ライフサイエンスコーパス: social defeat

1 e resident-intruder model for social stress (social defeat).

2 d immobility in the forced swim test, as did social defeat.

3 ojections mimicked the behavioral effects of social defeat.

4 th addiction and depression models including social defeat.

5 d decreased neurogenesis are consequences of social defeat.

6 conomic status) and mice subject to repeated social defeat.

7 red for restoration of normal behavior after social defeat.

8 ls, none of these molecules were affected by social defeat.

9 precipitating the depressive phenotype after social defeat.

10 that were susceptible, but not resilient to social defeat.

11 scimol on aggression were dependent on prior social defeat.

12 ith a novel intruder 24 hours after an acute social defeat.

13 or not a hamster has previously experienced social defeat.

14 gs of miniature EPSCs (mEPSCs) in mice after social defeat.

15 an increase in the frequency of mEPSCs after social defeat.

16 TLR4) and macrophages (CD14 and CD86) after social defeat.

17 e to reverse behavioral pathology induced by social defeat.

18 al warm temperature also was evaluated after social defeat.

19 nhances the activation of orexin cells after social defeat.

20 t make some mice resistant to the effects of social defeat.

21 changes in cholecystokinin (CCK-8) following social defeat.

22 NST to modulate agonistic behavior following social defeat.

23 n male and female California mice exposed to social defeat.

24 no effect was observed on other symptoms of social defeat.

25 d signaling molecules in response to chronic social defeat, 2) brain reward function during social de

26 o subthreshold stress (i.e., single cycle of social defeat) 24 days after RSD, and immune and behavio

27 DRN GABA and 5-HT neurons in mice exposed to social defeat, a model that induces long-lasting avoidan

28 ses in IkappaB kinase (IKK) in the NAc after social defeat, a molecular pathway that has been shown t

29 Repeated social defeat also increased the presence of deramified

30 Repeated social defeat also significantly increased the number of

31 about how a behavioral interaction, such as social defeat, alters the development of adaptive immuni

32 Here we show that social defeat, although not producing depression by itse

33 on during the circadian peak, adrenalectomy, social defeat and acute injections of alcohol on these c

34 social avoidance in mice exposed to chronic social defeat and concurrently prevented the electrophys

35 Importantly, for both social defeat and environmental enrichment, how glucocor

36 day), and 3) forced swim test behavior after social defeat and fluoxetine treatment.

37 cial defeat, 2) brain reward function during social defeat and long-term treatment with the antidepre

38 These effects emerge after social defeat and require Oxtr specifically coupled to t

39 in neurogenesis drive changes in mood after social defeat and that glucocorticoids secreted during e

40 te) granulocytes in mice subject to repeated social defeat, and these effects were blocked by pharmac

41 In contrast, MS180 rats exposed to social defeat as adults had increased slc6a4 mRNA expres

42 ults highlight more robust CCK modulation by social defeat as compared with 3 other neuropeptide syst

43 substitution to study social affiliation and social defeat behaviors.

44 ce that are repeatedly subjected to bouts of social defeat by a larger and aggressive CD-1 mouse resu

45 at an inbred population of mice subjected to social defeat can be separated into susceptible and unsu

46 Social defeat caused a weakening of functional connectiv

47 ignificant increase in cold preference after social defeat compared to the baseline.

48 ffected with MDD and rats exposed to chronic social defeat (CSD) stress, which is used to model depre

49 missive behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent soci

50 cial disruption (SDR) that involves repeated social defeat during intermale aggression results in inc

51 Our results revealed that social defeat engaged DRN GABA neurons and drove GABAerg

52 mygdala (BLA) of animals that are exposed to social defeat enhances subsequent defeat-induced changes

53 ol group, and active coping behaviors during social defeat episodes were associated with subsequent r

54 to chronic unpredictable stress and chronic social defeat exhibit low leptin levels in plasma.

55 caine seeking in stressed animals long after social defeat exposure.

