

165 ve analyzed the mitotic function of SENP6, a small ubiquitin-like modifier (SUMO) protease that disas

166 Small ubiquitin-like modifier (SUMO) proteases are requi

167 Small ubiquitin-like modifier (SUMO) proteases regulate

168 Some of these genes encode small ubiquitin-like modifier (SUMO) proteases specific

169 In this study of two pore-associated small ubiquitin-like modifier (SUMO) proteases, sentrin/

170 eins both as targets for modification by the small ubiquitin-like modifier (SUMO) protein and as cata

171 The E3 small ubiquitin-like modifier (SUMO) protein ligase prot

172 this process, an extremely limited number of small ubiquitin-like modifier (SUMO) protein ligases (E3

173 a proportion of DELLAs is conjugated to the Small Ubiquitin-like Modifier (SUMO) protein, the extent

174 cation pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SU

175 Small ubiquitin-like modifier (SUMO) proteins act in DNA

176 Conjugation by small ubiquitin-like modifier (SUMO) proteins at two syn

177 Conjugation of small ubiquitin-like modifier (SUMO) proteins has been s

178 t posttranslational modification of Kv1.5 by small ubiquitin-like modifier (SUMO) proteins modulates

179 Posttranslational modifications with small ubiquitin-like modifier (SUMO) proteins regulate m

180 Modification of TDG by small ubiquitin-like modifier (SUMO) proteins weakens it

181 ovalent modification of cellular proteins by small ubiquitin-like modifier (SUMO) proteins, regulates

182 tional modifications, such as conjugation of small ubiquitin-like modifier (SUMO) proteins.

183 e also been identified as E3 ligases for the small ubiquitin-like modifier (SUMO) proteins.

184 ls depends on their covalent modification by small ubiquitin-like modifier (SUMO) proteins.

185 Small ubiquitin-like modifier (SUMO) regulates diverse c

186 karyotes, the conjugation of proteins to the small ubiquitin-like modifier (SUMO) regulates numerous

187 Structural studies of the E1 for the Ubl small ubiquitin-like modifier (SUMO) revealed a single a

188 of this particular antiviral response is the small ubiquitin-like modifier (SUMO) signaling pathway.

189 e IIalpha (TopoIIalpha), a major centromeric small ubiquitin-like modifier (SUMO) substrate.

190 enzyme with strict specificity for its plant small ubiquitin-like modifier (SUMO) substrates.

191 ols has allowed elucidation and study of the small ubiquitin-like modifier (SUMO) system in this unic

192 Covalent attachment of the small ubiquitin-like modifier (SUMO) to key targets in t

193 jugating enzyme that transfers the activated small ubiquitin-like modifier (SUMO) to protein substrat

194 Conjugation of the small ubiquitin-like modifier (SUMO) to protein substrat

195 Sumoylation, a process of adding small ubiquitin-like modifier (SUMO) to proteins posttra

196 how that MEL-18 is able to interact with the small ubiquitin-like modifier (SUMO) ubiquitin carrier p

197 The small ubiquitin-like modifier (SUMO), initially characte

198 When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually repre

199 sites of post-translational modification by small ubiquitin-like modifier (SUMO), we have examined w

200 Here we demonstrate that small ubiquitin-like modifier (SUMO)- and folate-depende

201 global hyposumoylation and redistribution of small ubiquitin-like modifier (SUMO)-1 conjugates into d

202 n this study, we determined the occupancy of Small Ubiquitin-like MOdifier (SUMO)-1 on chromatin in H

203 t of Htt (Httex1p) can be modified either by small ubiquitin-like modifier (SUMO)-1 or by ubiquitin o

204 l 4,5-bisphosphate synthesis, is modified by small ubiquitin-like modifier (SUMO)-1.

205 Global increases in small ubiquitin-like modifier (SUMO)-2/3 conjugation are

206 We previously identified Arkadia as a small ubiquitin-like modifier (SUMO)-binding protein wit

207 The function of small ubiquitin-like modifier (SUMO)-binding proteins is

208 IE1 caused loss of the small ubiquitin-like modifier (SUMO)-conjugated forms of

209 Here, we show that UBC-9, the sole E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme,

210 ntification of Ubc9 and PIASy, the E2 and E3 small ubiquitin-like modifier (SUMO)-conjugating enzymes

211 a conserved family of proteins that contain small ubiquitin-like modifier (SUMO)-like domains.

