ライフサイエンスコーパス: snoRNA

1 We found 61 miRNAs and 135 snoRNAs to be significantly changed in expression in myo

2 27 snoRNAs in young versus old serum and 18 snoRNAs in old sham versus old experimental osteoarthrit

3 the repertoire of Arabidopsis snoRNAs to 188 snoRNA genes with 294 gene variants.

4 nterest was the prognostic value of HBII-239 snoRNA, which was significantly over-expressed in cases

5 n serum we found differential presence of 27 snoRNAs in young versus old serum and 18 snoRNAs in old

6 identified 21 novel, noncanonical miRNAs (3 snoRNA-derived and 2 tRNA-derived miRNAs and 16 miRtrons

7 f 6 snoRNAs in young versus old joints and 5 snoRNAs in old sham versus old experimental osteoarthrit

8 that originate from the full-length MBII-52 snoRNA through additional processing steps.

9 identified differential expression (DE) of 6 snoRNAs in young versus old joints and 5 snoRNAs in old

10 3% of the canonical snoRNAs, leaving only 76 snoRNA sequences as orphan.

11 ding small nucleolar RNAs (including HBII-85 snoRNAs) which were not expressed in peripheral lymphocy

12 homeostasis and is the first to implicate a snoRNA in this cellular function.

13 Snord116 is a snoRNA gene cluster of unknown function that can localiz

14 ings represent the first identification of a snoRNA overexpressed as a consequence of a chromosomal t

15 by mutational analysis of a yeast box H/ACA snoRNA that mediates both processing and modification.

16 asses of small nucleolar RNAs, the box H/ACA snoRNAs and the box C/D snoRNAs.

17 RNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-s

18 known ncRNA classes including C/D and H/ACA snoRNAs, our screen identified one new family of small R

19 between miRNA precursors and some box H/ACA snoRNAs.

20 necessary for stable expression of box H/ACA snoRNAs.

21 with a broad range of box C/D and box H/ACA snoRNAs.

22 required for recruitment of the late-acting snoRNAs SNORD56 and SNORD68, earlier snoRNAs are not aff

23 Here, we identify several late-acting snoRNAs that bind pre-40S particles in human cells and s

24 p with the basepairing sites of the affected snoRNAs.

25 h a 5'-monophosphate, for some, but not all, snoRNAs.

26 While 53% of the sdRNAs contain an snoRNA box C motif and boxes D and D' are also common in

27 out of all the ncRNAs, only tRNA, miRNA and snoRNA can be predicted with a satisfying sensitivity an

28 affect expression of DNA damage response and snoRNA genes, respectively.

29 NA species, including mRNA, miRNA, rRNA, and snoRNA.

30 ed genomic loci that give rise to snoRNA and snoRNA-like genes.

31 Thus, coilin couples snRNA and snoRNA biogenesis, making CBs the cellular hub of small

32 /snoRNA genes, and reduces nascent snRNA and snoRNA synthesis.

33 dinylation depends on both site-specific and snoRNA-guided pseudouridine synthases.

34 roteins associate specifically with tRNA and snoRNA genes undergoing Pol III transcription.

35 NPP-13 is required for cleavage of tRNA and snoRNA precursors into mature RNAs, whereas Pol II trans

36 nscripts that contained miRNAs, lincRNAs and snoRNAs.

37 investigate the involvement of microRNAs and snoRNAs in the relapse-remission dynamics of MS in perip

38 of unique sites in human and yeast mRNAs and snoRNAs.

39 cribed genes encoding ribosomal proteins and snoRNAs.

40 rDNA locus, directly contacts both rRNA and snoRNAs, and promotes rRNA transcription, processing and

41 small nuclear and nucleolar RNAs (snRNAs and snoRNAs).

42 Here we report that like snRNAs and snoRNAs, some Rev/RRE-dependent HIV-1 RNAs are TMG-cappe

43 Full-length sequences of Arabidopsis snoRNAs and scaRNAs have been obtained from cDNA librari

44 results expand the repertoire of Arabidopsis snoRNAs to 188 snoRNA genes with 294 gene variants.

45 The C/D and C'/D' RNPs of the archaeal snoRNA-like RNP (sRNP) are spatially and functionally co

46 sed into essential cellular factors, such as snoRNA and miRNA.

47 ically regulated chromatin decondensation at snoRNA clusters in human and mouse brain.