56 Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a

57 hibited an increase in BDNF levels following social defeat, HR individuals did not.

58 According to the social defeat hypothesis, the long-term experience of ex

59 Protection from social defeat in G-allele carriers was associated with a

60 Acute social defeat in mice activates the hypothalamic-pituita

61 ere we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribut

62 Here we show that repeated social defeat in mice increased c-Fos staining in brain

63 ents compared behavioral effects of repeated social defeat in mice with forebrain GR deletion and in

64 Subthreshold social defeat in RSD-sensitized mice increased periphera

65 R), a social stressor that involves repeated social defeat in subordinate mice.

66 Furthermore, social defeat increased anxiety-like behavior and caused

67 Single or repeated social defeat increased both brain and plasma concentrat

68 Last, repeated social defeat increased c-Fos activation in IL-1 recepto

69 nalysis of microglia indicated that repeated social defeat increased levels of interleukin (IL)-1beta

70 Social defeat increased slc6a4 mRNA expression, but only

71 Moreover, subthreshold social defeat increased social avoidance in RSD-sensitiz

72 These findings indicate that repeated social defeat-induced anxiety-like behavior and enhanced

73 (mPFC) neuronal activity is associated with social defeat-induced depression- and anxiety-like behav

74 Repeated social defeat-induced macrophage recruitment to the brai

75 bition of Rac1 activity in the NAc increases social defeat-induced social avoidance and anhedonia in

76 e gyrus of the hippocampus of LR rats led to social defeat-induced social avoidance, whereas its acti

77 Social defeat induces long-lasting increases in OT produ

78 The combined data suggest that chronic social defeat induces molecular changes that reduce myel

79 Social defeat is a powerful experience that often leads

80 activation of IKK signaling pathways during social defeat is both necessary and sufficient to induce

81 Conditioned defeat is a social defeat model in Syrian hamsters in which individu

82 A robust female social defeat model is a critical first step in the iden

83 In the social defeat model of chronic stress, calorie restricti

84 Ac), a key brain reward region, in the mouse social defeat model of depression.

85 ute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflamm

86 In the social defeat model, we observed further that many of th

87 The ES mice were exposed to the social defeat of a PS mouse by a larger, more aggressive

88 e examined acute and long-lasting effects of social defeat on OT neurons in male and female Californi

89 with or without subsequent exposure to adult social defeat on slc6a4 mRNA expression in the dorsal ra

90 ogically relevant stressor, namely threat of social defeat, on dopamine concentrations in nucleus acc

91 ts robust antidepressant-like effects in the social defeat paradigm and other behavioral assays.

92 We report a new version of the social defeat paradigm that works in female mice.

93 tine's antidepressant effects in the chronic social defeat paradigm, whereas inhibition of CaMKII act

94 decreased resilience to repeated stress in a social defeat paradigm.

95 and MS-275, in the tail suspension test and social defeat paradigm.

96 C57BL/6 mice by subjecting them to a 10-day social defeat paradigm.

97 ne neurons of mice undergoing a subthreshold social-defeat paradigm rapidly induced a susceptible phe

98 expression, reveals clear differences in the social defeat phenotype induced by Fosb gene manipulatio

99 the pVTA and CRF-R2 in the aVTA during each social defeat prevented escalated cocaine self-administr

100 demonstrates that the experience of repeated social defeat prior to a primary viral infection signifi

101 c stress, mice were subjected to the chronic social defeat procedure.

