ライフサイエンスコーパス: small vessel disease

1 d venular diameter, and markers for cerebral small vessel disease.

2 EPVS) are a promising neuroimaging marker of small vessel disease.

3 rns of brain injury supported both large and small vessel disease.

4 dase pathway in the pathogenesis of cerebral small vessel disease.

5 ascular risk factors known to cause sporadic small vessel disease.

6 neuroimaging and genetic markers of cerebral small vessel disease.

7 Disease-type disease rather than to cerebral small vessel disease.

8 , which belongs to the continuum of cerebral small vessel disease.

9 whole brain atrophy in symptomatic cerebral small vessel disease.

10 finding appears to be related to underlying small vessel disease.

11 ibutions to quality of life in patients with small vessel disease.

12 (MRI) are a neuroimaging marker of cerebral small vessel disease.

13 ld identify a homogeneous subpopulation with small vessel disease.

14 r spaces may reflect the underlying cerebral small vessel disease.

15 ebrovascular diseases secondary to large and small vessel disease.

16 bnormalities, resemble symptoms and signs of small vessel disease.

17 function over time in patients with cerebral small vessel disease.

18 the brain are important markers of aging and small-vessel disease.

19 ent type of stroke caused mainly by cerebral small-vessel disease.

20 ied a COL4A1 mutation in a human family with small-vessel disease.

21 tify CTEPH patients with significant distal, small-vessel disease.

22 n the settings of vascular calcification and small-vessel disease.

23 l large-vessel disease compared with that of small-vessel disease.

24 resting-state CBF is a marker of CMB-related small-vessel disease.

25 other magnetic resonance imaging markers of small-vessel disease.

26 bal brain atrophy and an increased burden of small-vessel disease.

27 arge-vessel and cardioembolic stroke but not small-vessel disease.

28 inding and may be a useful endophenotype for small vessel diseases.

29 because of chronic joint pain or evidence of small-vessel disease (0.7%).

30 7.2% versus 24.1+/-15.9%, P<0.0001; and mean small-vessel disease, 11.7+/-14.6 versus 14.1+/-8.7, P=0

31 coma is associated with evidence of cerebral small vessel disease; 2) that imaging biomarkers of cere

32 ss of Notch signaling with ischemic cerebral small-vessel disease, a prevalent human condition.

33 for precisely how amyloid-beta and cerebral small vessel disease affect cognitive impairment remain

34 amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of

35 we scored the severity of arteriolosclerotic small vessel disease and cerebral amyloid angiopathy, an

36 investigations into the connections between small vessel disease and delayed seizures are warranted.

37 of cognitive dysfunction in stroke, cerebral small vessel disease and dementia.

38 The resulting cerebral small vessel disease and heart failure may contribute to

39 non-demyelinating disorders such as chronic small vessel disease and other inflammatory, granulomato

40 ear if and how associations between cerebral small-vessel disease and Alzheimer disease (AD) patholog

41 ebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for co

42 CADASIL and their mechanistic connection to small-vessel disease and GOM accumulation remain enigmat

43 , hypertension, lacunar stroke and ischaemic small vessel disease, and have generated interest as a m

44 validated mutations that cause porencephaly, small vessel disease, and hereditary angiopathy, nephrop

45 sights into the longitudinal pathogenesis of small vessel disease, and imply that therapies aimed at

46 abetes, dyslipidemia, smoking, infarcts from small-vessel disease, and "other definite" causes and wo

47 neuroimaging and genetic markers of cerebral small vessel disease: APOE variants epsilon2/epsilon4, c

48 ion, white matter microstructural changes in small vessel disease are associated with apathy but not

49 Y ON THIS ARTICLE: Amyloid-beta and cerebral small vessel disease are the two major causes of cogniti

50 an age at which white matter findings due to small-vessel disease are common.

51 atter lesions (WMLs)-an imaging surrogate of small vessel disease-are associated with a higher rate o

52 pathy and depression can be distinguished in small vessel disease both in terms of their relative rel

53 ctural imaging features to gauge total brain small vessel disease burden in CAA.

54 The cerebral small vessel disease burdens were assessed with white ma

55 bidities, cognition, hippocampal volume, and small-vessel disease but not on gait speed (0.85 vs 0.92

56 e potential neuroimaging markers of cerebral small vessel disease, but their functional significance

57 sms remain unclear, but may include cerebral small vessel disease caused by COPD.

58 CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that ste

59 e severity of structural vascular pathology (small vessel disease, cerebral amyloid angiopathy or VWF

60 In small vessel disease, cerebrospinal fluid (CSF) markers

61 pathy (CAA) is a common age related cerebral small vessel disease, characterised by progressive depos

62 patients, 33% of stroke was due to cerebral small vessel disease compared with 14% in the white stro

63 cognitive impairment, but also for cerebral small vessel disease (CSVD) and Abeta-positivity.

64 Cerebral small vessel disease (cSVD) is a heterogeneous group of

65 pression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms

66 Patients with cerebral small-vessel disease (CSVD) exhibit perturbed end-artery

67 nges, which may contribute to post-stroke or small vessel disease dementia.

68 us early and late manifestations of cerebral small vessel disease (eg, microbleeds and white matter h

69 appears aggravated in patients with cerebral small-vessel disease, especially in apolipoprotein E eps

70 nt membrane and COL4A1 mutations cause adult small vessel disease, familial porencephaly and heredita

71 cts of cerebrovascular disease, particularly small vessel disease, from those of Alzheimer's disease

72 ee of apathy and depression found within the small vessel disease group.