48 RNA Polymerase II (Pol II) transcription at snoRNAs and other noncoding RNAs in yeast.

49 H/ACA box snoRNA classifier showed an F-score of 93 % (an improvem

50 garding the previous version), while C/D box snoRNA classifier, an F-Score of 94 % (improvement of 14

51 ch is different from the traditional C/D box snoRNA function in non-mRNA methylation.

52 We recently found that the C/D box snoRNA HBII-52 changes the alternative splicing of the s

53 data indicate that not a traditional C/D box snoRNA MBII-52, but a processed version lacking the snoR

54 We demonstrate that the mouse C/D box snoRNA MBII-85 (SNORD116) is processed into at least fiv

55 nformation of these organisms, but H/ACA box snoRNAs identification was improved for the other ones.

56 fy snoRNAs in vertebrates and also H/ACA box snoRNAs in invertebrates organisms.

57 rosophilids, 69 % and 76.67 %, for H/ACA box snoRNAs were predicted, respectively, showing that snoRe

58 new features for both box C/D and H/ACA box snoRNAs; developing a more sophisticated technique in th

59 onserved processing pattern for some C/D box snoRNAs and abundant expression of longer, non-coding RN

60 al copies of the cluster of SNORD116 C/D box snoRNAs and their host transcript, 116HG, on human chrom

61 Report 2.0, to predict H/ACA box and C/D box snoRNAs, an efficient method to find true positives and

62 es near known functional elements of C/D box snoRNAs.

63 h proteins associated with canonical C/D box snoRNAs.

64 ted but rather are terminated on each end by snoRNAs and their associated proteins.

65 s a protein complex different from canonical snoRNAs found in the insoluble nuclear fraction.

66 le modification site to 83% of the canonical snoRNAs, leaving only 76 snoRNA sequences as orphan.

67 Three related capped snoRNAs with a distinct gene organization and structure

68 n-coding genes as well as several non-coding snoRNAs.

69 The RNA components of these complexes (snoRNAs) contain one or two guide sequences, which, thro

70 The RNA component (snoRNA) contains guide regions that base-pair with the t

71 3-Trm112 interacts directly with the box C/D snoRNA U3-associated DEAH RNA helicase Dhr1 supposedly i

72 sulting in haploinsufficiency of the box C/D snoRNA U60.

73 s in the gene SNORD118, encoding the box C/D snoRNA U8, cause the cerebral microangiopathy leukoencep

74 One box C/D snoRNA, HBII-180C, was analysed in greater detail, revea

75 ns of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of

76 All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1,

77 airing' was also found in many human box C/D snoRNAs and can stimulate methylation by up to five-fold

78 small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide

79 RNA-sequencing analysis reveals that box C/D snoRNAs as a class are present in the cytoplasm, where t

80 he nucleocytoplasmic distribution of box C/D snoRNAs from the ribosomal protein L13a (Rpl13a) locus.

81 We previously showed that box C/D snoRNAs from the Rpl13a locus are unexpected mediators o

82 Analysis of >2000 yeast box C/D snoRNAs identified additional conserved sequences in man

83 ining and test phases of boxes H/ACA and C/D snoRNAs, in both versions of snoReport, are discussed.

84 iRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D

85 ors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity

86 in precursors showing similarity to box C/D snoRNAs.

87 egulatory RNAs may have evolved from box C/D snoRNAs.

88 een a subset of miRNA precursors and box C/D snoRNAs.

89 RNAs, the box H/ACA snoRNAs and the box C/D snoRNAs.

90 omplex but gets released upon binding to C/D snoRNAs; (c) the dynamics of the R2TP complex, which app

91 me quantitative PCR (qRT-PCR) we demonstrate snoRNA expression levels in murine ageing and OA joints

92 convenient and efficient approach to deplete snoRNA, small Cajal body RNA (scaRNA) and small nuclear

93 ata uncover an essential role of deregulated snoRNA biogenesis in tumors and a new mechanism of nucle

94 latory element analysis of these deregulated snoRNA genes identified strong enrichment of a common Et

95 and 15 new variants of previously described snoRNAs.

96 ridylation at these positions using designer snoRNAs results in near complete rescue of splicing and

97 We propose that each snoRNA forms two different snoRNPs, subtly different in

98 -acting snoRNAs SNORD56 and SNORD68, earlier snoRNAs are not affected by DDX21 depletion.

99 We demonstrate that when the elevated snoRNA pathway is suppressed, the tumor suppressor p53 c

100 e extent of the contributions of the encoded snoRNAs is unknown.