102 In Syrian hamsters (Mesocricetus auratus), social defeat produces a subsequent increase in submissi

103 Our results suggest that adolescent social defeat produces both deficits in anxiety response

104 We tested whether chronic social defeat produces structural alterations in the mPF

105 Social defeat profoundly and persistently decreased brai

106 At the end of the social defeat protocol, body weights, food and water int

107 In the ventral tegmental area, social defeat, regardless of susceptibility or resilienc

108 Despite social defeats, resilient mice with normal sociability s

109 In Syrian hamsters, even a single social defeat results in conditioned defeat, which inclu

110 Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitizatio

111 Our previous work using repeated social defeat (RSD) in mice showed that recruitment of p

112 Repeated social defeat (RSD) is a murine stressor that primes per

113 Repeated social defeat (RSD) is a murine stressor that recapitula

114 In a model of repeated social defeat (RSD), elevated IL-1beta expression in the

115 Using a chronic social defeat (SD) stress model, learned helplessness (L

116 ehavioral analysis confirmed that the 14-day social defeat sessions resulted in induction of depressi

117 ed for thermal preference after 5 successive social defeat sessions.

118 Mice adrenalectomized before social defeat showed enhanced behavioral resiliency and

119 e socially avoidant by the stress of chronic social defeats showed depressed neural activity in the l

120 inistration of cocaine immediately following social defeat significantly reduced the number of Fos-LI

121 rate that adult mice which underwent chronic social defeat stress (CSDS) displayed elevated anxiety-l

122 Exposure of Ghsr-null mice to chronic social defeat stress (CSDS) elicits more severe depressi

123 Chronic social defeat stress (CSDS) is a well-established rodent

124 nt-like activity of vmPFC DBS in the chronic social defeat stress (CSDS) model of depression (n = 8-1

125 Chronic social defeat stress (CSDS) produces persistent behavior

126 monitored in mice after exposure to chronic social defeat stress (CSDS), a model of prolonged psycho

127 educed in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces be

128 Here we examined the effects of chronic social defeat stress (CSDS), an ethological form of stre

129 an subjects and in mice subjected to chronic social defeat stress (CSDS).

130 osome transgenic mice that underwent chronic social defeat stress (CSDS).

131 ts to NAc regulate susceptibility to chronic social defeat stress (CSDS).

132 was microinjected into the VTA 20 min before social defeat stress (or handling) on days 1, 4, 7, and

133 Repeated social defeat stress (R-SDS) reduces the expression of D

134 ter exposure to either subthreshold repeated social defeat stress (RSDS) or a purely emotional stress

135 Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological

136 Single social defeat stress (S-SDS) induces D1 receptor-mediate

137 ubmissive behavioral traits developed during social defeat stress (SD).

138 Using social defeat stress (SDS) in mice, here we identified a

139 iciency leads to increased susceptibility to social defeat stress (SDS), a model of psychosocial stre

140 ed enhanced susceptibility to a subthreshold social defeat stress (SSDS) as observed by reduced socia

141 We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CA

142 We hypothesized that chronic social defeat stress alters synaptic strength or connect

143 a2 subunit knockdown decreased resilience to social defeat stress and c-fos immunoreactivity in the B

144 tal period increases susceptibility to adult social defeat stress and causes long-lasting transcripti

145 oth the decrease in Rac1 transcription after social defeat stress and depression-related behavior, su

146 r, we find that female mice undergo repeated social defeat stress and develop social avoidance, decre

147 Both social defeat stress and environmental enrichment stimul

148 VL function renders mice more susceptible to social defeat stress and promotes depression-like behavi

149 e-induced behaviors, indicating that chronic social defeat stress and repeated cocaine exposure regul

150 e exposed mice to chronic cocaine or chronic social defeat stress and used two-photon laser scanning

151 C57BL/6 mice underwent 10 days of social defeat stress and were subsequently tested for so

152 nd those susceptible or resilient to chronic social defeat stress at multiple time points.

153 rring transcriptional phenomena that control social defeat stress behavior.

154 Episodic social defeat stress consists of four brief confrontatio

155 Here we show that chronic social defeat stress decreases messenger RNA and protein

156 Our results suggest that experience of social defeat stress during adolescent development can c

157 tudy, the authors investigated the impact of social defeat stress during mid-adolescence on adult mal

158 ult male rats previously exposed to repeated social defeat stress during mid-adolescence.