73 alent CMBs, and markers of cerebral ischemic small-vessel disease, heavy alcohol consumption (vs ligh

74 imaging markers of the severity and type of small-vessel disease (hypertensive arteriopathy or cereb

75 kely harbor a more advanced form of cerebral small vessel disease in need of efficacious therapeutic

76 ease; 2) that imaging biomarkers of cerebral small vessel disease in POAG and NTG will show different

77 Evidence of small vessel disease in the retina increases the likelih

78 adjuvant therapies and subclinical cerebral small-vessel disease in survivors of breast cancer.

79 gnitive impairment, and other MRI markers of small vessel disease, in a patient cohort of ischaemic s

80 and to magnetic resonance imaging markers of small-vessel disease including increased white matter hy

81 nce of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and

82 Cerebral small vessel disease, including microvascular lesions, i

83 Cerebral small vessel disease is a common condition associated wi

84 Small vessel disease is a stroke subtype characterized b

85 Small vessel disease is associated with high rates of ap

86 suggest that apathy, but not depression, in small vessel disease is related to damage to cortical-su

87 MR evidence of cerebral small vessel disease is strongly associated with a diagn

88 Although cerebral small-vessel disease is an important cause of cognitive

89 of frontal-subcortical circuits by cerebral small-vessel disease is thought to predispose to depress

90 antineutrophil cytoplasmic antibody-positive small vessel diseases, is largely restricted to case rep

91 lopathy (CADASIL), the most common inherited small-vessel disease, is associated with vascular aggreg

92 thy (CARASIL), an inherited form of cerebral small vessel disease leading to early-onset stroke and p

93 The most common monogenic cause of small-vessel disease leading to ischemic stroke and vasc

94 Small vessel disease (mainly hypertensive arteriopathy a

95 =3 sulci; disseminated, >/=4 sulci), and key small vessel disease markers.

96 we hypothesized that CSF markers related to small vessel disease may also be applicable as biomarker

97 ere protein mutations (ie, myocyte disarray, small vessel disease, myocardial scarring).

98 Participants with small vessel disease (n = 118; mean age = 68.9 years; 65

99 Small-vessel diseases of the brain underlie 20 to 30 per

100 Although severe small vessel disease or cerebral amyloid angiopathy may

101 e lowest in cortex from patients with severe small vessel disease or cerebral amyloid angiopathy, nei

102 types cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52).

103 rs than the large artery disease (p<0.0001), small vessel disease (p=0.001), and cardioembolic (p=0.0

104 with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger

105 bnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and

106 thrombotic material or coexistent intrinsic small-vessel disease, remains a major determinant of poo

107 evidence of concept validity of a total MRI small vessel disease score in CAA.

108 corporated into a prespecified ordinal total small vessel disease score, ranging from 0 to 6 points.

109 independently associated with the total MRI small vessel disease score.

110 e gave a higher estimate of the frequency of small vessel disease stroke, particularly in white patie

111 Our results also support the view that small vessel diseases such as CAA can cause cortical atr

112 Small vessel disease (SVD) and amyloid deposition may pr

113 Patients with cerebral small vessel disease (SVD) can present as isolated lacun

114 Cerebral small vessel disease (SVD) causes focal lacunar infarcti

115 tients with late-onset AD have more comorbid small vessel disease (SVD) contributing to clinical seve

116 The term cerebral small vessel disease (SVD) describes a range of neuroima

117 Cerebral small vessel disease (SVD) is a common accompaniment of

118 Cerebral small vessel disease (SVD) is a common cause of vascular

119 Cerebral small vessel disease (SVD) is a leading cause of stroke

120 Cerebral small vessel disease (SVD) is characterised by progressi

121 ular smooth muscle, is a genetic paradigm of small vessel disease (SVD) of the brain.

122 to assess whether and how single markers of small vessel disease (SVD) or a combination thereof expl

123 arterioles (PAs), a major target of cerebral small vessel disease (SVD), and determined whether relax

124 aneous intracerebral hemorrhage (ICH) due to small vessel disease (SVD), but the association between

125 is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cogniti

126 association is possibly mediated by cerebral small vessel disease (SVD), which has been associated wi

127 lacunar strokes are associated with cerebral small vessel disease (SVD), which is the commonest vascu

128 he brain and may reflect underlying cerebral small vessel disease (SVD).

129 e of white matter lesion related to cerebral small vessel disease (SVD).

130 ingly recognized, particularly from cerebral small vessel disease (SVD).

131 -associated manifestations of human cerebral small vessel disease (SVD).

132 Several hereditary small vessel diseases (SVDs) of the brain have been repo

133 oke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cogn

134 ith the hypothesis that PVS reflect cerebral small vessel disease; the different associations for bas

135 The mechanisms linking small-vessel disease to cognitive impairment are not wel

136 A relative excess of small vessel disease was observed in black patients with

137 y, percentage of fibrosis, and percentage of small-vessel disease were correlated with the genotype.

138 SIVD results from small-vessel disease, which produces either arteriolar o

139 hy and magnetic resonance imaging markers of small vessel disease (white matter hyperintensities or l

140 dinal cohort of 99 subjects with symptomatic small vessel disease, who were followed-up for >/=1 year

141 Treatment of small-vessel disease with a paclitaxel DEB was associate