101 n, supporting our hypothesis that endogenous snoRNAs can activate PKR.

102 iculties in depleting these RNAs, especially snoRNAs.

103 Our results establish snoRNAs as novel markers of musculoskeletal ageing and o

104 nucleotides of the differentially expressed snoRNAs were concentrated in the 28S and 18S ribosomal R

105 vely as well as cell type specific expressed snoRNAs.

106 At least five snoRNAs could be depleted simultaneously.

107 ction to recruit the machinery essential for snoRNA processing.

108 ther, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding

109 luminates a previously unrecognized role for snoRNAs in metabolic regulation.

110 uncovered additional non-canonical roles for snoRNAs.

111 Here, we selectively deleted four snoRNAs encoded within the introns of the ribosomal prot

112 lth of small fragments (<35 nt) derived from snoRNAs (termed sdRNAs) that stably accumulate in the ce

113 s (54%), relatively few (12%) contain a full snoRNA guide region.

114 e abundance of different sdRNAs from a given snoRNA varies.

115 a result of increased levels of the guiding snoRNAs.

116 cluding numerous unannotated mouse and human snoRNAs.

117 to construct an up-to-date catalog of human snoRNAs we have combined data from various databases, de

118 lso demonstrated that a subset of identified snoRNAs bind and activate PKR in vitro; the presence of

119 owing that snoReport 2.0 is good to identify snoRNAs in vertebrates and also H/ACA box snoRNAs in inv

120 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss.

121 Importantly, snoRNAs could be dramatically depleted in mice by system

122 loss, perhaps facilitated by innovations in snoRNA processing, is distinct from that observed in pro

123 reveals a broad requirement for the Paf1C in snoRNA 3'-end formation in S. cerevisiae, implicates the

124 onal regulators Bur1-Bur2, Rad6, and Set2 in snoRNA 3'-end formation.

125 rgets of this uncharacterized snRNP included snoRNA intermediates hosted within ribosomal protein (RP

126 were detected in all fractions, with intron, snoRNA and lncRNA interactions enriched in the nucleus.

127 ch SmD3 regulates the expression of intronic snoRNAs likely involves effects of SmD3 on the levels of

128 ified additional conserved sequences in many snoRNAs that are complementary to regions adjacent to th

129 sdRNA profiles of many snoRNAs are specific and resemble the cleavage profiles

130 Like miRNAs, snoRNAs are globally down-regulated in tumor cells compa

131 Moreover, snoRNAs lacking specific CB retention signals traffic th

132 Although most snoRNAs reside in the nucleolus, a growing body of evide

133 hromosomal domain containing multiple mRNAs, snoRNAs, and microRNAs was activated surrounding the int

134 ails the association of thousands of ncRNAs--snoRNA, miRNA, siRNA, piRNA and long ncRNA--within human

135 anscripts in paf1Delta cells and uncover new snoRNA targets of Paf1.

136 We have identified 31 novel snoRNA genes (9 box C/D and 22 box H/ACA) and 15 new var

137 The majority of the novel snoRNA genes were found in new gene clusters or as part

138 that snoRNA expression and the abundance of snoRNA-containing intron lariats are decreased in SmD3 m

139 An 8-fold allele-specific decondensation of snoRNA chromatin was developmentally regulated specifica

140 ification domain disrupt 3'-end formation of snoRNA transcripts and identify a previously uncharacter

141 in the introns, nor affecting the levels of snoRNA isoforms with high sequence similarities.

142 bservations suggest a link between levels of snoRNA that target spliceosomal RNAs, spliceosomal funct

143 t, our study characterizes the plasticity of snoRNA expression identifying both constitutively as wel

144 The dual polyadenylation of snoRNA intermediates is carried out by both PAP2 and PAP

145 response pathways through the regulation of snoRNA expression.

146 Overlapping basepairing of snoRNAs with pre-rRNAs often necessitates sequential and

147 We show that all classes of snoRNAs concentrate in CBs.

148 of a single member of the MBII-52 cluster of snoRNAs by RNase protection and northern blot analysis s

149 e for NXF3 in regulating the distribution of snoRNAs between the nuclear and cytoplasmic compartments

150 The primary function of snoRNAs is targeting specific nucleotides of ribosomal R

151 lencing of either PAP1 or PAP2, the level of snoRNAs is reduced.