159 Intermittent social defeat stress escalates later cocaine self-admini

160 Mice subjected to chronic social defeat stress exhibited similar reductions in lev

161 tidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a t

162 D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artif

163 resent study, we investigated the effects of social defeat stress in male rats on the operant escape

164 Here we show that repeated social defeat stress in mice activated threat appraisal

165 We have recently validated chronic social defeat stress in mice as a model in which a depre

166 We find that chronic social defeat stress in mice causes a transient decrease

167 Chronic social defeat stress in mice produces a susceptible phen

168 We show that chronic social defeat stress in mice produces progressive altera

169 Here, we show that repeated social defeat stress in rats causes persistent enhanceme

170 Chronic social defeat stress increased hyperpolarization-activat

171 Additionally, chronic social defeat stress induces a prolonged reduction in th

172 h wild-type mice; and 5) exposure to chronic social defeat stress induces blood glucocorticoids and a

173 Intermittent social defeat stress induces both locomotor and dopamine

174 Social defeat stress induces persistent cross-sensitizat

175 Chronic social defeat stress induces the formation of stubby exc

176 rainstem structures after a brief episode of social defeat stress is related to behavioral sensitizat

177 this study we show that a single episode of social defeat stress is sufficient to specifically induc

178 In a social defeat stress model of depression, depressed (sus

179 In the chronic social defeat stress model of depression, we report that

180 Using a chronic social defeat stress model, we explored whether the susc

181 Chronic social defeat stress of mice increases IkappaK activity

182 1, 14, 17, and 20, animals were subjected to social defeat stress or a nonstressful control condition

183 at DeltaFosB is induced in NAc after chronic social defeat stress or after chronic antidepressant tre

184 a separate group of rats underwent a single social defeat stress or control handling and were challe

185 ue-Dawley rats underwent a single episode of social defeat stress or control handling, followed by am

186 Lymphocytes from mice undergoing chronic social defeat stress or from unstressed control mice wer

187 d cocaine administration prior to subchronic social defeat stress potentiated depressive-like behavio

188 and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.

189 Social defeat stress produced social avoidance (a model

190 Chronic social defeat stress regulates the expression of Fosb in

191 enhanced alcohol consumption in response to social defeat stress relative to their wild-type litterm

192 Repeated social defeat stress resulted in repeated episodes of dr

193 active Rac1 in the NAc of mice after chronic social defeat stress reverses depression-related behavio

194 entate gyrus neurogenesis is increased after social defeat stress selectively in mice that display pe

195 velop depressive-like symptoms after chronic social defeat stress show distinct changes in the activi

196 Here, we show that chronic (10 d) social defeat stress significantly increased the in vivo

197 rd-associated region, in response to chronic social defeat stress was both necessary and sufficient f

198 Mice subjected to chronic social defeat stress were stratified into resilient and

199 We investigated the effect of chronic social defeat stress, a mouse model of depression, on bl

200 efrontal cortex (mPFC) of mice after chronic social defeat stress, a mouse model of depression.

201 Moreover, chronic social defeat stress, a rodent model of depression, pers

202 sant, ketamine, in mice subjected to chronic social defeat stress, a validated depression model, and

203 Using chronic social defeat stress, an animal model of mood and anxiet

204 We found that chronic social defeat stress, an animal model recapitulating som

205 induced relapse to cocaine use in rats using social defeat stress, an ethologically valid psychosocia

206 In the present study, we show that chronic social defeat stress, an ethologically validated model o

207 We applied chronic social defeat stress, an ethologically validated mouse m

208 and synaptic results were obtained following social defeat stress, and intracerebroventricular inject

209 gia (NIH), novelty-suppressed feeding (NSF), social defeat stress, and learned helplessness.