212 nts a class of ubiquitin ligases that target Small Ubiquitin-like Modifier (SUMO)-modified proteins f

213 on, we used de-SUMOylation enzyme of sentrin/Small Ubiquitin-like MOdifier (SUMO)-specific protease 2

214 Two Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 7

215 s, both of which are implicated in ubiquitin/small ubiquitin-like modifier (SUMO)-targeted protein de

216 Like the small ubiquitin-like modifier (SUMO)-targeted ubiquitin

217 we demonstrate that RNF4, a highly conserved small ubiquitin-like modifier (SUMO)-targeted ubiquitin

218 Here, we show that human RNF4, a small ubiquitin-like modifier (SUMO)-targeted ubiquitin

219 Although Slx5/Slx8 is a small ubiquitin-like modifier (SUMO)-targeted ubiquitin

220 validated substrates for modification by the Small Ubiquitin-like Modifier (SUMO).

221 role in cardiogenesis and is a target of the small ubiquitin-like modifier (SUMO).

222 posttranslational modification (PTM) by the small ubiquitin-like modifier (SUMO).

223 undergoes PML-dependent hyper-sumoylation by small ubiquitin-like modifier (SUMO)2/3 but not SUMO1, u

224 nal modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation.

225 nhibitory and transrepressor activities to a small ubiquitin-like modifier (SUMO-1) protein consensus

226 el mechanism of Sp1 regulation involving the small ubiquitin-like modifier (SUMO-1).

227 te that IE72 is covalently conjugated to the small ubiquitin-like modifier (SUMO-1).

228 ting macrophages, some IRF8 is conjugated to small ubiquitin-like modifiers (SUMO) 2/3 through the ly

229 Small ubiquitin-like modifiers (SUMO) are covalently con

230 ough post-translational modifications by the small ubiquitin-like modifiers (SUMO) are known to be im

231 lved the crystal structure of the E2 for the small ubiquitin-like modifiers (SUMO) in complex with an

232 Using yeast two-hybrid screening, small ubiquitin-like modifiers (SUMO-1, SUMO-2, and SUMO

233 Here we show that tethering of a small, ubiquitin-like modifier (SUMO) moiety to p53 mark

234 The protein called 'small ubiquitin-like modifier' (SUMO) is post-translatio

235 nslational modification of substrates by the small ubiquitin-like modifier, SUMO, regulates diverse b

236 t-translational modification mediated by the small ubiquitin-like modifier, SUMO.

237 e we analyzed the modification of PKR by the small ubiquitin-like modifiers SUMO1 and SUMO2 and evalu

238 show that FXR is covalently modified by the small ubiquitin-like modifier (Sumo1), an important regu

239 en for proteins binding noncovalently to the small ubiquitin-like modifier SUMO2.

240 cifically induces modification of Rta by the small ubiquitin-like modifiers SUMO2 and SUMO3.

241 , whether human septins could be modified by small ubiquitin-like modifiers (SUMOs) and what roles th

242 The mammalian small ubiquitin-like modifiers (SUMOs) are actively invo

243 The small ubiquitin-like modifiers (SUMOs) are posttranslati

244 Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) regulate many cel

245 The small ubiquitin-like modifiers (SUMOs) regulate many ess

246 sttranslational modifications of proteins by small ubiquitin-like modifiers (SUMOs) regulate protein

247 sites and conjugates these proteins with the small ubiquitin-like modifiers (SUMOs) through its SUMO

248 The posttranslational addition of small ubiquitin-like modifiers (SUMOs) to other intracel

249 Posttranslational modification by small ubiquitin-like modifiers (SUMOs), known as SUMOyla

250 The covalent attachment of SUMO (small ubiquitin-like modifier) to other intracellular pr

251 We have previously described a role for the small ubiquitin-like modifier type 1 (SUMO-1) as a regul

252 orm-alpha (HSP90-SUMO1, where SUMO indicates small ubiquitin-like modifier), while no reactivity with