152 Overexpression of snoRNAs guiding modification on H69 provided a slight gr

153 This study determined expression patterns of snoRNAs in joint ageing and OA and examined them as pote

154 Profiling the expression patterns of snoRNAs is the initial step in determining their functio

155 t mice resulted in strong down-regulation of snoRNAs and reversed the prometastatic phenotype of muta

156 d loss of associated exons, but retention of snoRNAs within introns.

157 ab3-Sen1 pathway mediates the termination of snoRNAs and cryptic unstable transcripts (CUTs).

158 -independent termination of transcription of snoRNAs, however, remained unaffected in the absence of

159 f JCI, Chu et al. find that ACA11, an orphan snoRNA encoded in an intron of the WHSC1 gene, is aberra

160 or snRNAs and are therefore putative orphan snoRNAs potentially reflecting wider functions for these

161 Orphans snoRNAs are encoded outside of ribosomal protein genes a

162 ufficient to downregulate RP genes and other snoRNAs implicated in the control of oxidative stress.

163 cating Prp43 in their release, whereas other snoRNAs showed reduced preribosome association.

164 The dual polyadenylation of the precursor snoRNAs by PAPs may function to recruit the machinery es

165 ves and false negatives, allowing to predict snoRNAs with high quality.

166 increase the average lengths of preprocessed snoRNA, CUT, and SUT transcripts, while slowed Pol II tr

167 This processed snoRNA functions in alternative splice-site selection.

168 Deficiency of the paternal 15q11-q13 snoRNA HBII-85 locus is necessary to cause the neurodeve

169 rmine how Paf1C-dependent functions regulate snoRNA formation, we used high-density tiling arrays to

170 Detailed examination of Paf1-regulated snoRNA genes revealed locus-specific requirements for Pa

171 the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosoma

172 orphan box H/ACA class small nucleolar RNA (snoRNA) encoded within an intron of WHSC1, was highly ex

173 -52 and related C/D box small nucleolar RNA (snoRNA) expression units have been implicated as a cause

174 re we analyze noncoding small nucleolar RNA (snoRNA) genes in which introns, rather than exons, are t

175 spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.

176 ermination at noncoding small nucleolar RNA (snoRNA) genes.

177 upted allele of the U60 small nucleolar RNA (snoRNA) host gene, resulting in haploinsufficiency of th

178 pre-rRNA and causes U14 small nucleolar RNA (snoRNA) to remain associated with pre-rRNA.

179 the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting

180 monstrated, that the U3 small nucleolar RNA (snoRNA), a nucleolar component required for ribosome bio

181 ll nuclear RNA (snRNA), small nucleolar RNA (snoRNA), and telomerase RNA, is further hypermethylated

182 ike that of a box H/ACA small nucleolar RNA (snoRNA), with a U-rich internal loop that hybridizes to

183 333-nucleotide-long U3 small nucleolar RNA (snoRNA).

184 h the CUT and SUT classes of non-coding RNA, snoRNAs and, most prominently, pre-tRNAs and other Pol I

185 ch are guided by H/ACA small nucleolar RNAs (snoRNA).

186 cluding ribosomal RNA, small nucleolar RNAs (snoRNAs) and 7SK RNA.

187 on-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo tra

188 Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs) ar

189 cessing of a subset of small nucleolar RNAs (snoRNAs) and tRNAs transcribed by RNA polymerase (Pol) I

190 Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the p

191 ear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs) are all enriched in virions.

192 found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' proce

193 Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ri

194 Small nucleolar RNAs (snoRNAs) are emerging as an important new class of genes

195 Box C/D small nucleolar RNAs (snoRNAs) are evolutionarily conserved non-protein-coding

196 Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoprotein

197 se mRNA and identified small nucleolar RNAs (snoRNAs) as a new class of m6A-containing non-coding RNA

198 For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-And

199 Small nucleolar RNAs (snoRNAs) function mainly as guides for the post-transcri

200 Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and s

201 Small nucleolar RNAs (snoRNAs) guide nucleotide modifications of cellular RNAs

202 Most small nucleolar RNAs (snoRNAs) guide rRNA nucleotide modifications, some parti

203 evidence suggests that small nucleolar RNAs (snoRNAs) have malfunctioning roles in tumorigenesis.