210 electively in susceptible mice after chronic social defeat stress, and overexpression of DeltaFosB in

211 vivo, ACY-738 promoted resilience to chronic social defeat stress, and serotonin-selective viral over

212 In a murine model of acute social defeat stress, Asb1 gene expression was significa

213 After chronic social defeat stress, chronic administration of imiprami

214 downregulated in NAc of mice susceptible to social defeat stress, effects not seen in resilient mice

215 (P70), reactivity to aversive stimuli (i.e., social defeat stress, forced swimming, and elevated plus

216 Mice resilient to social defeat stress, however, exhibit stable normal fir

217 rimental approaches for studying depression, social defeat stress, in particular, has been shown to h

218 the induction of depressive-like symptoms by social defeat stress, low-novelty-seeking rats [low resp

219 After chronic social defeat stress, resilient animals displayed an upr

220 yed increased susceptibility to subthreshold social defeat stress, suggesting that neuronal VGF, expr

221 ctrophysiological adaptations in response to social defeat stress, which are normalized by antidepres

222 course of cross-sensitization after a single social defeat stress, which normally produces transient

223 males as one commonly used paradigm-chronic social defeat stress-has proven challenging to implement

224 K signaling results in a reversal of chronic social defeat stress-induced social avoidance behavior.

225 eptor containing MSNs of mice susceptible to social defeat stress.

226 behavioral abnormalities seen after chronic social defeat stress.

227 ty to stress using a murine model of chronic social defeat stress.

228 thin the ventral tegmental area (VTA) during social defeat stress.

229 substrate 1 (Rac1) expression after chronic social defeat stress.

230 ke inhibitor antidepressant, fluoxetine; and social defeat stress.

231 spine morphology in mice undergoing an acute social defeat stress.

232 depressive-like behaviors induced by chronic social defeat stress.

233 ve mutant of GSK3beta promoted resilience to social defeat stress.

234 regulation of this pathway in the NAc due to social defeat stress.

235 oral susceptibility vs resilience to chronic social defeat stress.

236 ey behavioral abnormality induced by chronic social defeat stress.

237 ens (NAc) by chronic cocaine use and chronic social defeat stress.

238 patients and in mice chronically exposed to social defeat stress.

239 reverse translated in a mouse model of acute social defeat stress.

240 (40 mg/kg, i.p.) immediately or 1 week after social defeat stress.

241 Fosb gene in NAc regulates susceptibility to social defeat stress.

242 d in the NAc of resilient mice after chronic social defeat stress.

243 rons prevents social avoidance after chronic social defeat stress.

244 ours of cocaine withdrawal and after chronic social defeat stress.

245 lf-administration, and resilience to chronic social defeat stress.

246 uding in vivo recordings in mice and chronic social defeat stress.

247 mice and mice that are resilient to chronic social defeat stress.

248 phe nucleus of vulnerable mice after chronic social defeat stress.

249 uces social avoidance following subthreshold social defeat stress.

250 l mediator of depression-related outcomes to social defeat stress.

251 increases after mice are exposed to chronic social defeat stress.

252 of these neurons mediates susceptibility to social-defeat stress in freely behaving mice.

253 in levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlat

254 e reward signals, is upregulated by repeated social-defeat stress, a highly validated mouse model of

255 tal cortex (mPFC), induced susceptibility to social-defeat stress.

256 ent mice that had been subjected to repeated social-defeat stress.

257 Immediately after social defeat, stress-exposed mice (irrespective of whet

258 n this model, hamsters that have experienced social defeat subsequently display only submissive-defen

259 class III histone deacetylase, after chronic social defeat suggest a role for this enzyme in mediatin

260 as MDL 11,939 blocks 5-HT2A receptors during social defeat to disrupt the development of the conditio

261 , or 2.0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat te

262 , or 3.0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat te

263 h SHI reported experiencing more feelings of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=

264 Brains harvested 6 hr after social defeat were dissected into 12 regions (olfactory

265 on in all regions studied in mice 24 h after social defeat when compared to control (naive) mice (P<0

266 antagonist directly into the VTA before each social defeat would prevent the development of later (1)