204 expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic b

205 pression of miRNAs and small nucleolar RNAs (snoRNAs) in right ventricular myocardium from 16 infants

206 lipotoxic conditions, small nucleolar RNAs (snoRNAs) in the rpL13a gene accumulate in the cytosol an

207 dentified a cluster of small nucleolar RNAs (snoRNAs) that are highly up-regulated in p53 mutant tumo

208 d the expression of 80 small nucleolar RNAs (snoRNAs) using high-throughput quantitative PCR.

209 ingly, several hundred small nucleolar RNAs (snoRNAs) were identified as coilin interactors, includin

210 However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs crucial in ribosoma

211 ng small nuclear RNAs, small nucleolar RNAs (snoRNAs), cryptic unstable transcripts (CUTs), and upstr

212 coding RNAs, including small nucleolar RNAs (snoRNAs), have been identified in different organisms, w

213 known binding sites on small nucleolar RNAs (snoRNAs), pre-mRNAs and cryptic, unstable non-protein-co

214 ng microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), piwi-associated R

215 ters of genes encoding small nucleolar RNAs (snoRNAs), SNRPN through UBE3A(15q11-q13/7qC) and GTL2(14

216 NAD(+)-capped intronic small nucleolar RNAs (snoRNAs), suggesting NAD(+) caps can be added to 5'-proc

217 ic loci, which include small nucleolar RNAs (snoRNAs), transfer RNAs (tRNAs) and introns, whereas end

218 very rate </= 5%) were small nucleolar RNAs (snoRNAs).

219 a subset of associated small nucleolar RNAs (snoRNAs).

220 nation of at least two small nucleolar RNAs (snoRNAs).

221 ession of a cluster of small nucleolar RNAs (snoRNAs).

222 re two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs

223 XF1, decreases or increases cytosolic Rpl13a snoRNAs, respectively.

224 Islets from mice lacking Rpl13a snoRNAs demonstrated blunted oxidative stress responses.

225 Loss of Rpl13a snoRNAs altered mitochondrial metabolism and lowered rea

226 inishes cytosolic localization of the Rpl13a snoRNAs through a mechanism that is dependent on NXF3 bu

227 rapid cytoplasmic accumulation of the Rpl13a snoRNAs through a mechanism that requires superoxide and

228 ow that NXF3 associates not only with Rpl13a snoRNAs, but also with a broad range of box C/D and box

229 expressing only catalytic point mutants, six snoRNAs that guide modifications close to helix 34 accum

230 ough controlling both mRNA elongation and sn/snoRNA synthesis, the 7SK snRNP is a key regulator of nu

231 nes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal clus

232 its RNAPII recruitment to RNAPII-specific sn/snoRNA genes, and reduces nascent snRNA and snoRNA synth

233 nents of the 7SK snRNP on RNAPII-specific sn/snoRNA genes.

234 usters and suppresses the expression of U sn/snoRNA and histone genes.

235 o a 108 kb region that includes the SNORD116 snoRNA cluster and the Imprinted in Prader-Willi (IPW) n

236 The SNORD50A-SNORD50B snoRNA locus was deleted in 10-40% of 12 common cancers,

237 SNORD50A and SNORD50B snoRNAs thus directly bind and inhibit K-Ras and are rec

238 However, for the snR13 snoRNA the unusual C/D motif and extra base-pairing, whi

239 domain and functions together with the snR30 snoRNA, while human hUTP23 is associated with U17, the h

240 Utp23 interacts with the 3 half of the snR30 snoRNA.

241 -subclasses that exist in eukaryotes: snRNA, snoRNA, RNase P, RNase MRP, Y RNA or telomerase RNA.

242 trons and various RNA classes (ncRNA, snRNA, snoRNA) and less variability after degradation.

243 Surprisingly, at some snoRNAs, this function of Rad6 appears to be primarily i

244 f FGFR3 pre-mRNA, supporting a role for some snoRNAs in the regulation of splicing.

245 The levels of all seven tested snoRNA/scaRNAs and four snRNAs were reduced by 80-95%, a

246 We demonstrate that snoRNA expression analysis may be useful in both the dia

247 We show that snoRNA expression and the abundance of snoRNA-containing

248 Our results suggest that snoRNA expression profiles may have a diagnostic and pro

249 s are also present in the cytoplasm and that snoRNAs move between the nucleus and cytoplasm by a mech

250 d cells, followed by RT-qPCR, confirmed that snoRNAs were enriched in PKRWT samples after PA treatmen

251 s, a growing body of evidence indicates that snoRNAs are also present in the cytoplasm and that snoRN

252 We report that snoRNAs and fibrillarin (FBL, an enzymatic small nucleol

253 These findings suggest that snoRNAs may orchestrate the response to environmental st

254 target prediction methods we re-estimate the snoRNA target RNA interaction network.

255 terminal C/D and internal C/D motifs in the snoRNA, adjacent to the guide region, function as bindin

256 MBII-52, but a processed version lacking the snoRNA stem is the predominant MBII-52 RNA missing in PW

257 l types shows a dramatic perturbation of the snoRNA expression profile.

258 ctivities involve direct base-pairing of the snoRNA with pre-rRNA using different domains.

259 ovides novel insights into the extent of the snoRNA-rRNA interactions required for efficient methylat

260 In the present study, the snoRNA signature was robust enough to differentiate anap

261 Together, the results suggest that the snoRNA hairpins function in a coordinated manner and tha

262 Major substrates of PAP1 are the snoRNAs and lncRNAs.

263 erns in fetal myocardium, especially for the snoRNAs.

264 he nucleolar localization of a number of the snoRNAs and the localization to nuclear bodies of two pu

265 sslinked to sequences flanking A2 and to the snoRNAs U3, U14, snR30, and snR10, which are required fo

266 These snoRNAs primarily interact with Fip1, a component of cle

267 ach case, the internal C/D motifs from these snoRNAs differ from the consensus.

268 Loss of these snoRNAs also increased binding by farnesyltransferase to

269 have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich S

270 This snoRNA (snR10) contains canonical 5'- and 3'-hairpin str

271 n 750 curated genomic loci that give rise to snoRNA and snoRNA-like genes.

272 essential for high-affinity Nop58 binding to snoRNAs.

273 ential for the recruitment of the exosome to snoRNAs and to human telomerase RNA.

274 e sequential recruitment of core proteins to snoRNAs.

275 ely expressed non-coding RNAs such as tRNAs, snoRNAs, rRNAs and snRNAs preferentially produce small 5

276 ional preference for small RNA genes (tRNAs, snoRNAs and snRNAs) suggesting a putative role for RNA i

277 Of particular interest are U snoRNA host genes (Uhgs), a family of diurnal cycling no

278 ponents has significant consequences for U14 snoRNA dynamics.

279 e Mpp10 protein inhibited the release of U14 snoRNA from pre-rRNA, just as was seen with Dbp4-deplete

280 lays an important role in the release of U14 snoRNA from pre-rRNA.

281 s associated with U3 snoRNA but not with U14 snoRNA.

282 as an RNA duplex formed by the 5' ETS and U3 snoRNA as well as the 3' boundary of the 18S rRNA.

283 In eukaryotic ribosome biogenesis, U3 snoRNA base pairs with the pre-rRNA to promote its proce

284 t growth is restored when a complementary U3 snoRNA is expressed.

285 dient analyses revealed that depletion of U3 snoRNA or the Mpp10 protein inhibited the release of U14

286 nucleotide reactivity, we found that the U3 snoRNA is indeed required for folding of the pre-18S rRN

287 oth cleavages require base-pairing by the U3 snoRNA to the central pseudoknot elements of the 18S rRN

288 kely the initial anchor that recruits the U3 snoRNA to the pre-rRNA, is a prerequisite for the subseq

289 the requirement of binding sites for the U3 snoRNA, it showed that a large segment of the 5' externa

290 tinin (HA)-tagged Dbp4 is associated with U3 snoRNA but not with U14 snoRNA.

291 rRNA in the A1 mutant suggests that the U60 snoRNA modulates cholesterol trafficking by a mechanism

292 tion and mutational studies revealed the U60 snoRNA to be the essential feature from this locus that

293 features of ribosome maturation, such as U8 snoRNA-assisted processing of the 5.8S and 28S rRNA prec

294 it complexes and promotes displacement of U8 snoRNA from pre-rRNA, which is necessary for the removal

295 2.5 angstrom resolution reveals that unlike snoRNAs, the U-rich loop of the ENE engages its target t

296 we demonstrated PKR activation in cells upon snoRNA transfection, supporting our hypothesis that endo

297 affecting expression of the host genes where snoRNAs are embedded in the introns, nor affecting the l

298 n unprecedented and unexpected model whereby snoRNAs play a role in the activation of PKR under metab

299 Four yeast snoRNAs are unusual in that they are predicted to methyl

300 mal and other abundant RNAs, including yeast snoRNAs, the RNA subunit of the signal recognition parti